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[193128_at] thyrotropin-releasing hormone receptor

Description R12C12.3 /REP_DB=WormBase Gene ID /WP=CE02848 /TR=Q21957 /GB=AAC46782.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=thyrotropin-releasing hormone receptor
Cluster 6grp_highest_10_10 > 32      6grp_high1_10_10 > 23      4grp_highest_8_8 > 39      4grp_high_8_8 > 12      6grp_highest_nonorm > 70      6grp_total > 13      4grp_total > 12      6grp_highest_sub > De      6grp_high1_sub > 02      6grp_total_sub > Decrease      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 509
1 2 3 4 range
A 301.4
(-0.1)
P 		196.6
(-1.9)
P 		130.5
(-3)
P 		489.2
(3)
P 		359
B 270.7
(-1.7)
P 		199.4
(-2.6)
P 		167.2
(-3)
P 		639.6
(3)
P 		472
C 302.3
(-0.9)
P 		249.8
(-1.8)
P 		176
(-3)
P 		538.7
(3)
P 		363
avr 291.5
(-1) 		215.3
(-2.1) 		157.9
(-3) 		555.8
(3) 		398

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 205
1 2 3 4 5 6 range
A 354.2
(3)
P 		303.6
(1.5)
P 		320.6
(2)
P 		271.4
(0.6)
P 		183.4
(-2)
P 		149.9
(-3)
P 		204
B 225
(-0.7)
P 		311.4
(3)
P 		190.7
(-2.1)
P 		216.8
(-1)
P 		254.5
(0.6)
P 		169.9
(-3)
P 		142
C 318.4
(1.7)
P 		354.8
(3)
P 		264.6
(-0.3)
P 		265.2
(-0.2)
P 		190
(-3)
P 		189.1
(-3)
P 		166
avr 299.2
(2.1) 		323.3
(3) 		258.6
(0.5) 		251.1
(0.2) 		209.3
(-1.5) 		169.6
(-3) 		154
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 102
1 2 3 4 range
A 109.7
(3)
P 		42.7
(-2.3)
P 		34.1
(-3)
P 		71.6
(-0)
P 		76
B 86.3
(-0.1)
P 		49.3
(-2.3)
P 		38.7
(-3)
P 		136.3
(3)
P 		98
C 100.1
(3)
P 		71.8
(-1.4)
P 		61.3
(-3)
P 		90.8
(1.6)
P 		39
avr 98.7
(2.9) 		54.6
(-1.9) 		44.7
(-3) 		99.6
(3) 		55

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 82
1 2 3 4 5 6 range
A 65.3
(-0.6)
P 		108
(3)
P 		69.8
(-0.2)
P 		68.8
(-0.3)
P 		55.4
(-1.4)
P 		36.5
(-3)
P 		72
B 78.3
(0.3)
P 		103.7
(3)
P 		46.3
(-3)
P 		57.4
(-1.8)
P 		103.4
(3)
P 		63.4
(-1.2)
P 		57
C 118
(3)
P 		108.3
(2.1)
P 		67.4
(-1.7)
P 		53.3
(-3)
P 		61.5
(-2.2)
P 		63.3
(-2.1)
P 		65
avr 87.2
(0.8) 		106.7
(3) 		61.2
(-2.2) 		59.8
(-2.4) 		73.4
(-0.8) 		54.4
(-3) 		52
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193128_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4718
Sequence Type Exemplar sequence
Representative Public ID R12C12.3 NCBI
Target Description R12C12.3 /REP_DB=WormBase Gene ID /WP=CE02848 /TR=Q21957 /GB=AAC46782.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=thyrotropin-releasing hormone receptor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062803(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062803 NCBI Caenorhabditis elegans R12C12.3 (R12C12.3) mRNA, complete cds. 11/11 None
SNAP00000025493 ENSEMBL cdna:SNAP chromosome:CEL140:II:6029566:6031138:-1 11/11 None
GENEFINDER00000025589 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:6029566:6033174:-1 11/11 None
R12C12.3 ENSEMBL cdna:known chromosome:CEL140:II:6029447:6031138:-1 gene:R12C12.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:6029562-6031135(-) 100.0 100.0
Public Domain and Genome References
Gene Title thyrotropin-releasing hormone receptor
Ensembl R12C12.3
Entrez Gene 187838 Entrez gene
SwissProt Q21957 EMBL-EBI
WormBase CE02848 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7186 G-protein coupled receptor protein signaling pathway inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
1584 rhodopsin-like receptor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_495204 R12C12.3 [Caenorhabditis elegans] gb|AAC46782.1| Hypothetical protein R12C12.3 [Caenorhabditis elegans] 1.0E-174
blast CAE59239 Hypothetical protein CBG02563 [Caenorhabditis briggsae] 1.0E-172
blast CAE59073 Hypothetical protein CBG02360 [Caenorhabditis briggsae] 4.0E-72
blast AAN84821 Hypothetical protein F21C10.12 [Caenorhabditis elegans] ref|NP_872220.1| F21C10.12 [Caenorhabditis elegans] 4.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR000276 EMBL-EBI Rhodopsin-like GPCR superfamily 2.2E-11
Pfam IPR000276 EMBL-EBI Rhodopsin-like GPCR superfamily 2.2E-11
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495204.1 7 10-32,45-67,91-113,133-155,175-197,231-250,270-292
R12C12.3 7 10-32,45-67,91-113,133-155,175-197,231-250,270-292
SNAP00000025493 7 10-32,45-67,91-113,133-155,175-197,231-250,270-292
GENEFINDER00000025589 8 13-32,55-77,90-112,135-157,177-199,219-241,275-294,314-336
Sequence
Target Sequence 
>C. ELEGANS:193128_AT
gtggtacttcatgttctacttcatcatattatcagtaatcttcgattacttccttccgtt
ccttatcatgactatcgccaattatcatgtcatcagagcacttcaagaaagcgacgaggt
tatcacaggcttggccgttcagaagcgaaaagatcagaaaacaactgtaatgctgctagt
ggtaaccattttcttcgcgttctgccatctattctcaatgtttctcaaagttgctgaaag
tatttttggaggattccttacacaaaccagtttctactgggaagtgttcgccgagttcac
aatctttttgataatcttccatacgtcaagcactttcttcatatactacggattttcgga
gaaatttcgaacaatattccatgacatcatcagatgtcgccaaaggctggatgatgtaaa
atgctcgacctacttgccagttaactcat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGGTACTTCATGTTCTACTTCATC 374 489 537 Antisense
TTCCGTTCCTTATCATGACTATCGC 319 699 590 Antisense
CTATCGCCAATTATCATGTCATCAG 46 225 608 Antisense
GGTTATCACAGGCTTGGCCGTTCAG 435 505 654 Antisense
TAGTGGTAACCATTTTCTTCGCGTT 82 655 713 Antisense
GGAGGATTCCTTACACAAACCAGTT 598 515 784 Antisense
GTTTCTACTGGGAAGTGTTCGCCGA 250 451 806 Antisense
TGTTCGCCGAGTTCACAATCTTTTT 671 561 821 Antisense
AATCTTCCATACGTCAAGCACTTTC 79 171 849 Antisense
AGCACTTTCTTCATATACTACGGAT 644 75 865 Antisense
TCGACCTACTTGCCAGTTAACTCAT 294 601 961 Antisense
Sequence Source Affymetrix Proprietary Database