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[193532_at] glycogen synthase kinase (CDC2/CDKX subfamily)

Description C44H4.6 /REP_DB=WormBase Gene ID /WP=CE08727 /TR=Q93372 /GB=CAB01863.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=glycogen synthase kinase (CDC2-CDKX subfamily)
Cluster 6grp_total > 46      4grp_total > 10      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 122
1 2 3 4 range
A 29.3
(-2.4)
A 		97.3
(1.1)
A 		17.6
(-3)
A 		134.4
(3)
A 		117
B 33.3
(-3)
A 		47.1
(-2.1)
A 		57.2
(-1.4)
A 		123.5
(3)
A 		90
C 57.5
(-0.7)
A 		12.1
(-3)
A 		62.4
(-0.5)
A 		132.8
(3)
A 		121
avr 40
(-3) 		52.2
(-2.2) 		45.7
(-2.6) 		130.2
(3) 		90

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 85
1 2 3 4 5 6 range
A 63.6
(0.4)
A 		77
(1.5)
A 		41.3
(-1.6)
A 		25.1
(-3)
A 		48.7
(-0.9)
A 		93.8
(3)
A 		69
B 55.3
(-2.7)
A 		75.7
(1.4)
A 		53.8
(-3)
A 		62.9
(-1.2)
A 		54
(-3)
A 		83.6
(3)
A 		30
C 68
(2.3)
A 		76
(3)
A 		45.1
(0.3)
A 		8.4
(-3)
A 		30.5
(-1)
A 		52.2
(0.9)
A 		68
avr 62.3
(1.1) 		76.2
(3) 		46.7
(-1) 		32.1
(-3) 		44.4
(-1.3) 		76.5
(3) 		44
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 23
1 2 3 4 range
A 10.7
(-0.8)
A 		21.1
(3)
A 		4.6
(-3)
A 		19.7
(2.5)
A 		17
B 10.6
(-3)
A 		11.6
(-2.6)
A 		13.3
(-2)
A 		26.3
(3)
A 		16
C 19
(1.9)
A 		3.5
(-3)
A 		21.7
(2.8)
A 		22.4
(3)
A 		19
avr 13.4
(-2.3) 		12.1
(-3) 		13.2
(-2.4) 		22.8
(3) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 30
1 2 3 4 5 6 range
A 11.7
(-1.5)
A 		27.4
(3)
A 		9
(-2.3)
A 		6.4
(-3)
A 		14.7
(-0.6)
A 		22.8
(1.7)
A 		21
B 19.2
(-1)
A 		25.2
(1)
A 		13.1
(-3)
A 		16.7
(-1.8)
A 		21.9
(-0.1)
A 		31.2
(3)
A 		18
C 25.2
(3)
A 		23.2
(2.5)
A 		11.5
(-0.5)
A 		1.7
(-3)
A 		9.9
(-0.9)
A 		17.5
(1)
A 		24
avr 18.7
(0.7) 		25.3
(3) 		11.2
(-2) 		8.3
(-3) 		15.5
(-0.5) 		23.8
(2.5) 		17
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193532_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17689
Sequence Type Exemplar sequence
Representative Public ID C44H4.6 NCBI
Target Description C44H4.6 /REP_DB=WormBase Gene ID /WP=CE08727 /TR=Q93372 /GB=CAB01863.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=glycogen synthase kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078028(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078028 NCBI Caenorhabditis elegans C44H4.6 (C44H4.6) mRNA, complete cds. 11/11 None
GENEFINDER00000043726 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:14595963:14599080:-1 11/11 None
SNAP00000043720 ENSEMBL cdna:SNAP chromosome:CEL140:X:14596398:14599071:-1 11/11 None
C44H4.6 ENSEMBL cdna:known chromosome:CEL140:X:14596398:14599080:-1 gene:C44H4.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:14596397-14599080(-) 100.0 100.0
Public Domain and Genome References
Gene Title glycogen synthase kinase (CDC2/CDKX subfamily)
Ensembl C44H4.6
Entrez Gene 183461 Entrez gene
SwissProt Q93372 EMBL-EBI
WormBase CE08727 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01863 Hypothetical protein C44H4.6 [Caenorhabditis elegans] ref|NP_510429.1| C44H4.6 [Caenorhabditis elegans] 0.0
blast CAE63205 Hypothetical protein CBG07560 [Caenorhabditis briggsae] 0.0
blast NP_001027597 glycogen synthase kinase alpha/beta [Ciona intestinalis] dbj|BAE06824.1| glycogen synthase kinase alpha/beta [Ciona intestinalis] dbj|BAA92186.1| glycogen synthase kinase [Ciona intestinalis] 4.0E-75
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-62
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-62
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-62
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 3.0E-62
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 2.0E-62
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 4.1E-72
Pfam IPR000719 EMBL-EBI Protein kinase 4.1E-72
Sequence
Target Sequence 
>C. ELEGANS:193532_AT
gccgaacattacgtacatttgctcaagatattatcgtgctccggaactcatatttggctc
aaaaaactatgatacctcaatagacacatggtcagttggcactgtagttggcgagttact
ccacaactctccaatattcctggcggactcggcagttgatattctagcgctgcaaatcaa
agcattcggtactccttcaaaagaagacatggctaaatggaactacgaatatgttcatat
tccatacgatacaataaccggagttggaattcagaaattcattggaagaaaactttcctt
atccaccctcgagttgctcaacagtttgatgaaaatggatccgaaacttcgtataaaacc
atacgaggctctgactcttccatacttcgatgatctgagagacccccactacaagctgcc
cagcggtgctccgatcccgccacttttcgattggctcgagagagagtacattgccaacca
cg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCCGAACATTACGTACATTTGCTCA 291 285 576 Antisense
GTGCTCCGGAACTCATATTTGGCTC 196 473 611 Antisense
GTTGGCGAGTTACTCCACAACTCTC 11 435 682 Antisense
CCACAACTCTCCAATATTCCTGGCG 682 275 696 Antisense
TTCCTGGCGGACTCGGCAGTTGATA 451 695 712 Antisense
ATCAAAGCATTCGGTACTCCTTCAA 447 27 751 Antisense
CCACCCTCGAGTTGCTCAACAGTTT 138 275 878 Antisense
AAACCATACGAGGCTCTGACTCTTC 609 125 931 Antisense
CTGACTCTTCCATACTTCGATGATC 275 239 946 Antisense
CCGCCACTTTTCGATTGGCTCGAGA 347 261 1012 Antisense
GAGAGAGAGTACATTGCCAACCACG 468 393 1033 Antisense
Sequence Source Affymetrix Proprietary Database