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[193487_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description M04C9.5 /REP_DB=WormBase Gene ID /WP=CE12408 /TR=P90932 /GB=CAB06021.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster 6grp_highest_10_10 > 64      6grp_high1_10_10 > 46      4grp_high_8_8 > 27      6grp_highest_nonorm > 90      6grp_total > 46      4grp_total > 44      6grp_highest_sub > Cu      6grp_high1_sub > Cu      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 148
1 2 3 4 range
A 111.3
(-1.7)
P 		156.7
(3)
P 		134.9
(0.7)
A 		98.9
(-3)
P 		58
B 135
(0.4)
P 		187.9
(3)
M 		63.8
(-3)
P 		135.9
(0.5)
P 		124
C 211.3
(3)
P 		148.1
(-0.7)
P 		107.5
(-3)
P 		116.5
(-2.5)
P 		104
avr 152.5
(1.9) 		164.2
(3) 		102.1
(-3) 		117.1
(-1.6) 		62

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 78
1 2 3 4 5 6 range
A 102.3
(-0.6)
P 		93.2
(-3)
P 		113.1
(2.3)
P 		101.3
(-0.9)
P 		104.5
(-0)
P 		115.9
(3)
P 		23
B 155.6
(3)
P 		136.3
(0.7)
P 		126
(-0.5)
P 		120.5
(-1.1)
P 		104.5
(-3)
P 		120.9
(-1.1)
P 		51
C 124.8
(1.7)
P 		138.4
(3)
P 		102.2
(-0.6)
P 		133.2
(2.5)
P 		77.6
(-3)
P 		125.9
(1.8)
P 		61
avr 127.6
(3) 		122.6
(2.1) 		113.8
(0.4) 		118.3
(1.3) 		95.5
(-3) 		120.9
(1.7) 		32
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 56
1 2 3 4 range
A 40.5
(3)
P 		34
(1.5)
P 		35.3
(1.8)
A 		14.5
(-3)
P 		26
B 43.1
(2.4)
P 		46.4
(3)
M 		14.8
(-3)
P 		29
(-0.3)
P 		32
C 70
(3)
P 		42.6
(-0.3)
P 		37.5
(-0.9)
P 		19.6
(-3)
P 		50
avr 51.2
(3) 		41
(1) 		29.2
(-1.4) 		21
(-3) 		30

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 35
1 2 3 4 5 6 range
A 18.9
(-3)
P 		33.2
(3)
P 		24.6
(-0.6)
P 		25.7
(-0.1)
P 		31.5
(2.3)
P 		28.2
(0.9)
P 		14
B 54.1
(3)
P 		45.4
(0.8)
P 		30.6
(-3)
P 		31.9
(-2.7)
P 		42.4
(0)
P 		45.1
(0.7)
P 		24
C 46.3
(3)
P 		42.2
(1.8)
P 		26
(-2.7)
P 		26.8
(-2.5)
P 		25.1
(-3)
P 		42.2
(1.8)
P 		21
avr 39.8
(2.8) 		40.3
(3) 		27.1
(-3) 		28.1
(-2.5) 		33
(-0.3) 		38.5
(2.2) 		13
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193487_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2337
Sequence Type Exemplar sequence
Representative Public ID M04C9.5 NCBI
Target Description M04C9.5 /REP_DB=WormBase Gene ID /WP=CE12408 /TR=P90932 /GB=CAB06021.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060092(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060092 NCBI Caenorhabditis elegans M04C9.5 (M04C9.5) mRNA, complete cds. 11/11 None
M04C9.5 ENSEMBL cdna:known chromosome:CEL140:I:9367970:9371049:1 gene:M04C9.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000035492 7/11 Cross Hyb Matching Probes None
SNAP00000035489 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9367900-9370980(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Ensembl M04C9.5
Entrez Gene 187442 Entrez gene
SwissProt P90932 EMBL-EBI
WormBase CE12408 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:254747_AT serine/threonine protein kinase (MHK) at
CANINE_2:CFAAFFX.4258.1.S1_AT similar to intestinal cell kinase cfa
CANINE_2:CFAAFFX.4258.1.S1_S_AT similar to intestinal cell kinase cfa
CHICKEN:GGA.12148.1.S1_AT intestinal cell (MAK-like) kinase gga
HG-U133_PLUS_2:204569_AT intestinal cell (MAK-like) kinase hs
HG-U133A:204569_AT intestinal cell (MAK-like) kinase hs
HG-U133A_2:204569_AT intestinal cell (MAK-like) kinase hs
HU35KSUBA:R56728_AT intestinal cell (MAK-like) kinase hs
HU35KSUBA:RC_AA428139_S_AT intestinal cell (MAK-like) kinase hs
HU35KSUBD:RC_H98848_AT intestinal cell (MAK-like) kinase hs
U133_X3P:G7662387_3P_S_AT intestinal cell (MAK-like) kinase hs
U133_X3P:G7662387_3P_AT intestinal cell (MAK-like) kinase hs
U133_X3P:HS2.108850.2.S1_3P_AT intestinal cell (MAK-like) kinase hs
U133_X3P:204569_3P_AT intestinal cell (MAK-like) kinase hs
HG-U133_PLUS_2:1552837_AT intestinal cell (MAK-like) kinase hs
HG-U95AV2:41431_AT intestinal cell (MAK-like) kinase hs
MG-U74BV2:106078_AT intestinal cell kinase mm
MOE430B:1455687_AT intestinal cell kinase mm
MOUSE430_2:1455687_AT intestinal cell kinase mm
MG-U74BV2:106079_G_AT intestinal cell kinase mm
MG-U74BV2:162996_AT intestinal cell kinase mm
MOE430A:1448310_AT intestinal cell kinase mm
MOUSE430A_2:1448310_AT intestinal cell kinase mm
MOUSE430_2:1448310_AT intestinal cell kinase mm
MOE430B:1454243_AT intestinal cell kinase mm
MOUSE430_2:1454243_AT intestinal cell kinase mm
MU19KSUBA:TC16191_AT Intestinal cell kinase, mRNA (cDNA clone MGC:28949 IMAGE:4224269) mm
RG-U34A:D26178_AT intestinal cell kinase rn
RAE230A:1387948_AT intestinal cell kinase rn
RAT230_2:1387948_AT intestinal cell kinase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB06021 Hypothetical protein M04C9.5 [Caenorhabditis elegans] ref|NP_492493.1| M04C9.5 [Caenorhabditis elegans] 0.0
blast CAE74447 Hypothetical protein CBG22182 [Caenorhabditis briggsae] 0.0
blast XP_392924 PREDICTED: similar to intestinal cell kinase [Apis mellifera] 1.0E-124
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 5.0E-77
hanks 3.1.7 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; PCTAIRE1 2.0E-79
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.1E-91
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492493.1 1 13-35
M04C9.5 1 13-35
Sequence
Target Sequence 
>C. ELEGANS:193487_AT
agttgttagtcaaccagctcctggaagtattcgaaagacaagtgcagcttcagttaaaag
tgatacgaaagcaatgacagctaaggcggcaaagaaagattacattggatcagaaaatgt
gtctcctcaacaaccagccaaagttattgaccgtcacataaatcgcaatctacctctcaa
taaggaaactctttttgaaaaatcagataacaagcctctgggaccaacaaaatcaaatga
agcaaagccgacagcaaaggagatatatttatcaaaaagcaaatatgtgcccggtactgt
caaaaataaattcaaaaaatctttaaaatggttggacttgctcataccttatttgaattg
ccaagtatccaaagacactcatcaaaatcaaataatgacaacaaatggattaactggaac
aactaaaacgacaacattttctgcaaaaaaagagggtcgaacggcagttcaaacaaggtt
cgagtatgcgtacggttcgtcgttttgttcttctcataaatctctcttt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGTTGTTAGTCAACCAGCTCCTGGA 158 63 1014 Antisense
AGAAAATGTGTCTCCTCAACAACCA 194 73 1125 Antisense
ACCAGCCAAAGTTATTGACCGTCAC 355 85 1146 Antisense
TAAATCGCAATCTACCTCTCAATAA 275 641 1172 Antisense
GATAACAAGCCTCTGGGACCAACAA 653 361 1219 Antisense
GCAAATATGTGCCCGGTACTGTCAA 584 317 1292 Antisense
GTTGGACTTGCTCATACCTTATTTG 288 435 1344 Antisense
GCCAAGTATCCAAAGACACTCATCA 691 277 1373 Antisense
CAAGGTTCGAGTATGCGTACGGTTC 67 161 1487 Antisense
TGCGTACGGTTCGTCGTTTTGTTCT 640 557 1500 Antisense
TTGTTCTTCTCATAAATCTCTCTTT 705 705 1518 Antisense
Sequence Source Affymetrix Proprietary Database