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[193363_at] zinc-finger homeodomain protein

Description F28F9.1 /REP_DB=WormBase Gene ID /WP=CE09762 /GEN=zag-1 /TR=Q94196 /GB=AAB09122.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=zinc-finger homeodomain protein
Cluster 6grp_total > 04      4grp_total > 44      6grp_cgc > 41      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 236
1 2 3 4 range
A 357.6
(3)
A 		275.7
(0)
A 		191.2
(-3)
A 		211.9
(-2.3)
A 		166
B 380.4
(3)
A 		338
(1.3)
A 		232.7
(-3)
A 		279.4
(-1.1)
A 		148
C 269.9
(-0.2)
A 		395.8
(3)
A 		228.7
(-1.2)
A 		159.4
(-3)
A 		236
avr 336
(3) 		336.5
(3) 		217.5
(-3) 		216.9
(-3) 		120

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 360
1 2 3 4 5 6 range
A 440.7
(3)
A 		421
(2.6)
A 		116.2
(-2.9)
A 		361.5
(1.6)
A 		328.1
(1)
A 		108.2
(-3)
A 		333
B 372.9
(3)
A 		335.2
(2.1)
A 		118.8
(-3)
A 		299.3
(1.3)
A 		208
(-0.9)
A 		145.1
(-2.4)
A 		254
C 467.7
(3)
P 		287.8
(-0)
A 		215
(-1.3)
A 		228.5
(-1)
A 		256.9
(-0.6)
A 		112.6
(-3)
A 		355
avr 427.1
(3) 		348
(1.4) 		150
(-2.4) 		296.4
(0.4) 		264.3
(-0.2) 		122
(-3) 		305
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 103
1 2 3 4 range
A 130.2
(3)
A 		59.9
(-1.3)
A 		50
(-1.9)
A 		31
(-3)
A 		99
B 121.3
(3)
A 		83.5
(-0.4)
A 		53.9
(-3)
A 		59.5
(-2.5)
A 		67
C 89.3
(1.3)
A 		113.8
(3)
A 		79.7
(0.6)
A 		26.9
(-3)
A 		87
avr 113.6
(3) 		85.7
(0.8) 		61.2
(-1.2) 		39.1
(-3) 		75

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 148
1 2 3 4 5 6 range
A 81.2
(-0.3)
A 		149.7
(3)
A 		25.3
(-3)
A 		91.7
(0.2)
A 		99
(0.6)
A 		26.3
(-3)
A 		124
B 129.7
(3)
A 		111.6
(1.9)
A 		28.9
(-3)
A 		79.3
(0)
A 		84.5
(0.3)
A 		54.1
(-1.5)
A 		101
C 173.4
(3)
P 		87.8
(-0.8)
A 		54.7
(-2.2)
A 		45.9
(-2.6)
A 		83.1
(-1)
A 		37.7
(-3)
A 		136
avr 128.1
(3) 		116.4
(2.2) 		36.3
(-3) 		72.3
(-0.6) 		88.9
(0.4) 		39.4
(-2.8) 		92
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193363_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10981
Sequence Type Exemplar sequence
Representative Public ID F28F9.1 NCBI
Target Description F28F9.1 /REP_DB=WormBase Gene ID /WP=CE09762 /GEN=zag-1 /TR=Q94196 /GB=AAB09122.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=zinc-finger homeodomain protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068023(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068023 NCBI Caenorhabditis elegans Zinc finger plus homeodomain, Axon Guidance family member (zag-1) (zag-1) mRNA, complete cds. 10/11 None
SNAP00000002095 ENSEMBL cdna:SNAP chromosome:CEL140:IV:3859630:3861118:1 10/11 None
GENEFINDER00000002099 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:3855844:3861118:1 11/11 None
F28F9.1 ENSEMBL cdna:known chromosome:CEL140:IV:3855837:3861563:1 gene:F28F9.1 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:3855849-3861124(+) 98.48 100.0
Public Domain and Genome References
Gene Title zinc-finger homeodomain protein
Gene Symbol zag-1
Ensembl F28F9.1
Entrez Gene 177144 Entrez gene
SwissProt Q94196 EMBL-EBI
WormBase CE34546 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1604603_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE:1590320_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE:1583358_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE_2:CFA.12856.1.A1_S_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE_2:CFA.18085.1.S1_S_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE_2:CFA.3267.1.A1_S_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE_2:CFAAFFX.6947.1.S1_S_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
CANINE_2:CFAAFFX.6949.1.S1_S_AT similar to Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2) cfa
DROSOPHILA_2:1628262_A_AT Zn finger homeodomain 1 dm
DROSGENOME1:141676_AT Zn finger homeodomain 1 dm
CHICKEN:GGA.3548.1.S1_AT transcription factor 8 (represses interleukin 2 expression) gga
CHICKEN:GGAAFFX.20792.1.S1_S_AT transcription factor 8 (represses interleukin 2 expression) gga
HG-U133_PLUS_2:210875_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U133A:210875_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U133A_2:210875_S_AT transcription factor 8 (represses interleukin 2 expression) hs
U133_X3P:G529172_3P_A_AT transcription factor 8 (represses interleukin 2 expression) hs
U133_X3P:HS.232068.2.A1_3P_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U133A_2:212758_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U133_PLUS_2:212758_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U133A:212758_S_AT transcription factor 8 (represses interleukin 2 expression) hs
HG-U95B:57311_AT Serine palmitoyltransferase, long chain base subunit 1 hs
HG-U95C:58210_AT Serine palmitoyltransferase, long chain base subunit 1 hs
HG-U95D:74451_AT Serine palmitoyltransferase, long chain base subunit 1 hs
HU35KSUBD:RC_AA255488_I_AT Serine palmitoyltransferase, long chain base subunit 1 hs
HU35KSUBD:RC_AA371432_AT Serine palmitoyltransferase, long chain base subunit 1 hs
HU35KSUBD:RC_AA406078_AT Serine palmitoyltransferase, long chain base subunit 1 hs
MOUSE430_2:1420243_AT zinc finger homeobox 1a mm
MOE430A:1420243_AT zinc finger homeobox 1a mm
MOUSE430A_2:1420243_AT zinc finger homeobox 1a mm
MG-U74AV2:99052_AT zinc finger homeobox 1a mm
MOUSE430_2:1443005_AT zinc finger homeobox 1a mm
MOE430B:1443005_AT zinc finger homeobox 1a mm
MU11KSUBA:D76432_S_AT zinc finger homeobox 1a mm
MOE430A:1418926_AT zinc finger homeobox 1a mm
MOUSE430A_2:1418926_AT zinc finger homeobox 1a mm
MOUSE430_2:1418926_AT zinc finger homeobox 1a mm
MOE430B:1446127_AT Zinc finger homeobox 1a (Zfhx1a), mRNA mm
MOUSE430_2:1446127_AT Zinc finger homeobox 1a (Zfhx1a), mRNA mm
RG-U34A:U51584_S_AT transcription factor 8 (represses interleukin 2 expression) rn
RG-U34A:U51583_AT transcription factor 8 (represses interleukin 2 expression) rn
RAE230A:1370965_AT transcription factor 8 (represses interleukin 2 expression) rn
RAT230_2:1370965_AT transcription factor 8 (represses interleukin 2 expression) rn
RAE230A:1376673_AT Transcription factor 8 (represses interleukin 2 expression) rn
RAT230_2:1376673_AT Transcription factor 8 (represses interleukin 2 expression) rn
RAE230A:1380200_AT Transcription factor 8 (represses interleukin 2 expression) rn
RAT230_2:1380200_AT Transcription factor 8 (represses interleukin 2 expression) rn
RG-U34C:RC_AI102906_AT Transcription factor 8 (represses interleukin 2 expression) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3676 nucleic acid binding inferred from electronic annotation QuickGO AmiGO
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
3700 transcription factor activity inferred from electronic annotation QuickGO AmiGO
5489 electron transporter activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
20037 heme binding inferred from electronic annotation QuickGO AmiGO
16564 transcriptional repressor activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB09122 Zinc finger plus homeodomain, axon guidance protein 1 [Caenorhabditis elegans] ref|NP_500424.3| Zinc finger plus homeodomain, Axon Guidance family member (zag-1) [Caenorhabditis elegans] gb|AAP43944.1| ZAG-1 [Caenorhabditis elegans] gb|AAP37457.1| ZAG-1 [Caenorhabditis elegans] 0.0
blast CAE65670 Hypothetical protein CBG10736 [Caenorhabditis briggsae] 0.0
blast CAE65670 Hypothetical protein CBG10736 [Caenorhabditis briggsae] 1.0E-142
blast AAB09122 Zinc finger plus homeodomain, axon guidance protein 1 [Caenorhabditis elegans] ref|NP_500424.3| Zinc finger plus homeodomain, Axon Guidance family member (zag-1) [Caenorhabditis elegans] gb|AAP43944.1| ZAG-1 [Caenorhabditis elegans] gb|AAP37457.1| ZAG-1 [Caenorhabditis elegans] 1.0E-107
blast CAE65670 Hypothetical protein CBG10736 [Caenorhabditis briggsae] 1.0E-100
blast XP_396050 PREDICTED: similar to ENSANGP00000017421 [Apis mellifera] 6.0E-46
blast XP_396050 PREDICTED: similar to ENSANGP00000017421 [Apis mellifera] 2.0E-45
Protein Domains
Database ID Description E-Value
scop a.4.1.Homeodomain All alpha proteins; DNA/RNA-binding 3-helical bundle; Homeodomain-like; Homeodomain 3.0000001167616E-17
scop a.4.1.Homeodomain All alpha proteins; DNA/RNA-binding 3-helical bundle; Homeodomain-like; Homeodomain 1.99999996755032E-17
Pfam IPR001356 EMBL-EBI Homeobox 1.6E-16
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 6.0E-6
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 4.3E-5
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 3.0E-5
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 4.3E-5
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 3.0E-5
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 4.3E-5
Pfam IPR007087 EMBL-EBI Zn-finger, C2H2 type 3.0E-5
Sequence
Target Sequence 
>C. ELEGANS:193363_AT
aaacctttttggcatatctcagcggtaaaaatttttttgatagcctgggcttccgtgaag
atataagagctgtaagatatgtgattatttattccaataaacaaatttttgaaaagcttt
attacccgccaagatatgctcttacaaataactttcaagacatgcaacaaaaatcatccg
aagacgacgcctcatccctttgctccaacgaatccaagcttctcaaattccccacgaccc
ccctaaaagaggaagagggtctcttctcgtgcgatcaatgtgacaaggtgttcggcaagc
aaagttcactggctcgacacaaatacgaacattctggccaacgcccttataaatgtgaca
tctgcgagaaggcgttcaagcacaagcatcacctgaccgagcacaagcggctccactccg
gcgagaagccattccaatgtgacaaatgcctgaagagattctcccattctggaagttaca
gtcagcacatgaaccaccgctattcgtactgcaaaccgtaccgggagcagccagcttcac
cgtccgacgttttgaacg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAACCTTTTTGGCATATCTCAGCGG 497 125 1442 Antisense
AAAATCATCCGAAGACGACGCCTCA 11 135 1611 Antisense
TGCTCCAACGAATCCAAGCTTCTCA 116 583 1642 Antisense
GTCTCTTCTCGTGCGATCAATGTGA 686 469 1700 Antisense
CAAAGTTCACTGGCTCGACACAAAT 265 191 1741 Antisense
CATTCTGGCCAACGCCCTTATAAAT 242 215 1771 Antisense
GTTCAAGCACAAGCATCACCTGACC 657 443 1815 Antisense
TACAGTCAGCACATGAACCACCGCT 646 641 1918 Antisense
CACCGCTATTCGTACTGCAAACCGT 268 201 1936 Antisense
TGCAAACCGTACCGGGAGCAGCCAG 542 573 1951 Antisense
GCTTCACCGTCCGACGTTTTGAACG 461 305 1975 Antisense
Sequence Source Affymetrix Proprietary Database