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[193404_at] initiation factor 4E (EIF-4E)

Description C05D9.5 /REP_DB=WormBase Gene ID /WP=CE07931 /GEN=ife-4 /TR=SW:Q22888 /GB=AAF98601.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=initiation factor 4E (EIF-4E)
Cluster 6grp_highest_10_10 > 05      6grp_high1_10_10 > 50      4grp_highest_8_8 > 32      4grp_high_8_8 > 43      6grp_highest_nonorm > 71      6grp_total > 40      4grp_total > 52      6grp_highest_sub > 03_04      6grp_cgc > 83      6grp_high1_sub > 03_04      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 180
1 2 3 4 range
A 298.4
(2.2)
P 		318
(3)
P 		251.5
(0.3)
P 		168
(-3)
P 		150
B 211.2
(2.3)
P 		220.8
(3)
P 		181.8
(0.2)
P 		137.7
(-3)
P 		83
C 235.2
(0.2)
P 		303.1
(3)
P 		230.4
(0)
P 		157.3
(-3)
P 		146
avr 248.3
(1.5) 		280.6
(3) 		221.2
(0.2) 		154.3
(-3) 		126

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 279
1 2 3 4 5 6 range
A 362
(3)
P 		318.8
(1.5)
P 		352.4
(2.7)
P 		299.3
(0.9)
P 		192.2
(-2.7)
P 		184.8
(-3)
P 		177
B 272.7
(-1.2)
P 		341.7
(0.4)
P 		453.3
(3)
P 		328.8
(0.1)
P 		248.1
(-1.8)
P 		196.1
(-3)
P 		257
C 234.9
(-1.4)
P 		298.2
(0.2)
P 		311.8
(0.6)
P 		406.5
(3)
P 		188.9
(-2.6)
P 		174.5
(-3)
P 		232
avr 289.9
(0.4) 		319.6
(1.3) 		372.5
(3) 		344.9
(2.1) 		209.7
(-2.2) 		185.1
(-3) 		187
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 84
1 2 3 4 range
A 108.7
(3)
P 		69
(0.2)
P 		65.8
(-0.1)
P 		24.6
(-3)
P 		84
B 67.3
(3)
P 		54.5
(1)
P 		42.1
(-1)
P 		29.3
(-3)
P 		38
C 77.9
(2.1)
P 		87.1
(3)
P 		80.3
(2.3)
P 		26.5
(-3)
P 		61
avr 84.6
(3) 		70.2
(1.5) 		62.7
(0.7) 		26.8
(-3) 		58

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 69
1 2 3 4 5 6 range
A 66.7
(-1.1)
P 		113.4
(3)
P 		76.7
(-0.2)
P 		75.9
(-0.3)
P 		58
(-1.9)
P 		45
(-3)
P 		68
B 94.9
(0.2)
P 		113.7
(3)
P 		110.1
(2.5)
P 		87.1
(-0.9)
P 		100.8
(1.1)
P 		73.1
(-3)
P 		41
C 87.1
(2.3)
P 		91
(3)
P 		79.4
(0.9)
P 		81.7
(1.3)
P 		61.1
(-2.5)
P 		58.4
(-3)
P 		33
avr 82.9
(0.1) 		106
(3) 		88.7
(0.8) 		81.6
(-0.1) 		73.3
(-1.2) 		58.8
(-3) 		47
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193404_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18215
Sequence Type Exemplar sequence
Representative Public ID C05D9.5 NCBI
Target Description C05D9.5 /REP_DB=WormBase Gene ID /WP=CE07931 /GEN=ife-4 /TR=SW:Q22888 /GB=AAF98601.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=initiation factor 4E (EIF-4E)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075809(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075809 NCBI Caenorhabditis elegans Initiation Factor 4E (eIF4E) family member (ife-4) (ife-4) mRNA, complete cds. 11/11 None
SNAP00000015510 ENSEMBL cdna:SNAP chromosome:CEL140:X:1104211:1106039:1 11/11 None
GENEFINDER00000015522 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:1104211:1106039:1 11/11 None
C05D9.5 ENSEMBL cdna:known chromosome:CEL140:X:1104209:1106039:1 gene:C05D9.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:1104210-1106039(+) 100.0 100.0
Public Domain and Genome References
Gene Title initiation factor 4E (EIF-4E)
Gene Symbol ife-4
Ensembl C05D9.5
Entrez Gene 180464 Entrez gene
SwissProt Q22888 EMBL-EBI
WormBase CE07931 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583311_AT similar to Eukaryotic translation initiation factor 4E type 3 (eIF4E type 3) (eIF-4E type 3) (mRNA cap-binding protein type 3) (Eukaryotic translation initiation factor 4E-like 3) (Eukaryotic translation initiation factor 4E homologous protein) (mR... cfa
CANINE_2:CFAAFFX.17653.1.S1_S_AT similar to Eukaryotic translation initiation factor 4E type 3 (eIF4E type 3) (eIF-4E type 3) (mRNA cap-binding protein type 3) (Eukaryotic translation initiation factor 4E-like 3) (Eukaryotic translation initiation factor 4E homologous protein) (mR... cfa
CANINE_2:CFAAFFX.21343.1.S1_AT similar to Eukaryotic translation initiation factor 4E type 3 (eIF4E type 3) (eIF-4E type 3) (mRNA cap-binding protein type 3) (Eukaryotic translation initiation factor 4E-like 3) (Eukaryotic translation initiation factor 4E homologous protein) (mR... cfa
DROSOPHILA_2:1625051_AT dm
CHICKEN:GGA.1103.2.S1_A_AT eukaryotic translation initiation factor 4E member 2 gga
HG-U133_PLUS_2:213570_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A_2:213570_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A:213570_AT eukaryotic translation initiation factor 4E member 2 hs
HU35KSUBA:RC_AA608850_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A:209393_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133_PLUS_2:209393_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A_2:209393_S_AT eukaryotic translation initiation factor 4E member 2 hs
U133_X3P:G3172338_3P_S_AT eukaryotic translation initiation factor 4E member 2 hs
U133_X3P:HS.19122.1.S1_3P_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A_2:213571_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-FOCUS:213571_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133_PLUS_2:213571_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U133A:213571_S_AT eukaryotic translation initiation factor 4E member 2 hs
HG-U95AV2:32229_AT eukaryotic translation initiation factor 4E member 2 hs
HU35KSUBA:RC_AA262783_AT Eukaryotic translation initiation factor 4E member 2 hs
HU35KSUBC:RC_AA086427_AT Eukaryotic translation initiation factor 4E member 2 hs
U133_X3P:HS.306915.0.S1_3P_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U133_PLUS_2:226734_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U133B:226734_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U95C:63829_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U95E:91510_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U133_PLUS_2:244302_AT Eukaryotic translation initiation factor 4E member 2 hs
HG-U133B:244302_AT Eukaryotic translation initiation factor 4E member 2 hs
U133_X3P:HS.292026.0.A1_3P_AT Eukaryotic translation initiation factor 4E member 2 hs
MOUSE430A_2:1435803_A_AT eukaryotic translation initiation factor 4E member 2 mm
MOE430A:1435803_A_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430_2:1435803_A_AT eukaryotic translation initiation factor 4E member 2 mm
MU11KSUBA:AA267137_S_AT eukaryotic translation initiation factor 4E member 2 mm
MU11KSUBB:MSA.7866.0_S_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74AV2:96843_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74AV2:161911_F_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74BV2:163974_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74CV2:166644_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74CV2:169734_AT eukaryotic translation initiation factor 4E member 2 mm
MOE430A:1421985_A_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430A_2:1421985_A_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430_2:1421985_A_AT eukaryotic translation initiation factor 4E member 2 mm
MOE430A:1435804_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430A_2:1435804_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430_2:1435804_AT eukaryotic translation initiation factor 4E member 2 mm
MOE430A:1421986_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430A_2:1421986_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430_2:1421986_AT eukaryotic translation initiation factor 4E member 2 mm
MOE430B:1455108_AT eukaryotic translation initiation factor 4E member 2 mm
MOUSE430_2:1455108_AT eukaryotic translation initiation factor 4E member 2 mm
MG-U74BV2:163117_AT eukaryotic translation initiation factor 4E member 2 mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6413 translational initiation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3723 RNA binding inferred from electronic annotation QuickGO AmiGO
3743 translation initiation factor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF98601 Initiation factor 4e (eif4e) family protein 4 [Caenorhabditis elegans] ref|NP_508210.1| Initiation Factor 4E (eIF4E) family member (ife-4) [Caenorhabditis elegans] gb|AAF62414.1| translation initiation factor eIF4E isoform 4 [Caenorhabditis elegans] sp|Q22888|IF4E4_CAEEL Eukaryotic translation initiation factor 4E-4 (eIF4E-4) (eIF-4E-4) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) 1.0E-123
blast AAF98601 Initiation factor 4e (eif4e) family protein 4 [Caenorhabditis elegans] ref|NP_508210.1| Initiation Factor 4E (eIF4E) family member (ife-4) [Caenorhabditis elegans] gb|AAF62414.1| translation initiation factor eIF4E isoform 4 [Caenorhabditis elegans] sp|Q22888|IF4E4_CAEEL Eukaryotic translation initiation factor 4E-4 (eIF4E-4) (eIF-4E-4) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) 1.0E-120
blast CAE60512 Hypothetical protein CBG04131 [Caenorhabditis briggsae] 1.0E-101
blast CAE60512 Hypothetical protein CBG04131 [Caenorhabditis briggsae] 7.0E-99
blast NP_075803 eukaryotic translation initiation factor 4E member 2 [Mus musculus] dbj|BAB31251.1| unnamed protein product [Mus musculus] 6.0E-55
blast BAD92756.1 eukaryotic translation initiation factor 4E member 2 variant [Homo sapiens] 1.0E-54
Protein Domains
Database ID Description E-Value
Pfam IPR001040 EMBL-EBI Eukaryotic translation initiation factor 4E (eIF-4E) 6.7E-124
Pfam IPR001040 EMBL-EBI Eukaryotic translation initiation factor 4E (eIF-4E) 4.5E-120
Sequence
Target Sequence 
>C. ELEGANS:193404_AT
ttgatggaagatgctccggtcggctctgacgatcaccaacttcaatattcatacacattt
tcgtatttcatgaggccaactggcaaattcgatccggaagattatgctagttatgtgcag
cctgttggaataatgaagtctgtcgagcaattttggagtattatggtgcatttcaaacgg
ccaactgaaatgtgcgacaaagctgacattcacttcttcaaaactggcgtcaaaccagtg
tgggaagatccggcgaactgcaaaggtggaaaatggattatccgactgaagaaaggattg
tcgacaagaatttgggagaatctgctcatggcaatcattggagagcagtttttggttgga
gatgagctctgtggagctgtgtgctcaattcgcaatcaggaagatattatatcattatgg
aatagaaacgcagacgacaccccagtaaccaacagaatccgagaaactcttcgatcggtg
ctccaactgcctcagaacacggtactag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGATGGAAGATGCTCCGGTCGGCT 473 705 70 Antisense
GACGATCACCAACTTCAATATTCAT 123 379 97 Antisense
GGCCAACTGGCAAATTCGATCCGGA 453 543 143 Antisense
GCGACAAAGCTGACATTCACTTCTT 282 289 263 Antisense
TTCACTTCTTCAAAACTGGCGTCAA 178 687 278 Antisense
GTGGGAAGATCCGGCGAACTGCAAA 340 489 309 Antisense
GAGCTGTGTGCTCAATTCGCAATCA 480 387 443 Antisense
AATAGAAACGCAGACGACACCCCAG 280 173 490 Antisense
CACCCCAGTAACCAACAGAATCCGA 614 199 507 Antisense
CGAGAAACTCTTCGATCGGTGCTCC 294 251 529 Antisense
CAACTGCCTCAGAACACGGTACTAG 671 185 553 Antisense
Sequence Source Affymetrix Proprietary Database