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[193204_at] G-protein beta subunit GPB-2

Description F28C1.2 /REP_DB=WormBase Gene ID /WP=CE24928 /GEN=egl-10 /TR=SW:P49809 /GB=CAA99844.2 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=G-protein coupled receptor
Cluster 6grp_total > 76      4grp_total > 30      6grp_cgc > 48      6grp_cgc_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 86
1 2 3 4 range
A 103
(3)
A 		41.6
(-3)
A 		50
(-2.2)
A 		94.9
(2.2)
A 		61
B 110.3
(3)
P 		86.7
(1)
P 		38.9
(-3)
A 		70.4
(-0.4)
A 		71
C 71.7
(0.9)
A 		51.3
(-0.8)
A 		24.5
(-3)
A 		97.8
(3)
A 		73
avr 95
(3) 		59.9
(-0.7) 		37.8
(-3) 		87.7
(2.2) 		57

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 44
1 2 3 4 5 6 range
A 58.5
(1.4)
A 		35
(-1.9)
A 		26.8
(-3)
A 		43.7
(-0.6)
A 		52.2
(0.5)
A 		69.9
(3)
A 		43
B 31.6
(-3)
A 		42.1
(-1.4)
A 		70.5
(3)
A 		57.1
(0.9)
A 		43.7
(-1.1)
A 		64.5
(2.1)
A 		39
C 61.9
(2.5)
A 		60.5
(2)
A 		46.9
(-3)
A 		63.2
(3)
A 		55.9
(0.3)
A 		62.6
(2.8)
A 		16
avr 50.7
(-1.5) 		45.9
(-3) 		48.1
(-2.3) 		54.7
(-0.3) 		50.6
(-1.6) 		65.7
(3) 		20
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 29
1 2 3 4 range
A 37.5
(3)
A 		9
(-3)
A 		13.1
(-2.1)
A 		13.9
(-2)
A 		29
B 35.2
(3)
P 		21.4
(-0.2)
P 		9
(-3)
A 		15
(-1.6)
A 		26
C 23.8
(3)
A 		14.8
(-0.5)
A 		8.5
(-3)
A 		16.5
(0.1)
A 		15
avr 32.2
(3) 		15.1
(-1.7) 		10.2
(-3) 		15.1
(-1.7) 		22

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 18
1 2 3 4 5 6 range
A 10.8
(-0.3)
A 		12.4
(0.5)
A 		5.8
(-3)
A 		11.1
(-0.2)
A 		15.8
(2.4)
A 		17
(3)
A 		11
B 11
(-3)
A 		14
(-1.6)
A 		17.1
(-0.2)
A 		15.1
(-1.1)
A 		17.8
(0.1)
A 		24
(3)
A 		13
C 22.9
(3)
A 		18.5
(0.6)
A 		11.9
(-3)
A 		12.7
(-2.6)
A 		18.1
(0.4)
A 		21
(2)
A 		11
avr 14.9
(-0.8) 		15
(-0.8) 		11.6
(-3) 		13
(-2.1) 		17.2
(0.7) 		20.7
(3) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193204_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14100
Sequence Type Exemplar sequence
Representative Public ID F28C1.2 NCBI
Target Description F28C1.2 /REP_DB=WormBase Gene ID /WP=CE24928 /GEN=egl-10 /TR=SW:P49809 /GB=CAA99844.2 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=G-protein coupled receptor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073724(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073724 NCBI Caenorhabditis elegans EGg Laying defective family member (egl-10) (egl-10) mRNA, complete cds. 11/11 None
SNAP00000044354 ENSEMBL cdna:SNAP chromosome:CEL140:V:12458316:12460986:-1 11/11 None
GENEFINDER00000044358 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:12457109:12462732:-1 11/11 None
F28C1.2 ENSEMBL cdna:known chromosome:CEL140:V:12457760:12465596:-1 gene:F28C1.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:12459046-12462777(-) 98.92 98.92
Public Domain and Genome References
Gene Title G-protein beta subunit GPB-2
Gene Symbol egl-10
Ensembl F28C1.2
Entrez Gene 179707 Entrez gene
SwissProt P49809 EMBL-EBI
WormBase CE24928 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1625057_AT Regulator of G-protein signaling 7 dm
DROSGENOME1:144033_AT Regulator of G-protein signaling 7 dm
CHICKEN:GGA.12563.1.S1_AT regulator of G-protein signalling 7 gga
CHICKEN:GGA.351.1.S1_AT regulator of G-protein signalling 7 gga
CHICKEN:GGA.351.2.S1_S_AT regulator of G-protein signalling 7 gga
HG-U133_PLUS_2:206290_S_AT regulator of G-protein signalling 7 hs
HG-U133A:206290_S_AT regulator of G-protein signalling 7 hs
HG-FOCUS:206290_S_AT regulator of G-protein signalling 7 hs
HG-U133A_2:206290_S_AT regulator of G-protein signalling 7 hs
HUGENEFL:U32439_AT regulator of G-protein signalling 7 hs
U133_X3P:G11140808_3P_A_AT regulator of G-protein signalling 7 hs
U133_X3P:HS2.79348.2.S1_3P_S_AT regulator of G-protein signalling 7 hs
HG-U133_PLUS_2:1554500_A_AT regulator of G-protein signalling 7 hs
HG-U95AV2:40653_AT regulator of G-protein signalling 7 hs
HG-U133_PLUS_2:216970_AT regulator of G-protein signalling 7 hs
HG-U133A_2:216970_AT regulator of G-protein signalling 7 hs
HG-U133A:216970_AT regulator of G-protein signalling 7 hs
HG-U95D:90684_AT Regulator of G-protein signalling 7 hs
MOUSE430_2:1450659_AT regulator of G protein signaling 7 mm
MOE430A:1450659_AT regulator of G protein signaling 7 mm
MOUSE430A_2:1450659_AT regulator of G protein signaling 7 mm
MG-U74AV2:93645_AT regulator of G protein signaling 7 mm
RG-U34B:RC_AI069964_AT regulator of G-protein signaling 7 rn
RAE230A:1368373_AT regulator of G-protein signaling 7 rn
RAT230_2:1368373_AT regulator of G-protein signaling 7 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7186 G-protein coupled receptor protein signaling pathway inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
8277 regulation of G-protein coupled receptor protein signaling pathway inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5834 heterotrimeric G-protein complex inferred from electronic annotation QuickGO AmiGO
43005 neuron projection inferred from direct assay QuickGO AmiGO
5737 cytoplasm inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4871 signal transducer activity inferred from electronic annotation QuickGO AmiGO
16299 regulator of G-protein signaling activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99844 Hypothetical protein F28C1.2 [Caenorhabditis elegans] ref|NP_506125.1| EGg Laying defective family member (egl-10) [Caenorhabditis elegans] sp|P49809|EGL10_CAEEL Regulator of G-protein signaling egl-10 (Egg laying defective protein 10) gb|AAC46965.1| G protein signaling regulator 0.0
blast CAE75494 Hypothetical protein CBG23499 [Caenorhabditis briggsae] 0.0
blast EAA10807 ENSANGP00000002611 [Anopheles gambiae str. PEST] ref|XP_316659.2| ENSANGP00000002611 [Anopheles gambiae str. PEST] 3.0E-94
Protein Domains
Database ID Description E-Value
Pfam IPR001770 EMBL-EBI G-protein, gamma subunit 1.1E-25
Pfam IPR000591 EMBL-EBI Pleckstrin putative G-protein interacting domain 1.8E-29
Pfam IPR000342 EMBL-EBI Regulator of G protein 3.6E-53
Pfam IPR001770 EMBL-EBI G-protein, gamma subunit 1.1E-25
Pfam IPR000342 EMBL-EBI Regulator of G protein 3.6E-53
Pfam IPR001770 EMBL-EBI G-protein, gamma subunit 1.1E-25
Pfam IPR000591 EMBL-EBI Pleckstrin putative G-protein interacting domain 1.8E-29
Pfam IPR000342 EMBL-EBI Regulator of G protein 3.6E-53
Sequence
Target Sequence 
>C. ELEGANS:193204_AT
gaacaacgtcgagtatttgatccactgttaacgcctcctggatctcaggctgatcctttt
caatcacagcctaatccatggattaacgatactgttgatttttggcaacatgataaaatt
acgggagacatccaaacccgccgactcaagctttgggaggatagttttgaagaattactt
gctgattcattaggtcgagaaactcttcaaaaattccttgacaaagaatattctggagaa
aacttgcggttttggtgggaggtacaaaagctgcgaaagtgcagttcaagaatggttcca
gttatggtaacagagatttacaacgagtttatcgatacaaatgcggcaacgtcgccggtc
aatgtggattgtaaagtgatggaagtgaccgaagacaatttaaagaatccaaatcggtgg
agttttgatgaagcagcggatcatatctactgccttatgaagaacgatagttatcaacgc
tttcttcgttcaga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAACAACGTCGAGTATTTGATCCAC 114 353 1111 Antisense
GTATTTGATCCACTGTTAACGCCTC 539 451 1123 Antisense
CCTCCTGGATCTCAGGCTGATCCTT 464 265 1144 Antisense
CAGGCTGATCCTTTTCAATCACAGC 270 209 1156 Antisense
TTCAATCACAGCCTAATCCATGGAT 1 685 1169 Antisense
ACCCGCCGACTCAAGCTTTGGGAGG 503 89 1246 Antisense
ATTACTTGCTGATTCATTAGGTCGA 119 9 1284 Antisense
ACAAATGCGGCAACGTCGCCGGTCA 472 81 1447 Antisense
AACGTCGCCGGTCAATGTGGATTGT 613 135 1458 Antisense
CAGCGGATCATATCTACTGCCTTAT 256 203 1544 Antisense
GTTATCAACGCTTTCTTCGTTCAGA 331 447 1580 Antisense
Sequence Source Affymetrix Proprietary Database