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[193584_s_at] Peptidyl-prolyl cis-trans isomerases

Description ZK520.5 /REP_DB=WormBase Gene ID /WP=CE16730 /GEN=cyp-7 /TR=O46022 /GB=CAB07303.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Peptidyl-prolyl cis-trans isomerases
Cluster 6grp_total > 87      4grp_total > 0      6grp_cgc > 58      6grp_cgc_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 64
1 2 3 4 range
A 5.6
(-3)
A 		5.7
(-3)
A 		36.3
(3)
A 		15.9
(-1)
A 		31
B 25.5
(0.1)
A 		3.2
(-3)
A 		28.9
(0.6)
A 		45.9
(3)
A 		43
C 10.3
(-2.6)
A 		5.7
(-3)
A 		10.6
(-2.5)
A 		67.6
(3)
A 		62
avr 13.8
(-1.6) 		4.9
(-3) 		25.3
(0.2) 		43.1
(3) 		38

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 138
1 2 3 4 5 6 range
A 3.2
(-3)
A 		3.3
(-3)
A 		6.4
(-2.8)
A 		10.6
(-2.6)
A 		40
(-1.2)
A 		123.7
(3)
A 		121
B 6.3
(-3)
A 		34
(-1.8)
A 		6.2
(-3)
A 		7.2
(-3)
A 		88.3
(0.7)
A 		140.6
(3)
A 		134
C 2.2
(-3)
A 		17.5
(-2.2)
A 		32.9
(-1.4)
A 		40.1
(-1)
A 		44
(-0.8)
A 		114.3
(3)
A 		112
avr 3.9
(-3) 		18.3
(-2.3) 		15.2
(-2.4) 		19.3
(-2.2) 		57.4
(-0.4) 		126.2
(3) 		122
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 11
1 2 3 4 range
A 2.1
(-2.3)
A 		1.2
(-3)
A 		9.5
(3)
A 		2.3
(-2.2)
A 		8
B 8.1
(1.9)
A 		0.8
(-3)
A 		6.7
(0.9)
A 		9.8
(3)
A 		9
C 3.4
(-1.9)
A 		1.6
(-3)
A 		3.7
(-1.7)
A 		11.4
(3)
A 		10
avr 4.5
(0) 		1.2
(-3) 		6.6
(1.9) 		7.8
(3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 52
1 2 3 4 5 6 range
A 0.6
(-3)
A 		1.2
(-2.9)
A 		1.4
(-2.8)
A 		2.7
(-2.6)
A 		12.1
(-0.7)
A 		30.1
(3)
A 		30
B 2.2
(-2.9)
A 		11.3
(-1.8)
A 		1.5
(-3)
A 		1.9
(-3)
A 		35.9
(1.1)
A 		52.4
(3)
A 		51
C 0.8
(-3)
A 		5.4
(-2.3)
A 		8.4
(-1.8)
A 		8.1
(-1.8)
A 		14.2
(-0.9)
A 		38.3
(3)
A 		38
avr 1.2
(-3) 		6
(-2.3) 		3.8
(-2.6) 		4.2
(-2.5) 		20.7
(-0) 		40.3
(3) 		39
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193584_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7521
Sequence Type Exemplar sequence
Representative Public ID ZK520.5 NCBI
Target Description ZK520.5 /REP_DB=WormBase Gene ID /WP=CE16730 /GEN=cyp-7 /TR=O46022 /GB=CAB07303.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Peptidyl-prolyl cis-trans isomerases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067427(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067427 NCBI Caenorhabditis elegans CYclophyliN family member (cyn-2) (cyn-2) mRNA, complete cds. 11/11 A 
SNAP00000038075 ENSEMBL cdna:SNAP chromosome:CEL140:III:13692248:13693207:1 11/11 None
GENEFINDER00000038080 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13692248:13693207:1 11/11 None
ZK520.5.2 ENSEMBL cdna:known chromosome:CEL140:III:13692232:13693327:1 gene:ZK520.5 11/11 None
ZK520.5.1 ENSEMBL cdna:known chromosome:CEL140:III:13692232:13693266:1 gene:ZK520.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13692243-13693203(+) 100.0 100.0
Public Domain and Genome References
Gene Title Peptidyl-prolyl cis-trans isomerases
Gene Symbol cyn-2
Ensembl ZK520.5
Entrez Gene 176807 Entrez gene
SwissProt P52010 EMBL-EBI
WormBase CE16730 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:18556_AT peptidyl-prolyl cis-trans isomerase / cyclophilin (CYP2) / rotamase at
ATH1-121501:264019_AT peptidyl-prolyl cis-trans isomerase / cyclophilin (CYP2) / rotamase at
CANINE:1582729_S_AT peptidylprolyl isomerase A cfa
CANINE:1597888_AT peptidylprolyl isomerase A cfa
CANINE:1584943_AT peptidylprolyl isomerase A cfa
CANINE_2:CFA.16324.1.S1_S_AT peptidylprolyl isomerase A cfa
CANINE_2:CFA.7255.1.A1_AT Peptidylprolyl isomerase A cfa
CANINE:1593000_AT Peptidylprolyl isomerase A cfa
CANINE:1594275_X_AT Peptidylprolyl isomerase A cfa
CANINE:1594276_S_AT Peptidylprolyl isomerase A cfa
CANINE:1594277_X_AT Peptidylprolyl isomerase A cfa
CANINE:1595775_S_AT Peptidylprolyl isomerase A cfa
CANINE:1584404_AT Peptidylprolyl isomerase A cfa
DROSOPHILA_2:1631760_AT dm
DROSGENOME1:153219_AT dm
DROSOPHILA_2:1639564_A_AT dm
MU11KSUBB:MSA.42241.0_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.41209.0_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.38219.0_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.36304.0_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:X52803_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.21737.0_F_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.25769.0_F_AT peptidylprolyl isomerase A mm
MG-U74AV2:101207_AT peptidylprolyl isomerase A mm
MOE430A:1417451_A_AT peptidylprolyl isomerase A mm
MOUSE430A_2:1417451_A_AT peptidylprolyl isomerase A mm
MOUSE430_2:1417451_A_AT peptidylprolyl isomerase A mm
MU11KSUBB:MSA.16287.0_F_AT Peptidylprolyl isomerase A (Ppia), mRNA mm
MU11KSUBB:MSA.29538.0_F_AT Peptidylprolyl isomerase A (Ppia), mRNA mm
MU19KSUBC:TC39396_F_AT Peptidylprolyl isomerase A (Ppia), mRNA mm
RT-U34:RC_AA818858_S_AT peptidylprolyl isomerase A rn
RG-U34A:RC_AA818858_S_AT peptidylprolyl isomerase A rn
RT-U34:M19533MRNA_I_AT peptidylprolyl isomerase A rn
RG-U34A:M19533MRNA_I_AT peptidylprolyl isomerase A rn
RT-U34:RC_AI228674_S_AT peptidylprolyl isomerase A rn
RG-U34A:RC_AI228674_S_AT peptidylprolyl isomerase A rn
RAE230A:1398850_AT peptidylprolyl isomerase A rn
RAT230_2:1398850_AT peptidylprolyl isomerase A rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6457 protein folding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07303 Hypothetical protein ZK520.5 [Caenorhabditis elegans] ref|NP_499828.1| CYclophyliN family member (cyn-2) [Caenorhabditis elegans] sp|P52010|CYP2_CAEEL Peptidyl-prolyl cis-trans isomerase 2 (PPIase) (Rotamase) (Cyclophilin-2) pir||T27882 peptidylprolyl isomerase (EC 5.2.1.8) ZK520.5 [similarity] - Caenorhabditis elegans 2.0E-75
blast AAC47127 cyclophilin isoform 2 (cyp-2) 4.0E-73
Protein Domains
Database ID Description E-Value
Pfam IPR002130 EMBL-EBI Peptidyl-prolyl cis-trans isomerase, cyclophilin type 2.4E-116
Sequence
Target Sequence 
>C. ELEGANS:193584_S_AT
gaaacggcaccggcggagaatcgattcatggcgagaagtttgacgacgagaacttcaagg
agaagcataccggacccggagtcttgtcgatggcaaactgtggggcgaacacaaacggct
cgcaattcttcctgtgcacagtcaaaaccacgtggctagacggaaaacacgtggttttcg
gcaaagtgatcgaaggaatggatgtggtgaaggcgatcgagtcgaaaggatccgaagatg
gggcaccgtcg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAACGGCACCGGCGGAGAATCGAT 444 355 242 Antisense
GTCGATGGCAAACTGTGGGGCGAAC 108 473 327 Antisense
GTGGGGCGAACACAAACGGCTCGCA 669 451 341 Antisense
AACACAAACGGCTCGCAATTCTTCC 497 133 349 Antisense
GCAATTCTTCCTGTGCACAGTCAAA 322 323 363 Antisense
CAGTCAAAACCACGTGGCTAGACGG 390 199 380 Antisense
GTGGCTAGACGGAAAACACGTGGTT 421 485 393 Antisense
ACACGTGGTTTTCGGCAAAGTGATC 483 101 408 Antisense
GGATGTGGTGAAGGCGATCGAGTCG 669 513 441 Antisense
GGCGATCGAGTCGAAAGGATCCGAA 71 543 453 Antisense
AGGATCCGAAGATGGGGCACCGTCG 311 1 468 Antisense
Sequence Source Affymetrix Proprietary Database