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[193403_s_at] serine-threonine protein kinase

Description Y59A8B.14 /REP_DB=WormBase Gene ID /WP=CE27410 /GEN=par-4 /TR=Q9GN62 /GB=CAC14418.2 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine protein kinase
Cluster 6grp_total > 65      4grp_total > 43      6grp_cgc > 36      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 41
1 2 3 4 range
A 2.5
(-3)
A 		42.2
(3)
A 		3.9
(-2.8)
A 		6.3
(-2.4)
A 		40
B 2.1
(-3)
A 		4.2
(-2)
A 		14.2
(3)
A 		2.3
(-2.9)
A 		12
C 3.6
(-0.3)
A 		5.9
(3)
A 		1.7
(-3)
A 		5.5
(2.4)
A 		4
avr 2.7
(-3) 		17.4
(3) 		6.6
(-1.4) 		4.7
(-2.2) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 7
1 2 3 4 5 6 range
A 7.4
(3)
A 		5.1
(-1.6)
A 		6
(0.2)
A 		5
(-1.8)
A 		4.4
(-3)
A 		7.4
(3)
A 		3
B 2.5
(-2.3)
A 		2.2
(-2.6)
A 		1.7
(-3)
A 		8.7
(3)
A 		1.8
(-2.9)
A 		7
(1.5)
A 		7
C 4.3
(0.6)
A 		3.7
(-0.2)
A 		6.2
(3)
A 		2.2
(-2.1)
A 		4.1
(0.3)
A 		1.5
(-3)
A 		5
avr 4.7
(1.1) 		3.7
(-2.1) 		4.6
(0.8) 		5.3
(3) 		3.4
(-3) 		5.3
(3) 		2
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 9
1 2 3 4 range
A 0.9
(-3)
A 		9.2
(3)
A 		1
(-2.9)
A 		0.9
(-3)
A 		8
B 0.7
(-2.6)
A 		1
(-1.9)
A 		3.3
(3)
A 		0.5
(-3)
A 		3
C 1.2
(0.3)
A 		1.7
(3)
A 		0.6
(-3)
A 		0.9
(-1.4)
A 		1
avr 0.9
(-2.8) 		4
(3) 		1.6
(-1.5) 		0.8
(-3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2
1 2 3 4 5 6 range
A 1.4
(-1.8)
A 		1.8
(3)
A 		1.3
(-3)
A 		1.3
(-3)
A 		1.3
(-3)
A 		1.8
(3)
A 		1
B 0.9
(-1.6)
A 		0.7
(-2.2)
A 		0.4
(-3)
A 		2.3
(2.2)
A 		0.7
(-2.2)
A 		2.6
(3)
A 		2
C 1.6
(3)
A 		1.1
(0.5)
A 		1.6
(3)
A 		0.4
(-3)
A 		1.3
(1.5)
A 		0.5
(-2.5)
A 		1
avr 1.3
(-0.6) 		1.2
(-1.8) 		1.1
(-3) 		1.3
(-0.6) 		1.1
(-3) 		1.6
(3) 		1
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193403_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13601
Sequence Type Exemplar sequence
Representative Public ID Y59A8B.14 NCBI
Target Description Y59A8B.14 /REP_DB=WormBase Gene ID /WP=CE27410 /GEN=par-4 /TR=Q9GN62 /GB=CAC14418.2 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075132(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075132 NCBI Caenorhabditis elegans abnormal embryonic PARtitioning of cytoplasm family member (par-4) (par-4) mRNA, complete cds. 11/11 A 
SNAP00000043005 ENSEMBL cdna:SNAP chromosome:CEL140:V:18106780:18117164:1 9/11 None
GENEFINDER00000043026 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:18106796:18110152:1 11/11 None
Y59A8B.14 ENSEMBL cdna:known chromosome:CEL140:V:18101250:18109442:1 gene:Y59A8B.14 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:18101260-18110097(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine-threonine protein kinase
Gene Symbol par-4
Ensembl Y59A8B.14
Entrez Gene 180185 Entrez gene
SwissProt Q9GN62 EMBL-EBI
WormBase CE27410 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.21039.1.S1_S_AT similar to Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase LKB1) cfa
CANINE_2:CFAAFFX.29867.1.S1_AT similar to Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase LKB1) cfa
DROSOPHILA_2:1635781_S_AT Metallothionein A promoter construct of Martin dm
DROSGENOME1:153119_AT Metallothionein A promoter construct of Martin dm
CHICKEN:GGA.12596.1.S1_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) gga
HG-U133_PLUS_2:204292_X_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133A:204292_X_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133A_2:204292_X_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HU35KSUBD:RC_AA436398_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
U133_X3P:G4507270_3P_S_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
U133_X3P:HS.155647.0.S1_3P_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133_PLUS_2:231017_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133B:231017_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133A_2:41657_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-FOCUS:41657_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133_PLUS_2:41657_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133A:41657_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U95AV2:41657_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U95D:74967_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U95E:86312_AT serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133_PLUS_2:231019_X_AT Serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
HG-U133B:231019_X_AT Serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
U133_X3P:HS.155647.0.A1_3P_AT Serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
U133_X3P:HS.155647.0.A1_3P_X_AT Serine/threonine kinase 11 (Peutz-Jeghers syndrome) hs
MOUSE430_2:1448062_AT serine/threonine kinase 11 mm
MOUSE430A_2:1448062_AT serine/threonine kinase 11 mm
MOE430A:1448062_AT serine/threonine kinase 11 mm
MU11KSUBA:AA198899_AT serine/threonine kinase 11 mm
MU11KSUBB:MSA.18758.0_S_AT serine/threonine kinase 11 mm
MG-U74AV2:160372_AT serine/threonine kinase 11 mm
MOE430A:1418644_A_AT serine/threonine kinase 11 mm
MOUSE430A_2:1418644_A_AT serine/threonine kinase 11 mm
MOUSE430_2:1418644_A_AT serine/threonine kinase 11 mm
RG-U34B:RC_AI045508_AT serine/threonine kinase 11 (predicted) rn
RAE230A:1375364_AT serine/threonine kinase 11 (predicted) rn
RAT230_2:1375364_AT serine/threonine kinase 11 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5938 cell cortex inferred from direct assay QuickGO AmiGO
5737 cytoplasm inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAC14418 Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] emb|CAC15862.2| Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] ref|NP_507533.1| abnormal embryonic PARtitioning of cytoplasm family member (par-4) [Caenorhabditis elegans] gb|AAD45355.1| putative serine-threonine kinase PAR-4 [Caenorhabditis elegans] 0.0
blast CAE61699 Hypothetical protein CBG05647 [Caenorhabditis briggsae] 0.0
blast CAB60573 Hypothetical protein Y37H2A.1 [Caenorhabditis elegans] ref|NP_507534.1| Y37H2A.1 [Caenorhabditis elegans] 0.0
blast CAC14418 Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] emb|CAC15862.2| Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] ref|NP_507533.1| abnormal embryonic PARtitioning of cytoplasm family member (par-4) [Caenorhabditis elegans] gb|AAD45355.1| putative serine-threonine kinase PAR-4 [Caenorhabditis elegans] 1.0E-113
blast CAC14418 Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] emb|CAC15862.2| Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] ref|NP_507533.1| abnormal embryonic PARtitioning of cytoplasm family member (par-4) [Caenorhabditis elegans] gb|AAD45355.1| putative serine-threonine kinase PAR-4 [Caenorhabditis elegans] 1.0E-110
blast CAB60325 Hypothetical protein Y24F12A.1 [Caenorhabditis elegans] ref|NP_502188.1| Y24F12A.1 [Caenorhabditis elegans] 9.0E-88
blast EAA08443 ENSANGP00000016595 [Anopheles gambiae str. PEST] ref|XP_312848.2| ENSANGP00000016595 [Anopheles gambiae str. PEST] 5.0E-64
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-60
hanks 2.2.7 CaMK Group; CaMK II KIN1/SNF1/Nim1; AKIN10 1.0E-58
hanks 1.1.1 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); cAPKa 4.0E-5
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.6E-64
Pfam IPR000719 EMBL-EBI Protein kinase 3.4E-17
Pfam IPR001130 EMBL-EBI TatD-related deoxyribonuclease 6.8E-36
Pfam IPR001130 EMBL-EBI TatD-related deoxyribonuclease 2.3E-20
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-14
Sequence
Target Sequence 
>C. ELEGANS:193403_S_AT
tttacccattaatttgacttctgaagcagtcctcgaacgtggctcatttcccggcttcaa
atttctcgaagcaaaacccggagatggtcctgacggtgtcgaaggatccgaagattcggc
agcacctctgggacctcaacgacgtccctcatcccgatcaatgccaacgtgtgcaccgcc
cggtccagcagctggaaatgctcaaaattcgactgctgaaaatggtgctgaaactgatgg
tgttgcttcagcttcagatcctcctcctactgctgctcctggagctccaccgcgacgccg
aaaacgcaactttttctcgtgtatctttcgttctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTACCCATTAATTTGACTTCTGAA 473 673 1413 Antisense
TGAAGCAGTCCTCGAACGTGGCTCA 107 575 1434 Antisense
GCAAAACCCGGAGATGGTCCTGACG 262 317 1483 Antisense
GGTCCTGACGGTGTCGAAGGATCCG 417 501 1498 Antisense
TCATCCCGATCAATGCCAACGTGTG 61 623 1561 Antisense
CGATCAATGCCAACGTGTGCACCGC 422 249 1567 Antisense
CCGCCCGGTCCAGCAGCTGGAAATG 292 261 1588 Antisense
GGTGCTGAAACTGATGGTGTTGCTT 210 501 1636 Antisense
ATGGTGTTGCTTCAGCTTCAGATCC 565 49 1649 Antisense
GCCGAAAACGCAACTTTTTCTCGTG 559 283 1709 Antisense
TTTTTCTCGTGTATCTTTCGTTCTC 412 675 1723 Antisense
Sequence Source Affymetrix Proprietary Database