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[193101_s_at] PROTEIN-TYROSINE PHOSPHATASE

Description F59G1.5 /REP_DB=WormBase Gene ID /WP=CE02705 /GEN=ptp-2 /TR=Q21055 /GB=AAK31531.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=PROTEIN-TYROSINE PHOSPHATASE
Cluster 6grp_highest_10_10 > 32      6grp_high1_10_10 > 03      4grp_highest_8_8 > 33      4grp_high_8_8 > 50      6grp_highest_nonorm > 81      6grp_total > 35      4grp_total > 61      6grp_highest_sub > De      6grp_cgc > 34      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 255
1 2 3 4 range
A 393.9
(3)
P 		275.3
(-0.8)
P 		265.2
(-1.2)
P 		208.6
(-3)
P 		185
B 333.3
(3)
P 		299.7
(2)
P 		322.7
(2.7)
P 		139.2
(-3)
P 		194
C 349.1
(3)
P 		331.3
(2.4)
P 		324
(2.2)
P 		166.4
(-3)
P 		183
avr 358.8
(3) 		302.1
(1.2) 		304
(1.2) 		171.4
(-3) 		187

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 238
1 2 3 4 5 6 range
A 182.3
(-2.6)
P 		305.5
(3)
P 		198.1
(-1.9)
P 		174.1
(-3)
P 		195.8
(-2)
P 		303.3
(2.9)
P 		131
B 228.3
(-0.3)
P 		244.2
(1.9)
P 		251.9
(3)
P 		209.8
(-2.8)
P 		227.2
(-0.4)
P 		208.7
(-3)
P 		43
C 398
(3)
P 		290.2
(0.3)
P 		312.3
(0.8)
P 		267.4
(-0.3)
P 		209
(-1.8)
P 		160.3
(-3)
P 		238
avr 269.5
(2.1) 		280
(3) 		254.1
(0.8) 		217.1
(-2.4) 		210.7
(-3) 		224.1
(-1.8) 		69
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 115
1 2 3 4 range
A 143.4
(3)
P 		59.8
(-1.4)
P 		69.3
(-0.9)
P 		30.5
(-3)
P 		113
B 106.3
(3)
P 		74
(0.5)
P 		74.8
(0.5)
P 		29.7
(-3)
P 		77
C 115.5
(3)
P 		95.3
(1.6)
P 		112.9
(2.8)
P 		28.1
(-3)
P 		87
avr 121.7
(3) 		76.4
(0.1) 		85.7
(0.7) 		29.4
(-3) 		92

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 114
1 2 3 4 5 6 range
A 33.6
(-3)
P 		108.6
(3)
P 		43.1
(-2.2)
P 		44.2
(-2.2)
P 		59.1
(-1)
P 		73.8
(0.2)
P 		75
B 79.4
(0.9)
P 		81.3
(1.2)
P 		61.2
(-2.1)
P 		55.6
(-3)
P 		92.3
(3)
P 		77.8
(0.6)
P 		37
C 147.5
(3)
P 		88.6
(-0.8)
P 		79.5
(-1.3)
P 		53.8
(-3)
P 		67.6
(-2.1)
P 		53.7
(-3)
P 		94
avr 86.8
(2.1) 		92.8
(3) 		61.3
(-1.5) 		51.2
(-3) 		73
(0.1) 		68.4
(-0.5) 		42
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193101_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4289
Sequence Type Exemplar sequence
Representative Public ID F59G1.5 NCBI
Target Description F59G1.5 /REP_DB=WormBase Gene ID /WP=CE02705 /GEN=ptp-2 /TR=Q21055 /GB=AAK31531.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=PROTEIN-TYROSINE PHOSPHATASE
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062783(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062783 NCBI Caenorhabditis elegans Protein Tyrosine Phosphatase family member (ptp-2) (ptp-2) mRNA, complete cds. 11/11 A 
SNAP00000017903 ENSEMBL cdna:SNAP chromosome:CEL140:II:5918675:5920931:1 11/11 None
GENEFINDER00000017912 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:5918424:5920931:1 11/11 None
F59G1.5.2 ENSEMBL cdna:known chromosome:CEL140:II:5918589:5921580:1 gene:F59G1.5 11/11 None
F59G1.5.1 ENSEMBL cdna:known chromosome:CEL140:II:5918610:5921580:1 gene:F59G1.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5918671-5920928(+) 100.0 100.0
Public Domain and Genome References
Gene Title PROTEIN-TYROSINE PHOSPHATASE
Gene Symbol ptp-2
Ensembl F59G1.5
Entrez Gene 174003 Entrez gene
SwissProt Q21055 EMBL-EBI
WormBase CE02705 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605771_AT similar to protein tyrosine phosphatase, non-receptor type 11 cfa
CANINE_2:CFAAFFX.14053.1.S1_AT similar to protein tyrosine phosphatase, non-receptor type 11 cfa
CHICKEN:GGA.482.1.S1_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) gga
HG-U95AV2:1870_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HC-G110:1870_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95AV2:1871_G_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HC-G110:1871_G_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A:205867_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:205867_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A_2:205867_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A:205868_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:205868_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-FOCUS:205868_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A_2:205868_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A:209895_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A_2:209895_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:209895_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:209896_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A_2:209896_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A:209896_S_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A_2:212610_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133A:212610_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:212610_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HUGENEFL:U79291_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HUGENEFL:D13540_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
U133_X3P:G7770146_RC_3P_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
U133_X3P:G292406_3P_A_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
U133_X3P:G13430845_3P_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
U133_X3P:HS2.22868.1.S1_3P_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
U133_X3P:HS.83572.0.S1_3P_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U133_PLUS_2:1552637_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95AV2:38443_AT protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95E:76756_I_AT Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95E:76759_R_AT Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95D:81420_AT Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
HG-U95D:91527_AT Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) hs
MOE430A:1427699_A_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430A_2:1427699_A_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430_2:1427699_A_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430A_2:1421196_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOE430A:1421196_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430_2:1421196_AT protein tyrosine phosphatase, non-receptor type 11 mm
MU11KSUBA:D84372_S_AT protein tyrosine phosphatase, non-receptor type 11 mm
MG-U74AV2:102874_AT protein tyrosine phosphatase, non-receptor type 11 mm
MG-U74BV2:114636_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOE430A:1451225_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430A_2:1451225_AT protein tyrosine phosphatase, non-receptor type 11 mm
MOUSE430_2:1451225_AT protein tyrosine phosphatase, non-receptor type 11 mm
MU19KSUBC:TC37289_AT Protein tyrosine phosphatase, non-receptor type 11, mRNA (cDNA clone IMAGE:3490108) mm
RG-U34A:U09307_AT protein tyrosine phosphatase, non-receptor type 11 rn
RG-U34A:U57499_AT protein tyrosine phosphatase, non-receptor type 11 rn
RG-U34A:U57499_G_AT protein tyrosine phosphatase, non-receptor type 11 rn
RG-U34B:RC_AI012725_S_AT protein tyrosine phosphatase, non-receptor type 11 rn
RAE230A:1387668_AT protein tyrosine phosphatase, non-receptor type 11 rn
RAT230_2:1387668_AT protein tyrosine phosphatase, non-receptor type 11 rn
RAE230B:1396927_AT Protein tyrosine phosphatase, non-receptor type 11 rn
RAT230_2:1396927_AT Protein tyrosine phosphatase, non-receptor type 11 rn
RAE230B:1396948_AT Protein tyrosine phosphatase, non-receptor type 11 rn
RAT230_2:1396948_AT Protein tyrosine phosphatase, non-receptor type 11 rn
RG-U34A:RC_AI138070_AT Protein tyrosine phosphatase, non-receptor type 11 rn
RG-U34A:RC_AI171525_AT Protein tyrosine phosphatase, non-receptor type 11 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6470 protein amino acid dephosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4721 phosphoprotein phosphatase activity inferred from electronic annotation QuickGO AmiGO
4725 protein tyrosine phosphatase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK31531 Protein tyrosine phosphatase protein 2 [Caenorhabditis elegans] ref|NP_495184.1| Protein Tyrosine Phosphatase family member (ptp-2) [Caenorhabditis elegans] gb|AAC21678.1| protein tyrosine phosphatase [Caenorhabditis elegans] 0.0
blast CAE59221 Hypothetical protein CBG02539 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 2.2E-14
Pfam IPR000980 EMBL-EBI SH2 motif 1.4E-17
Pfam IPR000242 EMBL-EBI Tyrosine specific protein phosphatase 2.3E-115
Pfam IPR000980 EMBL-EBI SH2 motif 2.2E-14
Pfam IPR000980 EMBL-EBI SH2 motif 1.4E-17
Pfam IPR000242 EMBL-EBI Tyrosine specific protein phosphatase 2.3E-115
Sequence
Target Sequence 
>C. ELEGANS:193101_S_AT
ggatgtccactacatccttacgcagtactcaatttcctcgaagatgtcgatcgtgaatat
gattatttcaatgctcaaccaattgctgcatcattgcctcaagggccgatcgttgttcat
tgtagtgctggaattggtagaacaggtaccgtacttgtattggacgcacttctgaaccaa
gtgaagaaagtcggattattgtgtccgatggatgtatacaagatggttaagtacgtcaga
acatatcgatctggactcgttcaaacagagcaacaatatcaattcctttacaaagcactc
gcattttacttgaagaataataacccctaccctgtgaaatcgttcattgatggagacacg
gatgccttcgattttccacgacgtcttcgtccgacgccaaatgcttcacgtccatcgtca
gctagacaagtaacatcttctcggccttcttcctctgcgtcatcccgtacttctcattct
cgcccccgaactgggccacaagcggagccaattttcgagcgcagcacttctt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGATGTCCACTACATCCTTACGCAG 179 515 1444 Antisense
CTTACGCAGTACTCAATTTCCTCGA 289 219 1460 Antisense
GCATCATTGCCTCAAGGGCCGATCG 700 307 1531 Antisense
GGCCGATCGTTGTTCATTGTAGTGC 283 543 1547 Antisense
GTACTTGTATTGGACGCACTTCTGA 47 461 1594 Antisense
AACATATCGATCTGGACTCGTTCAA 375 137 1683 Antisense
TGAAGAATAATAACCCCTACCCTGT 320 575 1754 Antisense
GAGACACGGATGCCTTCGATTTTCC 526 391 1796 Antisense
TTCACGTCCATCGTCAGCTAGACAA 694 685 1848 Antisense
CCCGAACTGGGCCACAAGCGGAGCC 223 253 1928 Antisense
CCAATTTTCGAGCGCAGCACTTCTT 596 277 1951 Antisense
Sequence Source Affymetrix Proprietary Database