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[193459_s_at]

Description K11E8.1B /REP_DB=WormBase Gene ID /WP=CE28052 /GEN=unc-43 /GB=CAC42357.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=calcium-calmodulin dependent protein kinase
Cluster 6grp_highest_10_10 > 40      6grp_high1_10_10 > 05      4grp_highest_8_8 > 58      4grp_high_8_8 > 33      6grp_highest_nonorm > 60      6grp_total > 15      4grp_total > 46      6grp_highest_sub > De      6grp_cgc > 22      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 663
1 2 3 4 range
A 647.6
(3)
P 		389.5
(-0.5)
P 		200.6
(-3)
P 		245.3
(-2.4)
P 		447
B 649.7
(3)
P 		362
(-1.8)
P 		297.5
(-2.9)
P 		289.8
(-3)
P 		360
C 863.7
(3)
P 		413.6
(-2)
P 		376.1
(-2.4)
P 		320.4
(-3)
P 		543
avr 720.3
(3) 		388.4
(-1.6) 		291.4
(-2.9) 		285.2
(-3) 		435

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 503
1 2 3 4 5 6 range
A 552.2
(3)
P 		488.8
(1.5)
P 		432.5
(0.2)
P 		291.6
(-3)
P 		425
(0.1)
P 		319.2
(-2.4)
P 		261
B 525.5
(2.3)
P 		557.5
(3)
P 		438.1
(0.5)
P 		266.2
(-3)
P 		303.3
(-2.2)
P 		265.5
(-3)
P 		292
C 768.8
(3)
P 		524.3
(-0.2)
P 		350.2
(-2.5)
P 		309.5
(-3)
P 		377.8
(-2.1)
P 		335.4
(-2.7)
P 		459
avr 615.5
(3) 		523.5
(1.3) 		406.9
(-0.8) 		289.1
(-3) 		368.7
(-1.5) 		306.7
(-2.7) 		326
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 250
1 2 3 4 range
A 235.8
(3)
P 		84.6
(-1.5)
P 		52.4
(-2.5)
P 		35.9
(-3)
P 		200
B 207.2
(3)
P 		89.4
(-1.9)
P 		68.9
(-2.7)
P 		61.8
(-3)
P 		145
C 285.9
(3)
P 		118.9
(-1.3)
P 		131.1
(-1)
P 		54
(-3)
P 		232
avr 243
(3) 		97.6
(-1.5) 		84.1
(-2) 		50.6
(-3) 		192

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 223
1 2 3 4 5 6 range
A 101.8
(-1.3)
P 		173.8
(3)
P 		94.2
(-1.8)
P 		73.9
(-3)
P 		128.2
(0.3)
P 		77.7
(-2.8)
P 		100
B 182.8
(2.9)
P 		185.6
(3)
P 		106.4
(-1.1)
P 		70.5
(-3)
P 		123.2
(-0.3)
P 		99
(-1.5)
P 		115
C 284.9
(3)
P 		160
(-0.4)
P 		89.1
(-2.3)
P 		62.2
(-3)
P 		122.3
(-1.4)
P 		112.3
(-1.7)
P 		223
avr 189.8
(3) 		173.1
(2.2) 		96.6
(-1.6) 		68.9
(-3) 		124.6
(-0.2) 		96.3
(-1.6) 		121
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193459_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9256
Sequence Type Exemplar sequence
Representative Public ID K11E8.1B NCBI
Target Description K11E8.1B /REP_DB=WormBase Gene ID /WP=CE28052 /GEN=unc-43 /GB=CAC42357.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=calcium-calmodulin dependent protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_001028125(11), NM_001028131(11), NM_001028132(11), NM_001028122(11), NM_001028128(11), NM_001028127(11), NM_001028124(11), NM_001028126(11), NM_001028129(11), NM_001028130(11), NM_001028123(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_001028125 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028131 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028132 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028122 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028128 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028127 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028124 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028126 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028129 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028130 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
NM_001028123 NCBI Caenorhabditis elegans UNCoordinated family member (unc-43) (unc-43) mRNA, complete cds. 11/11 None
SNAP00000001604 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10337505:10339625:-1 11/11 None
GENEFINDER00000001606 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10336307:10339154:-1 11/11 None
K11E8.1d ENSEMBL cdna:known chromosome:CEL140:IV:10324241:10340517:-1 gene:K11E8.1 11/11 A 
K11E8.1k ENSEMBL cdna:known chromosome:CEL140:IV:10324241:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1l ENSEMBL cdna:known chromosome:CEL140:IV:10324241:10340528:-1 gene:K11E8.1 11/11 A 
K11E8.1e ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1h ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1c ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1a ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1f ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1g ENSEMBL cdna:known chromosome:CEL140:IV:10324967:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1i ENSEMBL cdna:known chromosome:CEL140:IV:10328371:10340140:-1 gene:K11E8.1 11/11 A 
K11E8.1b.2 ENSEMBL cdna:known chromosome:CEL140:IV:10338670:10340528:-1 gene:K11E8.1 11/11 A 
K11E8.1b.1 ENSEMBL cdna:known chromosome:CEL140:IV:10338670:10340529:-1 gene:K11E8.1 11/11 A 
K11E8.1b.3 ENSEMBL cdna:known chromosome:CEL140:IV:10338670:10348943:-1 gene:K11E8.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Splice Variants
Entrez Total Refseq Isoforms Total Detected By This Probeset Refseq Probesets
177921 12 11 NM_001028122 172058_x_at (11), 175821_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028123 187759_s_at (11), 193459_s_at (11)
NM_001028124 172058_x_at (9), 175820_s_at (11), 175821_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028125 172058_x_at (11), 175821_s_at (11), 175824_s_at (11), 187759_s_at (11), 193459_s_at (11)
NM_001028126 172058_x_at (11), 175820_s_at (11), 175821_s_at (11), 193459_s_at (11)
NM_001028127 172058_x_at (11), 175821_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028128 172058_x_at (11), 175821_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028129 172058_x_at (11), 175820_s_at (11), 175821_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028130 172058_x_at (11), 173423_at (11), 193459_s_at (11)
NM_001028131 175821_s_at (11), 175824_s_at (11), 193459_s_at (11), 193463_s_at (11)
NM_001028132 172058_x_at (9), 175821_s_at (11), 175824_s_at (11), 193459_s_at (11)
NM_001028133 175821_s_at (11), 193463_s_at (11)
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10338675-10339607(-) 100.0 100.0
Public Domain and Genome References
Ensembl K11E8.1
Functional Annotations
Protein Similarities
Method ID Description E-Value
blast CAC42326 Hypothetical protein K11E8.1d [Caenorhabditis elegans] emb|CAC42364.1| Hypothetical protein K11E8.1d [Caenorhabditis elegans] ref|NP_001023296.1| UNCoordinated family member (unc-43) [Caenorhabditis elegans] gb|AAD53949.1| calcium/calmodulin dependent protein kinase II [Caenorhabditis elegans] 0.0
blast CAC42323 Hypothetical protein K11E8.1g [Caenorhabditis elegans] emb|CAC42361.1| Hypothetical protein K11E8.1g [Caenorhabditis elegans] ref|NP_001023299.1| UNCoordinated family member (unc-43) [Caenorhabditis elegans] gb|AAF63320.1| calcium/calmodulin-dependent protein kinase II isoform B [Caenorhabditis elegans] 0.0
blast CAC42327 Hypothetical protein K11E8.1f [Caenorhabditis elegans] emb|CAC42365.1| Hypothetical protein K11E8.1f [Caenorhabditis elegans] ref|NP_001023298.1| UNCoordinated family member (unc-43) [Caenorhabditis elegans] gb|AAF63323.1| calcium/calmodulin-dependent protein kinase II isoform E [Caenorhabditis elegans] 0.0
blast CAA94242 Hypothetical protein K11E8.1a [Caenorhabditis elegans] emb|CAC42358.1| Hypothetical protein K11E8.1a [Caenorhabditis elegans] ref|NP_001023293.1| UNCoordinated family member (unc-43) [Caenorhabditis elegans] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-61
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-63
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-66
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-66
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-66
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-66
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-67
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-67
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-67
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-68
hanks 2.2.5 CaMK Group; CaMK II KIN1/SNF1/Nim1; SNF1 9.0E-22
hanks 2.1.5 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DmCamKII 1.0E-132
hanks 2.1.5 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DmCamKII 1.0E-133
hanks 2.1.5 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DmCamKII 1.0E-137
hanks 2.1.5 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DmCamKII 1.0E-138
hanks 2.1.5 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DmCamKII 1.0E-139
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-97
Pfam IPR000719 EMBL-EBI Protein kinase 8.6E-42
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-92
Pfam IPR000719 EMBL-EBI Protein kinase 1.2E-91
Sequence
Target Sequence 
>C. ELEGANS:193459_S_AT
cagttgttcgtcgttgtgttcataaaaccacgggcctcgagtttgctgccaaaatcatca
acacaaagaagctatccgctcgtgactttcagaaacttgagagggaagccagaatttgca
gaaaactccagcatccaaatattgttagactacacgacagtattcaagaggaatcattcc
attatctggtttttgatctcgttaccggaggagaactgtttgaggacattgttgctcgcg
agttttattcagaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CAGTTGTTCGTCGTTGTGTTCATAA 344 207 47 Antisense
TAAAACCACGGGCCTCGAGTTTGCT 334 639 69 Antisense
GGCCTCGAGTTTGCTGCCAAAATCA 689 539 79 Antisense
ATCAACACAAAGAAGCTATCCGCTC 262 27 103 Antisense
CTATCCGCTCGTGACTTTCAGAAAC 155 225 118 Antisense
GAAAACTCCAGCATCCAAATATTGT 327 355 167 Antisense
GTTAGACTACACGACAGTATTCAAG 548 445 190 Antisense
GAATCATTCCATTATCTGGTTTTTG 160 329 217 Antisense
GTTACCGGAGGAGAACTGTTTGAGG 482 445 247 Antisense
GTTTGAGGACATTGTTGCTCGCGAG 364 451 264 Antisense
GTTGCTCGCGAGTTTTATTCAGAAG 1 441 277 Antisense
Sequence Source Affymetrix Proprietary Database