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[193300_at] molybdenum/thiazole biosynthesis cofactor

Description F42G8.6 /REP_DB=WormBase Gene ID /WP=CE28320 /TR=O44510 /GB=AAB92067.2 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=molybdenum-thiazole biosynthesis cofactor
Cluster 6grp_highest_10_10 > 46      6grp_high1_10_10 > 53      4grp_highest_8_8 > 49      4grp_high_8_8 > 42      6grp_highest_nonorm > 81      6grp_total > 64      4grp_total > 54      6grp_high1_sub > 03      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 129
1 2 3 4 range
A 237.6
(3)
P 		205.9
(1.1)
P 		214.5
(1.6)
P 		136.5
(-3)
P 		101
B 257.6
(3)
P 		215.8
(-1.2)
P 		198
(-3)
P 		231.2
(0.3)
P 		60
C 264.7
(2.8)
P 		265.4
(3)
P 		241.1
(-3)
P 		245
(-2)
P 		24
avr 253.3
(3) 		229
(0) 		217.9
(-1.3) 		204.2
(-3) 		49

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 222
1 2 3 4 5 6 range
A 192.8
(-2.6)
P 		274.8
(-0.4)
P 		401.4
(3)
P 		295.7
(0.1)
P 		179.5
(-3)
P 		198.1
(-2.5)
P 		222
B 190.9
(-3)
P 		233.8
(0.1)
P 		273.8
(3)
P 		266.3
(2.5)
P 		248.1
(1.1)
P 		254.7
(1.6)
P 		83
C 205.9
(-3)
P 		270.1
(0.2)
P 		221.5
(-2.2)
P 		228.7
(-1.9)
P 		228.7
(-1.9)
P 		327.6
(3)
P 		122
avr 196.5
(-3) 		259.6
(0.7) 		298.9
(3) 		263.6
(0.9) 		218.8
(-1.7) 		260.1
(0.7) 		102
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 68
1 2 3 4 range
A 86.5
(3)
P 		44.7
(-0.8)
P 		56.1
(0.3)
P 		20
(-3)
P 		67
B 82.2
(3)
P 		53.3
(-1.8)
P 		45.9
(-3)
P 		49.3
(-2.4)
P 		36
C 87.6
(3)
P 		76.3
(1.5)
P 		84
(2.5)
P 		41.3
(-3)
P 		46
avr 85.4
(3) 		58.1
(-0.4) 		62
(0.1) 		36.9
(-3) 		49

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 74
1 2 3 4 5 6 range
A 35.5
(-3)
P 		97.7
(3)
P 		87.4
(2)
P 		75
(0.8)
P 		54.2
(-1.2)
P 		48.2
(-1.8)
P 		62
B 66.4
(-3)
P 		77.8
(-1)
P 		66.5
(-3)
P 		70.5
(-2.3)
P 		100.8
(3)
P 		95
(2)
P 		34
C 76.3
(-0.1)
P 		82.4
(0.4)
P 		56.4
(-2)
P 		46
(-3)
P 		74
(-0.4)
P 		109.7
(3)
P 		64
avr 59.4
(-3) 		86
(3) 		70.1
(-0.6) 		63.8
(-2) 		76.3
(0.8) 		84.3
(2.6) 		27
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193300_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9460
Sequence Type Exemplar sequence
Representative Public ID F42G8.6 NCBI
Target Description F42G8.6 /REP_DB=WormBase Gene ID /WP=CE28320 /TR=O44510 /GB=AAB92067.2 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=molybdenum-thiazole biosynthesis cofactor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068958(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068958 NCBI Caenorhabditis elegans F42G8.6 (F42G8.6) mRNA, complete cds. 10/11 A 
SNAP00000028276 ENSEMBL cdna:SNAP chromosome:CEL140:IV:8130600:8132132:1 10/11 None
GENEFINDER00000028289 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:8130600:8132132:1 10/11 None
F42G8.6 ENSEMBL cdna:known chromosome:CEL140:IV:8130600:8132173:1 gene:F42G8.6 10/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:8130605-8131945(+) 100.0 100.0
Public Domain and Genome References
Gene Title molybdenum/thiazole biosynthesis cofactor
Ensembl F42G8.6
Entrez Gene 177607 Entrez gene
SwissProt O44510 EMBL-EBI
WormBase CE28320 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16634_S_AT molybdenum cofactor synthesis protein 3 / molybdopterin synthase sulphurylase (CNX5) at
ATH1-121501:248108_AT molybdenum cofactor synthesis protein 3 / molybdopterin synthase sulphurylase (CNX5) at
CANINE:1599158_AT similar to Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) cfa
CANINE_2:CFAAFFX.18015.1.S1_AT similar to Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) cfa
DROSOPHILA_2:1635016_AT dm
DROSGENOME1:146040_AT dm
HG-U133_PLUS_2:206141_AT molybdenum cofactor synthesis 3 hs
HG-U133A:206141_AT molybdenum cofactor synthesis 3 hs
HG-FOCUS:206141_AT molybdenum cofactor synthesis 3 hs
HG-U133A_2:206141_AT molybdenum cofactor synthesis 3 hs
HU35KSUBB:RC_W52284_AT molybdenum cofactor synthesis 3 hs
U133_X3P:G7657338_3P_AT molybdenum cofactor synthesis 3 hs
HG-U95AV2:35399_AT molybdenum cofactor synthesis 3 hs
HG-U95B:46987_I_AT molybdenum cofactor synthesis 3 hs
HG-U95B:46988_R_AT molybdenum cofactor synthesis 3 hs
MG-U74CV2:139229_R_AT molybdenum cofactor synthesis 3 mm
MOE430B:1428924_AT molybdenum cofactor synthesis 3 mm
MOUSE430_2:1428924_AT molybdenum cofactor synthesis 3 mm
MG-U74BV2:106919_AT molybdenum cofactor synthesis 3 mm
MU19KSUBA:TC14585_AT molybdenum cofactor synthesis 3 mm
MG-U74BV2:112959_AT PREDICTED: molybdenum cofactor synthesis 3 [Mus musculus], mRNA sequence mm
MOUSE430_2:1439242_AT PREDICTED: molybdenum cofactor synthesis 3 [Mus musculus], mRNA sequence mm
MOE430B:1439242_AT PREDICTED: molybdenum cofactor synthesis 3 [Mus musculus], mRNA sequence mm
MU19KSUBA:TC23679_AT PREDICTED: molybdenum cofactor synthesis 3 [Mus musculus], mRNA sequence mm
RAE230A:1377409_AT Molybdenum cofactor synthesis 3 (predicted) rn
RAT230_2:1377409_AT Molybdenum cofactor synthesis 3 (predicted) rn
RAE230A:1386800_AT Molybdenum cofactor synthesis 3 (predicted) rn
RAT230_2:1386800_AT Molybdenum cofactor synthesis 3 (predicted) rn
YEAST_2:1778409_AT Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB92067 Hypothetical protein F42G8.6 [Caenorhabditis elegans] ref|NP_501359.1| F42G8.6 [Caenorhabditis elegans] 0.0
blast CAE58418 Hypothetical protein CBG01549 [Caenorhabditis briggsae] 0.0
blast XP_786162 PREDICTED: similar to Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Strongylocentrotus purpuratus] 6.0E-99
Protein Domains
Database ID Description E-Value
Pfam IPR000594 EMBL-EBI UBA/THIF-type NAD/FAD binding fold 1.0E-49
Pfam IPR007901 EMBL-EBI MoeZ/MoeB 1.6E-51
Pfam IPR001763 EMBL-EBI Rhodanese-like 1.9E-12
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_501359.1 1 40-62
F42G8.6 1 40-62
SNAP00000028276 1 40-62
GENEFINDER00000028289 1 40-62
Sequence
Target Sequence 
>C. ELEGANS:193300_AT
aatgatgtctgtgttcttcttaatattcctcttgtcagtggaagtgctcttcgatgggat
ggacaattatcagtttatcattatggatcagattgtccttgttatcggtgtttattccct
tctccgccggatccaaattctgtgacaaattgcaatgaaggcggagtacttggaccaatt
gttggagtaattggaagcatgcaagctttagaggtcatgaaaattgcagcaaaagttaga
actactcttgctggccaattgttgctatttgatggacgcgaaggaaaatcaagaacgatt
cgattgcgaaaaagggatccgaaatgtgaagtttgtggtgataatccaacaattactgct
ccaatcgattatgttttattctgtggagcaggtgctcatgacaagatcgaaaatcttaaa
ttattagaattgtcggatcgcgtgaatgttacagagtatcgaaacaaaagaagagaacaa
aaacccgttctactggatacacgaccatcgttggaatttgagattgcacacctgcctgag
gcaatcagtctgttgcacactgtctcaatat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATGATGTCTGTGTTCTTCTTAATA 237 163 445 Antisense
TCTTCTTAATATTCCTCTTGTCAGT 158 617 459 Antisense
GAAGTGCTCTTCGATGGGATGGACA 689 333 485 Antisense
GGATCAGATTGTCCTTGTTATCGGT 164 511 529 Antisense
TGTTATCGGTGTTTATTCCCTTCTC 646 561 544 Antisense
CGCCGGATCCAAATTCTGTGACAAA 547 257 569 Antisense
GAAGGCGGAGTACTTGGACCAATTG 482 333 601 Antisense
AACTACTCTTGCTGGCCAATTGTTG 88 141 684 Antisense
ATCCAACAATTACTGCTCCAATCGA 671 39 788 Antisense
GAGCAGGTGCTCATGACAAGATCGA 358 389 830 Antisense
AGTCTGTTGCACACTGTCTCAATAT 569 61 991 Antisense
Sequence Source Affymetrix Proprietary Database