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[193555_s_at] serine/threonine protein kinase

Description Y60A3A.1 /REP_DB=WormBase Gene ID /WP=CE24516 /GEN=unc-51 /TR=SW:Q23023 /GB=CAB60406.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine protein kinase
Cluster 6grp_highest_10_10 > 60      6grp_high1_10_10 > 17      4grp_highest_8_8 > 55      4grp_high_8_8 > 19      6grp_highest_nonorm > 60      6grp_total > 07      4grp_total > 29      6grp_highest_sub > De      6grp_cgc > 12      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 460
1 2 3 4 range
A 754.1
(3)
P 		562.7
(0.2)
P 		346.8
(-3)
P 		725.2
(2.6)
P 		407
B 674.5
(1.2)
P 		440.7
(-2)
P 		363.1
(-3)
P 		806.9
(3)
P 		444
C 709.3
(3)
P 		554.3
(0.3)
P 		365.1
(-3)
P 		635.8
(1.7)
P 		344
avr 712.6
(2.8) 		519.2
(-0.3) 		358.3
(-3) 		722.6
(3) 		364

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 603
1 2 3 4 5 6 range
A 520.6
(1.6)
P 		607.2
(3)
P 		241.9
(-3)
P 		363.9
(-1)
P 		278.9
(-2.4)
P 		481.3
(0.9)
P 		365
B 499.7
(3)
P 		385.2
(0.2)
P 		309.8
(-1.6)
P 		323.8
(-1.3)
P 		253.8
(-3)
P 		254.8
(-3)
P 		246
C 803.3
(3)
P 		330.7
(-1.7)
P 		507.2
(0.1)
P 		248.1
(-2.5)
P 		444.9
(-0.6)
P 		200.2
(-3)
P 		603
avr 607.9
(3) 		441
(-0.4) 		353
(-2.2) 		311.9
(-3) 		325.9
(-2.7) 		312.1
(-3) 		296
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 191
1 2 3 4 range
A 274.6
(3)
P 		122.1
(-2)
P 		90.7
(-3)
P 		106.2
(-2.5)
P 		184
B 215.1
(3)
P 		108.9
(-1.9)
P 		84.1
(-3)
P 		172
(1)
P 		131
C 234.8
(3)
P 		159.4
(-0.5)
P 		127.3
(-2.1)
P 		107.2
(-3)
P 		128
avr 241.5
(3) 		130.1
(-1.7) 		100.7
(-3) 		128.5
(-1.8) 		141

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 248
1 2 3 4 5 6 range
A 96
(-1.4)
P 		216
(3)
P 		52.7
(-3)
P 		92.3
(-1.5)
P 		84.2
(-1.8)
P 		117.2
(-0.6)
P 		163
B 173.9
(3)
P 		128.2
(0.2)
P 		75.2
(-3)
P 		85.8
(-2.4)
P 		103.1
(-1.3)
P 		95
(-1.8)
P 		99
C 297.7
(3)
P 		100.9
(-1.8)
P 		129.1
(-1.1)
P 		49.9
(-3)
P 		144
(-0.7)
P 		67
(-2.6)
P 		248
avr 189.2
(3) 		148.4
(0.8) 		85.7
(-2.5) 		76
(-3) 		110.4
(-1.2) 		93.1
(-2.1) 		113
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193555_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12774
Sequence Type Exemplar sequence
Representative Public ID Y60A3A.1 NCBI
Target Description Y60A3A.1 /REP_DB=WormBase Gene ID /WP=CE24516 /GEN=unc-51 /TR=SW:Q23023 /GB=CAB60406.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075468(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075468 NCBI Caenorhabditis elegans UNCoordinated family member (unc-51) (unc-51) mRNA, complete cds. 11/11 None
SNAP00000032819 ENSEMBL cdna:SNAP chromosome:CEL140:V:19994244:20017314:-1 11/11 None
GENEFINDER00000032845 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:19994244:19997534:-1 11/11 None
Y60A3A.1.1 ENSEMBL cdna:known chromosome:CEL140:V:19993995:20002482:-1 gene:Y60A3A.1 11/11 None
Y60A3A.1.2 ENSEMBL cdna:known chromosome:CEL140:V:19993998:20002484:-1 gene:Y60A3A.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:19994243-20002417(-) 97.82 100.0
Public Domain and Genome References
Gene Title serine/threonine protein kinase
Gene Symbol unc-51
Ensembl Y60A3A.1
Entrez Gene 180311 Entrez gene
SwissProt Q23023 EMBL-EBI
WormBase CE24516 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1627886_AT Autophagy-specific gene 1 dm
DROSGENOME1:153938_AT Autophagy-specific gene 1 dm
CHICKEN:GGA.11715.1.S1_S_AT unc-51-like kinase 2 (C. elegans) gga
CHICKEN:GGAAFFX.26295.1.S1_S_AT unc-51-like kinase 2 (C. elegans) gga
HG-U133A:204063_S_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133A_2:204063_S_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133_PLUS_2:204063_S_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBA:N71210_S_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBB:RC_N29916_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBB:RC_F02984_S_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBD:RC_AA418868_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBD:RC_Z38788_AT unc-51-like kinase 2 (C. elegans) hs
HU35KSUBD:RC_T10146_AT unc-51-like kinase 2 (C. elegans) hs
U133_X3P:G7662209_3P_A_AT unc-51-like kinase 2 (C. elegans) hs
U133_X3P:HS.151406.0.S1_3P_A_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133_PLUS_2:1554112_A_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133A_2:204062_S_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133_PLUS_2:204062_S_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133A:204062_S_AT unc-51-like kinase 2 (C. elegans) hs
HG-U95AV2:39776_AT unc-51-like kinase 2 (C. elegans) hs
HG-U133_PLUS_2:215154_AT Unc-51-like kinase 2 (C. elegans) hs
HG-U133A_2:215154_AT Unc-51-like kinase 2 (C. elegans) hs
HG-U133A:215154_AT Unc-51-like kinase 2 (C. elegans) hs
HU35KSUBD:RC_AA504115_AT Unc-51-like kinase 2 (C. elegans) hs
U133_X3P:HS.168762.0.S1_3P_S_AT Unc-51-like kinase 2 (C. elegans) hs
U133_X3P:HS.168762.0.S1_3P_AT Unc-51-like kinase 2 (C. elegans) hs
HG-U95AV2:36439_AT Unc-51-like kinase 2 (C. elegans) hs
HG-U95D:67247_R_AT Unc-51-like kinase 2 (C. elegans) hs
HG-U95D:83709_R_AT Unc-51-like kinase 2 (C. elegans) hs
MG-U74AV2:95537_AT Unc-51 like kinase 2 (C. elegans) mm
MG-U74BV2:164782_I_AT Unc-51 like kinase 2 (C. elegans) mm
MOE430A:1417846_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430A_2:1417846_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430_2:1417846_AT Unc-51 like kinase 2 (C. elegans) mm
MOE430A:1448858_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430A_2:1448858_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430_2:1448858_AT Unc-51 like kinase 2 (C. elegans) mm
MOE430A:1417847_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430A_2:1417847_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430_2:1417847_AT Unc-51 like kinase 2 (C. elegans) mm
MOE430B:1439591_AT Unc-51 like kinase 2 (C. elegans) mm
MOUSE430_2:1439591_AT Unc-51 like kinase 2 (C. elegans) mm
MG-U74BV2:108942_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MOE430B:1447152_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MOUSE430_2:1447152_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MOE430B:1447153_X_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MOUSE430_2:1447153_X_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MU11KSUBB:MSA.8011.0_S_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MU19KSUBB:TC28216_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MU19KSUBB:TC29565_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MU19KSUBB:TC32213_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
MU19KSUBC:TC35075_AT Serine/threonine kinase UNC51.2 (Unc51.2) mm
RG-U34A:RC_AA892500_AT Unc-51 like kinase 2 (C. elegans) (predicted) rn
RG-U34C:RC_AI229467_AT Unc-51 like kinase 2 (C. elegans) (predicted) rn
RAE230A:1392474_AT Unc-51 like kinase 2 (C. elegans) (predicted) rn
RAT230_2:1392474_AT Unc-51 like kinase 2 (C. elegans) (predicted) rn
RG-U34C:RC_AI070603_AT Unc-51 like kinase 2 (C. elegans) (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB60406 Hypothetical protein Y60A3A.1 [Caenorhabditis elegans] emb|CAA86114.1| serine/threonine kinase [Caenorhabditis elegans] ref|NP_507869.1| UNCoordinated family member (unc-51) [Caenorhabditis elegans] sp|Q23023|UNC51_CAEEL Serine/threonine-protein kinase unc-51 (Uncoordinated protein 51) prf||2021343A Ser/Thr kinase 0.0
blast CAE56821 Hypothetical protein CBG24635 [Caenorhabditis briggsae] 0.0
blast CAE56821 Hypothetical protein CBG24635 [Caenorhabditis briggsae] 1.0E-170
Protein Families
Method ID Description E-Value
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 1.0E-70
hanks 1.1.1 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); cAPKa 1.0E-19
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.2E-86
Pfam IPR000719 EMBL-EBI Protein kinase 2.7E-39
Sequence
Target Sequence 
>C. ELEGANS:193555_S_AT
gcgaagcttcgatttgtcgccgagctcgtcgatacccttatccacgtggccgagcagaag
gacaatccgttggcgtcggcgatggcttcaaggagacagcttttgactactggaacctca
acgactaatacatcgtcaccgtaccggagagccgagcagctggtggtgtacgtcagagct
ctgcacatgctctcctcagcactgctcttggctcagactaacgtggcaaatcgggtactt
catccgagtgtcgccgtgcagcaggtgctcaatcagctcaacgacaagtatcatcagtgt
ttggtccgctcccaggagcttgcctcgcttggcctccccggacaggatccggcgatggcg
gttatctcggcggaaagaatcatgtacagacatgcgatagaactgtgccaggctgctgct
cttgacgagctttttggaaacccccagctgtgcagtcagaggtaccagaccgcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCGAAGCTTCGATTTGTCGCCGAGC 197 289 1972 Antisense
TACATCGTCACCGTACCGGAGAGCC 588 641 2100 Antisense
GAGAGCCGAGCAGCTGGTGGTGTAC 160 395 2118 Antisense
GTACGTCAGAGCTCTGCACATGCTC 691 457 2139 Antisense
TGCTCTTGGCTCAGACTAACGTGGC 202 581 2174 Antisense
TCGGGTACTTCATCCGAGTGTCGCC 160 599 2202 Antisense
GCAGGTGCTCAATCAGCTCAACGAC 602 311 2232 Antisense
AGTATCATCAGTGTTTGGTCCGCTC 582 61 2258 Antisense
AGGATCCGGCGATGGCGGTTATCTC 634 55 2315 Antisense
GATAGAACTGTGCCAGGCTGCTGCT 109 425 2367 Antisense
GTGCAGTCAGAGGTACCAGACCGCC 26 481 2421 Antisense
Sequence Source Affymetrix Proprietary Database