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[193454_at] multidrug resistance protein (p-glycoprotein)

Description C30H6.6 /REP_DB=WormBase Gene ID /WP=CE15650 /TR=O45278 /GB=CAB02812.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=multidrug resistance protein (p-glycoprotein)
Cluster 6grp_high1_10_10 > 30      6grp_total > 43      4grp_total > 47      6grp_cgc > 91      6grp_high1_sub > 03      6grp_cgc_sub > 03      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 124
1 2 3 4 range
A 119.1
(3)
A 		13.7
(-3)
A 		49.7
(-1)
A 		27
(-2.2)
A 		105
B 118.2
(3)
A 		30.7
(-1.8)
A 		7.7
(-3)
A 		53.9
(-0.5)
A 		111
C 131.5
(3)
A 		21.2
(-3)
A 		50.8
(-1.4)
A 		49.6
(-1.5)
A 		110
avr 122.9
(3) 		21.9
(-3) 		36.1
(-2.2) 		43.5
(-1.7) 		101

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 178
1 2 3 4 5 6 range
A 236.7
(1.2)
P 		154.2
(-2.2)
P 		282.2
(3)
P 		193.6
(-0.6)
P 		134.3
(-3)
A 		206
(-0.1)
M 		148
B 228.7
(0.4)
P 		131.7
(-3)
A 		301.9
(3)
P 		186.2
(-1.1)
P 		136
(-2.8)
P 		169.2
(-1.7)
P 		170
C 224
(1.7)
P 		152.5
(-1.6)
A 		250.5
(3)
P 		182.4
(-0.2)
A 		123.7
(-3)
M 		209.4
(1.1)
P 		127
avr 229.8
(1) 		146.1
(-2.4) 		278.2
(3) 		187.4
(-0.7) 		131.3
(-3) 		194.9
(-0.4) 		147
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 42
1 2 3 4 range
A 43.4
(3)
A 		3
(-3)
A 		13
(-1.5)
A 		3.9
(-2.9)
A 		40
B 37.7
(3)
A 		7.6
(-2)
A 		1.8
(-3)
A 		11.5
(-1.4)
A 		36
C 43.5
(3)
A 		6.1
(-3)
A 		17.7
(-1.1)
A 		8.4
(-2.6)
A 		37
avr 41.5
(3) 		5.6
(-3) 		10.8
(-2.1) 		7.9
(-2.6) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 46
1 2 3 4 5 6 range
A 43.6
(-2.1)
P 		54.8
(1.1)
P 		61.5
(3)
P 		49.1
(-0.5)
P 		40.5
(-3)
A 		50.2
(-0.2)
M 		21
B 79.6
(3)
P 		43.8
(-3)
A 		73.3
(1.9)
P 		49.3
(-2.1)
P 		55.2
(-1.1)
P 		63.1
(0.2)
P 		36
C 83
(3)
P 		46.5
(-1.7)
A 		63.7
(0.5)
P 		36.7
(-3)
A 		40
(-2.6)
M 		70.1
(1.3)
P 		46
avr 68.7
(3) 		48.4
(-2.1) 		66.2
(2.4) 		45
(-3) 		45.2
(-2.9) 		61.1
(1.1) 		24
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193454_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9836
Sequence Type Exemplar sequence
Representative Public ID C30H6.6 NCBI
Target Description C30H6.6 /REP_DB=WormBase Gene ID /WP=CE15650 /TR=O45278 /GB=CAB02812.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=multidrug resistance protein (p-glycoprotein)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070697(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070697 NCBI Caenorhabditis elegans HAlF transporter (PGP related) family member (haf-1) (haf-1) mRNA, complete cds. 11/11 None
SNAP00000029653 ENSEMBL cdna:SNAP chromosome:CEL140:IV:17377485:17380257:1 9/11 None
GENEFINDER00000029659 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:17376391:17379200:1 11/11 None
C30H6.6 ENSEMBL cdna:known chromosome:CEL140:IV:17376382:17379268:1 gene:C30H6.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:17377165-17379206(+) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance protein (p-glycoprotein)
Gene Symbol haf-1
Ensembl C30H6.6
Entrez Gene 178522 Entrez gene
SwissProt O45278 EMBL-EBI
WormBase CE15650 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02812 Hypothetical protein C30H6.6 [Caenorhabditis elegans] ref|NP_503098.1| HAlF transporter (PGP related) family member (haf-1) [Caenorhabditis elegans] 0.0
blast CAE57441 Hypothetical protein CBG00403 [Caenorhabditis briggsae] 0.0
blast CAB09418 Hypothetical protein F57A10.3 [Caenorhabditis elegans] ref|NP_506927.1| HAlF transporter (PGP related) family member (haf-3) [Caenorhabditis elegans] 1.0E-166
blast CAE56320 Hypothetical protein CBG23985 [Caenorhabditis briggsae] 1.0E-159
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.5E-24
Pfam IPR003439 EMBL-EBI ABC transporter 2.7E-62
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 9.8E-19
Pfam IPR003439 EMBL-EBI ABC transporter 4.3E-57
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.9E-26
Pfam IPR003439 EMBL-EBI ABC transporter 2.7E-62
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000029659 3 93-112,148-170,226-248
Sequence
Target Sequence 
>C. ELEGANS:193454_AT
gttgatctacgcgacctgaatgctacaacatggagacatgcaattggaaccgttggtcag
gagcctgttctgttcacttgctccattcgagaaaatatattgatgggaacagagcatccg
gagaaagttagccagtacgagctggaggaagccgcacagctggctaacgcattggatttt
attcaaggatttgagaatggttttgagacgatggtcggagagcacggatgcaagttatct
ggaggccaaaaacaacgaatcgcgatcgcacgtgcactgatttcaaagccaaaaatcatg
attcttgatgaagcaactagcgctcttgatgcaacctctgactatttgattcgaatgact
ttggataatttgctgaaaaatcataatttgacagtattggttattgcacatagactcgcc
acaatgcaacaagctgaccaagtggtttacgtgaatagaggtcgaatcgaaggccaagga
acatttgatgaaatgatgaaaattcagaattcgattgttgagcaagaagcaaggcgtcga
ggcatccc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTGATCTACGCGACCTGAATGCTA 642 437 1162 Antisense
GGAACCGTTGGTCAGGAGCCTGTTC 435 525 1207 Antisense
GTACGAGCTGGAGGAAGCCGCACAG 630 457 1296 Antisense
CCGCACAGCTGGCTAACGCATTGGA 245 261 1313 Antisense
GACGATGGTCGGAGAGCACGGATGC 255 379 1368 Antisense
CAACGAATCGCGATCGCACGTGCAC 203 185 1414 Antisense
GCACGTGCACTGATTTCAAAGCCAA 215 313 1429 Antisense
GAAGCAACTAGCGCTCTTGATGCAA 403 341 1471 Antisense
GATGCAACCTCTGACTATTTGATTC 71 413 1489 Antisense
GTTATTGCACATAGACTCGCCACAA 74 449 1561 Antisense
AAGAAGCAAGGCGTCGAGGCATCCC 654 151 1685 Antisense
Sequence Source Affymetrix Proprietary Database