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[193465_at] Isocitrate and isopropylmalate dehydrogenases

Description C34F6.8 /REP_DB=WormBase Gene ID /WP=CE15677 /TR=O17643 /GB=CAB03943.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Isocitrate and isopropylmalate dehydrogenases
Cluster 6grp_highest_10_10 > 13      6grp_high1_10_10 > 21      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 32      6grp_total > 32      4grp_total > 60      6grp_high1_sub > 03      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1530
1 2 3 4 range
A 1495
(0.9)
P 		2006.9
(3)
P 		1852.3
(2.4)
P 		574.6
(-3)
P 		1432
B 1580.9
(1.8)
P 		1563.1
(1.7)
P 		1811.9
(3)
P 		628.8
(-3)
P 		1183
C 1637.2
(2.6)
P 		1446.5
(1.7)
P 		1709.8
(3)
P 		477.2
(-3)
P 		1233
avr 1571
(1.9) 		1672.2
(2.4) 		1791.3
(3) 		560.2
(-3) 		1231

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1086
1 2 3 4 5 6 range
A 1687.5
(3)
P 		1503.4
(1.7)
P 		1642.6
(2.7)
P 		1366
(0.8)
P 		923
(-2.2)
P 		804.3
(-3)
P 		883
B 1559.5
(1.1)
P 		1313.6
(-0.3)
P 		1884.7
(3)
P 		1423.3
(0.3)
P 		874.1
(-2.9)
P 		851.5
(-3)
P 		1033
C 1525.2
(1.8)
P 		1592.5
(2.2)
P 		1713.5
(3)
P 		1342.8
(0.6)
P 		914
(-2.2)
P 		799.2
(-3)
P 		914
avr 1590.7
(2) 		1469.8
(1.2) 		1746.9
(3) 		1377.4
(0.6) 		903.7
(-2.4) 		818.3
(-3) 		929
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 515
1 2 3 4 range
A 544.3
(3)
P 		435.7
(1.6)
P 		484.2
(2.2)
P 		84.1
(-3)
P 		460
B 504.1
(3)
P 		386
(1.1)
P 		419.9
(1.6)
P 		134
(-3)
P 		370
C 541.9
(2.4)
P 		415.9
(0.9)
P 		595.9
(3)
P 		80.5
(-3)
P 		515
avr 530.1
(3) 		412.5
(1.4) 		500
(2.6) 		99.5
(-3) 		431

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 370
1 2 3 4 5 6 range
A 311.1
(-1)
P 		534.7
(3)
P 		357.7
(-0.1)
P 		346.4
(-0.3)
P 		278.5
(-1.5)
P 		195.8
(-3)
P 		339
B 542.6
(3)
P 		437.2
(0.2)
P 		457.7
(0.7)
P 		377
(-1.4)
P 		355.1
(-2)
P 		317.5
(-3)
P 		225
C 565.3
(3)
P 		485.9
(1.4)
P 		436.1
(0.4)
P 		270
(-2.9)
P 		295.8
(-2.4)
P 		267.5
(-3)
P 		298
avr 473
(2.7) 		485.9
(3) 		417.2
(1.2) 		331.1
(-1.1) 		309.8
(-1.7) 		260.3
(-3) 		226
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193465_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16435
Sequence Type Exemplar sequence
Representative Public ID C34F6.8 NCBI
Target Description C34F6.8 /REP_DB=WormBase Gene ID /WP=CE15677 /TR=O17643 /GB=CAB03943.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Isocitrate and isopropylmalate dehydrogenases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077474(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077474 NCBI Caenorhabditis elegans C34F6.8 (C34F6.8) mRNA, complete cds. 11/11 None
SNAP00000004407 ENSEMBL cdna:SNAP chromosome:CEL140:X:11215929:11217952:1 11/11 None
GENEFINDER00000004418 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:11215929:11217952:1 11/11 None
C34F6.8.1 ENSEMBL cdna:known chromosome:CEL140:X:11215619:11218066:1 gene:C34F6.8 11/11 None
C34F6.8.3 ENSEMBL cdna:known chromosome:CEL140:X:11215619:11218066:1 gene:C34F6.8 11/11 None
C34F6.8.2 ENSEMBL cdna:known chromosome:CEL140:X:11215923:11218066:1 gene:C34F6.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:11215928-11217952(+) 100.0 100.0
Public Domain and Genome References
Gene Title Isocitrate and isopropylmalate dehydrogenases
Ensembl C34F6.8
Entrez Gene 181311 Entrez gene
SwissProt O17643 EMBL-EBI
WormBase CE15677 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262962_AT isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putative at
ATGENOME1:17469_AT isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putative at
CANINE:1604453_AT similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial cfa
CANINE:1597496_S_AT similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial cfa
CANINE_2:CFA.278.2.S1_A_AT similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial cfa
CANINE_2:CFA.278.2.S1_S_AT similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial cfa
HG-U133_PLUS_2:210045_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U133A_2:210045_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U133A:210045_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U133A:210046_S_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U133_PLUS_2:210046_S_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-FOCUS:210046_S_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U133A_2:210046_S_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HUGENEFL:X69433_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
U133_X3P:G1277202_3P_A_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U95AV2:32332_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U95E:73027_R_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U95E:79776_R_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
HG-U95D:82364_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
U133_X3P:HS.5337.1.S2_3P_X_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial hs
MG-U74AV2:95693_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial mm
MU11KSUBA:U51167_S_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial mm
MOE430A:1450048_A_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial mm
MOUSE430A_2:1450048_A_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial mm
MOUSE430_2:1450048_A_AT isocitrate dehydrogenase 2 (NADP+), mitochondrial mm
MOE430B:1458383_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial, mRNA (cDNA clone MGC:68036 IMAGE:6515657) mm
MOUSE430_2:1458383_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial, mRNA (cDNA clone MGC:68036 IMAGE:6515657) mm
MU19KSUBA:TC18475_AT Isocitrate dehydrogenase 2 (NADP+), mitochondrial, mRNA (cDNA clone MGC:68036 IMAGE:6515657) mm
RG-U34A:RC_AA891785_AT similar to NADP+-specific isocitrate dehydrogenase rn
RG-U34A:RC_AA891785_G_AT similar to NADP+-specific isocitrate dehydrogenase rn
RG-U34C:RC_AI172491_AT similar to NADP+-specific isocitrate dehydrogenase rn
RAE230A:1388403_AT similar to NADP+-specific isocitrate dehydrogenase rn
RAT230_2:1388403_AT similar to NADP+-specific isocitrate dehydrogenase rn
YEAST_2:1779660_AT Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6092 main pathways of carbohydrate metabolism inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4450 isocitrate dehydrogenase (NADP+) activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03943 Hypothetical protein C34F6.8 [Caenorhabditis elegans] ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] 0.0
blast CAE70680 Hypothetical protein CBG17397 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001804 EMBL-EBI Isocitrate/isopropylmalate dehydrogenase 1.3E-107
Sequence
Target Sequence 
>C. ELEGANS:193465_AT
gctctggaggatttgtgtgggcttgcaagaactacgacggagatgtgcaaagtgacattg
ttgctcaaggatacggatcgctcggtctcatgtcttcagttttgatgtgtcccgacggaa
agacaattgaagcagaagctgcgcatggaacagtcactcgacattatcgtgaacatcaga
agggtaactcgacgtctacaaacccaattgcgtctatctttgcttggacaagaggtcttc
atcacagaggcgtacttgacaataatgaagcattgaagacgttctcccttactttggaaa
aggcatgcattgacactgtcgaggagggaaaaatgacgaaagatctttcaatttgcattc
atggaaccaagaagggaaccgagaaaggagcttatcttattactgaagattttctgtccg
ctattgacacc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCTCTGGAGGATTTGTGTGGGCTTG 184 299 860 Antisense
TGGGCTTGCAAGAACTACGACGGAG 690 551 877 Antisense
GCTCAAGGATACGGATCGCTCGGTC 60 303 922 Antisense
TCGGTCTCATGTCTTCAGTTTTGAT 37 607 941 Antisense
TCAGTTTTGATGTGTCCCGACGGAA 658 621 955 Antisense
GCTGCGCATGGAACAGTCACTCGAC 261 297 997 Antisense
TAACTCGACGTCTACAAACCCAATT 22 637 1044 Antisense
AACCCAATTGCGTCTATCTTTGCTT 371 145 1060 Antisense
AGAGGTCTTCATCACAGAGGCGTAC 34 67 1090 Antisense
AAAGGCATGCATTGACACTGTCGAG 537 115 1158 Antisense
AGATTTTCTGTCCGCTATTGACACC 385 65 1266 Antisense
Sequence Source Affymetrix Proprietary Database