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[193211_at] protein farnesyltransferase beta subunit

Description F23B12.6 /REP_DB=WormBase Gene ID /WP=CE09598 /TR=Q19752 /GB=CAB01167.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=protein farnesyltransferase beta subunit
Cluster 6grp_highest_10_10 > 48      6grp_high1_10_10 > 84      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 74      6grp_total > 74      4grp_total > 58      6grp_cgc > 66      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 270
1 2 3 4 range
A 629.2
(0.4)
P 		716.4
(3)
P 		630.2
(0.5)
P 		513.4
(-3)
P 		203
B 673.6
(-3)
P 		733.1
(0.9)
P 		766.2
(3)
P 		715
(-0.3)
P 		93
C 708.9
(0.2)
P 		729.2
(1)
P 		783.1
(3)
P 		624.7
(-3)
P 		158
avr 670.6
(-0.1) 		726.2
(3) 		726.5
(3) 		617.7
(-3) 		109

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 402
1 2 3 4 5 6 range
A 439.2
(-3)
P 		681.1
(0.7)
P 		677.4
(0.6)
P 		836.7
(3)
P 		580.2
(-0.9)
P 		741.2
(1.6)
P 		398
B 548.5
(-0.9)
P 		434.5
(-3)
P 		759.4
(3)
P 		619.2
(0.4)
P 		691.7
(1.7)
P 		722.3
(2.3)
P 		325
C 521.5
(-2.5)
P 		494.8
(-3)
P 		701.1
(1.1)
P 		716
(1.4)
P 		779.3
(2.7)
P 		794.5
(3)
P 		300
avr 503.1
(-3) 		536.8
(-2.2) 		712.6
(2) 		724
(2.3) 		683.7
(1.3) 		752.7
(3) 		250
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 198
1 2 3 4 range
A 229.1
(3)
P 		155.5
(0.1)
P 		164.8
(0.5)
P 		75.2
(-3)
P 		154
B 214.8
(3)
P 		181
(-0.3)
P 		177.5
(-0.6)
P 		152.4
(-3)
P 		62
C 234.7
(1.6)
P 		209.6
(0.7)
P 		272.9
(3)
P 		105.3
(-3)
P 		168
avr 226.2
(3) 		182
(0.7) 		205.1
(1.9) 		111
(-3) 		115

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 200
1 2 3 4 5 6 range
A 81
(-3)
P 		242.2
(3)
P 		147.5
(-0.5)
P 		212.2
(1.9)
P 		175.1
(0.5)
P 		180.5
(0.7)
P 		161
B 190.9
(-1)
P 		144.6
(-3)
P 		184.4
(-1.2)
P 		164
(-2.1)
P 		281
(3)
P 		269.4
(2.5)
P 		136
C 193.3
(-0.6)
P 		151
(-2.7)
P 		178.5
(-1.3)
P 		144
(-3)
P 		252.2
(2.3)
P 		266
(3)
P 		122
avr 155.1
(-3) 		179.3
(-1.3) 		170.1
(-1.9) 		173.4
(-1.7) 		236.1
(2.8) 		238.6
(3) 		84
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193211_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12805
Sequence Type Exemplar sequence
Representative Public ID F23B12.6 NCBI
Target Description F23B12.6 /REP_DB=WormBase Gene ID /WP=CE09598 /TR=Q19752 /GB=CAB01167.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=protein farnesyltransferase beta subunit
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074179(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074179 NCBI Caenorhabditis elegans Temporarily Assigned Gene name family member (tag-114) (tag-114) mRNA, complete cds. 11/11 None
GENEFINDER00000025815 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:14450331:14452032:1 11/11 None
F23B12.6.2 ENSEMBL cdna:known chromosome:CEL140:V:14450285:14452155:1 gene:F23B12.6 11/11 None
F23B12.6.1 ENSEMBL cdna:known chromosome:CEL140:V:14450329:14452155:1 gene:F23B12.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000025806 4/11 Cross Hyb Matching Probes None
SNAP00000025807 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:14450330-14452032(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein farnesyltransferase beta subunit
Gene Symbol tag-114
Ensembl F23B12.6
Entrez Gene 179946 Entrez gene
SwissProt Q19752 EMBL-EBI
WormBase CE09598 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:13245_S_AT protein farnesyltransferase beta subunit (ERA1) at
ATGENOME1:18488_G_AT protein farnesyltransferase beta subunit (ERA1) at
ATGENOME1:18487_AT protein farnesyltransferase beta subunit (ERA1) at
ATH1-121501:249405_AT protein farnesyltransferase beta subunit (ERA1) at
CANINE_2:CFA.17360.1.S1_S_AT similar to farnesyltransferase, CAAX box, beta cfa
CANINE_2:CFAAFFX.24827.1.S1_AT similar to farnesyltransferase, CAAX box, beta cfa
DROSOPHILA_2:1633362_AT dm
DROSGENOME1:154769_AT dm
HG-U95AV2:1773_AT farnesyltransferase, CAAX box, beta hs
HG-U133A:1773_AT farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:1773_AT farnesyltransferase, CAAX box, beta hs
HG-FOCUS:1773_AT farnesyltransferase, CAAX box, beta hs
HC-G110:1773_AT farnesyltransferase, CAAX box, beta hs
HG-U133A_2:1773_AT farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:204764_AT farnesyltransferase, CAAX box, beta hs
HG-U133A_2:204764_AT farnesyltransferase, CAAX box, beta hs
HG-U133A:204764_AT farnesyltransferase, CAAX box, beta hs
HU35KSUBA:T31862_AT farnesyltransferase, CAAX box, beta hs
HUGENEFL:L00635_AT farnesyltransferase, CAAX box, beta hs
U133_X3P:G10835058_3P_S_AT farnesyltransferase, CAAX box, beta hs
U133_X3P:HS.276.0.A1_3P_AT farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:225851_AT farnesyltransferase, CAAX box, beta hs
HG-U133B:225851_AT farnesyltransferase, CAAX box, beta hs
HG-U95AV2:37488_AT farnesyltransferase, CAAX box, beta hs
HG-U95B:51164_AT farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:222174_AT Farnesyltransferase, CAAX box, beta hs
HG-U133A_2:222174_AT Farnesyltransferase, CAAX box, beta hs
HG-U133A:222174_AT Farnesyltransferase, CAAX box, beta hs
U133_X3P:HS2.385615.1.S1_3P_AT Farnesyltransferase, CAAX box, beta hs
U133_X3P:HS.296748.0.S1_3P_AT Farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:1568865_AT Farnesyltransferase, CAAX box, beta hs
HG-U133_PLUS_2:233283_AT Farnesyltransferase, CAAX box, beta hs
HG-U133B:233283_AT Farnesyltransferase, CAAX box, beta hs
HU35KSUBB:RC_AA165116_AT Farnesyltransferase, CAAX box, beta hs
MU11KSUBA:AA396235_S_AT farnesyltransferase, CAAX box, beta mm
MG-U74AV2:96218_AT farnesyltransferase, CAAX box, beta mm
MOE430A:1434309_AT farnesyltransferase, CAAX box, beta mm
MOUSE430A_2:1434309_AT farnesyltransferase, CAAX box, beta mm
MOUSE430_2:1434309_AT farnesyltransferase, CAAX box, beta mm
MOE430B:1459043_AT Farnesyltransferase, CAAX box, beta (Fntb), mRNA mm
MOUSE430_2:1459043_AT Farnesyltransferase, CAAX box, beta (Fntb), mRNA mm
MG-U74CV2:167593_AT Farnesyltransferase, CAAX box, beta (Fntb), mRNA mm
MU19KSUBB:TC28988_AT Farnesyltransferase, CAAX box, beta (Fntb), mRNA mm
RG-U34A:RC_AI136396_AT farnesyltransferase, CAAX box, beta rn
RG-U34A:RC_AI230914_AT farnesyltransferase, CAAX box, beta rn
RAE230A:1370829_AT farnesyltransferase, CAAX box, beta rn
RAT230_2:1370829_AT farnesyltransferase, CAAX box, beta rn
YEAST_2:1777327_AT Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01167 Hypothetical protein F23B12.6 [Caenorhabditis elegans] ref|NP_506580.1| Temporarily Assigned Gene name family member (tag-114) [Caenorhabditis elegans] 0.0
blast CAE60896 Hypothetical protein CBG04611 [Caenorhabditis briggsae] 0.0
blast CAI20594 novel protein similar to vertebrate farnesyltransferase, CAAX box, beta (FNTB) [Danio rerio] emb|CAH69069.1| novel protein similar to vertebrate farnesyltransferase, CAAX box, beta (FNTB) [Danio rerio] ref|NP_001002128.1| farnesyltransferase, CAAX box, beta [Danio rerio] gb|AAH71443.1| Farnesyltransferase, CAAX box, beta [Danio rerio] 1.0E-89
Protein Domains
Database ID Description E-Value
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 0.65
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 2.4E-9
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 3.5E-12
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 1.3E-13
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 9.5E-11
Pfam IPR001330 EMBL-EBI Prenyltransferase/squalene oxidase 6.9E-8
Sequence
Target Sequence 
>C. ELEGANS:193211_AT
atgcgagattgtgggcctacctatggatgagatatcaaatggtgtggccgaatggattat
cagctgccagagctttgaaggtggtttcggaggagaaccgtatacagaggcacacggagg
atacactttctgcgcggtcgcctcgttggttctgttaaacagattccgtcttgctgatat
ggaaggtctccttcgttgggccacgcgccggcagatgcgatttgagggtggtttccaggg
aagaacaaataaacttgttgatggatgctacagcttctggcaaggtgccatcttcccact
tttggacggagaaatggaacgagaaggccgatcattggagaaaggtcttttcgaggcgcg
aatgctt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGCGAGATTGTGGGCCTACCTATG 136 43 606 Antisense
GGATTATCAGCTGCCAGAGCTTTGA 567 509 659 Antisense
CACACGGAGGATACACTTTCTGCGC 339 195 716 Antisense
TCGCCTCGTTGGTTCTGTTAAACAG 246 599 743 Antisense
AAACAGATTCCGTCTTGCTGATATG 338 129 762 Antisense
TATGGAAGGTCTCCTTCGTTGGGCC 419 653 783 Antisense
CACGCGCCGGCAGATGCGATTTGAG 135 201 807 Antisense
GATGGATGCTACAGCTTCTGGCAAG 272 407 865 Antisense
GCTTCTGGCAAGGTGCCATCTTCCC 607 305 878 Antisense
CCATCTTCCCACTTTTGGACGGAGA 383 269 893 Antisense
AGGTCTTTTCGAGGCGCGAATGCTT 695 57 948 Antisense
Sequence Source Affymetrix Proprietary Database