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[193374_s_at] DNA polymerase alpha associated subunit

Description R01H10.1 /REP_DB=WormBase Gene ID /WP=CE20022 /TR=SW:Q21625 /GB=CAA21753.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=DNA polymerase alpha associated subunit
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 79      4grp_highest_8_8 > 01      4grp_high_8_8 > 53      6grp_highest_nonorm > 91      6grp_total > 59      4grp_total > 58      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 299
1 2 3 4 range
A 158.3
(-2.3)
P 		310.1
(3)
P 		234.1
(0.4)
P 		137
(-3)
P 		173
B 169.1
(-0.4)
P 		254.1
(1.9)
P 		294.9
(3)
P 		73
(-3)
P 		222
C 223
(-0.3)
P 		372.3
(3)
P 		301.3
(1.4)
P 		97.7
(-3)
P 		275
avr 183.5
(-0.7) 		312.2
(3) 		276.8
(2) 		102.6
(-3) 		210

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 209
1 2 3 4 5 6 range
A 222
(-0.7)
P 		178
(-2)
P 		145.1
(-3)
P 		161.5
(-2.5)
P 		210.2
(-1.1)
P 		347.1
(3)
P 		202
B 227.4
(1.3)
P 		146.5
(-2.6)
P 		167.1
(-1.6)
P 		138.5
(-3)
P 		244.3
(2.2)
P 		261.6
(3)
P 		123
C 248.6
(2.3)
P 		150.8
(-3)
P 		207.8
(0.1)
P 		175.8
(-1.6)
P 		260.9
(3)
P 		250.7
(2.4)
P 		110
avr 232.7
(0.5) 		158.4
(-3) 		173.3
(-2.3) 		158.6
(-3) 		238.5
(0.8) 		286.5
(3) 		128
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 91
1 2 3 4 range
A 57.6
(1.8)
P 		67.3
(3)
P 		61.2
(2.2)
P 		20.1
(-3)
P 		47
B 53.9
(1.4)
P 		62.8
(2.4)
P 		68.3
(3)
P 		15.6
(-3)
P 		53
C 73.8
(0.8)
P 		107
(3)
P 		105
(2.9)
P 		16.5
(-3)
P 		91
avr 61.8
(1.3) 		79
(3) 		78.2
(2.9) 		17.4
(-3) 		62

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 68
1 2 3 4 5 6 range
A 40.9
(-1.9)
P 		63.3
(0.6)
P 		31.6
(-3)
P 		41
(-1.9)
P 		63.4
(0.6)
P 		84.5
(3)
P 		53
B 79.1
(1.1)
P 		48.8
(-1.8)
P 		40.6
(-2.6)
P 		36.7
(-3)
P 		99.3
(3)
P 		97.6
(2.8)
P 		63
C 92.1
(3)
P 		46
(-1.9)
P 		52.9
(-1.1)
P 		35.4
(-3)
P 		84.4
(2.2)
P 		83.9
(2.1)
P 		57
avr 70.7
(0.9) 		52.7
(-1.2) 		41.7
(-2.5) 		37.7
(-3) 		82.4
(2.3) 		88.7
(3) 		51
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193374_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7254
Sequence Type Exemplar sequence
Representative Public ID R01H10.1 NCBI
Target Description R01H10.1 /REP_DB=WormBase Gene ID /WP=CE20022 /TR=SW:Q21625 /GB=CAA21753.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=DNA polymerase alpha associated subunit
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066867(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066867 NCBI Caenorhabditis elegans cell DIVision defective family member (div-1) (div-1) mRNA, complete cds. 11/11 None
R01H10.1 ENSEMBL cdna:known chromosome:CEL140:III:10244964:10248794:-1 gene:R01H10.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000005988 3/11 Cross Hyb Matching Probes None
GENEFINDER00000006000 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:10245083-10248431(-) 96.52 100.0
Public Domain and Genome References
Gene Title DNA polymerase alpha associated subunit
Gene Symbol div-1
Ensembl R01H10.1
Entrez Gene 176439 Entrez gene
SwissProt Q21625 EMBL-EBI
WormBase CE28840 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:260192_AT DNA polymerase alpha subunit B family at
CANINE:1590322_AT similar to polymerase (DNA directed), alpha 2 (70kD subunit) cfa
CANINE_2:CFA.14506.1.A1_AT similar to polymerase (DNA directed), alpha 2 (70kD subunit) cfa
CANINE_2:CFAAFFX.21139.1.S1_AT similar to polymerase (DNA directed), alpha 2 (70kD subunit) cfa
DROSOPHILA_2:1628372_A_AT DNA polymerase 73kD dm
DROSGENOME1:143575_AT DNA polymerase 73kD dm
HG-U95AV2:1775_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HC-G110:1775_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HU35KSUBD:RC_H95849_F_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HUGENEFL:L24559_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HG-U133A:204441_S_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HG-U133_PLUS_2:204441_S_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HG-FOCUS:204441_S_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
HG-U133A_2:204441_S_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
U133_X3P:G4505928_3P_A_AT polymerase (DNA directed), alpha 2 (70kD subunit) hs
MOUSE430_2:1456713_AT polymerase (DNA directed), alpha 2 mm
MOE430B:1456713_AT polymerase (DNA directed), alpha 2 mm
MOUSE430A_2:1425794_AT polymerase (DNA directed), alpha 2 mm
MOE430A:1425794_AT polymerase (DNA directed), alpha 2 mm
MOUSE430_2:1425794_AT polymerase (DNA directed), alpha 2 mm
MU11KSUBA:D13546_S_AT polymerase (DNA directed), alpha 2 mm
MG-U74AV2:98006_AT polymerase (DNA directed), alpha 2 mm
MG-U74AV2:161739_R_AT polymerase (DNA directed), alpha 2 mm
MOE430A:1448369_AT polymerase (DNA directed), alpha 2 mm
MOUSE430A_2:1448369_AT polymerase (DNA directed), alpha 2 mm
MOUSE430_2:1448369_AT polymerase (DNA directed), alpha 2 mm
MU11KSUBB:MSA.37958.0_S_AT Polymerase (DNA directed), alpha 2, mRNA (cDNA clone MGC:36147 IMAGE:5343583) mm
RG-U34A:AJ011606_AT polymerase (DNA directed), alpha 2 rn
RAE230A:1387795_AT polymerase (DNA directed), alpha 2 rn
RAT230_2:1387795_AT polymerase (DNA directed), alpha 2 rn
YEAST_2:1774459_AT B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6260 DNA replication inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA83467 Hypothetical protein R01H10.1 [Caenorhabditis elegans] emb|CAA21753.2| Hypothetical protein R01H10.1 [Caenorhabditis elegans] ref|NP_499268.1| cell DIVision defective family member (div-1) [Caenorhabditis elegans] sp|Q21625|DPOA2_CAEEL DNA polymerase alpha subunit B (Division delayed protein 1) 0.0
blast T27359 hypothetical protein R01H10.1 - Caenorhabditis elegans 0.0
blast S43564 R01H10.1 protein (clone R01H10) - Caenorhabditis elegans 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR007200 EMBL-EBI DNA polymerase alpha subunit B 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:193374_S_AT
agtgatcattcaaccgaacgcatcccgtgatctttgtgttcctccggtcttcccaagtgc
tccgttccaacagaaccgaaaactcgataaaatcaagaaagagctgatcttcgtcgccga
tccatgcattttccgaatcagcggtgtcgaggtggcaatgactagcagtgagcctattca
agcgttgagcaatacggaattccatcgatccgcaaatcaggagaacattgatcgtgtcgc
ccgtctcagcagtcatcttctcactcagcagtgcatgtatccattggagccaacggaagt
tccagcgtccatgggagatttgctcgatgtctgctgtatcggctcgactcctcatatcgt
ttttgcaccgacaaagcttgcgccatcagcaaaatgtgtgaatggaagtgtgttcattaa
ctcatctacactcgccaaagggccaacaggaaactatgcaaaaatgtcgattaacctgaa
tgccggagaactcatgcccggggagacggtc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGTGATCATTCAACCGAACGCATCC 569 59 1275 Antisense
GATCCATGCATTTTCCGAATCAGCG 81 417 1393 Antisense
GAATCAGCGGTGTCGAGGTGGCAAT 68 327 1409 Antisense
GAATTCCATCGATCCGCAAATCAGG 401 323 1471 Antisense
AGGAGAACATTGATCGTGTCGCCCG 173 57 1493 Antisense
TCATCTTCTCACTCAGCAGTGCATG 69 621 1527 Antisense
GGAGCCAACGGAAGTTCCAGCGTCC 639 521 1560 Antisense
AGATTTGCTCGATGTCTGCTGTATC 330 65 1590 Antisense
TCGACTCCTCATATCGTTTTTGCAC 618 601 1618 Antisense
GTTCATTAACTCATCTACACTCGCC 340 443 1686 Antisense
AGAACTCATGCCCGGGGAGACGGTC 296 71 1761 Antisense
Sequence Source Affymetrix Proprietary Database