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[193187_s_at] ATP-binding transport family

Description F57C12.4 /REP_DB=WormBase Gene ID /WP=CE26370 /GEN=mrp-2 /TR=Q20943 /GB=AAA83299.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=ATP-binding transport family
Cluster 6grp_highest_10_10 > 50      6grp_high1_10_10 > 16      4grp_highest_8_8 > 50      4grp_high_8_8 > 32      6grp_highest_nonorm > 60      6grp_total > 16      4grp_total > 47      6grp_highest_sub > De      6grp_cgc > 22      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 675
1 2 3 4 range
A 798.5
(3)
P 		219.4
(-2.5)
P 		179.1
(-2.9)
P 		166.4
(-3)
P 		632
B 838.2
(3)
P 		221.4
(-2.5)
P 		221
(-2.5)
P 		163
(-3)
P 		675
C 786.7
(3)
P 		216.5
(-2.6)
P 		213.4
(-2.6)
P 		170.5
(-3)
P 		616
avr 807.8
(3) 		219.1
(-2.5) 		204.5
(-2.6) 		166.6
(-3) 		641

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 859
1 2 3 4 5 6 range
A 739.1
(3)
P 		542.5
(1.1)
P 		208.4
(-2.2)
P 		196.3
(-2.3)
P 		173.7
(-2.5)
P 		124.3
(-3)
P 		615
B 919.5
(3)
P 		620.1
(0.7)
P 		256.9
(-2)
P 		245.1
(-2.1)
P 		129.3
(-3)
P 		144.1
(-2.9)
P 		790
C 983.4
(3)
P 		546.3
(-0.2)
P 		338.4
(-1.7)
P 		198.7
(-2.7)
P 		161.4
(-2.9)
P 		152.7
(-3)
P 		831
avr 880.7
(3) 		569.6
(0.5) 		267.9
(-2) 		213.4
(-2.4) 		154.8
(-2.9) 		140.4
(-3) 		740
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 266
1 2 3 4 range
A 290.7
(3)
P 		47.6
(-2.5)
P 		46.8
(-2.5)
P 		24.4
(-3)
P 		266
B 267.3
(3)
P 		54.7
(-2.5)
P 		51.2
(-2.6)
P 		34.7
(-3)
P 		233
C 260.4
(3)
P 		62.2
(-2.1)
P 		74.4
(-1.8)
P 		28.7
(-3)
P 		232
avr 272.8
(3) 		54.8
(-2.4) 		57.5
(-2.3) 		29.3
(-3) 		244

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 334
1 2 3 4 5 6 range
A 136.2
(0.9)
P 		192.9
(3)
P 		45.4
(-2.4)
P 		49.8
(-2.3)
P 		52.4
(-2.2)
P 		30.3
(-3)
P 		163
B 320
(3)
P 		206.4
(0.5)
P 		62.4
(-2.8)
P 		64.9
(-2.7)
P 		52.6
(-3)
P 		53.7
(-3)
P 		267
C 364.5
(3)
P 		166.7
(-0.7)
P 		86.1
(-2.1)
P 		40
(-3)
P 		52.2
(-2.8)
P 		51.1
(-2.8)
P 		325
avr 273.6
(3) 		188.7
(0.8) 		64.6
(-2.5) 		51.6
(-2.8) 		52.4
(-2.8) 		45
(-3) 		229
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193187_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18370
Sequence Type Exemplar sequence
Representative Public ID F57C12.4 NCBI
Target Description F57C12.4 /REP_DB=WormBase Gene ID /WP=CE26370 /GEN=mrp-2 /TR=Q20943 /GB=AAA83299.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=ATP-binding transport family
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075720(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075720 NCBI Caenorhabditis elegans Multidrug Resistance Protein family member (mrp-2) (mrp-2) mRNA, complete cds. 11/11 None
SNAP00000008051 ENSEMBL cdna:SNAP chromosome:CEL140:X:563828:571151:-1 11/11 None
GENEFINDER00000008059 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:563828:572644:-1 11/11 None
F57C12.4 ENSEMBL cdna:known chromosome:CEL140:X:563735:572644:-1 gene:F57C12.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:563827-572644(-) 100.0 100.0
Public Domain and Genome References
Gene Title ATP-binding transport family
Gene Symbol mrp-2
Ensembl F57C12.4
Entrez Gene 180408 Entrez gene
SwissProt Q20943 EMBL-EBI
WormBase CE26370 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:14731_S_AT glutathione S-conjugate ABC transporter (MRP2) at
ATH1-121501:267319_AT glutathione S-conjugate ABC transporter (MRP2) at
CANINE:1582474_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 cfa
CANINE_2:CFA.3224.1.S1_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 cfa
CANINE_2:CFAAFFX.27890.1.S1_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 cfa
DROSOPHILA_2:1636634_A_AT dm
DROSGENOME1:141704_AT dm
CHICKEN:GGA.1310.1.S1_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 gga
CHICKEN:GGA.17061.1.S1_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 gga
CHICKEN:GGAAFFX.20375.1.S1_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 gga
CHICKEN:GGAAFFX.4138.1.S1_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 gga
HG-U95AV2:1896_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HC-G110:1896_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133A_2:202805_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133A:202805_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133_PLUS_2:202805_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HUGENEFL:X78338_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HUGENEFL:L05628_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
U133_X3P:G9955961_3P_A_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
U133_X3P:HS.89433.4.S3_3P_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133A_2:202804_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-FOCUS:202804_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133_PLUS_2:202804_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U133A:202804_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U95AV2:34016_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U95AV2:34017_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U95AV2:34384_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HG-U95D:74340_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
HU35KSUBC:RC_N66741_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hs
MOE430A:1421378_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOUSE430A_2:1421378_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOUSE430_2:1421378_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MG-U74AV2:99329_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MG-U74BV2:117110_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOE430A:1452233_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOUSE430A_2:1452233_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOUSE430_2:1452233_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 mm
MOE430B:1446002_AT ATP-binding cassette protein (Abcc1b) mm
MOUSE430_2:1446002_AT ATP-binding cassette protein (Abcc1b) mm
MOUSE430_2:1459270_AT ATP-binding cassette protein (Abcc1b) mm
MOE430B:1459270_AT ATP-binding cassette protein (Abcc1b) mm
MU19KSUBB:TC28800_AT ATP-binding cassette protein (Abcc1b) mm
MU19KSUBC:TC35180_AT ATP-binding cassette protein (Abcc1b) mm
MU19KSUBC:TC35180_G_AT ATP-binding cassette protein (Abcc1b) mm
RT-U34:X96394_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RG-U34A:X96394_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RT-U34:X90642MRNA_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RG-U34A:X90642MRNA_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAE230A:1371005_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAT230_2:1371005_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAE230A:1372178_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAT230_2:1372178_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAE230B:1381500_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RAT230_2:1381500_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
RG-U34C:RC_AI146058_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 1 rn
YEAST_2:1779445_AT Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA83299 Multidrug resistance protein family protein 2 [Caenorhabditis elegans] ref|NP_508121.1| Multidrug Resistance Protein family member (mrp-2) [Caenorhabditis elegans] 0.0
blast AAB07022 multidrug resistance related protein 0.0
blast CAE63648 Hypothetical protein CBG08146 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.5E-39
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.3E-42
Pfam IPR003439 EMBL-EBI ABC transporter 1.2E-43
Pfam IPR003439 EMBL-EBI ABC transporter 9.5E-48
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.5E-15
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 3.1E-16
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.3E-42
Pfam IPR003439 EMBL-EBI ABC transporter 1.2E-43
Pfam IPR003439 EMBL-EBI ABC transporter 9.5E-48
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.5E-39
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.3E-42
Pfam IPR003439 EMBL-EBI ABC transporter 1.2E-43
Pfam IPR003439 EMBL-EBI ABC transporter 9.5E-48
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508121.1 16 39-61,74-96,106-128,135-157,172-194,298-317,332-354,410-432,436-458,522-544,559-581,954-976,1013-1035,1083-1105,1109-1128,1192-1214
F57C12.4 16 39-61,74-96,106-128,135-157,172-194,298-317,332-354,410-432,436-458,522-544,559-581,954-976,1013-1035,1083-1105,1109-1128,1192-1214
SNAP00000008051 13 2-21,36-58,65-87,102-124,262-284,426-448,514-536,551-573,946-968,1005-1027,1075-1097,1101-1120,1184-1206
GENEFINDER00000008059 15 64-83,93-115,122-144,159-181,285-304,319-341,397-419,423-445,509-531,546-568,941-963,1000-1022,1070-1092,1096-1115,1179-1201
Sequence
Target Sequence 
>C. ELEGANS:193187_S_AT
aggaaagagttctcttaccctcgcacttttccgtattattgaggctgatggagggagtat
tgaaattgatggtattaacattgccaatcttcaactggagcagttgagaagttgcttaac
gattgtgccacaagatcctgtgttgttctccggaacaatgaaaatgaacttagatccatt
ttctgcctatagcgattcacaagtgtgggaagctttagaaaatgctcatttaaagccatt
tgtgaaatctttacaagacggtctcgaacacaaaatttcagaaggtggtgaaaatttgag
tgttggccaacggcagctgatatgtttggcgcgcgcactgctcagaaaaacaaaagtact
ggtgcttgatgaggcagccgctgcggttgatgtggagacggatagtctcattcaaaaaac
aattcgtgagcagttcaaggaatgtactgttctaacaattgcacatcgtctgaacactgt
gatggacagtgatcgtcttttggtactggacaaaggacgcgttgcggaattcgattcacc
aaagaaccttctcgcaaacccggatggaatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGGAAAGAGTTCTCTTACCCTCGCA 231 55 3984 Antisense
CACAAGATCCTGTGTTGTTCTCCGG 8 195 4112 Antisense
GAACTTAGATCCATTTTCTGCCTAT 155 349 4149 Antisense
TGAGTGTTGGCCAACGGCAGCTGAT 568 567 4280 Antisense
GCGCGCGCACTGCTCAGAAAAACAA 680 287 4312 Antisense
ACTGGTGCTTGATGAGGCAGCCGCT 548 97 4341 Antisense
AGCCGCTGCGGTTGATGTGGAGACG 23 81 4359 Antisense
GTTCTAACAATTGCACATCGTCTGA 705 443 4432 Antisense
GGACGCGTTGCGGAATTCGATTCAC 15 523 4498 Antisense
GATTCACCAAAGAACCTTCTCGCAA 313 431 4516 Antisense
CCTTCTCGCAAACCCGGATGGAATT 216 269 4530 Antisense
Sequence Source Affymetrix Proprietary Database