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[193222_at] acetylcholine receptor protein

Description ZC504.2 /REP_DB=WormBase Gene ID /WP=CE28381 /GEN=acr-8 /TR=Q23355 /GB=CAA90341.2 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=acetylcholine receptor protein
Cluster 6grp_highest_10_10 > 21      6grp_high1_10_10 > 11      4grp_highest_8_8 > 40      4grp_high_8_8 > 42      6grp_highest_nonorm > 70      6grp_total > 13      4grp_total > 53      6grp_highest_sub > De      6grp_cgc > 30      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 313
1 2 3 4 range
A 371.9
(3)
P 		266.8
(0.6)
P 		250.8
(0.2)
P 		112.2
(-3)
P 		260
B 409.5
(3)
P 		318.1
(1.2)
P 		243.6
(-0.2)
P 		96.5
(-3)
P 		313
C 406.7
(3)
P 		342.7
(1.3)
P 		264.8
(-0.8)
P 		181
(-3)
P 		226
avr 396
(3) 		309.2
(1) 		253.1
(-0.2) 		129.9
(-3) 		266

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 275
1 2 3 4 5 6 range
A 366.9
(3)
P 		306.6
(1.5)
P 		306
(1.4)
P 		272.9
(0.6)
P 		155.5
(-2.4)
P 		132.7
(-3)
P 		234
B 308
(2.7)
P 		319
(3)
P 		247.5
(1.1)
P 		258
(1.4)
P 		179.7
(-0.7)
P 		91.8
(-3)
P 		227
C 321.7
(3)
P 		319.9
(2.9)
P 		294.9
(2.2)
P 		280.9
(1.8)
P 		122.1
(-2.8)
P 		116.3
(-3)
P 		205
avr 332.2
(3) 		315.2
(2.5) 		282.8
(1.6) 		270.6
(1.3) 		152.4
(-1.9) 		113.6
(-3) 		219
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 119
1 2 3 4 range
A 135.4
(3)
P 		57.9
(-0.9)
P 		65.6
(-0.5)
P 		16.4
(-3)
P 		119
B 130.6
(3)
P 		78.6
(0.2)
P 		56.4
(-1)
P 		20.6
(-3)
P 		110
C 134.6
(3)
P 		98.5
(0.9)
P 		92.3
(0.6)
P 		30.5
(-3)
P 		104
avr 133.5
(3) 		78.3
(0) 		71.4
(-0.4) 		22.5
(-3) 		111

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 87
1 2 3 4 5 6 range
A 67.6
(-0.2)
P 		109.1
(3)
P 		66.6
(-0.3)
P 		69.2
(-0.1)
P 		46.9
(-1.9)
P 		32.3
(-3)
P 		77
B 107.2
(3)
P 		106.2
(2.9)
P 		60.1
(-0.9)
P 		68.3
(-0.2)
P 		73
(0.2)
P 		34.2
(-3)
P 		73
C 119.2
(3)
P 		97.6
(1.4)
P 		75
(-0.3)
P 		56.5
(-1.7)
P 		39.5
(-3)
P 		38.9
(-3)
P 		80
avr 98
(2.5) 		104.3
(3) 		67.2
(-0.2) 		64.7
(-0.4) 		53.1
(-1.4) 		35.1
(-3) 		69
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193222_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17023
Sequence Type Exemplar sequence
Representative Public ID ZC504.2 NCBI
Target Description ZC504.2 /REP_DB=WormBase Gene ID /WP=CE28381 /GEN=acr-8 /TR=Q23355 /GB=CAA90341.2 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=acetylcholine receptor protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077344(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077344 NCBI Caenorhabditis elegans AcetylCholine Receptor family member (acr-8) (acr-8) mRNA, complete cds. 11/11 None
GENEFINDER00000031670 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:10410803:10416519:1 11/11 None
SNAP00000031664 ENSEMBL cdna:SNAP chromosome:CEL140:X:10413765:10416519:1 11/11 None
ZC504.2 ENSEMBL cdna:known chromosome:CEL140:X:10412691:10416558:1 gene:ZC504.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10412307-10416519(+) 100.0 100.0
Public Domain and Genome References
Gene Title acetylcholine receptor protein
Gene Symbol acr-8
Ensembl ZC504.2
Entrez Gene 181246 Entrez gene
SwissProt Q23355 EMBL-EBI
WormBase CE36679 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
6811 ion transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
45211 postsynaptic membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4889 nicotinic acetylcholine-activated cation-selective channel activity inferred from electronic annotation QuickGO AmiGO
5216 ion channel activity inferred from electronic annotation QuickGO AmiGO
5230 extracellular ligand-gated ion channel activity inferred from electronic annotation QuickGO AmiGO
30594 neurotransmitter receptor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90341 Hypothetical protein ZC504.2 [Caenorhabditis elegans] ref|NP_509745.2| AcetylCholine Receptor family member (acr-8) [Caenorhabditis elegans] 0.0
blast CAE70577 Hypothetical protein CBG17234 [Caenorhabditis briggsae] 0.0
blast CAB01685 Hypothetical protein C35C5.5 [Caenorhabditis elegans] ref|NP_509932.2| LEVamisole resistant family member (lev-8) [Caenorhabditis elegans] 1.0E-124
Protein Domains
Database ID Description E-Value
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.7E-50
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 4.2E-89
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.7E-50
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 2.5E-47
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 3.2E-11
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.7E-50
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 6.5E-21
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 3.2E-11
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509745.2 4 252-274,283-305,315-337,457-479
ZC504.2 4 252-274,283-305,315-337,457-479
GENEFINDER00000031670 6 65-87,122-141,330-352,362-381,394-416,532-554
SNAP00000031664 4 130-152,162-181,194-216,332-354
Sequence
Target Sequence 
>C. ELEGANS:193222_AT
gacgggatggttcatcattcccaatgcctcactggatgaaagttgtatttatacatactc
ttccacggtatatttgtataaaaacagcagaagaagatgatgggagcgatcgaggatcga
gtatttctgatatcgggccttttatggattcacgaagaccatcaccatttttcataacag
ttaatgaacgtcagttgaatggacggttatcagaattaaaaaagaaaggaatgcatccag
acttgatcagaaacatgattcaaaatgttgaatttattgccgaatattttaattctttga
aaaaagaagacaaggtctcagaggattggtcttatgttgcaaatgtaattgacagaattt
tcctcatcattttttctataatgaacgttgtcggaacttgggtgatcctattgaactctc
ctgctctatttgataatcggacgccgttattcataaactccgtggctcgtccgttatctg
gtgatacatttgaacattttatcaatgagaacttcactcaacttgcctggtgggccagca
caatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACGGGATGGTTCATCATTCCCAAT 392 377 1301 Antisense
TCATTCCCAATGCCTCACTGGATGA 618 619 1315 Antisense
GAGTATTTCTGATATCGGGCCTTTT 411 397 1419 Antisense
AAGACCATCACCATTTTTCATAACA 29 155 1455 Antisense
GAACGTTGTCGGAACTTGGGTGATC 383 345 1683 Antisense
TTGGGTGATCCTATTGAACTCTCCT 448 707 1698 Antisense
GAACTCTCCTGCTCTATTTGATAAT 411 349 1713 Antisense
GGACGCCGTTATTCATAAACTCCGT 637 523 1739 Antisense
GCTCGTCCGTTATCTGGTGATACAT 621 297 1765 Antisense
TGAGAACTTCACTCAACTTGCCTGG 167 569 1806 Antisense
ACTTGCCTGGTGGGCCAGCACAATC 488 103 1821 Antisense
Sequence Source Affymetrix Proprietary Database