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[193083_s_at] Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain

Description F10C2.1 /REP_DB=WormBase Gene ID /WP=CE09305 /GEN=kin-13 /TR=P90828 /GB=CAB04076.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=KIN-13 C-like protein kinase
Cluster 6grp_high1_10_10 > 16      4grp_high_8_8 > 41      6grp_total > 26      4grp_total > 54      6grp_cgc > 15      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 178
1 2 3 4 range
A 247.5
(3)
P 		133.3
(-2.1)
P 		113.1
(-3)
P 		116.9
(-2.8)
P 		134
B 171.5
(3)
P 		152.3
(1.8)
P 		128.3
(0.3)
M 		74.4
(-3)
P 		97
C 222.9
(3)
P 		150
(0.2)
P 		125.8
(-0.8)
P 		69.3
(-3)
P 		154
avr 214
(3) 		145.2
(-0.2) 		122.4
(-1.3) 		86.9
(-3) 		127

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 139
1 2 3 4 5 6 range
A 116.1
(1)
P 		157
(3)
P 		63.8
(-1.6)
P 		100.6
(0.2)
P 		34.5
(-3)
A 		106
(0.5)
M 		123
B 118.3
(3)
P 		93.1
(0.7)
P 		84.5
(-0)
P 		64.6
(-1.8)
P 		51.8
(-3)
M 		85.5
(0)
P 		67
C 173.2
(3)
P 		68.6
(-2.6)
P 		80.7
(-2)
P 		84.8
(-1.8)
P 		67
(-2.7)
P 		62.1
(-3)
P 		111
avr 135.9
(3) 		106.2
(0.9) 		76.3
(-1.2) 		83.3
(-0.7) 		51.1
(-3) 		84.5
(-0.6) 		85
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 78
1 2 3 4 range
A 90.1
(3)
P 		28.9
(-2)
P 		29.6
(-2)
P 		17.1
(-3)
P 		73
B 54.7
(3)
P 		37.6
(0.4)
P 		29.7
(-0.9)
M 		15.9
(-3)
P 		39
C 73.8
(3)
P 		43.1
(0)
P 		43.8
(0.1)
P 		11.7
(-3)
P 		62
avr 72.9
(3) 		36.5
(-0.8) 		34.4
(-1) 		14.9
(-3) 		58

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 54
1 2 3 4 5 6 range
A 21.4
(-1.5)
P 		55.8
(3)
P 		13.9
(-2.5)
P 		25.5
(-1)
P 		10.4
(-3)
A 		25.8
(-1)
M 		45
B 41.2
(3)
P 		31
(0.5)
P 		20.5
(-2.2)
P 		17.1
(-3)
P 		21.1
(-2)
M 		31.9
(0.7)
P 		24
C 64.2
(3)
P 		20.9
(-2.5)
P 		20.5
(-2.6)
P 		17.1
(-3)
P 		21.7
(-2.4)
P 		20.8
(-2.5)
P 		47
avr 42.3
(3) 		35.9
(1.4) 		18.3
(-2.9) 		19.9
(-2.5) 		17.7
(-3) 		26.2
(-0.9) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193083_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14485
Sequence Type Exemplar sequence
Representative Public ID F10C2.1 NCBI
Target Description F10C2.1 /REP_DB=WormBase Gene ID /WP=CE09305 /GEN=kin-13 /TR=P90828 /GB=CAB04076.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=KIN-13 C-like protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073613(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073613 NCBI Caenorhabditis elegans Protein Kinase C family member (pkc-1) (pkc-1) mRNA, complete cds. 11/11 A 
SNAP00000025556 ENSEMBL cdna:SNAP chromosome:CEL140:V:12026191:12026726:-1 11/11 None
GENEFINDER00000025568 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:12026171:12027043:-1 11/11 None
F57F5.5.1 ENSEMBL cdna:known chromosome:CEL140:V:12017011:12026748:-1 gene:F57F5.5 11/11 None
F57F5.5.2 ENSEMBL cdna:known chromosome:CEL140:V:12017698:12026748:-1 gene:F57F5.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:12026170-12026726(-) 100.0 100.0
Public Domain and Genome References
Gene Title Phorbol esters / diacylglycerol binding domain (2 domains), Protein kinase C terminal domain
Gene Symbol pkc-1
Ensembl F57F5.5
Entrez Gene 179649 Entrez gene
SwissProt P34885 EMBL-EBI
WormBase CE29092 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.4783.1.S1_S_AT similar to Protein kinase C, epsilon type (nPKC-epsilon) cfa
CANINE_2:CFAAFFX.4797.1.S1_S_AT similar to Protein kinase C, epsilon type (nPKC-epsilon) cfa
DROSOPHILA_2:1631059_AT Protein C kinase 98E dm
DROSGENOME1:151525_AT Protein C kinase 98E dm
DROSGENOME1:142305_AT Protein C kinase 98E dm
CHICKEN:GGAAFFX.6286.1.S1_S_AT similar to Protein kinase C, epsilon type (nPKC-epsilon) gga
CHICKEN:GGAAFFX.6286.3.S1_S_AT similar to Protein kinase C, epsilon type (nPKC-epsilon) gga
HG-U95AV2:417_AT protein kinase C, epsilon hs
HC-G110:417_AT protein kinase C, epsilon hs
HG-U95AV2:32891_AT protein kinase C, epsilon hs
HG-U133_PLUS_2:206248_AT protein kinase C, epsilon hs
HG-U133A:206248_AT protein kinase C, epsilon hs
HG-FOCUS:206248_AT protein kinase C, epsilon hs
HG-U133A_2:206248_AT protein kinase C, epsilon hs
HU35KSUBB:RC_H98006_AT protein kinase C, epsilon hs
HU35KSUBD:RC_AA481519_S_AT protein kinase C, epsilon hs
HUGENEFL:X65293_AT protein kinase C, epsilon hs
U133_X3P:G4885562_3P_AT protein kinase C, epsilon hs
U133_X3P:HS.24379.0.A1_3P_AT protein kinase C, epsilon hs
HG-U133_PLUS_2:226101_AT protein kinase C, epsilon hs
HG-U133B:226101_AT protein kinase C, epsilon hs
HG-U95C:49044_AT protein kinase C, epsilon hs
HG-U133_PLUS_2:234609_AT Protein kinase C, epsilon hs
HG-U133B:234609_AT Protein kinase C, epsilon hs
HU35KSUBD:RC_AA398294_AT Protein kinase C, epsilon hs
U133_X3P:HS.306773.0.S1_3P_X_AT Protein kinase C, epsilon hs
U133_X3P:HS.306773.0.S1_3P_AT Protein kinase C, epsilon hs
U133_X3P:HS.306771.0.S1_3P_AT Protein kinase C, epsilon hs
U133_X3P:HS.296704.0.S1_3P_X_AT Protein kinase C, epsilon hs
U133_X3P:HS.296704.0.S1_3P_AT Protein kinase C, epsilon hs
U133_X3P:HS.186104.0.S1_3P_AT Protein kinase C, epsilon hs
U133_X3P:HS.179991.0.A1_3P_X_AT Protein kinase C, epsilon hs
U133_X3P:HS.179991.0.A1_3P_AT Protein kinase C, epsilon hs
U133_X3P:234089_3P_AT Protein kinase C, epsilon hs
U133_X3P:216766_3P_AT Protein kinase C, epsilon hs
HG-U133A_2:216766_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:216766_AT Protein kinase C, epsilon hs
HG-U133A:216766_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:232622_AT Protein kinase C, epsilon hs
HG-U133B:232622_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:234089_AT Protein kinase C, epsilon hs
HG-U133B:234089_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:236459_AT Protein kinase C, epsilon hs
HG-U133B:236459_AT Protein kinase C, epsilon hs
HG-U95B:59772_AT Protein kinase C, epsilon hs
HG-U95E:78964_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:1566540_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:1566541_AT Protein kinase C, epsilon hs
HG-U133A_2:216753_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:216753_AT Protein kinase C, epsilon hs
HG-U133A:216753_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:234619_AT Protein kinase C, epsilon hs
HG-U133B:234619_AT Protein kinase C, epsilon hs
HG-U133_PLUS_2:239011_AT Protein kinase C, epsilon hs
HG-U133B:239011_AT Protein kinase C, epsilon hs
HG-U95B:42680_AT Protein kinase C, epsilon hs
HG-U95B:43319_AT Protein kinase C, epsilon hs
HG-U95D:68054_AT Protein kinase C, epsilon hs
HG-U95E:77265_F_AT Protein kinase C, epsilon hs
HG-U95E:77267_F_AT Protein kinase C, epsilon hs
HG-U95D:89956_AT Protein kinase C, epsilon hs
HU35KSUBB:RC_AA150260_AT Protein kinase C, epsilon hs
HU35KSUBB:RC_R17939_AT Protein kinase C, epsilon hs
HU35KSUBB:RC_T87109_AT Protein kinase C, epsilon hs
HU35KSUBD:RC_AA398643_AT Protein kinase C, epsilon hs
HU35KSUBD:RC_AA431725_AT Protein kinase C, epsilon hs
HU35KSUBD:RC_AA481519_I_AT Protein kinase C, epsilon hs
U133_X3P:HS.155281.0.A1_3P_AT Protein kinase C, epsilon hs
MU11KSUBA:AA198947_AT protein kinase C, epsilon mm
MG-U74AV2:94161_AT protein kinase C, epsilon mm
MG-U74AV2:103223_AT protein kinase C, epsilon mm
MOE430A:1449956_AT protein kinase C, epsilon mm
MOUSE430A_2:1449956_AT protein kinase C, epsilon mm
MOUSE430_2:1449956_AT protein kinase C, epsilon mm
MOE430A:1452878_AT protein kinase C, epsilon mm
MOUSE430A_2:1452878_AT protein kinase C, epsilon mm
MOUSE430_2:1452878_AT protein kinase C, epsilon mm
MOE430B:1437861_S_AT protein kinase C, epsilon mm
MOUSE430_2:1437861_S_AT protein kinase C, epsilon mm
MOE430B:1437860_AT protein kinase C, epsilon mm
MOUSE430_2:1437860_AT protein kinase C, epsilon mm
MU19KSUBA:TC22106_AT Protein kinase C, epsilon (Prkce), mRNA mm
MU19KSUBB:TC27527_AT Protein kinase C, epsilon (Prkce), mRNA mm
MU19KSUBB:TC29414_AT Protein kinase C, epsilon (Prkce), mRNA mm
RG-U34A:M18331_G_AT protein kinase C, epsilon rn
RG-U34A:M15523_S_AT protein kinase C, epsilon rn
RG-U34A:M18331_AT protein kinase C, epsilon rn
RG-U34A:RC_AA799421_AT protein kinase C, epsilon rn
RAE230A:1374593_AT protein kinase C, epsilon rn
RAT230_2:1374593_AT protein kinase C, epsilon rn
RAE230A:1374466_AT Protein kinase C, epsilon rn
RAT230_2:1374466_AT Protein kinase C, epsilon rn
RAE230B:1378644_AT Protein kinase C, epsilon rn
RAT230_2:1378644_AT Protein kinase C, epsilon rn
RAE230B:1395186_AT Protein kinase C, epsilon rn
RAT230_2:1395186_AT Protein kinase C, epsilon rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4697 protein kinase C activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB00101 Hypothetical protein F57F5.5 [Caenorhabditis elegans] emb|CAC70080.1| Hypothetical protein F57F5.5 [Caenorhabditis elegans] ref|NP_506014.1| Protein Kinase C family member (pkc-1) [Caenorhabditis elegans] sp|P34885|KPC1B_CAEEL Protein kinase C-like 1B (PKC1B) 0.0
blast AAA18259 protein kinase C 0.0
blast CAE75370 Hypothetical protein CBG23354 [Caenorhabditis briggsae] 0.0
blast T20697 hypothetical protein F10C2.1 - Caenorhabditis elegans 3.0E-79
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 5.0E-66
hanks 1.2.12 AGC group; AGC I Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family; CePKC1B 1.0E-155
Protein Domains
Database ID Description E-Value
Pfam IPR000008 EMBL-EBI C2 domain 1.4E-16
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 1.6E-24
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 9.3E-27
Pfam IPR000719 EMBL-EBI Protein kinase 8.7E-79
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 1.0E-44
Pfam IPR000008 EMBL-EBI C2 domain 1.4E-16
Sequence
Target Sequence 
>C. ELEGANS:193083_S_AT
caacttcgcccgacagagtggtcgcgacggtttagacaggatgaagctgcaaccgctgca
atcgactcttatgtgaacgtggattgggatgaatatcatataggaaagacgcaagttcgg
cccaagactaatgaacctcgttggaatgaagaatttacagcttcgggagtacatcaagga
aaagccatcggattttcggtatttcacagttgtgtaatgccacccgacgatttcgttgcg
aatacccgaatagcgtttgatcagtt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CAACTTCGCCCGACAGAGTGGTCGC 676 187 58 Antisense
GAGTGGTCGCGACGGTTTAGACAGG 71 401 73 Antisense
GACAGGATGAAGCTGCAACCGCTGC 345 369 92 Antisense
AACCGCTGCAATCGACTCTTATGTG 82 147 108 Antisense
TAGGAAAGACGCAAGTTCGGCCCAA 232 651 158 Antisense
TCGGCCCAAGACTAATGAACCTCGT 162 605 174 Antisense
GAATTTACAGCTTCGGGAGTACATC 632 321 208 Antisense
ATCGGATTTTCGGTATTTCACAGTT 348 35 244 Antisense
TCACAGTTGTGTAATGCCACCCGAC 548 627 261 Antisense
CCACCCGACGATTTCGTTGCGAATA 369 273 277 Antisense
ATACCCGAATAGCGTTTGATCAGTT 321 23 299 Antisense
Sequence Source Affymetrix Proprietary Database