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[193371_at] guanylate cyclase (2 domains)

Description C06A12.4 /REP_DB=WormBase Gene ID /WP=CE27797 /GEN=gcy-27 /TR=Q9XU42 /GB=CAB06040.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster 6grp_total > 0      4grp_total > 21      6grp_total_sub > Hat      6grp_cgc > 64      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 135
1 2 3 4 range
A 100
(1.9)
A 		49.4
(-2.1)
A 		37.2
(-3)
A 		114.4
(3)
A 		77
B 83.8
(3)
A 		64.4
(0.6)
A 		34.6
(-3)
A 		47.7
(-1.4)
P 		49
C 81.6
(-1.3)
A 		47.9
(-3)
A 		51.2
(-2.8)
A 		169.4
(3)
P 		122
avr 88.5
(1.1) 		53.9
(-1.9) 		41
(-3) 		110.5
(3) 		70

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 103
1 2 3 4 5 6 range
A 84.9
(3)
A 		83.1
(2.6)
A 		60
(-2.8)
A 		62
(-2.3)
A 		59.2
(-3)
A 		77.3
(1.2)
A 		26
B 17.9
(-3)
A 		92.9
(3)
P 		73.6
(1.5)
A 		42.9
(-1)
A 		50.3
(-0.4)
A 		82.5
(2.2)
P 		75
C 70.4
(-0.6)
M 		78.9
(-0)
P 		42.2
(-2.6)
A 		120.8
(3)
A 		87.7
(0.6)
A 		37.2
(-3)
A 		84
avr 57.7
(-3) 		85
(3) 		58.6
(-2.8) 		75.2
(0.8) 		65.7
(-1.2) 		65.7
(-1.2) 		27
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 28
1 2 3 4 range
A 36.4
(3)
A 		10.7
(-2.8)
A 		9.7
(-3)
A 		16.7
(-1.4)
A 		27
B 26.7
(3)
A 		15.9
(-0.5)
A 		8
(-3)
A 		10.2
(-2.3)
P 		19
C 27
(2.4)
A 		13.8
(-3)
A 		17.8
(-1.4)
A 		28.6
(3)
P 		15
avr 30
(3) 		13.5
(-2.4) 		11.8
(-3) 		18.5
(-0.8) 		18

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 25
1 2 3 4 5 6 range
A 15.6
(-2.1)
A 		29.5
(3)
A 		13.1
(-3)
A 		15.7
(-2)
A 		17.9
(-1.2)
A 		18.8
(-0.9)
A 		16
B 6.2
(-3)
A 		30.9
(3)
P 		17.9
(-0.2)
A 		11.4
(-1.7)
A 		20.4
(0.4)
A 		30.7
(3)
P 		25
C 26.1
(2.2)
M 		24.1
(1.5)
P 		10.7
(-3)
A 		24.3
(1.6)
A 		28.4
(3)
A 		12.5
(-2.4)
A 		18
avr 16
(-2.1) 		28.2
(3) 		13.9
(-3) 		17.1
(-1.7) 		22.2
(0.5) 		20.7
(-0.1) 		14
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193371_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8537
Sequence Type Exemplar sequence
Representative Public ID C06A12.4 NCBI
Target Description C06A12.4 /REP_DB=WormBase Gene ID /WP=CE27797 /GEN=gcy-27 /TR=Q9XU42 /GB=CAB06040.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070709(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070709 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-27) (gcy-27) mRNA, complete cds. 10/11 None
SNAP00000012314 ENSEMBL cdna:SNAP chromosome:CEL140:IV:17432932:17436586:-1 11/11 None
GENEFINDER00000012318 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:17432812:17439917:-1 11/11 None
C06A12.4 ENSEMBL cdna:known chromosome:CEL140:IV:17432932:17436586:-1 gene:C06A12.4 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:17432937-17436592(-) 99.94 100.0
Public Domain and Genome References
Gene Title guanylate cyclase (2 domains)
Gene Symbol gcy-27
Ensembl C06A12.4
Entrez Gene 191654 Entrez gene
SwissProt Q9XU42 EMBL-EBI
WormBase CE27797 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB06040 Hypothetical protein C06A12.4 [Caenorhabditis elegans] ref|NP_503110.1| Guanylyl CYclase family member (gcy-27) [Caenorhabditis elegans] 0.0
blast AAF68380 guanylyl cyclase [Caenorhabditis elegans] 0.0
blast CAA92186 Hypothetical protein R01E6.1 [Caenorhabditis elegans] ref|NP_510266.3| ODoRant response abnormal family member (odr-1) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.2E-46
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 9.3
Pfam IPR001054 EMBL-EBI Guanylate cyclase 6.3E-35
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 9.3
Pfam IPR001054 EMBL-EBI Guanylate cyclase 6.3E-35
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000012318 2 30-52,73-95
Sequence
Target Sequence 
>C. ELEGANS:193371_AT
aatcgctcccgctagaagttatgcatcggcaacggttatgtttgtccaaatatgtgactt
cattgtaattttgaagcgacgtcctccaaaagaagttgaaactactggcgaaacctacat
ggtggcatccggtgtacccaacgagaatgaaggacggcatgtattcgaagtcgcggaaat
gagtttggaaattcgtgctatatcgttgtcatatacactagaaaatgacaaaaactacaa
gcttcgagttcgaataggattccacgcaggtcctattgctgccggtgtaatcggaattaa
aaatcctcgctactgtctttttggtgacactgtaaatttcgcgtccagaatgcaatcaaa
ctgtcctcccctgcaaattcaaactagcgaaattacagcaagaatgctattggccactca
tgagtat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATCGCTCCCGCTAGAAGTTATGCA 237 169 1236 Antisense
GCATCGGCAACGGTTATGTTTGTCC 303 301 1258 Antisense
GAAGCGACGTCCTCCAAAAGAAGTT 337 341 1308 Antisense
AAACCTACATGGTGGCATCCGGTGT 404 125 1346 Antisense
GCATCCGGTGTACCCAACGAGAATG 245 287 1360 Antisense
GGACGGCATGTATTCGAAGTCGCGG 87 525 1387 Antisense
GATTCCACGCAGGTCCTATTGCTGC 642 433 1493 Antisense
TCCTCGCTACTGTCTTTTTGGTGAC 462 593 1539 Antisense
GTGACACTGTAAATTTCGCGTCCAG 64 483 1559 Antisense
TCCTCCCCTGCAAATTCAAACTAGC 385 591 1599 Antisense
AATGCTATTGGCCACTCATGAGTAT 548 165 1638 Antisense
Sequence Source Affymetrix Proprietary Database