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[193105_at] NA(+)/Ca(2+),K(+)- exchanger

Description Y32F6B.2 /REP_DB=WormBase Gene ID /WP=CE16611 /GEN=ncx-5 /TR=O62088 /GB=CAA16315.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=NA(+)-Ca(2+),K(+)- exchanger
Cluster 6grp_high1_10_10 > 37      4grp_highest_8_8 > 55      4grp_high_8_8 > 19      6grp_total > 27      4grp_total > 21      6grp_cgc > 05      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 83
1 2 3 4 range
A 104.8
(0.6)
P 		110.7
(1.3)
P 		74.4
(-3)
P 		124.7
(3)
P 		50
B 122.4
(0.5)
P 		117.6
(-0.2)
P 		95.8
(-3)
P 		141.8
(3)
P 		46
C 135.5
(0.9)
P 		105.1
(-2)
P 		95.2
(-3)
P 		157.7
(3)
P 		63
avr 120.9
(0.7) 		111.1
(-0.4) 		88.5
(-3) 		141.4
(3) 		53

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 79
1 2 3 4 5 6 range
A 113.3
(1.5)
P 		80.5
(-1)
P 		93
(-0)
P 		55.2
(-3)
P 		131.9
(3)
P 		80
(-1.1)
P 		77
B 121.4
(3)
P 		93.3
(0.2)
P 		101.1
(1)
P 		61
(-3)
P 		79.5
(-1.2)
P 		70.7
(-2)
P 		60
C 85.6
(-0.1)
P 		113.5
(2.3)
P 		70.3
(-1.5)
M 		110.5
(2)
P 		52.6
(-3)
P 		121.6
(3)
P 		69
avr 106.8
(3) 		95.8
(0.9) 		88.1
(-0.6) 		75.6
(-3) 		88
(-0.6) 		90.8
(-0.1) 		31
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 27
1 2 3 4 range
A 38.2
(3)
P 		24
(-1.3)
P 		19.5
(-2.6)
P 		18.2
(-3)
P 		20
B 39
(3)
P 		29
(-0.6)
P 		22.2
(-3)
P 		30.2
(-0.1)
P 		17
C 44.8
(3)
P 		30.2
(-1.8)
P 		33.2
(-0.8)
P 		26.6
(-3)
P 		18
avr 40.7
(3) 		27.7
(-2) 		25
(-3) 		25
(-3) 		16

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 28
1 2 3 4 5 6 range
A 20.9
(-1.4)
P 		28.6
(0.4)
P 		20.2
(-1.6)
P 		14
(-3)
P 		39.8
(3)
P 		19.5
(-1.7)
P 		26
B 42.2
(3)
P 		31.1
(0.4)
P 		24.5
(-1.1)
P 		16.2
(-3)
P 		32.3
(0.7)
P 		26.3
(-0.7)
P 		26
C 31.7
(0.7)
P 		34.6
(1.5)
P 		17.9
(-2.8)
M 		22.2
(-1.7)
P 		17
(-3)
P 		40.7
(3)
P 		24
avr 31.6
(3) 		31.4
(2.9) 		20.9
(-1.6) 		17.5
(-3) 		29.7
(2.2) 		28.8
(1.8) 		14
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193105_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12117
Sequence Type Exemplar sequence
Representative Public ID Y32F6B.2 NCBI
Target Description Y32F6B.2 /REP_DB=WormBase Gene ID /WP=CE16611 /GEN=ncx-5 /TR=O62088 /GB=CAA16315.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=NA(+)-Ca(2+),K(+)- exchanger
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073289(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073289 NCBI Caenorhabditis elegans Na/Ca eXchangers family member (ncx-5) (ncx-5) mRNA, complete cds. 11/11 None
Y32F6B.2 ENSEMBL cdna:known chromosome:CEL140:V:10489055:10491459:-1 gene:Y32F6B.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10489054-10491459(-) 100.0 100.0
Public Domain and Genome References
Gene Title NA(+)/Ca(2+),K(+)- exchanger
Gene Symbol ncx-5
Ensembl Y32F6B.2
Entrez Gene 191715 Entrez gene
SwissProt O62088 EMBL-EBI
WormBase CE16611 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1599940_AT similar to Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) cfa
CANINE_2:CFAAFFX.3347.1.S1_S_AT similar to Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) cfa
CANINE_2:CFAAFFX.3350.1.S1_AT similar to Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) cfa
DROSGENOME1:151600_AT dm
DROSOPHILA_2:1630874_S_AT dm
DROSGENOME1:142518_AT dm
CHICKEN:GGAAFFX.21811.1.S1_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 gga
HG-U133_PLUS_2:220867_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 hs
HG-U133A:220867_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 hs
HG-FOCUS:220867_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 hs
HG-U133A_2:220867_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 hs
U133_X3P:G9966786_3P_A_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 hs
MOE430B:1453885_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 mm
MOUSE430_2:1453885_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 mm
MOE430B:1440366_AT Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (Slc24a2), mRNA mm
MOUSE430_2:1440366_AT Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (Slc24a2), mRNA mm
MOUSE430_2:1445393_AT Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (Slc24a2), mRNA mm
MOE430B:1445393_AT Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (Slc24a2), mRNA mm
MU19KSUBA:TC22681_S_AT Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (Slc24a2), mRNA mm
RN-U34:RC_AI007603_S_AT potassium-dependent sodium-calcium exchanger rn
RG-U34B:RC_AI007603_S_AT potassium-dependent sodium-calcium exchanger rn
RN-U34:AF027506_S_AT potassium-dependent sodium-calcium exchanger rn
RG-U34A:AF027506_S_AT potassium-dependent sodium-calcium exchanger rn
RAE230B:1383444_AT potassium-dependent sodium-calcium exchanger rn
RAT230_2:1383444_AT potassium-dependent sodium-calcium exchanger rn
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94912 Hypothetical protein Y32F6B.2 [Caenorhabditis elegans] emb|CAA16315.1| Hypothetical protein Y32F6B.2 [Caenorhabditis elegans] ref|NP_505690.1| Na/Ca eXchangers family member (ncx-5) [Caenorhabditis elegans] 0.0
blast CAE64806 Hypothetical protein CBG09599 [Caenorhabditis briggsae] 0.0
blast NP_113931 potassium-dependent sodium-calcium exchanger [Rattus norvegicus] ref|XP_579529.1| PREDICTED: hypothetical protein XP_579529 [Rattus norvegicus] sp|O54701|NCKX2_RAT Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) gb|AAC19405.1| potassium-dependent sodium-calcium exchanger [Rattus norvegicus] 1.0E-132
Protein Domains
Database ID Description E-Value
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 6.3E-34
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 1.5E-39
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_505690.1 9 32-51,104-126,133-155,165-187,422-444,457-479,492-514,524-546,559-581
Y32F6B.2 9 32-51,104-126,133-155,165-187,422-444,457-479,492-514,524-546,559-581
Sequence
Target Sequence 
>C. ELEGANS:193105_AT
tttacctattccttgcaccaattacatttccactggcatacacacttccagatgttagga
aaccgagtcttagaaagttttttgcaataacgttcattggagcaattctttggattgctg
cgtattcatacctaatggtttggtgggcaaatacaatcggcgaaacatttggaatcccaa
ctgaaattatgggattaactattctggcagcaggaacaagtatcccagatcttataacaa
gtgttattgttgccagaaaaggtctcggtgacatggcagtctcctcatcgattggatcaa
atctatttgatgtttgtgttggacttccgattccttggctcattcattttgcaatcggag
tcttcaaatccgaaccaacacaaaacatatcagtaacatcgaatgggcttgtttgttcac
ttggtctgctcttcgcaatgttaattgtccttctcacatgtgttgcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTACCTATTCCTTGCACCAATTAC 120 673 1196 Antisense
GCACCAATTACATTTCCACTGGCAT 219 315 1210 Antisense
GGCATACACACTTCCAGATGTTAGG 342 537 1230 Antisense
TTGGATTGCTGCGTATTCATACCTA 610 707 1305 Antisense
GGGATTAACTATTCTGGCAGCAGGA 351 495 1386 Antisense
AAGGTCTCGGTGACATGGCAGTCTC 582 159 1454 Antisense
GCAGTCTCCTCATCGATTGGATCAA 64 313 1471 Antisense
GATTCCTTGGCTCATTCATTTTGCA 538 433 1524 Antisense
GAATGGGCTTGTTTGTTCACTTGGT 290 333 1596 Antisense
TTGGTCTGCTCTTCGCAATGTTAAT 533 705 1616 Antisense
AATTGTCCTTCTCACATGTGTTGCC 29 179 1638 Antisense
Sequence Source Affymetrix Proprietary Database