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[193464_s_at] prolyl 4-hydroxylase alpha subunit

Description F35G2.4 /REP_DB=WormBase Gene ID /WP=CE05811 /GEN=phy-2 /TR=Q20065 /GB=CAA93469.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=prolyl 4-hydroxylase alpha subunit
Cluster 6grp_highest_10_10 > 38      6grp_high1_10_10 > 82      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 45      6grp_total > 70      4grp_total > 58      6grp_highest_sub > 04      6grp_cgc > 76      6grp_high1_sub > 04      6grp_cgc_sub > 03_04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1361
1 2 3 4 range
A 631.2
(-0.7)
P 		1024.7
(1.2)
P 		1382
(3)
P 		180.2
(-3)
P 		1202
B 735.5
(-0.3)
P 		1414.8
(3)
P 		1215.8
(2)
P 		162.8
(-3)
P 		1252
C 655.3
(-0.9)
P 		1464
(2.7)
P 		1524.2
(3)
P 		182.9
(-3)
P 		1341
avr 674
(-0.5) 		1301.2
(2.6) 		1374
(3) 		175.3
(-3) 		1199

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3267
1 2 3 4 5 6 range
A 758.8
(-3)
P 		885.4
(-2.7)
P 		1900
(-0.6)
P 		3624.3
(3)
P 		2003.5
(-0.4)
P 		1507.6
(-1.4)
P 		2866
B 689.9
(-3)
P 		851.5
(-2.6)
P 		2334.4
(1)
P 		3177
(3)
P 		2291.9
(0.9)
P 		1589.2
(-0.8)
P 		2487
C 817.2
(-3)
P 		844.5
(-2.9)
P 		1846.6
(-1)
P 		3957.1
(3)
P 		2030.2
(-0.7)
P 		1715.1
(-1.3)
P 		3140
avr 755.3
(-3) 		860.5
(-2.8) 		2027
(-0.3) 		3586.1
(3) 		2108.5
(-0.1) 		1604
(-1.2) 		2831
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 505
1 2 3 4 range
A 229.8
(0.6)
P 		222.4
(0.5)
P 		361.3
(3)
P 		26.4
(-3)
P 		335
B 234.5
(0.8)
P 		349.4
(3)
P 		281.7
(1.7)
P 		34.7
(-3)
P 		315
C 216.9
(-0.8)
P 		420.9
(1.7)
P 		531.2
(3)
P 		30.8
(-3)
P 		500
avr 227.1
(0.3) 		330.9
(2) 		391.4
(3) 		30.6
(-3) 		361

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 791
1 2 3 4 5 6 range
A 139.9
(-3)
P 		314.9
(-1.7)
P 		413.8
(-0.9)
P 		919.2
(3)
P 		604.6
(0.6)
P 		367.1
(-1.3)
P 		779
B 240.1
(-3)
P 		283.4
(-2.6)
P 		566.9
(-0.2)
P 		841.5
(2.2)
P 		931.2
(3)
P 		592.6
(0.1)
P 		691
C 302.9
(-2.5)
P 		257.7
(-3)
P 		470
(-0.6)
P 		795.8
(3)
P 		656.9
(1.5)
P 		574.1
(0.5)
P 		538
avr 227.6
(-3) 		285.3
(-2.4) 		483.6
(-0.5) 		852.2
(3) 		730.9
(1.8) 		511.3
(-0.3) 		625
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193464_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10271
Sequence Type Exemplar sequence
Representative Public ID F35G2.4 NCBI
Target Description F35G2.4 /REP_DB=WormBase Gene ID /WP=CE05811 /GEN=phy-2 /TR=Q20065 /GB=CAA93469.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=prolyl 4-hydroxylase alpha subunit
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069916(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069916 NCBI Caenorhabditis elegans Proline HYdroxylase family member (phy-2) (phy-2) mRNA, complete cds. 11/11 None
F35G2.4.1 ENSEMBL cdna:known chromosome:CEL140:IV:12211088:12215958:-1 gene:F35G2.4 11/11 None
F35G2.4.2 ENSEMBL cdna:known chromosome:CEL140:IV:12211088:12215960:-1 gene:F35G2.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000015555 6/11 Cross Hyb Matching Probes None
GENEFINDER00000015561 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:12211188-12215963(-) 100.0 100.0
Public Domain and Genome References
Gene Title prolyl 4-hydroxylase alpha subunit
Gene Symbol phy-2
Ensembl F35G2.4
Entrez Gene 178170 Entrez gene
SwissProt Q20065 EMBL-EBI
WormBase CE05811 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16221_AT oxidoreductase, 2OG-Fe(II) oxygenase family protein at
CANINE:1600033_AT similar to Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) cfa
CANINE_2:CFA.21239.1.S1_S_AT similar to Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) cfa
CANINE_2:CFA.21239.2.S1_AT similar to Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) cfa
CANINE_2:CFAAFFX.22481.1.S1_AT similar to Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) cfa
CANINE_2:CFAAFFX.22494.1.S1_S_AT similar to Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) cfa
DROSOPHILA_2:1628705_AT prolyl-4-hydroxylase-alpha EFB dm
DROSGENOME1:150892_AT prolyl-4-hydroxylase-alpha EFB dm
DROSGENOME1:141636_AT prolyl-4-hydroxylase-alpha EFB dm
CHICKEN:GGA.17975.1.S1_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I gga
CHICKEN:GGA.3098.1.S1_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I gga
HG-U133_PLUS_2:207543_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U133A:207543_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-FOCUS:207543_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U133A_2:207543_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HUGENEFL:M24486_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
U133_X3P:G4505564_3P_A_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U95AV2:37037_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HU35KSUBC:RC_H89589_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
U133_X3P:HS2.41250.1.S1_3P_S_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U133_PLUS_2:1561151_A_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U95B:44476_R_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U95D:88134_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
HG-U95E:82787_R_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I hs
MOE430A:1426519_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MOUSE430A_2:1426519_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MOUSE430_2:1426519_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MU11KSUBA:U16162_S_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MG-U74AV2:104139_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MG-U74CV2:135753_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MOE430A:1452094_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MOUSE430A_2:1452094_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MOUSE430_2:1452094_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide mm
MG-U74BV2:105850_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide, mRNA (cDNA clone MGC:6332 IMAGE:3484815) mm
MU19KSUBA:TC16295_I_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide, mRNA (cDNA clone MGC:6332 IMAGE:3484815) mm
RG-U34A:X78949_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide rn
RG-U34C:RC_AI231310_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide rn
RAE230A:1370954_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide rn
RAT230_2:1370954_AT procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide rn
RG-U34B:RC_AI045674_AT Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
19538 protein metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93469 Hypothetical protein F35G2.4 [Caenorhabditis elegans] ref|NP_502317.1| Proline HYdroxylase family member (phy-2) [Caenorhabditis elegans] sp|Q20065|P4HA2_CAEEL Prolyl 4-hydroxylase alpha-2 subunit precursor (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit) 0.0
blast CAE62202 Hypothetical protein CBG06252 [Caenorhabditis briggsae] 0.0
blast CAB03452 Hypothetical protein Y47D3B.10 [Caenorhabditis elegans] emb|CAA21045.1| Hypothetical protein Y47D3B.10 [Caenorhabditis elegans] ref|NP_499464.1| DumPY : shorter than wild-type family member (dpy-18) [Caenorhabditis elegans] sp|Q10576|P4HA1_CAEEL Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) emb|CAB71298.1| prolyl 4-hydroxylase alpha subunit 1 [Caenorhabditis elegans] 1.0E-163
Protein Domains
Database ID Description E-Value
Pfam IPR005123 EMBL-EBI 2OG-Fe(II) oxygenase superfamily 5.3E-19
Sequence
Target Sequence 
>C. ELEGANS:193464_S_AT
ggagttggcttctccaaagctgaagcgagcaactgtccaaaattcgaaaactggcgagct
ggaacatgccacgtaccgtatctcaaaaagtgcttggttgaagggagatttggatccagt
tattgatagagtcaacagaagaattgaagatttcaccaatttgaaccaggctacttcaga
ggagcttcaggtagctaactacggtcttggaggtcactacgacccacatttcgactttgc
ccggaaagaagagaagaatgcattcaagacgctcaatactggaaaccgaattgcgactgt
tttattctatatgagtcaaccagaacgcggaggagcaaccgtcttcaatcatcttgga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAGTTGGCTTCTCCAAAGCTGAAG 324 517 1041 Antisense
GCTGAAGCGAGCAACTGTCCAAAAT 94 297 1059 Antisense
ACTGGCGAGCTGGAACATGCCACGT 134 97 1090 Antisense
CATGCCACGTACCGTATCTCAAAAA 10 211 1105 Antisense
GAACCAGGCTACTTCAGAGGAGCTT 377 345 1203 Antisense
AGCTAACTACGGTCTTGGAGGTCAC 337 75 1233 Antisense
TGGAGGTCACTACGACCCACATTTC 590 549 1248 Antisense
CACATTTCGACTTTGCCCGGAAAGA 398 195 1265 Antisense
GAATGCATTCAAGACGCTCAATACT 384 331 1296 Antisense
GAGTCAACCAGAACGCGGAGGAGCA 596 399 1353 Antisense
AGCAACCGTCTTCAATCATCTTGGA 597 75 1374 Antisense
Sequence Source Affymetrix Proprietary Database