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[193237_at] receptor-type guanylyl cyclase

Description C49H3.1 /REP_DB=WormBase Gene ID /WP=CE20579 /GEN=gcy-8 /TR=Q9GYQ4 /GB=AAF99901.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=receptor-type guanylyl cyclase
Cluster 6grp_highest_10_10 > 21      6grp_high1_10_10 > 01      4grp_high_8_8 > 11      6grp_highest_nonorm > 90      6grp_total > 14      4grp_total > 14      6grp_highest_sub > De      6grp_cgc > 30      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 165
1 2 3 4 range
A 171.1
(0.3)
P 		100.6
(-3)
P 		101.4
(-3)
P 		229
(3)
P 		128
B 128
(-0.2)
P 		122.9
(-0.4)
P 		64
(-3)
P 		200.9
(3)
P 		137
C 175.7
(3)
P 		68.9
(-3)
M 		83
(-2.2)
P 		138.7
(0.9)
P 		107
avr 158.3
(1.2) 		97.5
(-2.2) 		82.8
(-3) 		189.5
(3) 		107

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 206
1 2 3 4 5 6 range
A 170.1
(2.7)
P 		176.4
(3)
P 		136.7
(1.2)
P 		128.4
(0.8)
P 		107.8
(-0.2)
P 		46.4
(-3)
P 		130
B 251.9
(3)
P 		162
(-0.1)
P 		135.9
(-1)
P 		151.5
(-0.4)
P 		92.1
(-2.5)
P 		76.8
(-3)
P 		175
C 217.6
(3)
P 		163.4
(0.5)
P 		146.8
(-0.3)
P 		139
(-0.6)
P 		87.2
(-3)
P 		93.6
(-2.7)
P 		130
avr 213.2
(3) 		167.3
(1) 		139.8
(-0.1) 		139.6
(-0.1) 		95.7
(-2) 		72.3
(-3) 		141
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 48
1 2 3 4 range
A 62.3
(3)
P 		21.8
(-3)
P 		26.5
(-2.3)
P 		33.5
(-1.3)
P 		41
B 40.8
(2.6)
P 		30.4
(0.3)
P 		14.8
(-3)
P 		42.8
(3)
P 		28
C 58.2
(3)
P 		19.8
(-3)
M 		28.9
(-1.6)
P 		23.4
(-2.4)
P 		38
avr 53.8
(3) 		24
(-2.9) 		23.4
(-3) 		33.2
(-1.1) 		30

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 76
1 2 3 4 5 6 range
A 31.4
(-0.7)
P 		62.7
(3)
P 		29.8
(-0.8)
P 		32.6
(-0.5)
P 		32.5
(-0.5)
P 		11.3
(-3)
P 		51
B 87.6
(3)
P 		53.9
(-0.4)
P 		33
(-2.6)
P 		40.1
(-1.8)
P 		37.4
(-2.1)
P 		28.6
(-3)
P 		59
C 80.7
(3)
P 		49.8
(-0.5)
P 		37.4
(-1.9)
P 		27.9
(-3)
P 		28.2
(-3)
P 		31.3
(-2.6)
P 		53
avr 66.6
(3) 		55.5
(1.4) 		33.4
(-1.6) 		33.5
(-1.6) 		32.7
(-1.7) 		23.7
(-3) 		43
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193237_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9083
Sequence Type Exemplar sequence
Representative Public ID C49H3.1 NCBI
Target Description C49H3.1 /REP_DB=WormBase Gene ID /WP=CE20579 /GEN=gcy-8 /TR=Q9GYQ4 /GB=AAF99901.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=receptor-type guanylyl cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068923(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068923 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-8) (gcy-8) mRNA, complete cds. 11/11 None
SNAP00000004274 ENSEMBL cdna:SNAP chromosome:CEL140:IV:7932023:7933639:1 11/11 None
GENEFINDER00000004291 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:7932008:7933639:1 11/11 None
C49H3.1 ENSEMBL cdna:known chromosome:CEL140:IV:7928142:7933694:1 gene:C49H3.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:7928211-7933645(+) 100.0 100.0
Public Domain and Genome References
Gene Title receptor-type guanylyl cyclase
Gene Symbol gcy-8
Ensembl C49H3.1
Entrez Gene 177584 Entrez gene
SwissProt Q9GYQ4 EMBL-EBI
WormBase CE20579 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF99901 Guanylyl cyclase protein 8 [Caenorhabditis elegans] ref|NP_501324.1| Guanylyl CYclase family member (gcy-8) [Caenorhabditis elegans] 0.0
blast CAE70914 Hypothetical protein CBG17711 [Caenorhabditis briggsae] 0.0
blast NP_500309 Guanylyl CYclase family member (gcy-23) [Caenorhabditis elegans] gb|AAC17555.3| Guanylyl cyclase protein 23 [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 0.088
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 2.0E-71
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 6.0E-52
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 2.0E-71
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-7
Pfam IPR001054 EMBL-EBI Guanylate cyclase 2.0E-71
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_501324.1 1 531-553
C49H3.1 1 531-553
GENEFINDER00000004291 1 13-30
Sequence
Target Sequence 
>C. ELEGANS:193237_AT
aagttgttgctgttctcaatggaatatttgatggttttgatcaatttattgcaagaaaag
atgcatataaagtggaaacaattggagatgcttatatggttgtatcaggtgtaccagaag
aaaatggacatagacatattaatgagattgcgagtattgcattggatgttcataagtttc
tctcggagtttattgttccacataaacgtgacacaaaagttcaatgccgtctcggattcc
atacaggaccagttgcagctgcagttgttgggctcaatgctccaagatattgtctttttg
gagatactgtaaatatggcatcaagaatggaaagtaacagtgaacccggaaaaactcaaa
tttctgaaactgcaaagaaccttttactcaaagaatatcccgattatatttgtgaacaac
gtggtgaaattccaatcaaaggaaaaggattgtgcatgacatattggttaatgggaacaa
aatcagaaggatctggacgtagtggagcatatttggctccttcaatgaaatcggctggaa
ctggtttcacagga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGTTGTTGCTGTTCTCAATGGAAT 701 155 3014 Antisense
GGATGTTCATAAGTTTCTCTCGGAG 677 513 3177 Antisense
TTCTCTCGGAGTTTATTGTTCCACA 25 693 3191 Antisense
CACAAAAGTTCAATGCCGTCTCGGA 647 191 3225 Antisense
TGCCGTCTCGGATTCCATACAGGAC 144 585 3238 Antisense
ATACAGGACCAGTTGCAGCTGCAGT 344 23 3254 Antisense
GCAGCTGCAGTTGTTGGGCTCAATG 660 313 3268 Antisense
GGGCTCAATGCTCCAAGATATTGTC 524 493 3283 Antisense
GAAGGATCTGGACGTAGTGGAGCAT 692 333 3499 Antisense
AGCATATTTGGCTCCTTCAATGAAA 67 79 3519 Antisense
ATCGGCTGGAACTGGTTTCACAGGA 668 33 3543 Antisense
Sequence Source Affymetrix Proprietary Database