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[193516_at] Dual specificity phosphatase, catalytic domain

Description C24F3.2 /REP_DB=WormBase Gene ID /WP=CE18519 /TR=Q9XXK8 /GB=CAA18771.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Dual specificity phosphatase, catalytic domain
Cluster 6grp_high1_10_10 > 96      4grp_highest_8_8 > 22      4grp_high_8_8 > 06      6grp_total > 86      4grp_total > 09      6grp_high1_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 201
1 2 3 4 range
A 113.5
(-2.7)
P 		106.5
(-3)
P 		172.6
(-0.2)
P 		250
(3)
P 		144
B 117.9
(-2.7)
P 		153.5
(-1.6)
P 		107
(-3)
P 		307.3
(3)
P 		200
C 136.7
(-2.5)
P 		122.7
(-3)
P 		145.7
(-2.2)
P 		304
(3)
P 		181
avr 122.7
(-3) 		127.6
(-2.8) 		141.8
(-2.3) 		287.1
(3) 		164

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 578
1 2 3 4 5 6 range
A 84.9
(-3)
A 		106.2
(-2.7)
P 		214.3
(-1.4)
P 		317.1
(-0.2)
P 		311.5
(-0.2)
P 		574
(3)
P 		489
B 121.9
(-3)
P 		126.6
(-2.9)
P 		161.2
(-2.5)
P 		222.1
(-1.7)
P 		330.8
(-0.3)
P 		583.3
(3)
P 		461
C 88.9
(-3)
P 		135.3
(-2.5)
P 		162.6
(-2.2)
P 		378.2
(0)
P 		299.4
(-0.8)
P 		663.2
(3)
P 		574
avr 98.6
(-3) 		122.7
(-2.7) 		179.4
(-2) 		305.8
(-0.6) 		313.9
(-0.5) 		606.8
(3) 		508
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 42
1 2 3 4 range
A 41.3
(2)
P 		23.1
(-3)
P 		45.1
(3)
P 		36.6
(0.7)
P 		22
B 37.6
(-1.1)
P 		37.9
(-1.1)
P 		24.8
(-3)
P 		65.5
(3)
P 		41
C 45.2
(0.7)
P 		35.3
(-3)
P 		50.8
(2.8)
P 		51.3
(3)
P 		16
avr 41.4
(-0.1) 		32.1
(-3) 		40.2
(-0.4) 		51.1
(3) 		19

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 206
1 2 3 4 5 6 range
A 15.6
(-3)
A 		37.8
(-1.9)
P 		46.7
(-1.5)
P 		80.4
(0.1)
P 		94
(0.8)
P 		139.8
(3)
P 		124
B 42.4
(-2.9)
P 		42.2
(-2.9)
P 		39.1
(-3)
P 		58.8
(-2.3)
P 		134.4
(0.2)
P 		217.5
(3)
P 		178
C 33
(-3)
P 		41.3
(-2.7)
P 		41.4
(-2.7)
P 		76.1
(-1.6)
P 		96.9
(-1)
P 		222
(3)
P 		189
avr 30.3
(-3) 		40.4
(-2.6) 		42.4
(-2.6) 		71.8
(-1.5) 		108.4
(-0.1) 		193.1
(3) 		163
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193516_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9009
Sequence Type Exemplar sequence
Representative Public ID C24F3.2 NCBI
Target Description C24F3.2 /REP_DB=WormBase Gene ID /WP=CE18519 /TR=Q9XXK8 /GB=CAA18771.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Dual specificity phosphatase, catalytic domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069469(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069469 NCBI Caenorhabditis elegans C24F3.2 (C24F3.2) mRNA, complete cds. 11/11 None
SNAP00000043528 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10222768:10225585:1 11/11 None
GENEFINDER00000043532 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10222768:10223599:1 11/11 None
C24F3.2 ENSEMBL cdna:known chromosome:CEL140:IV:10222497:10223675:1 gene:C24F3.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10222546-10223605(+) 100.0 100.0
Public Domain and Genome References
Gene Title Dual specificity phosphatase, catalytic domain
Ensembl C24F3.2
Entrez Gene 177903 Entrez gene
SwissProt Q9XXK8 EMBL-EBI
WormBase CE18519 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6470 protein amino acid dephosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8138 protein tyrosine/serine/threonine phosphatase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02899 Hypothetical protein C24F3.3 [Caenorhabditis elegans] emb|CAA18774.2| Hypothetical protein C24F3.3 [Caenorhabditis elegans] ref|NP_501871.2| Nematode AStacin protease family member (nas-12) [Caenorhabditis elegans] sp|Q9XTD6|NAS12_CAEEL Zinc metalloproteinase nas-12 precursor (Nematode astacin 12) 1.0E-178
blast CAE59906 Hypothetical protein CBG03390 [Caenorhabditis briggsae] 1.0E-165
blast CAA18771 Hypothetical protein C24F3.2 [Caenorhabditis elegans] ref|NP_501870.1| C24F3.2 [Caenorhabditis elegans] 1.0E-148
blast CAA18771 Hypothetical protein C24F3.2 [Caenorhabditis elegans] ref|NP_501870.1| C24F3.2 [Caenorhabditis elegans] 1.0E-113
blast CAA18771 Hypothetical protein C24F3.2 [Caenorhabditis elegans] ref|NP_501870.1| C24F3.2 [Caenorhabditis elegans] 1.0E-103
blast NP_009171 dual specificity phosphatase 12 [Homo sapiens] emb|CAH74153.1| dual specificity phosphatase 12 [Homo sapiens] gb|AAP35279.1| dual specificity phosphatase 12 [Homo sapiens] gb|AAX32656.1| dual specificity phosphatase 12 [synthetic construct] gb|AAH06286.1| Dual specificity phosphatase 12 [Homo sapiens] sp|Q9UNI6|DUS12_HUMAN Dual specificity protein phosphatase 12 (Dual-specificity tyrosine phosphatase YVH1) gb|AAD51134.1| dual-specificity tyrosine phosphatase YVH1 [Homo sapiens] 4.0E-17
blast NP_071584 glucokinase-associated dual specificity phosphatase [Rattus norvegicus] gb|AAF87971.1| glucokinase-associated dual specificity phosphatase [Rattus norvegicus] 5.0E-17
Protein Domains
Database ID Description E-Value
Pfam IPR000340 EMBL-EBI Dual specificity protein phosphatase 3.3E-22
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.3E-64
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 1.1E-12
Pfam IPR000340 EMBL-EBI Dual specificity protein phosphatase 4.5E-22
Sequence
Target Sequence 
>C. ELEGANS:193516_AT
atgtaggtgttcactgtcttgcggctgtttcacgcagtgtgtctatttgtgcggcctatt
taatgtacaagaatcagtggcccgttgaaaaggcgttgaagatgatcgaaagtgtgagaa
aaacaattggtccaaatgcaggatttctcgcacaactgaagatctgggaacgatccggaa
tgagtttctccgctgatcagtacaaaaacttgaaaattgatattcctggaattacttgtg
tagattcaaaaactatttggcggcaacccgtgatcgacgatcaaaccaaagtgcgattca
aatgccgacaatgccggaaagtgatattcaacagcgacaatatagttcatccattagctg
aagcatgccaaaagtatctgatagaaccaatggcgtggctcaacgtctcaggtgcaacat
gctcagtaagccacacatgtggagcaaaacttgggactttcatcgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGTAGGTGTTCACTGTCTTGCGGC 539 47 272 Antisense
TCTTGCGGCTGTTTCACGCAGTGTG 84 619 288 Antisense
GCAGTGTGTCTATTTGTGCGGCCTA 639 311 305 Antisense
ATGCAGGATTTCTCGCACAACTGAA 135 43 407 Antisense
GGAATGAGTTTCTCCGCTGATCAGT 645 531 448 Antisense
CTATTTGGCGGCAACCCGTGATCGA 2 223 524 Antisense
GTGCGATTCAAATGCCGACAATGCC 606 477 562 Antisense
AGAACCAATGGCGTGGCTCAACGTC 639 71 654 Antisense
TCAACGTCTCAGGTGCAACATGCTC 518 631 671 Antisense
GCAACATGCTCAGTAAGCCACACAT 509 319 685 Antisense
GAGCAAAACTTGGGACTTTCATCGC 384 389 713 Antisense
Sequence Source Affymetrix Proprietary Database