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[193499_s_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description ZC504.3 /REP_DB=WormBase Gene ID /WP=CE03811 /TR=Q23357 /GB=CAA90342.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster 6grp_highest_10_10 > 73      6grp_high1_10_10 > 46      4grp_high_8_8 > 24      6grp_highest_nonorm > 90      6grp_total > 46      4grp_total > 39      6grp_highest_sub > Cu      6grp_high1_sub > Cu      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 153
1 2 3 4 range
A 218.7
(3)
P 		145.9
(-3)
P 		147.2
(-2.9)
M 		187.8
(0.5)
P 		73
B 264.5
(3)
P 		189.3
(-1.4)
P 		206.9
(-0.4)
P 		162
(-3)
P 		103
C 264.5
(3)
P 		111.7
(-3)
P 		138
(-2)
P 		174.3
(-0.5)
P 		153
avr 249.2
(3) 		149
(-3) 		164
(-2.1) 		174.7
(-1.5) 		100

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 99
1 2 3 4 5 6 range
A 212
(1.7)
P 		200.9
(0.5)
P 		183.9
(-1.5)
P 		191.4
(-0.6)
P 		170.9
(-3)
P 		223
(3)
P 		52
B 210.8
(3)
P 		204.6
(2.5)
P 		184.7
(0.8)
P 		138.7
(-3)
P 		139.4
(-2.9)
P 		171.4
(-0.3)
P 		72
C 190.6
(2)
P 		133
(-2.3)
P 		195
(2.3)
P 		124
(-3)
P 		125.1
(-2.9)
P 		203.7
(3)
P 		80
avr 204.5
(3) 		179.5
(0.5) 		187.9
(1.3) 		151.4
(-2.4) 		145.1
(-3) 		199.4
(2.5) 		59
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 60
1 2 3 4 range
A 79.6
(3)
P 		31.7
(-2.5)
P 		38.5
(-1.7)
M 		27.5
(-3)
P 		52
B 84.3
(3)
P 		46.7
(-1.5)
P 		47.9
(-1.4)
P 		34.5
(-3)
P 		50
C 87.6
(3)
P 		32.1
(-2.7)
P 		48.1
(-1.1)
P 		29.4
(-3)
P 		58
avr 83.8
(3) 		36.8
(-2.3) 		44.8
(-1.4) 		30.5
(-3) 		53

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 48
1 2 3 4 5 6 range
A 39.1
(-3)
P 		71.5
(3)
P 		40
(-2.8)
P 		48.6
(-1.2)
P 		51.6
(-0.7)
P 		54.3
(-0.2)
P 		32
B 73.3
(3)
P 		68.1
(2.1)
P 		44.9
(-1.7)
P 		36.7
(-3)
P 		56.6
(0.3)
P 		63.9
(1.5)
P 		37
C 70.7
(3)
P 		40.6
(-0.9)
P 		49.6
(0.2)
P 		24.9
(-3)
P 		40.5
(-1)
P 		68.2
(2.7)
P 		46
avr 61
(2.7) 		60.1
(2.5) 		44.8
(-1.1) 		36.7
(-3) 		49.6
(0) 		62.1
(3) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193499_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17155
Sequence Type Exemplar sequence
Representative Public ID ZC504.3 NCBI
Target Description ZC504.3 /REP_DB=WormBase Gene ID /WP=CE03811 /TR=Q23357 /GB=CAA90342.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077345(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077345 NCBI Caenorhabditis elegans ZC504.3 (ZC504.3) mRNA, complete cds. 11/11 None
SNAP00000031665 ENSEMBL cdna:SNAP chromosome:CEL140:X:10416926:10419679:-1 11/11 None
GENEFINDER00000031671 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:10416926:10419679:-1 11/11 None
ZC504.3 ENSEMBL cdna:known chromosome:CEL140:X:10416629:10420005:-1 gene:ZC504.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10416925-10420005(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Ensembl ZC504.3
Entrez Gene 181247 Entrez gene
SwissProt Q23357 EMBL-EBI
WormBase CE03811 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:247384_AT protein kinase family protein at
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90342 Hypothetical protein ZC504.3 [Caenorhabditis elegans] ref|NP_509746.1| ZC504.3 [Caenorhabditis elegans] 0.0
blast CAE70578 Hypothetical protein CBG17235 [Caenorhabditis briggsae] 0.0
blast AAA62523 Hypothetical protein B0495.2 [Caenorhabditis elegans] ref|NP_495617.1| B0495.2 [Caenorhabditis elegans] sp|Q09437|YP62_CAEEL Putative serine/threonine-protein kinase B0495.2 1.0E-178
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-72
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-72
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-72
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 9.0E-75
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 3.0E-75
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 2.0E-75
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-84
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-84
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-84
Sequence
Target Sequence 
>C. ELEGANS:193499_S_AT
gtcactctttggtacaggtcaccagagcttcttttggagccaaaaacatactcaacacca
gtcgacatgtggtctattggatgcatcatggccgaatttattatgatgaagccaatgttt
caaggggatagtgagcctaatcaagtgcaccaaatttttcaaatgatgggaactccaacg
gaacaaatttggccggacattaaagaactgaaagtatggaatatggttgagtttccacca
gtaaaacctggtcagctgaggagaatcttcaaaggagaaaagttagtgaatgaaactgga
tttgatcttttgaatggaatgctctgtctgaatccagcaaatcgattgactgcatccgaa
gctcttcaacatgactggttcagtgaacacccgaaagctgttcctccagaggaccttccc
gtgtacccagcaaagagtgagttgaatgcggcgcctcctgagaaccgaaggaaaaataga
ctagaagcattgttggctgatgaagaaccggaacgagcagcgcttttacgtcagttcaac
g

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCACTCTTTGGTACAGGTCACCAG 185 463 1717 Antisense
GGTCACCAGAGCTTCTTTTGGAGCC 499 501 1733 Antisense
AACATACTCAACACCAGTCGACATG 223 137 1761 Antisense
GGTCTATTGGATGCATCATGGCCGA 113 503 1787 Antisense
GGAATGCTCTGTCTGAATCCAGCAA 345 533 2032 Antisense
TCGATTGACTGCATCCGAAGCTCTT 40 603 2058 Antisense
GAAGCTCTTCAACATGACTGGTTCA 242 343 2074 Antisense
GTGAACACCCGAAAGCTGTTCCTCC 130 481 2099 Antisense
AGAGTGAGTTGAATGCGGCGCCTCC 65 69 2150 Antisense
GAAGAACCGGAACGAGCAGCGCTTT 645 339 2218 Antisense
GCAGCGCTTTTACGTCAGTTCAACG 404 313 2233 Antisense
Sequence Source Affymetrix Proprietary Database