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[193574_at] Dual specificity phosphatase, catalytic domain

Description C04F12.8 /REP_DB=WormBase Gene ID /WP=CE19681 /TR=Q9XVE7 /GB=CAB03837.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Dual specificity phosphatase, catalytic domain
Cluster 6grp_highest_10_10 > 99      6grp_high1_10_10 > 89      4grp_highest_8_8 > 39      4grp_high_8_8 > 04      6grp_highest_nonorm > 95      6grp_total > 99      4grp_total > 05      6grp_high1_sub > Cu      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 832
1 2 3 4 range
A 492.9
(-1.3)
P 		346.7
(-2.4)
P 		257
(-3)
P 		1088.5
(3)
P 		832
B 569.8
(-0.3)
P 		288.4
(-3)
P 		330.5
(-2.6)
P 		925
(3)
P 		637
C 571.6
(0.2)
P 		310.3
(-3)
P 		311
(-3)
P 		805.8
(3)
P 		496
avr 544.8
(-0.7) 		315.1
(-2.9) 		299.5
(-3) 		939.8
(3) 		640

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 878
1 2 3 4 5 6 range
A 839.9
(-0.1)
P 		535.9
(-2.5)
P 		472.5
(-3)
P 		578.9
(-2.2)
P 		1236.6
(3)
P 		909.7
(0.4)
P 		764
B 988.4
(1.8)
P 		578.3
(-1.8)
P 		444.2
(-3)
P 		687.5
(-0.9)
P 		1059.5
(2.4)
P 		1127.5
(3)
P 		683
C 693.4
(-0.2)
P 		643.3
(-0.6)
P 		358.8
(-3)
P 		683.1
(-0.2)
P 		945.9
(2)
P 		1066.1
(3)
P 		707
avr 840.6
(0.8) 		585.8
(-1.5) 		425.2
(-3) 		649.8
(-0.9) 		1080.7
(3) 		1034.4
(2.6) 		656
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 130
1 2 3 4 range
A 179.5
(3)
P 		75.3
(-2.6)
P 		67.2
(-3)
P 		159.3
(1.9)
P 		112
B 181.7
(2.3)
P 		71.2
(-3)
P 		76.6
(-2.7)
P 		197.1
(3)
P 		126
C 189.2
(3)
P 		89.2
(-3)
P 		108.4
(-1.8)
P 		135.9
(-0.2)
P 		100
avr 183.5
(3) 		78.6
(-3) 		84.1
(-2.7) 		164.1
(1.9) 		105

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 339
1 2 3 4 5 6 range
A 154.8
(-1.8)
P 		190.6
(-1.1)
P 		102.9
(-3)
P 		146.8
(-2)
P 		373.1
(3)
P 		221.5
(-0.4)
P 		270
B 343.9
(1.4)
P 		192.5
(-1.4)
P 		107.9
(-3)
P 		182.1
(-1.6)
P 		430.5
(3)
P 		420.5
(2.8)
P 		323
C 257
(0.7)
P 		196.3
(-0.6)
P 		91.3
(-3)
P 		137.4
(-2)
P 		306.1
(1.9)
P 		356.9
(3)
P 		266
avr 251.9
(0.4) 		193.1
(-0.9) 		100.7
(-3) 		155.4
(-1.8) 		369.9
(3) 		333
(2.2) 		269
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193574_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2355
Sequence Type Exemplar sequence
Representative Public ID C04F12.8 NCBI
Target Description C04F12.8 /REP_DB=WormBase Gene ID /WP=CE19681 /TR=Q9XVE7 /GB=CAB03837.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Dual specificity phosphatase, catalytic domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060179(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060179 NCBI Caenorhabditis elegans C04F12.8 (C04F12.8) mRNA, complete cds. 11/11 None
SNAP00000037406 ENSEMBL cdna:SNAP chromosome:CEL140:I:9705715:9707676:-1 11/11 None
GENEFINDER00000037418 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9705715:9707676:-1 11/11 None
C04F12.8 ENSEMBL cdna:known chromosome:CEL140:I:9705715:9707676:-1 gene:C04F12.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9705645-9707607(-) 100.0 100.0
Public Domain and Genome References
Gene Title Dual specificity phosphatase, catalytic domain
Ensembl C04F12.8
Entrez Gene 182228 Entrez gene
SwissProt Q9XVE7 EMBL-EBI
WormBase CE19681 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.9161.1.S1_AT similar to Dual specificity protein phosphatase 14 (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1 like protein tyrosine phosphatase) (MKP-L) cfa
CANINE_2:CFAAFFX.27780.1.S1_AT similar to Dual specificity protein phosphatase 14 (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1 like protein tyrosine phosphatase) (MKP-L) cfa
DROSOPHILA_2:1638101_AT dm
DROSGENOME1:150870_AT dm
CHICKEN:GGA.6368.1.S1_AT similar to Dual specificity protein phosphatase 14 (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1 like protein tyrosine phosphatase) (MKP-L) gga
HG-U133_PLUS_2:203367_AT dual specificity phosphatase 14 hs
HG-U133A:203367_AT dual specificity phosphatase 14 hs
HG-FOCUS:203367_AT dual specificity phosphatase 14 hs
HG-U133A_2:203367_AT dual specificity phosphatase 14 hs
HU35KSUBC:RC_Z38499_AT dual specificity phosphatase 14 hs
U133_X3P:G5902001_3P_AT dual specificity phosphatase 14 hs
HG-U95AV2:38272_AT dual specificity phosphatase 14 hs
MOUSE430_2:1431422_A_AT dual specificity phosphatase 14 mm
MOE430A:1431422_A_AT dual specificity phosphatase 14 mm
MOUSE430A_2:1431422_A_AT dual specificity phosphatase 14 mm
MG-U74BV2:165144_R_AT dual specificity phosphatase 14 mm
MG-U74BV2:162702_AT dual specificity phosphatase 14 mm
MG-U74CV2:171285_AT dual specificity phosphatase 14 mm
MU19KSUBA:TC25403_AT Dual specificity phosphatase 14, mRNA (cDNA clone MGC:6747 IMAGE:3592420) mm
MU19KSUBA:TC25403_G_AT Dual specificity phosphatase 14, mRNA (cDNA clone MGC:6747 IMAGE:3592420) mm
MU19KSUBC:TC38819_AT Dual specificity phosphatase 14, mRNA (cDNA clone MGC:6747 IMAGE:3592420) mm
RG-U34C:RC_AI236997_AT dual specificity phosphatase 14 (predicted) rn
RAE230A:1373324_AT dual specificity phosphatase 14 (predicted) rn
RAT230_2:1373324_AT dual specificity phosphatase 14 (predicted) rn
RG-U34C:RC_AI236997_AT similar to Dual specificity phosphatase 14 rn
RAE230A:1373324_AT similar to Dual specificity phosphatase 14 rn
RAT230_2:1373324_AT similar to Dual specificity phosphatase 14 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6470 protein amino acid dephosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4721 phosphoprotein phosphatase activity inferred from electronic annotation QuickGO AmiGO
8138 protein tyrosine/serine/threonine phosphatase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03837 Hypothetical protein C04F12.8 [Caenorhabditis elegans] ref|NP_492580.1| C04F12.8 [Caenorhabditis elegans] 1.0E-132
blast CAE60209 Hypothetical protein CBG03773 [Caenorhabditis briggsae] 1.0E-128
blast CAB03837 Hypothetical protein C04F12.8 [Caenorhabditis elegans] ref|NP_492580.1| C04F12.8 [Caenorhabditis elegans] 2.0E-82
blast CAE60209 Hypothetical protein CBG03773 [Caenorhabditis briggsae] 2.0E-79
blast XP_791539 PREDICTED: similar to Dual specificity protein phosphatase 14 (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) [Strongylocentrotus purpuratus] 1.0E-36
Protein Domains
Database ID Description E-Value
Pfam IPR000340 EMBL-EBI Dual specificity protein phosphatase 1.8E-43
Pfam IPR000340 EMBL-EBI Dual specificity protein phosphatase 1.4E-37
Sequence
Target Sequence 
>C. ELEGANS:193574_AT
aacacgaacatatgactctccgacaagcatatcactacgtcaaagcagctcgaccaatta
ttcgtccaaatgttggattctggaaacaaatggttgattatgagaaacgattgagaggaa
cagcatcagttaaaatggttcagacaccggaatgtgatatgccaattccagatgtttatg
cagatgatataagaagaatgcagattaatagggagatcagtaggcattcattgccttctg
cacagagctccgcgagcaagcagagagctttttcagcaagtacataccgtccatccgtat
catctgcctcatcccttgccacatcatcacttcgtcgagcatacagtccatcatcacttc
cggcttcaagtcttgctcttaccacttcatacagtctcttttctcctgctccaacaagaa
aaccacgtcaaagtctattctcaatgtactcaacttc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AACACGAACATATGACTCTCCGACA 244 133 344 Antisense
CTCTCCGACAAGCATATCACTACGT 235 231 359 Antisense
ATCACTACGTCAAAGCAGCTCGACC 359 27 374 Antisense
GCAGCTCGACCAATTATTCGTCCAA 128 315 388 Antisense
CATTCATTGCCTTCTGCACAGAGCT 559 215 568 Antisense
TTCAGCAAGTACATACCGTCCATCC 212 685 615 Antisense
CACATCATCACTTCGTCGAGCATAC 583 195 663 Antisense
CGTCGAGCATACAGTCCATCATCAC 585 245 676 Antisense
TTGCTCTTACCACTTCATACAGTCT 638 703 716 Antisense
AAAACCACGTCAAAGTCTATTCTCA 341 131 762 Antisense
GTCTATTCTCAATGTACTCAACTTC 519 469 776 Antisense
Sequence Source Affymetrix Proprietary Database