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[193074_s_at] phosphatidylinositol 3-kinase

Description B0334.8 /REP_DB=WormBase Gene ID /WP=CE23506 /GEN=age-1 /TR=Q17482 /GB=CAA91377.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=phosphatidylinositol 3-kinase
Cluster 6grp_highest_10_10 > 96      6grp_high1_10_10 > 69      4grp_highest_8_8 > 60      4grp_high_8_8 > 26      6grp_highest_nonorm > 83      6grp_total > 69      4grp_total > 30      6grp_highest_sub > Cu      6grp_cgc > 29      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 209
1 2 3 4 range
A 490.6
(3)
P 		368.1
(-2)
P 		342.7
(-3)
P 		443.5
(1.1)
P 		148
B 496.7
(3)
P 		414.3
(-0.3)
P 		347.3
(-3)
P 		452.9
(1.2)
P 		149
C 551.9
(3)
P 		450.3
(-0.6)
P 		384.2
(-3)
P 		420
(-1.7)
P 		168
avr 513.1
(3) 		410.9
(-1) 		358.1
(-3) 		438.8
(0.1) 		155

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 233
1 2 3 4 5 6 range
A 534.4
(1.4)
P 		498.2
(0.2)
P 		396.8
(-3)
P 		402.8
(-2.8)
P 		463.8
(-0.9)
P 		586
(3)
P 		189
B 466.7
(-2.8)
P 		471.6
(-2.6)
P 		475.9
(-2.5)
P 		460.8
(-3)
P 		471.5
(-2.6)
P 		630.2
(3)
P 		169
C 571.3
(2.2)
P 		466.3
(-1)
P 		468.5
(-0.9)
P 		397.5
(-3)
P 		598.9
(3)
P 		595.9
(2.9)
P 		201
avr 524.1
(0.4) 		478.7
(-1.1) 		447.1
(-2.1) 		420.4
(-3) 		511.4
(-0) 		604
(3) 		184
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 118
1 2 3 4 range
A 178.6
(3)
P 		79.9
(-2.2)
P 		89.6
(-1.7)
P 		64.9
(-3)
P 		114
B 158.4
(3)
P 		102.3
(-1.3)
P 		80.5
(-3)
P 		96.5
(-1.8)
P 		78
C 182.7
(3)
P 		129.5
(0.1)
P 		133.9
(0.4)
P 		70.8
(-3)
P 		112
avr 173.2
(3) 		103.9
(-1.3) 		101.3
(-1.5) 		77.4
(-3) 		96

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 155
1 2 3 4 5 6 range
A 98.5
(-2.2)
P 		177.2
(3)
P 		86.4
(-3)
P 		102.2
(-2)
P 		140
(0.5)
P 		142.7
(0.7)
P 		91
B 162.4
(-0.6)
P 		157
(-0.9)
P 		115.6
(-3)
P 		122
(-2.7)
P 		191.6
(0.8)
P 		235
(3)
P 		119
C 211.8
(3)
P 		142.3
(-0.2)
P 		119.2
(-1.2)
P 		79.9
(-3)
P 		193.8
(2.2)
P 		199.5
(2.4)
P 		132
avr 157.6
(0.7) 		158.8
(0.8) 		107.1
(-2.6) 		101.4
(-3) 		175.1
(1.9) 		192.4
(3) 		91
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193074_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3779
Sequence Type Exemplar sequence
Representative Public ID B0334.8 NCBI
Target Description B0334.8 /REP_DB=WormBase Gene ID /WP=CE23506 /GEN=age-1 /TR=Q17482 /GB=CAA91377.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=phosphatidylinositol 3-kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064061(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064061 NCBI Caenorhabditis elegans AGEing alteration family member (age-1) (age-1) mRNA, complete cds. 11/11 None
B0334.8 ENSEMBL cdna:known chromosome:CEL140:II:11519404:11526967:-1 gene:B0334.8 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000004774 6/11 Cross Hyb Matching Probes None
SNAP00000019022 5/11 Cross Hyb Matching Probes None
GENEFINDER00000019030 5/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11519609-11526848(-) 100.0 100.0
Public Domain and Genome References
Gene Title phosphatidylinositol 3-kinase
Gene Symbol age-1
Ensembl B0334.8
Entrez Gene 174762 Entrez gene
SwissProt Q94125 EMBL-EBI
WormBase CE23506 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.17516.1.S1_S_AT similar to phosphoinositide-3-kinase, catalytic, alpha polypeptide cfa
CHICKEN:GGAAFFX.5619.1.S1_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide gga
HG-U133A:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-FOCUS:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133A_2:204369_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HUGENEFL:Z29090_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:G5453891_3P_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95AV2:40704_AT phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HU35KSUBB:RC_AA088326_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:HS.122419.0.S1_3P_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
U133_X3P:HS.120905.0.S1_3P_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:231854_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133B:231854_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133_PLUS_2:235980_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U133B:235980_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95B:41969_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:81657_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:83177_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
HG-U95E:90039_AT Phosphoinositide-3-kinase, catalytic, alpha polypeptide hs
MG-U74BV2:105294_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBA:AA420333_RC_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBB:MSA.241.0_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU11KSUBB:MSA.241.0_G_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74AV2:92452_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74AV2:104461_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MG-U74BV2:107411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430A:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430A_2:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1460326_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430A:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430A_2:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1423144_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1429435_X_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1429435_X_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1429434_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1429434_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1453134_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1453134_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOE430B:1440054_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MOUSE430_2:1440054_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mm
MU19KSUBA:TC21049_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA mm
MU19KSUBC:TC41821_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA mm
RG-U34B:RC_AI030797_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230A:1374232_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1374232_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1396411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1396411_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1382366_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1382366_AT phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1379041_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1379041_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230A:1389143_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1389143_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAE230B:1393499_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RAT230_2:1393499_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RG-U34B:RC_AA964375_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
RG-U34B:RC_AA997895_AT Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5942 phosphoinositide 3-kinase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4428 inositol or phosphatidylinositol kinase activity inferred from electronic annotation QuickGO AmiGO
16303 phosphatidylinositol 3-kinase activity inferred from electronic annotation QuickGO AmiGO
16773 phosphotransferase activity, alcohol group as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91377 Hypothetical protein B0334.8 [Caenorhabditis elegans] emb|CAB57914.1| Hypothetical protein B0334.8 [Caenorhabditis elegans] ref|NP_496462.1| AGEing alteration family member (age-1) [Caenorhabditis elegans] sp|Q94125|AGE1_CAEEL Phosphatidylinositol 3-kinase age-1 (PI3-kinase) (PtdIns-3-kinase) (PI3K) (Ageing alteration protein 1) 0.0
blast AAC47459 AGE-1 [Caenorhabditis elegans] 0.0
blast CAE59483 Hypothetical protein CBG02868 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR003113 EMBL-EBI Phosphatidylinositol 3-kinase, p85-binding 3.9E-48
Pfam IPR000403 EMBL-EBI Phosphatidylinositol 3- and 4-kinase 1.5E-19
Pfam IPR000403 EMBL-EBI Phosphatidylinositol 3- and 4-kinase 2.6E-32
Pfam IPR002420 EMBL-EBI Phosphoinositide 3-kinase, C2 domain 1.2E-36
Pfam IPR001263 EMBL-EBI Phosphoinositide 3-kinase accessory domain PIK 7.3E-19
Pfam IPR000341 EMBL-EBI Phosphoinositide 3-kinase, ras-binding domain 9.8E-41
Sequence
Target Sequence 
>C. ELEGANS:193074_S_AT
gtgtcgatcgattcctatactcgtgtgttggatattcagttgccacgtacataatgggaa
tcaaggatcgtcacagtgataatctgatgctcactgaagatggaaaatatttccacattg
atttcggtcacattttgggacacggaaagaccaaacttgggatccagcgagatcgtcaac
cgtttattctaaccgaacactttatgacagtgattcgatcgggtaaatctgtggatggaa
attcgcatgagctacaaaaattcaaaacgttatgcgtcgaagcctacgaagtaatgtgga
ataatcgagatttgttcgtttccttgttcaccttgatgctcggaatggagttgcctgagc
tgtcgacgaaagcggatttggatcatttgaagaaaaccctcttctgcaatggagaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGTCGATCGATTCCTATACTCGTG 165 487 2930 Antisense
GGATATTCAGTTGCCACGTACATAA 407 509 2959 Antisense
ATATTTCCACATTGATTTCGGTCAC 669 19 3036 Antisense
TTTCGGTCACATTTTGGGACACGGA 24 671 3051 Antisense
TGGGATCCAGCGAGATCGTCAACCG 476 553 3087 Antisense
GATCGTCAACCGTTTATTCTAACCG 132 419 3100 Antisense
AAACGTTATGCGTCGAAGCCTACGA 681 113 3194 Antisense
CGAGATTTGTTCGTTTCCTTGTTCA 436 249 3235 Antisense
CTTGTTCACCTTGATGCTCGGAATG 112 215 3252 Antisense
GAATGGAGTTGCCTGAGCTGTCGAC 453 333 3272 Antisense
GAAAACCCTCTTCTGCAATGGAGAA 255 355 3321 Antisense
Sequence Source Affymetrix Proprietary Database