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[193080_at] cyclic nucleotide phosphodiesterase

Description C32E12.2 /REP_DB=WormBase Gene ID /WP=CE04134 /TR=SW:P91119 /GB=AAB53879.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=cyclic nucleotide phosphodiesterase
Cluster 6grp_high1_10_10 > 46      6grp_total > 26      4grp_total > 21      6grp_cgc > 24      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 176
1 2 3 4 range
A 106.1
(0.5)
P 		59.3
(-1.1)
A 		3.6
(-3)
A 		179.4
(3)
P 		176
B 162.9
(3)
P 		19.5
(-3)
A 		28.1
(-2.6)
P 		140.5
(2.1)
P 		143
C 120.5
(0.8)
P 		71
(-1.3)
A 		32.3
(-3)
A 		170.5
(3)
P 		138
avr 129.8
(1.6) 		49.9
(-1.8) 		21.3
(-3) 		163.5
(3) 		142

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 66
1 2 3 4 5 6 range
A 97.1
(2.3)
P 		101.8
(3)
P 		84.3
(0.4)
P 		60.8
(-3)
A 		76.1
(-0.8)
A 		99.4
(2.6)
P 		41
B 91.4
(2.1)
P 		100.6
(3)
P 		65.1
(-0.4)
A 		38.5
(-3)
A 		44.4
(-2.4)
P 		52.7
(-1.6)
A 		62
C 104.5
(3)
P 		101
(2.6)
P 		72.2
(-0.5)
P 		79.2
(0.3)
P 		49.3
(-3)
A 		56.7
(-2.2)
A 		55
avr 97.7
(2.5) 		101.1
(3) 		73.9
(-0.7) 		59.5
(-2.6) 		56.6
(-3) 		69.6
(-1.2) 		45
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 38.6
(3)
P 		12.9
(-1.1)
A 		1
(-3)
A 		26.3
(1)
P 		38
B 51.9
(3)
P 		4.8
(-3)
A 		6.5
(-2.8)
P 		29.9
(0.2)
P 		47
C 39.9
(3)
P 		20.4
(-1.1)
A 		11.2
(-3)
A 		28.7
(0.7)
P 		29
avr 43.5
(3) 		12.7
(-2) 		6.2
(-3) 		28.3
(0.6) 		37

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 29
1 2 3 4 5 6 range
A 17.9
(-2.3)
P 		36.2
(3)
P 		18.4
(-2.1)
P 		15.4
(-3)
A 		23
(-0.8)
A 		24.2
(-0.5)
P 		21
B 31.8
(2.6)
P 		33.5
(3)
P 		15.8
(-1.6)
A 		10.2
(-3)
A 		18
(-1)
P 		19.6
(-0.6)
A 		23
C 38.7
(3)
P 		30.8
(0.9)
P 		18.4
(-2.3)
P 		15.9
(-3)
P 		15.9
(-3)
A 		19
(-2.2)
A 		23
avr 29.5
(1.8) 		33.5
(3) 		17.5
(-1.9) 		13.8
(-3) 		19
(-1.4) 		20.9
(-0.8) 		20
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193080_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2404
Sequence Type Exemplar sequence
Representative Public ID C32E12.2 NCBI
Target Description C32E12.2 /REP_DB=WormBase Gene ID /WP=CE04134 /TR=SW:P91119 /GB=AAB53879.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=cyclic nucleotide phosphodiesterase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059143(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059143 NCBI Caenorhabditis elegans PhosphoDiEsterase family member (pde-5) (pde-5) mRNA, complete cds. 11/11 None
SNAP00000039919 ENSEMBL cdna:SNAP chromosome:CEL140:I:5197227:5199687:1 11/11 None
GENEFINDER00000039926 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:5197227:5200105:1 11/11 None
C32E12.2 ENSEMBL cdna:known chromosome:CEL140:I:5198087:5199687:1 gene:C32E12.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:5198086-5199687(+) 100.0 100.0
Public Domain and Genome References
Gene Title cyclic nucleotide phosphodiesterase
Gene Symbol pde-5
Ensembl C32E12.2
Entrez Gene 183125 Entrez gene
SwissProt P91119 EMBL-EBI
WormBase CE04134 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1586116_AT similar to phosphodiesterase 10A cfa
CANINE_2:CFA.7302.1.A1_AT similar to phosphodiesterase 10A cfa
CANINE_2:CFAAFFX.2127.1.S1_S_AT similar to phosphodiesterase 10A cfa
CHICKEN:GGAAFFX.7289.1.S1_AT similar to phosphodiesterase 10A gga
CHICKEN:GGAAFFX.7310.1.S1_AT similar to phosphodiesterase 10A gga
CHICKEN:GGAAFFX.7314.1.S1_AT similar to phosphodiesterase 10A gga
HG-U133_PLUS_2:211170_S_AT phosphodiesterase 10A hs
HG-U133A_2:211170_S_AT phosphodiesterase 10A hs
HG-U133A:211170_S_AT phosphodiesterase 10A hs
HG-U133_PLUS_2:211171_S_AT phosphodiesterase 10A hs
HG-U133A:211171_S_AT phosphodiesterase 10A hs
HG-U133A_2:211171_S_AT phosphodiesterase 10A hs
U133_X3P:G5902441_3P_A_AT phosphodiesterase 10A hs
U133_X3P:HS.128291.1.S2_3P_A_AT phosphodiesterase 10A hs
HG-U95AV2:35522_AT phosphodiesterase 10A hs
HG-U133_PLUS_2:237492_AT Phosphodiesterase 10A hs
HG-U133B:237492_AT Phosphodiesterase 10A hs
HG-U95B:51804_AT Phosphodiesterase 10A hs
HU35KSUBC:RC_H22985_AT Phosphodiesterase 10A hs
U133_X3P:HS.52132.0.A1_3P_AT Phosphodiesterase 10A hs
MOUSE430_2:1419390_AT phosphodiesterase 10A mm
MOE430A:1419390_AT phosphodiesterase 10A mm
MOUSE430A_2:1419390_AT phosphodiesterase 10A mm
MOE430A:1419389_AT phosphodiesterase 10A mm
MOUSE430A_2:1419389_AT phosphodiesterase 10A mm
MOUSE430_2:1419389_AT phosphodiesterase 10A mm
MG-U74BV2:108335_R_AT phosphodiesterase 10A mm
MG-U74BV2:111186_AT phosphodiesterase 10A mm
MOE430A:1432490_A_AT phosphodiesterase 10A mm
MOUSE430A_2:1432490_A_AT phosphodiesterase 10A mm
MOUSE430_2:1432490_A_AT phosphodiesterase 10A mm
MOE430B:1439618_AT phosphodiesterase 10A mm
MOUSE430_2:1439618_AT phosphodiesterase 10A mm
MOE430B:1458499_AT phosphodiesterase 10A mm
MOUSE430_2:1458499_AT phosphodiesterase 10A mm
RAE230A:1370669_A_AT phosphodiesterase 10A rn
RAT230_2:1370669_A_AT phosphodiesterase 10A rn
RAE230A:1368438_AT phosphodiesterase 10A rn
RAT230_2:1368438_AT phosphodiesterase 10A rn
RAE230B:1391295_AT Phosphodiesterase 10A rn
RAT230_2:1391295_AT Phosphodiesterase 10A rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
4114 3',5'-cyclic-nucleotide phosphodiesterase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB53879 Hypothetical protein C32E12.2 [Caenorhabditis elegans] ref|NP_491544.1| PhosphoDiEsterase family member (pde-5) [Caenorhabditis elegans] sp|P91119|PDE5_CAEEL Probable 3',5'-cyclic phosphodiesterase pde-5 0.0
blast CAE67366 Hypothetical protein CBG12836 [Caenorhabditis briggsae] 0.0
blast XP_797347 PREDICTED: similar to phosphodiesterase 10A, partial [Strongylocentrotus purpuratus] 1.0E-143
blast XP_797347 PREDICTED: similar to phosphodiesterase 10A, partial [Strongylocentrotus purpuratus] 1.0E-134
Protein Domains
Database ID Description E-Value
Pfam IPR003018 EMBL-EBI GAF 9.5E-22
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 1.0E-77
Pfam IPR003018 EMBL-EBI GAF 9.5E-22
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 3.5E-90
Pfam IPR003018 EMBL-EBI GAF 2.2E-15
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 1.0E-77
Sequence
Target Sequence 
>C. ELEGANS:193080_AT
gccgagttgcctaccacaattgggctcacggatggtctgttgctcacgcaatgtttgcca
cactgatgaacagtcctgatgctttcaccaaattggaggcgttggccctctacgtctcat
gcctctgccatgatctagatcatcgtggtaaaaacaacgcttatatgaaaacaatgtcta
ctccattagcatcaatctacagtacttctgtaatggaacgacatcatttcaatcaaacag
tcactattctccaacaagacggtcataatattctaaagtcattatcttctgaggactaca
aaaagactctgtcgctcataaaacattgcattttggcaaccgatttggcacttttcttct
ctaataaagcaaagttaaatgtcattttggataacaacacatttgatatcaaccggcagg
aacatagacttctcacccaagccgttatgatgacaggatgcgacttggttgcttct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCCGAGTTGCCTACCACAATTGGGC 268 285 566 Antisense
CAATTGGGCTCACGGATGGTCTGTT 174 179 582 Antisense
GTTGCTCACGCAATGTTTGCCACAC 687 439 604 Antisense
TGAACAGTCCTGATGCTTTCACCAA 646 573 632 Antisense
ATGCCTCTGCCATGATCTAGATCAT 423 41 684 Antisense
ATGTCTACTCCATTAGCATCAATCT 314 49 739 Antisense
GCATTTTGGCAACCGATTTGGCACT 473 307 893 Antisense
ATTTGGCACTTTTCTTCTCTAATAA 84 19 908 Antisense
GGCAGGAACATAGACTTCTCACCCA 438 533 980 Antisense
TTCTCACCCAAGCCGTTATGATGAC 502 691 995 Antisense
GACAGGATGCGACTTGGTTGCTTCT 361 369 1017 Antisense
Sequence Source Affymetrix Proprietary Database