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[193349_at] guanylate cyclase (2 domains)

Description F23H12.6 /REP_DB=WormBase Gene ID /WP=CE05709 /GEN=gcy-13 /TR=Q19768 /GB=CAA98947.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster 6grp_total > 66      4grp_total > 05      6grp_cgc > 55      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 129
1 2 3 4 range
A 11.1
(-2.1)
A 		8
(-3)
A 		8.8
(-2.8)
A 		28.5
(3)
A 		21
B 54
(0.8)
A 		6.6
(-3)
A 		35.6
(-0.7)
A 		80.9
(3)
A 		74
C 54.3
(-0.9)
A 		12.6
(-3)
A 		11.9
(-3)
A 		135.6
(3)
A 		124
avr 39.8
(-0.5) 		9.1
(-3) 		18.8
(-2.2) 		81.7
(3) 		73

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 44
1 2 3 4 5 6 range
A 10
(-1.8)
A 		10.6
(-1.7)
A 		12.6
(-1.1)
A 		10
(-1.8)
A 		5.9
(-3)
A 		26.8
(3)
A 		21
B 15.2
(-2.6)
A 		13.2
(-3)
A 		16.7
(-2.3)
A 		16.2
(-2.4)
A 		29.5
(0.4)
A 		42.2
(3)
A 		29
C 7.6
(-3)
A 		50.2
(3)
A 		16.3
(-1.8)
A 		14.5
(-2)
A 		11.5
(-2.5)
A 		12.1
(-2.4)
A 		43
avr 10.9
(-3) 		24.7
(2.1) 		15.2
(-1.4) 		13.6
(-2) 		15.6
(-1.2) 		27
(3) 		16
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 21
1 2 3 4 range
A 4
(2.5)
A 		1.7
(-3)
A 		2.3
(-1.6)
A 		4.2
(3)
A 		3
B 17.2
(3)
A 		1.6
(-3)
A 		8.3
(-0.4)
A 		17.2
(3)
A 		16
C 18
(1.5)
A 		3.6
(-3)
A 		4.1
(-2.8)
A 		22.9
(3)
A 		19
avr 13.1
(2.2) 		2.3
(-3) 		4.9
(-1.8) 		14.8
(3) 		13

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 14
1 2 3 4 5 6 range
A 1.8
(-3)
A 		3.8
(-0.4)
A 		2.7
(-1.9)
A 		2.5
(-2.1)
A 		1.8
(-3)
A 		6.5
(3)
A 		5
B 5.3
(-2.3)
A 		4.4
(-2.8)
A 		4
(-3)
A 		4.3
(-2.8)
A 		12
(1.1)
A 		15.7
(3)
A 		12
C 2.8
(-3)
A 		15.3
(3)
A 		4.2
(-2.3)
A 		2.9
(-3)
A 		3.7
(-2.6)
A 		4
(-2.4)
A 		13
avr 3.3
(-2.9) 		7.8
(2) 		3.6
(-2.6) 		3.2
(-3) 		5.8
(-0.2) 		8.7
(3) 		6
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193349_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14175
Sequence Type Exemplar sequence
Representative Public ID F23H12.6 NCBI
Target Description F23H12.6 /REP_DB=WormBase Gene ID /WP=CE05709 /GEN=gcy-13 /TR=Q19768 /GB=CAA98947.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073696(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073696 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-13) (gcy-13) mRNA, complete cds. 11/11 None
SNAP00000020015 ENSEMBL cdna:SNAP chromosome:CEL140:V:12366342:12372125:-1 10/11 None
GENEFINDER00000020022 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:12366342:12372125:-1 11/11 None
F23H12.6 ENSEMBL cdna:known chromosome:CEL140:V:12366342:12372125:-1 gene:F23H12.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:12366341-12372125(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase (2 domains)
Gene Symbol gcy-13
Ensembl F23H12.6
Entrez Gene 191646 Entrez gene
SwissProt Q19768 EMBL-EBI
WormBase CE05709 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
8528 peptide receptor activity, G-protein coupled inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98947 Hypothetical protein F23H12.6 [Caenorhabditis elegans] ref|NP_506097.1| Guanylyl CYclase family member (gcy-13) [Caenorhabditis elegans] 0.0
blast CAE75466 Hypothetical protein CBG23466 [Caenorhabditis briggsae] 0.0
blast CAE60828 Hypothetical protein CBG04537 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-10
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.0E-80
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.5E-37
Pfam IPR000719 EMBL-EBI Protein kinase 0.19
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-10
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.3E-83
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-10
Pfam IPR001054 EMBL-EBI Guanylate cyclase 2.2E-89
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_506097.1 1 435-457
F23H12.6 1 435-457
SNAP00000020015 1 435-457
GENEFINDER00000020022 1 435-457
Sequence
Target Sequence 
>C. ELEGANS:193349_AT
acagtctgtggagcccgaagcatttgaaagcgttacaatattcttctctgatgtcgtcgg
attcactgttgtcaacttgctcaatgatctttacaccacttttgacgcgattattgaaaa
gaatgactcctacaaggtagaaacgatcggcgacgcctatttagttgtctctgggctacc
tcgccgaaatggtacggaacatgttgcaaatattgccaatatgagtttggagctgatgga
cagccttcaagccttcaaaatcccacatttaccacaagaaaaagttcaaatccgaattgg
aatgcattctggatcttgtgtagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ACAGTCTGTGGAGCCCGAAGCATTT 404 107 2529 Antisense
TTCTTCTCTGATGTCGTCGGATTCA 220 691 2569 Antisense
GTCGTCGGATTCACTGTTGTCAACT 296 473 2581 Antisense
CTTGCTCAATGATCTTTACACCACT 600 217 2604 Antisense
TTACACCACTTTTGACGCGATTATT 277 681 2619 Antisense
GGTAGAAACGATCGGCGACGCCTAT 334 503 2664 Antisense
GCGACGCCTATTTAGTTGTCTCTGG 172 289 2678 Antisense
GGCTACCTCGCCGAAATGGTACGGA 486 509 2702 Antisense
TGGACAGCCTTCAAGCCTTCAAAAT 478 547 2765 Antisense
GCCTTCAAAATCCCACATTTACCAC 234 281 2779 Antisense
GAATGCATTCTGGATCTTGTGTAGC 298 331 2828 Antisense
Sequence Source Affymetrix Proprietary Database