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[193056_s_at] multidrug resistance-associated protein

Description E03G2.2 /REP_DB=WormBase Gene ID /WP=CE03119 /TR=Q19048 /GB=CAA92148.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance-associated protein
Cluster 6grp_highest_10_10 > 59      6grp_high1_10_10 > 94      4grp_highest_8_8 > 18      4grp_high_8_8 > 62      6grp_highest_nonorm > 83      6grp_total > 85      4grp_total > 59      6grp_highest_sub > In      6grp_cgc > 77      6grp_high1_sub > In      6grp_cgc_sub > 04_05_06      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 434
1 2 3 4 range
A 415.2
(-0)
P 		491.8
(1)
P 		634.5
(3)
P 		200.8
(-3)
P 		434
B 417.1
(2)
P 		323.5
(-1.5)
P 		444.1
(3)
P 		284
(-3)
P 		160
C 359.7
(-1.9)
P 		390.1
(-1)
P 		528
(3)
P 		321.9
(-3)
P 		206
avr 397.3
(-0.1) 		401.8
(-0) 		535.5
(3) 		268.9
(-3) 		267

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 370
1 2 3 4 5 6 range
A 321
(-3)
P 		413
(-1.3)
P 		403.6
(-1.5)
P 		605.3
(2.2)
P 		612.8
(2.4)
P 		647.3
(3)
P 		326
B 294.9
(-3)
P 		341
(-2.2)
P 		394
(-1.4)
P 		607.3
(2.1)
P 		584.4
(1.8)
P 		660.2
(3)
P 		365
C 322.6
(-3)
P 		339.9
(-2.7)
P 		534.3
(0.7)
P 		566.6
(1.3)
P 		544.5
(0.9)
P 		664.7
(3)
P 		342
avr 312.8
(-3) 		364.6
(-2.1) 		444
(-0.7) 		593.1
(1.9) 		580.6
(1.7) 		657.4
(3) 		345
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 155
1 2 3 4 range
A 151.2
(2.4)
P 		106.8
(0.4)
P 		165.9
(3)
P 		29.4
(-3)
P 		137
B 133
(3)
P 		79.9
(-1.4)
P 		102.9
(0.5)
P 		60.5
(-3)
P 		73
C 119.1
(-0)
P 		112.2
(-0.3)
P 		184
(3)
P 		54.3
(-3)
P 		130
avr 134.4
(2) 		99.6
(0) 		150.9
(3) 		48.1
(-3) 		103

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 187
1 2 3 4 5 6 range
A 59.2
(-3)
P 		146.9
(1.2)
P 		87.9
(-1.6)
P 		153.5
(1.5)
P 		184.9
(3)
P 		157.6
(1.7)
P 		126
B 102.6
(-2.7)
P 		113.5
(-2.3)
P 		95.7
(-3)
P 		160.9
(-0.4)
P 		237.4
(2.6)
P 		246.2
(3)
P 		151
C 119.6
(-2.2)
P 		103.7
(-3)
P 		136
(-1.4)
P 		113.9
(-2.5)
P 		176.2
(0.7)
P 		222.5
(3)
P 		119
avr 93.8
(-3) 		121.4
(-1.6) 		106.5
(-2.3) 		142.8
(-0.4) 		199.5
(2.5) 		208.8
(3) 		115
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193056_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17927
Sequence Type Exemplar sequence
Representative Public ID E03G2.2 NCBI
Target Description E03G2.2 /REP_DB=WormBase Gene ID /WP=CE03119 /TR=Q19048 /GB=CAA92148.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance-associated protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078215(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078215 NCBI Caenorhabditis elegans Multidrug Resistance Protein family member (mrp-3) (mrp-3) mRNA, complete cds. 11/11 None
SNAP00000041426 ENSEMBL cdna:SNAP chromosome:CEL140:X:15929925:15937879:-1 11/11 None
GENEFINDER00000041432 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:15929925:15939238:-1 11/11 None
E03G2.2 ENSEMBL cdna:known chromosome:CEL140:X:15929874:15937879:-1 gene:E03G2.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:15929924-15937879(-) 99.71 100.0
Public Domain and Genome References
Gene Title multidrug resistance-associated protein
Gene Symbol mrp-3
Ensembl E03G2.2
Entrez Gene 181677 Entrez gene
SwissProt Q19048 EMBL-EBI
WormBase CE03119 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92148 Hypothetical protein E03G2.2 [Caenorhabditis elegans] ref|NP_510616.1| Multidrug Resistance Protein family member (mrp-3) [Caenorhabditis elegans] 0.0
blast CAE69722 Hypothetical protein CBG15993 [Caenorhabditis briggsae] 0.0
blast AAB83980 multidrug resistance protein [Homo sapiens] 0.0
blast NP_032602 ATP-binding cassette, sub-family C, member 1 [Mus musculus] dbj|BAC26654.1| unnamed protein product [Mus musculus] sp|O35379|MRP1_MOUSE Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) gb|AAB80938.1| multidrug resistance protein [Mus musculus] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 3.3E-25
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.5E-25
Pfam IPR003439 EMBL-EBI ABC transporter 1.1E-22
Pfam IPR003439 EMBL-EBI ABC transporter 3.4E-41
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.8E-19
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.1E-23
Pfam IPR003439 EMBL-EBI ABC transporter 1.3E-22
Pfam IPR003439 EMBL-EBI ABC transporter 3.4E-41
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 3.3E-25
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 6.1E-29
Pfam IPR003439 EMBL-EBI ABC transporter 1.1E-24
Pfam IPR003439 EMBL-EBI ABC transporter 3.4E-41
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510616.1 10 43-65,80-102,260-282,375-397,463-482,832-854,884-906,960-994,1063-1085,1090-1112
E03G2.2 10 43-65,80-102,260-282,375-397,463-482,832-854,884-906,960-994,1063-1085,1090-1112
SNAP00000041426 10 43-65,80-102,242-264,269-291,376-398,803-825,855-877,935-957,1027-1049,1054-1076
GENEFINDER00000041432 15 15-37,59-81,91-108,120-142,157-179,336-358,451-473,539-558,568-590,931-953,989-1011,1056-1078,1083-1105,1170-1192,1197-1219
Sequence
Target Sequence 
>C. ELEGANS:193056_S_AT
agcaggaaaatcttcccttgctcttgctttgtttcgcattgtcgaggcagctgatggtaa
tatatctatagatcaaacaattacgtctcatattggacttcacgatctgagagaaaaatt
gacaattattccgcaagaaaatgtgttgtttgcaaatactttaagatttaatattgatcc
aaagggacagttcaccgatcaacagctgtggttagccctggagaactcgaatctgaaagc
acacgtagaattgctgccacacaagttggaaagccccgttgcggagggtggagagaattt
cagtgttggccaacgtcaacttctatgcctaaccagagctctgcttcgaaaatctaaagt
gcttgtgttggatgaagcgactgctggaatcgacaaccggactgatacaatggttcaagc
aactattcgtgaaaagtttgcggattccacaatcatcaccattgctcacagacttcatac
tatcattgactatgatcgaattattgtgatggatgctggtagaatcgtggaggacggaat
ccctggagagctactt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGCAGGAAAATCTTCCCTTGCTCTT 542 77 3597 Antisense
TGCTCTTGCTTTGTTTCGCATTGTC 157 581 3615 Antisense
AAGGGACAGTTCACCGATCAACAGC 175 157 3778 Antisense
GATCAACAGCTGTGGTTAGCCCTGG 525 411 3793 Antisense
ACACAAGTTGGAAAGCCCCGTTGCG 552 111 3855 Antisense
TGGCCAACGTCAACTTCTATGCCTA 45 545 3903 Antisense
TCTATGCCTAACCAGAGCTCTGCTT 304 615 3918 Antisense
GACTGCTGGAATCGACAACCGGACT 384 373 3975 Antisense
GTTTGCGGATTCCACAATCATCACC 526 451 4032 Antisense
ATCACCATTGCTCACAGACTTCATA 576 27 4051 Antisense
GGACGGAATCCCTGGAGAGCTACTT 92 523 4128 Antisense
Sequence Source Affymetrix Proprietary Database