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[193428_s_at] proteasome component (A-type)

Description C15H11.7 /REP_DB=WormBase Gene ID /WP=CE08184 /GEN=pas-1 /TR=SW:O17586 /GB=CAB02738.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=proteasome component (A-type)
Cluster 6grp_highest_10_10 > 39      6grp_high1_10_10 > 83      4grp_highest_8_8 > 10      4grp_high_8_8 > 54      6grp_highest_nonorm > 55      6grp_total > 70      4grp_total > 57      6grp_highest_sub > 04      6grp_cgc > 76      6grp_high1_sub > 04      6grp_cgc_sub > 03_04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1629
1 2 3 4 range
A 1333.5
(-1.7)
P 		2054.3
(1.7)
P 		2337.1
(3)
P 		1062.2
(-3)
P 		1275
B 1124.5
(-2.5)
P 		2072.1
(1.2)
P 		2528.4
(3)
P 		1008.2
(-3)
P 		1520
C 1415.4
(-1)
P 		2295.3
(2.3)
P 		2474.5
(3)
P 		899.7
(-3)
P 		1575
avr 1291.1
(-1.8) 		2140.6
(1.7) 		2446.7
(3) 		990
(-3) 		1457

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 871
1 2 3 4 5 6 range
A 1746.2
(-0.3)
P 		1588.8
(-3)
P 		1606.9
(-2.7)
P 		1943.5
(3)
P 		1684.8
(-1.4)
P 		1711.8
(-0.9)
P 		355
B 1451
(0.5)
P 		1072.5
(-3)
P 		1549.8
(1.5)
P 		1715.9
(3)
P 		1594.1
(1.9)
P 		1541.5
(1.4)
P 		643
C 1683
(1.2)
P 		1158.9
(-3)
P 		1911.8
(3)
P 		1846.6
(2.5)
P 		1776.1
(1.9)
P 		1546.9
(0.1)
P 		753
avr 1626.7
(0.8) 		1273.4
(-3) 		1689.5
(1.4) 		1835.3
(3) 		1685
(1.4) 		1600.1
(0.5) 		562
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 711
1 2 3 4 range
A 485.5
(1.3)
P 		445.9
(0.8)
P 		611
(3)
P 		155.5
(-3)
P 		456
B 358.6
(-0.7)
P 		511.8
(1.8)
P 		585.9
(3)
P 		214.9
(-3)
P 		371
C 468.5
(-0.3)
P 		659.9
(1.3)
P 		862.4
(3)
P 		151.7
(-3)
P 		711
avr 437.5
(0.1) 		539.2
(1.3) 		686.4
(3) 		174
(-3) 		512

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 326
1 2 3 4 5 6 range
A 321.9
(-3)
P 		565.1
(3)
P 		349.9
(-2.3)
P 		492.9
(1.2)
P 		508.4
(1.6)
P 		416.8
(-0.7)
P 		243
B 504.9
(0.1)
P 		357
(-3)
P 		376.3
(-2.6)
P 		454.5
(-1)
P 		647.7
(3)
P 		574.8
(1.5)
P 		291
C 623.8
(3)
P 		353.6
(-3)
P 		486.6
(-0)
P 		371.3
(-2.6)
P 		574.7
(1.9)
P 		517.8
(0.6)
P 		270
avr 483.5
(-0.2) 		425.2
(-2.3) 		404.3
(-3) 		439.6
(-1.8) 		576.9
(3) 		503.1
(0.4) 		173
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193428_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13967
Sequence Type Exemplar sequence
Representative Public ID C15H11.7 NCBI
Target Description C15H11.7 /REP_DB=WormBase Gene ID /WP=CE08184 /GEN=pas-1 /TR=SW:O17586 /GB=CAB02738.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=proteasome component (A-type)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074170(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074170 NCBI Caenorhabditis elegans Proteasome Alpha Subunit family member (pas-1) (pas-1) mRNA, complete cds. 11/11 None
SNAP00000026580 ENSEMBL cdna:SNAP chromosome:CEL140:V:14424359:14425206:-1 11/11 None
GENEFINDER00000026590 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:14424359:14425886:-1 11/11 None
C15H11.7.2 ENSEMBL cdna:known chromosome:CEL140:V:14424171:14425206:-1 gene:C15H11.7 11/11 None
C15H11.7.1 ENSEMBL cdna:known chromosome:CEL140:V:14424171:14425208:-1 gene:C15H11.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:14424358-14425206(-) 100.0 100.0
Public Domain and Genome References
Gene Title proteasome component (A-type)
Gene Symbol pas-1
Ensembl C15H11.7
Entrez Gene 179941 Entrez gene
SwissProt O17586 EMBL-EBI
WormBase CE08184 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:266036_S_AT 20S proteasome alpha subunit A2 (PAA2) at
CANINE:1603810_X_AT similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) cfa
CANINE:1603809_AT similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) cfa
CANINE:1596554_AT similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) cfa
CANINE:1585787_AT similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) cfa
CANINE_2:CFA.9494.1.S1_S_AT similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) cfa
DROSOPHILA_2:1633010_S_AT dm
DROSGENOME1:141501_AT dm
DROSOPHILA_2:1633010_S_AT Proteasome 6 subunit dm
DROSGENOME1:141501_AT Proteasome 6 subunit dm
CHICKEN:GGA.1001.1.S1_AT proteasome (prosome, macropain) subunit, alpha type, 6 gga
HG-U133A:208805_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
HG-U133_PLUS_2:208805_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
HG-U133A_2:208805_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
HUGENEFL:X59417_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
U133_X3P:G12804240_3P_S_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
U133_X3P:G12804240_3P_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
U133_X3P:208805_3P_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
HG-U95AV2:36122_AT proteasome (prosome, macropain) subunit, alpha type, 6 hs
HG-U95D:71040_AT Proteasome (prosome, macropain) subunit, alpha type, 6 hs
MU11KSUBA:AA185007_S_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MG-U74AV2:96952_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOE430A:1435317_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430A_2:1435317_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430_2:1435317_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOE430A:1437144_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430A_2:1437144_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430_2:1437144_X_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOE430A:1416506_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430A_2:1416506_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430_2:1416506_AT proteasome (prosome, macropain) subunit, alpha type 6 mm
MOUSE430_2:1435316_AT Proteasome subunit iota (Psma6) mm
MOE430A:1435316_AT Proteasome subunit iota (Psma6) mm
MOUSE430A_2:1435316_AT Proteasome subunit iota (Psma6) mm
YEAST_2:1778557_AT Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6511 ubiquitin-dependent protein catabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5839 proteasome core complex (sensu Eukaryota) inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4175 endopeptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02738 Hypothetical protein C15H11.7 [Caenorhabditis elegans] ref|NP_506571.1| Proteasome Alpha Subunit family member (pas-1) [Caenorhabditis elegans] sp|O17586|PSA6_CAEEL Proteasome subunit alpha type 6 (Proteasome subunit alpha 1) 1.0E-135
blast CAE60903 Hypothetical protein CBG04619 [Caenorhabditis briggsae] 1.0E-130
Protein Domains
Database ID Description E-Value
Pfam IPR001353 EMBL-EBI Peptidase T1, 20S proteasome 5.3E-53
Pfam IPR001353 EMBL-EBI Peptidase T1, 20S proteasome 5.3E-53
Sequence
Target Sequence 
>C. ELEGANS:193428_S_AT
atgcagctgtcattgccgttcaaaagcgtgttccagacagtctcatcgtcgctgataccg
tcacttcggtttatcaaatctctcagtctgttggatgctgcgccattggaatgatcccgg
atgctaaattccaaatcaagcgtgcacagggagaagctgctagctggaagtacaagaacg
gctacgatatgccatgcgagcttctcgccaaaaagatggctgatctcaaccagtattaca
cacaaaatgcggagatgcgtagtttgggatgtgctcttttgttcatttcctacgatgacg
agaaaggaccagaagtttatcgtgttgaccccgctggatactaccgtggtatgaaaggag
tatctgttggagtgaaacaacttccagcgacctcattcttggaaaagaaaattaagaaga
agtccgaattgacatccacagaagctattgaactcgccattgaggctcttcagacttcat
tgggaatcgacgttcgttccaaggatcttgaggttgtcgttgtcaccaaggataactcca
aattcaccaagctaaccagcg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGCAGCTGTCATTGCCGTTCAAAA 678 43 149 Antisense
AGCGTGTTCCAGACAGTCTCATCGT 127 81 173 Antisense
TCGCTGATACCGTCACTTCGGTTTA 53 595 197 Antisense
TCTCAGTCTGTTGGATGCTGCGCCA 481 611 229 Antisense
ACGATATGCCATGCGAGCTTCTCGC 690 93 332 Antisense
GCTCTTTTGTTCATTTCCTACGATG 119 299 421 Antisense
CAGAAGTTTATCGTGTTGACCCCGC 341 193 458 Antisense
GAGTGAAACAACTTCCAGCGACCTC 404 401 518 Antisense
GAACTCGCCATTGAGGCTCTTCAGA 497 347 598 Antisense
GAATCGACGTTCGTTCCAAGGATCT 604 327 632 Antisense
TCCAAATTCACCAAGCTAACCAGCG 210 587 685 Antisense
Sequence Source Affymetrix Proprietary Database