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[193579_at] Src homology domain 2, tyrosine-protein kinase

Description Y43C5B.2 /REP_DB=WormBase Gene ID /WP=CE19157 /TR=Q9XXE5 /GB=CAA19511.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase
Cluster 6grp_total > 99      4grp_total > 12      6grp_total_sub > Increase      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 130
1 2 3 4 range
A 23.4
(-1)
A 		18
(-1.7)
A 		9.1
(-3)
A 		51.3
(3)
A 		42
B 32.3
(-0.9)
A 		18.5
(-2)
A 		6.1
(-3)
A 		79.4
(3)
P 		73
C 18.9
(-2.7)
A 		21
(-2.6)
A 		12.6
(-3)
A 		136
(3)
P 		123
avr 24.9
(-1.8) 		19.2
(-2.3) 		9.3
(-3) 		88.9
(3) 		80

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 154
1 2 3 4 5 6 range
A 37.2
(-2.6)
A 		28.9
(-3)
A 		46.9
(-2.2)
P 		42.4
(-2.4)
A 		159.1
(3)
P 		104.1
(0.5)
P 		130
B 18.6
(-2.4)
A 		49
(-1.1)
A 		4.9
(-3)
A 		11.7
(-2.7)
A 		108.6
(1.4)
P 		145.7
(3)
P 		141
C 18.8
(-3)
A 		74.4
(-0.3)
P 		43.5
(-1.8)
A 		98.3
(0.8)
A 		92.9
(0.6)
P 		143.7
(3)
P 		125
avr 24.9
(-3) 		50.8
(-1.5) 		31.8
(-2.6) 		50.8
(-1.5) 		120.2
(2.4) 		131.2
(3) 		106
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 22
1 2 3 4 range
A 8.5
(3)
A 		3.9
(-1.5)
A 		2.4
(-3)
A 		7.5
(2)
A 		6
B 10.3
(0.4)
A 		4.6
(-1.8)
A 		1.4
(-3)
A 		16.9
(3)
P 		16
C 6.3
(-2.4)
A 		6
(-2.5)
A 		4.4
(-3)
A 		22.9
(3)
P 		19
avr 8.4
(-0.4) 		4.8
(-2) 		2.7
(-3) 		15.8
(3) 		13

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 53
1 2 3 4 5 6 range
A 6.9
(-3)
A 		10.3
(-2.5)
A 		10.2
(-2.5)
P 		10.8
(-2.4)
A 		48
(3)
P 		25.3
(-0.3)
P 		41
B 6.5
(-2.4)
A 		16.3
(-1.3)
A 		1.2
(-3)
A 		3.1
(-2.8)
A 		44.1
(1.8)
P 		54.3
(3)
P 		53
C 7
(-3)
A 		22.7
(-0.7)
P 		11.1
(-2.4)
A 		19.8
(-1.1)
A 		30.1
(0.4)
P 		48.1
(3)
P 		41
avr 6.8
(-3) 		16.4
(-1.4) 		7.5
(-2.9) 		11.2
(-2.3) 		40.7
(2.7) 		42.6
(3) 		36
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193579_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9575
Sequence Type Exemplar sequence
Representative Public ID Y43C5B.2 NCBI
Target Description Y43C5B.2 /REP_DB=WormBase Gene ID /WP=CE19157 /TR=Q9XXE5 /GB=CAA19511.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069506(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069506 NCBI Caenorhabditis elegans Y43C5B.2 (Y43C5B.2) mRNA, complete cds. 11/11 None
SNAP00000005325 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10351417:10352254:-1 11/11 None
Y43C5B.2 ENSEMBL cdna:known chromosome:CEL140:IV:10351417:10352254:-1 gene:Y43C5B.2 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000005328 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10351422-10352260(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, tyrosine-protein kinase
Ensembl Y43C5B.2
Entrez Gene 189849 Entrez gene
SwissProt Q9XXE5 EMBL-EBI
WormBase CE19157 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA19511 Hypothetical protein Y43C5B.2 [Caenorhabditis elegans] ref|NP_501907.1| Y43C5B.2 [Caenorhabditis elegans] 1.0E-139
blast CAE60278 Hypothetical protein CBG03859 [Caenorhabditis briggsae] 5.0E-71
blast NP_501309 protein KINase family member (kin-26) [Caenorhabditis elegans] gb|AAA82302.1| Protein kinase protein 26 [Caenorhabditis elegans] 3.0E-45
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 8.0E-19
Pfam IPR000719 EMBL-EBI Protein kinase 9.1E-14
Sequence
Target Sequence 
>C. ELEGANS:193579_AT
atctcggagcctcaagctggatcaccaagaagtaacatcctgagtgtgatgcactgcgtt
cctccaatggaagaagagatcaaacactatgtgatcaaaaccaaaggcgataagatcttc
atcgaaaaagtatcattcttgtcaatcccagaaatggtggagtggcacttgactaagaag
gaatcggttcaaaaagatgtgtttctcatcaaggcaatctcacgtcaagcttgggagctg
gaccacgacaatatcgagcctctgaagaagctgggagaaggtgcatttggagaagtgatg
atgggaacgatgaagtttcggaaaggaggaaagtcagttcaagtggcgatcaagcaggcg
aagctctcgaatctcacaaaggagcagatcaaagagttcatgggtgaagctcgtgtgatg
cgttcactttcacatccccatgtcgttcgcttttatggtgtgccccgtagaagagttaac
gttgcactatgtcggtcactgaacgagtttcttgctaaatgtcacagaaaattgcgttgc
gcaacgcctttttttgtgtgta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATCTCGGAGCCTCAAGCTGGATCAC 178 33 136 Antisense
CTGAGTGTGATGCACTGCGTTCCTC 524 237 175 Antisense
AAGTATCATTCTTGTCAATCCCAGA 318 157 263 Antisense
GTTTCTCATCAAGGCAATCTCACGT 82 451 336 Antisense
GGACCACGACAATATCGAGCCTCTG 27 523 375 Antisense
AAGCAGGCGAAGCTCTCGAATCTCA 608 151 487 Antisense
GCTCGTGTGATGCGTTCACTTTCAC 488 299 544 Antisense
TGTCGTTCGCTTTTATGGTGTGCCC 22 559 576 Antisense
TAACGTTGCACTATGTCGGTCACTG 645 637 612 Antisense
CGGTCACTGAACGAGTTTCTTGCTA 84 245 628 Antisense
TGCGCAACGCCTTTTTTTGTGTGTA 597 583 673 Antisense
Sequence Source Affymetrix Proprietary Database