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[193170_at] guanylate cyclase (2 domains)

Description B0024.6 /REP_DB=WormBase Gene ID /WP=CE05151 /GEN=gcy-6 /TR=Q9XVV4 /GB=CAA94879.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster 6grp_total > 93      4grp_total > 16      6grp_cgc > 99      6grp_total_sub > Hat      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 97
1 2 3 4 range
A 4.9
(-3)
A 		10
(-2.6)
A 		11.2
(-2.5)
A 		74.8
(3)
A 		70
B 5.9
(-3)
A 		13.1
(-2.1)
A 		54.5
(3)
A 		37
(0.8)
A 		49
C 11.3
(-3)
A 		34.7
(-1.5)
A 		22.4
(-2.3)
A 		102.1
(3)
M 		91
avr 7.4
(-3) 		19.3
(-1.9) 		29.4
(-0.9) 		71.3
(3) 		64

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 51
1 2 3 4 5 6 range
A 20.3
(-1.2)
A 		10.3
(-2.8)
A 		9
(-3)
A 		12.9
(-2.4)
A 		47.5
(3)
A 		18.2
(-1.6)
A 		39
B 54.6
(3)
A 		19.7
(-1.7)
A 		12.8
(-2.7)
A 		10.3
(-3)
A 		48.4
(2.2)
A 		17.5
(-2)
A 		44
C 3.7
(-3)
A 		41.4
(3)
A 		35.9
(2.1)
A 		28.8
(1)
A 		14
(-1.4)
A 		17.8
(-0.8)
A 		38
avr 26.2
(-0.2) 		23.8
(-1) 		19.2
(-2.4) 		17.3
(-3) 		36.6
(3) 		17.8
(-2.8) 		19
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 15
1 2 3 4 range
A 1.8
(-3)
A 		2.2
(-2.7)
A 		2.9
(-2.3)
A 		11
(3)
A 		9
B 1.9
(-3)
A 		3.2
(-2.3)
A 		12.6
(3)
A 		7.9
(0.4)
A 		11
C 3.7
(-3)
A 		10
(-0.2)
A 		7.8
(-1.2)
A 		17.2
(3)
M 		14
avr 2.5
(-3) 		5.1
(-1.4) 		7.8
(0.3) 		12
(3) 		10

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 18
1 2 3 4 5 6 range
A 3.7
(-2.2)
A 		3.7
(-2.2)
A 		2
(-3)
A 		3.3
(-2.4)
A 		14.3
(3)
A 		4.4
(-1.8)
A 		12
B 19
(2.8)
A 		6.6
(-1.6)
A 		3.1
(-2.9)
A 		2.7
(-3)
A 		19.6
(3)
A 		6.5
(-1.7)
A 		17
C 1.4
(-3)
A 		12.6
(3)
A 		9.1
(1.1)
A 		5.8
(-0.6)
A 		4.5
(-1.3)
A 		6
(-0.5)
A 		11
avr 8
(-0.2) 		7.6
(-0.5) 		4.7
(-2.5) 		3.9
(-3) 		12.8
(3) 		5.6
(-1.9) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193170_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11310
Sequence Type Exemplar sequence
Representative Public ID B0024.6 NCBI
Target Description B0024.6 /REP_DB=WormBase Gene ID /WP=CE05151 /GEN=gcy-6 /TR=Q9XVV4 /GB=CAA94879.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073249(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073249 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-6) (gcy-6) mRNA, complete cds. 11/11 None
GENEFINDER00000027147 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:10310888:10316948:-1 9/11 None
B0024.6 ENSEMBL cdna:known chromosome:CEL140:V:10310871:10316948:-1 gene:B0024.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000027133 3/11 Cross Hyb Matching Probes None
SNAP00000027134 5/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10310870-10316948(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase (2 domains)
Gene Symbol gcy-6
Ensembl B0024.6
Entrez Gene 191644 Entrez gene
SwissProt Q9XVV4 EMBL-EBI
WormBase CE05151 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94879 Hypothetical protein B0024.6 [Caenorhabditis elegans] ref|NP_505650.1| Guanylyl CYclase family member (gcy-6) [Caenorhabditis elegans] 0.0
blast CAE64787 Hypothetical protein CBG09580 [Caenorhabditis briggsae] 0.0
blast AAQ62451 Guanylyl cyclase protein 7, isoform b [Caenorhabditis elegans] ref|NP_001023955.1| Guanylyl CYclase family member (gcy-7) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.3E-15
Pfam IPR001054 EMBL-EBI Guanylate cyclase 2.9E-63
Pfam IPR001054 EMBL-EBI Guanylate cyclase 5.4E-9
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.2E-37
Pfam IPR000719 EMBL-EBI Protein kinase 2.3E-15
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.4E-74
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.2E-37
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_505650.1 2 542-564,711-728
B0024.6 2 542-564,711-728
GENEFINDER00000027147 2 498-520,664-681
Sequence
Target Sequence 
>C. ELEGANS:193170_AT
tagttttacaactctcgcaggaaagtgtactcctcttcaagtcgttaatttattaaacgg
attgtacacaatattcgatggaattattgaacagcacgatgtctacaaagttgaaactat
tggtgatggatattttgttgcttctggtgttcccagaaggaatggaaatgaacatacgag
aaatattgcaagcatgtcaatcaactttgttaaatccttggcggactttagcatacctca
tcttccaggggagaagattaaaattcgagttggatttcattgtggatccgttgtagccgg
tgttgttggactaacaatgccaagatattgcttatttggtgatgcggtcaatacggcaag
ccgaatggagagcaactctaaacgtaaaatattccagaagtccactaacataagttcttc
gtttcatttattttcagcggggcagattcatctttcggaagaagcaaatcaaatgttgat
gagacttggtggatttaccacagagccacgtggcgaagtcataatca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TAGTTTTACAACTCTCGCAGGAAAG 27 617 2886 Antisense
TGTACTCCTCTTCAAGTCGTTAATT 672 559 2911 Antisense
GATATTTTGTTGCTTCTGGTGTTCC 389 427 3014 Antisense
TCCTTGGCGGACTTTAGCATACCTC 387 579 3100 Antisense
GCATACCTCATCTTCCAGGGGAGAA 368 309 3116 Antisense
GGATCCGTTGTAGCCGGTGTTGTTG 405 511 3169 Antisense
GGTGATGCGGTCAATACGGCAAGCC 456 499 3223 Antisense
GTTCTTCGTTTCATTTATTTTCAGC 604 441 3299 Antisense
TCAGCGGGGCAGATTCATCTTTCGG 180 625 3319 Antisense
GGTGGATTTACCACAGAGCCACGTG 453 497 3373 Antisense
GAGCCACGTGGCGAAGTCATAATCA 435 385 3388 Antisense
Sequence Source Affymetrix Proprietary Database