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[193375_at] tyrosine-protein kinase (FES/FPS subfamily)

Description F01D4.3 /REP_DB=WormBase Gene ID /WP=CE09155 /TR=O17755 /GB=CAB02882.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 56      4grp_total > 35      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 28
1 2 3 4 range
A 18.5
(-0.2)
A 		21.4
(0.6)
A 		9
(-3)
A 		29.4
(3)
A 		20
B 7.1
(-2.7)
A 		29.6
(3)
A 		16.7
(-0.3)
A 		5.9
(-3)
A 		24
C 9.8
(-2.6)
A 		27.3
(1.4)
A 		7.9
(-3)
A 		34.2
(3)
A 		26
avr 11.8
(-2.8) 		26.1
(3) 		11.2
(-3) 		23.2
(1.8) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 64
1 2 3 4 5 6 range
A 30.4
(2.5)
A 		16.5
(-0.8)
A 		31
(2.6)
A 		6.8
(-3)
A 		10.1
(-2.2)
A 		32.7
(3)
A 		26
B 26.8
(0.2)
A 		14.5
(-1.8)
A 		9.7
(-2.5)
A 		6.7
(-3)
A 		10
(-2.5)
A 		44.6
(3)
A 		38
C 18.7
(-1.6)
A 		40.6
(0.5)
A 		30.2
(-0.5)
A 		67.4
(3)
A 		3.9
(-3)
A 		44.8
(0.9)
A 		64
avr 25.3
(0.2) 		23.9
(-0.1) 		23.6
(-0.1) 		27
(0.5) 		8
(-3) 		40.7
(3) 		33
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 7
1 2 3 4 range
A 6.8
(3)
A 		4.6
(0.1)
A 		2.3
(-3)
A 		4.3
(-0.3)
A 		5
B 2.3
(-2)
A 		7.3
(3)
A 		3.9
(-0.4)
A 		1.3
(-3)
A 		6
C 3.2
(-2.4)
A 		7.8
(3)
A 		2.7
(-3)
A 		5.8
(0.6)
A 		5
avr 4.1
(-1.2) 		6.6
(3) 		3
(-3) 		3.8
(-1.7) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 15
1 2 3 4 5 6 range
A 5.6
(0.8)
A 		5.9
(1.1)
A 		6.8
(1.9)
A 		1.7
(-3)
A 		3
(-1.7)
A 		7.9
(3)
A 		6
B 9.3
(0)
A 		4.8
(-1.8)
A 		2.4
(-2.8)
A 		1.8
(-3)
A 		4.1
(-2.1)
A 		16.6
(3)
A 		15
C 6.9
(-0.5)
A 		12.4
(1.9)
A 		7.7
(-0.2)
A 		13.5
(2.3)
A 		1.3
(-3)
A 		15
(3)
A 		14
avr 7.3
(-0.4) 		7.7
(-0.2) 		5.6
(-1.4) 		5.7
(-1.3) 		2.8
(-3) 		13.2
(3) 		10
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193375_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8463
Sequence Type Exemplar sequence
Representative Public ID F01D4.3 NCBI
Target Description F01D4.3 /REP_DB=WormBase Gene ID /WP=CE09155 /TR=O17755 /GB=CAB02882.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069533(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069533 NCBI Caenorhabditis elegans F01D4.3 (F01D4.3) mRNA, complete cds. 11/11 None
SNAP00000032305 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10473611:10475167:-1 11/11 None
GENEFINDER00000032312 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10473611:10475670:-1 11/11 None
F01D4.3 ENSEMBL cdna:known chromosome:CEL140:IV:10473611:10475014:-1 gene:F01D4.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10473616-10475020(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase (FES/FPS subfamily)
Ensembl F01D4.3
Entrez Gene 184053 Entrez gene
SwissProt O17755 EMBL-EBI
WormBase CE33771 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02882 Hypothetical protein F01D4.3 [Caenorhabditis elegans] ref|NP_501934.2| F01D4.3 [Caenorhabditis elegans] 0.0
blast NP_501307 T06C10.3 [Caenorhabditis elegans] gb|AAA82300.1| Hypothetical protein T06C10.3 [Caenorhabditis elegans] 1.0E-178
blast NP_501307 T06C10.3 [Caenorhabditis elegans] gb|AAA82300.1| Hypothetical protein T06C10.3 [Caenorhabditis elegans] 1.0E-173
blast T23792 hypothetical protein M176.9 - Caenorhabditis elegans 1.0E-163
blast T23792 hypothetical protein M176.9 - Caenorhabditis elegans 1.0E-162
Protein Families
Method ID Description E-Value
hanks 1.9.5 AGC group; AGC Other; DdK2 4.0E-68
hanks 1.9.5 AGC group; AGC Other; DdK2 2.0E-68
hanks 1.9.5 AGC group; AGC Other; DdK2 7.0E-70
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 0.0070
Pfam IPR000980 EMBL-EBI SH2 motif 0.043
Pfam IPR000719 EMBL-EBI Protein kinase 4.9E-59
Pfam IPR000719 EMBL-EBI Protein kinase 4.9E-59
Pfam IPR000980 EMBL-EBI SH2 motif 0.0070
Pfam IPR000980 EMBL-EBI SH2 motif 0.043
Pfam IPR000719 EMBL-EBI Protein kinase 4.9E-59
Sequence
Target Sequence 
>C. ELEGANS:193375_AT
ctggaactgttgtaccgattgcggagaaagttaggttttgtattggagcagccagaggaa
ttgagtatttacatcagaataactgtattcatcgtgacattgctgctcgtaattgtctgc
tcagtgaaaaagaggtcaaaatcacggactttggcctctctcgaaatggcccatcctaca
aaatcaaggcagcctgtaaacttccagtcaagtggctcgcaccagaaacattgtcatcgc
tttgcttcacttttgcaacagatgtgtacagctggggtattacttgttacgaagtgtttg
ccgatggtgccgagccttacgaaggcattccgaacgcaacagtcaaagcagacgttctca
acaacaagtttattcagatgcctccacactgcccggattctatcaaaaagtacatgagca
cattcatttttgttgatgcatcttgtcgagccagcatgaccatggcaatcggggactt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTGGAACTGTTGTACCGATTGCGGA 551 241 623 Antisense
GCTGCTCGTAATTGTCTGCTCAGTG 361 297 724 Antisense
TTGGCCTCTCTCGAAATGGCCCATC 469 703 773 Antisense
AAGGCAGCCTGTAAACTTCCAGTCA 418 161 808 Antisense
CAGTCAAGTGGCTCGCACCAGAAAC 592 207 827 Antisense
AGAAACATTGTCATCGCTTTGCTTC 404 73 846 Antisense
ACGAAGTGTTTGCCGATGGTGCCGA 301 91 911 Antisense
GAAGGCATTCCGAACGCAACAGTCA 508 333 943 Antisense
CAAGTTTATTCAGATGCCTCCACAC 236 185 987 Antisense
TGTTGATGCATCTTGTCGAGCCAGC 186 563 1053 Antisense
GCATGACCATGGCAATCGGGGACTT 263 309 1076 Antisense
Sequence Source Affymetrix Proprietary Database