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[193293_at] cathepsin-like cysteine protease

Description C52E4.1 /REP_DB=WormBase Gene ID /WP=CE08943 /GEN=cpr-1 /TR=Q18783 /GB=CAB01410.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=cathepsin-like cysteine protease
Cluster 6grp_highest_10_10 > 15      6grp_high1_10_10 > 40      4grp_highest_8_8 > 40      4grp_high_8_8 > 50      6grp_highest_nonorm > 09      6grp_total > 52      4grp_total > 53      6grp_highest_sub > 03      6grp_cgc > 91      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 16375
1 2 3 4 range
A 16153.6
(3)
P 		12608.5
(1.6)
P 		11620.7
(1.3)
P 		440.8
(-3)
P 		15713
B 16785.2
(3)
P 		11557.5
(1.1)
P 		9999.6
(0.5)
P 		477.8
(-3)
P 		16307
C 14996.6
(3)
P 		12467.5
(2)
P 		10614.2
(1.2)
P 		409.9
(-3)
P 		14587
avr 15978.5
(3) 		12211.2
(1.5) 		10744.8
(1) 		442.8
(-3) 		15536

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 11593
1 2 3 4 5 6 range
A 26967.7
(1.4)
P 		20492.7
(-2.7)
P 		29533.6
(3)
P 		25833.3
(0.7)
P 		21825
(-1.9)
P 		20044.2
(-3)
P 		9489
B 21806.7
(-1.4)
P 		22385
(-1)
P 		29854.5
(3)
P 		23061.7
(-0.7)
P 		20638.6
(-2)
P 		18786.9
(-3)
P 		11068
C 20221.7
(-1.9)
P 		22550.3
(-0.6)
P 		28985.7
(3)
P 		24920.4
(0.7)
P 		22799.1
(-0.5)
P 		18262
(-3)
P 		10724
avr 22998.7
(-0.7) 		21809.3
(-1.4) 		29457.9
(3) 		24605.1
(0.2) 		21754.2
(-1.4) 		19031
(-3) 		10427
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 5817
1 2 3 4 range
A 5881.5
(3)
P 		2737
(-0.2)
P 		3037.9
(0.1)
P 		64.5
(-3)
P 		5817
B 5352.7
(3)
P 		2854.4
(0.1)
P 		2317.1
(-0.5)
P 		101.8
(-3)
P 		5251
C 4964.3
(3)
P 		3584.5
(1.3)
P 		3699.4
(1.4)
P 		69.1
(-3)
P 		4895
avr 5399.5
(3) 		3058.6
(0.4) 		3018.1
(0.3) 		78.5
(-3) 		5321

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3505
1 2 3 4 5 6 range
A 4971.3
(-2.8)
P 		7288.2
(3)
P 		6431.8
(0.9)
P 		6551.9
(1.2)
P 		6585.8
(1.2)
P 		4880.1
(-3)
P 		2408
B 7587.7
(0.9)
P 		7451
(0.5)
P 		7249.6
(0)
P 		6108.2
(-3)
P 		8385.2
(3)
P 		7005.5
(-0.6)
P 		2277
C 7495.3
(3)
P 		6880.8
(1.5)
P 		7377.4
(2.7)
P 		5011.5
(-3)
P 		7377.5
(2.7)
P 		6113.3
(-0.3)
P 		2484
avr 6684.8
(0.1) 		7206.7
(2.1) 		7019.6
(1.3) 		5890.5
(-3) 		7449.5
(3) 		5999.6
(-2.6) 		1559
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193293_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12853
Sequence Type Exemplar sequence
Representative Public ID C52E4.1 NCBI
Target Description C52E4.1 /REP_DB=WormBase Gene ID /WP=CE08943 /GEN=cpr-1 /TR=Q18783 /GB=CAB01410.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=cathepsin-like cysteine protease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073601(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073601 NCBI Caenorhabditis elegans Cysteine PRotease related family member (cpr-1) (cpr-1) mRNA, complete cds. 11/11 None
SNAP00000019783 ENSEMBL cdna:SNAP chromosome:CEL140:V:11978105:11979285:1 11/11 None
GENEFINDER00000019791 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11977400:11979285:1 11/11 None
C52E4.1 ENSEMBL cdna:known chromosome:CEL140:V:11978139:11979343:1 gene:C52E4.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11977399-11979285(+) 100.0 100.0
Public Domain and Genome References
Gene Title cathepsin-like cysteine protease
Gene Symbol cpr-1
Ensembl C52E4.1
Entrez Gene 179637 Entrez gene
SwissProt P25807 EMBL-EBI
WormBase CE31896 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
8234 cysteine-type peptidase activity inferred from electronic annotation QuickGO AmiGO
8234 cysteine-type peptidase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01410 Hypothetical protein C52E4.1 [Caenorhabditis elegans] ref|NP_506002.2| Cysteine PRotease related family member (cpr-1) [Caenorhabditis elegans] sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor gb|AAB88058.1| gut-specific cysteine protease-1 [Caenorhabditis elegans] 0.0
blast T20148 probable cysteine proteinase (EC 3.4.22.-) C52E4.1 - Caenorhabditis elegans 0.0
blast CAE75359 Hypothetical protein CBG23343 [Caenorhabditis briggsae] 1.0E-163
Protein Domains
Database ID Description E-Value
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 1.4E-109
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 1.4E-109
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 1.4E-109
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000019791 1 13-30
Sequence
Target Sequence 
>C. ELEGANS:193293_AT
tgaccgtacctgcattgagaccaagggagcccaacaaccaatcatctctccagatgatct
tctctcctgctgcggatcttcctgcggaaatggatgtgaaggaggatacccaattcaagc
tctcagatggtgggactcaaagggagttgttactggtggagactaccacggagctggatg
caaaccatacccaattgccccatgcacatctggaaactgcccagaatccaagactccatc
ttgctcaatgagctgccaatctggatattcaactgcctacgccaaggacaagcacttcgg
agtctctgcctacgctgttccaaagaatgctgcatccatccaagctgaaatctacgctaa
tggaccagttgaggctgcattctctgtttacgaagacttctacaaatacaagagcggagt
ttacaagcacaccgccggaaagtacctcggaggacacgccattaagatcatcggatgggg
aactgagagcggatctccatactggctt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGACCGTACCTGCATTGAGACCAAG 674 567 414 Antisense
GGATACCCAATTCAAGCTCTCAGAT 174 509 517 Antisense
GGAGACTACCACGGAGCTGGATGCA 234 519 571 Antisense
AATTGCCCCATGCACATCTGGAAAC 694 177 606 Antisense
AAGACTCCATCTTGCTCAATGAGCT 352 153 643 Antisense
AATCTGGATATTCAACTGCCTACGC 504 169 671 Antisense
GGACAAGCACTTCGGAGTCTCTGCC 249 527 699 Antisense
TCTGCCTACGCTGTTCCAAAGAATG 584 609 718 Antisense
ATGCTGCATCCATCCAAGCTGAAAT 51 43 740 Antisense
GGACCAGTTGAGGCTGCATTCTCTG 516 521 775 Antisense
TGAGAGCGGATCTCCATACTGGCTT 6 567 897 Antisense
Sequence Source Affymetrix Proprietary Database