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[193046_at] multidrug resistance-associated protein

Description F21G4.2 /REP_DB=WormBase Gene ID /WP=CE09548 /TR=Q93552 /GB=CAA88549.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance-associated protein
Cluster 6grp_highest_10_10 > 95      6grp_high1_10_10 > 68      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 92      6grp_total > 68      4grp_total > 60      6grp_highest_sub > Cu      6grp_cgc > 29      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 305
1 2 3 4 range
A 312.9
(0.1)
P 		350
(0.9)
P 		442.3
(3)
P 		177.6
(-3)
P 		265
B 343.6
(-0.1)
P 		482.9
(3)
P 		393
(1)
P 		214.2
(-3)
P 		269
C 370.6
(3)
P 		193.8
(-3)
P 		348.6
(2.3)
P 		209
(-2.5)
P 		177
avr 342.4
(1.4) 		342.2
(1.4) 		394.6
(3) 		200.3
(-3) 		194

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 487
1 2 3 4 5 6 range
A 284.8
(-1.3)
P 		308.2
(-0.9)
P 		163.4
(-3)
P 		186.6
(-2.7)
P 		278.6
(-1.3)
P 		582
(3)
P 		419
B 239
(-1.9)
P 		319.4
(-0.4)
P 		184.5
(-2.9)
P 		179
(-3)
P 		266.6
(-1.4)
P 		500.6
(3)
P 		322
C 316.8
(1.2)
P 		254.6
(0)
P 		279.3
(0.5)
P 		95
(-3)
P 		343
(1.7)
P 		412.9
(3)
P 		318
avr 280.2
(-0.8) 		294.1
(-0.6) 		209.1
(-2) 		153.5
(-3) 		296.1
(-0.5) 		498.5
(3) 		345
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 97
1 2 3 4 range
A 113.9
(2.9)
P 		76
(0.3)
P 		115.6
(3)
P 		26
(-3)
P 		90
B 109.6
(2.2)
P 		119.3
(3)
P 		91.1
(0.7)
P 		45.6
(-3)
P 		74
C 122.7
(3)
P 		55.7
(-1.6)
P 		121.5
(2.9)
P 		35.2
(-3)
P 		88
avr 115.4
(3) 		83.7
(0.6) 		109.4
(2.5) 		35.6
(-3) 		80

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 168
1 2 3 4 5 6 range
A 52.5
(-2)
P 		109.6
(1.2)
P 		35.6
(-3)
P 		47.3
(-2.3)
P 		84.1
(-0.3)
P 		141.7
(3)
P 		106
B 83.2
(-1.4)
P 		106.3
(-0.4)
P 		44.8
(-3)
P 		47.4
(-2.9)
P 		108.3
(-0.3)
P 		186.7
(3)
P 		142
C 117.4
(2)
P 		77.7
(-0)
P 		71.1
(-0.4)
P 		19.1
(-3)
P 		111
(1.6)
P 		138.2
(3)
P 		119
avr 84.4
(-0.6) 		97.9
(0.1) 		50.5
(-2.4) 		37.9
(-3) 		101.1
(0.2) 		155.5
(3) 		118
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193046_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16489
Sequence Type Exemplar sequence
Representative Public ID F21G4.2 NCBI
Target Description F21G4.2 /REP_DB=WormBase Gene ID /WP=CE09548 /TR=Q93552 /GB=CAA88549.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance-associated protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077257(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077257 NCBI Caenorhabditis elegans Multidrug Resistance Protein family member (mrp-4) (mrp-4) mRNA, complete cds. 11/11 None
SNAP00000036628 ENSEMBL cdna:SNAP chromosome:CEL140:X:9884856:9889346:1 11/11 None
GENEFINDER00000036637 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:9885035:9889346:1 11/11 None
F21G4.2 ENSEMBL cdna:known chromosome:CEL140:X:9884254:9889627:1 gene:F21G4.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:9884253-9889346(+) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance-associated protein
Gene Symbol mrp-4
Ensembl F21G4.2
Entrez Gene 181202 Entrez gene
SwissProt Q93552 EMBL-EBI
WormBase CE09548 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:256308_S_AT ATP-binding cassette transport protein, putative at
CANINE:1601402_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) cfa
CANINE_2:CFAAFFX.26330.1.S1_S_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) cfa
CHICKEN:GGAAFFX.4695.1.S1_S_AT similar to Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion tranporter-D) (MOAT-D) gga
HG-U133_PLUS_2:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-FOCUS:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:208161_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95AV2:1930_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HC-G110:1930_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:209641_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A_2:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133A:214979_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HU35KSUBA:U66674_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HU35KSUBD:RC_T40902_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:G9955971_3P_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:G4102187_3P_A_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.90786.4.S1_3P_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.90786.4.S1_3P_A_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.298107.0.A1_3P_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
U133_X3P:HS.187913.0.A1_3P_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:230682_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:230682_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:239217_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:239217_X_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95AV2:38261_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95C:63137_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95E:67798_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133_PLUS_2:242553_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U133B:242553_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95E:85275_R_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
HG-U95D:87278_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 hs
MU11KSUBA:AA165775_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MG-U74AV2:103689_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOE430A:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430A_2:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430_2:1428988_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 mm
MOUSE430_2:1443206_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MOE430B:1443206_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MU19KSUBA:TC17629_AT Multidrug resistance-associated protein 3 (Abcc3) mm
MU11KSUBA:D17945_RC_AT Multidrug resistance-associated protein 3 (Abcc3) mm
RT-U34:AB010467_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RG-U34A:AB010467_S_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RAE230A:1369698_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
RAT230_2:1369698_AT ATP-binding cassette, sub-family C (CFTR/MRP), member 3 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88549 Hypothetical protein F21G4.2 [Caenorhabditis elegans] emb|CAB02667.1| Hypothetical protein F21G4.2 [Caenorhabditis elegans] ref|NP_509658.1| Multidrug Resistance Protein family member (mrp-4) [Caenorhabditis elegans] 0.0
blast CAE58730 Hypothetical protein CBG01916 [Caenorhabditis briggsae] 0.0
blast CAE63808 Hypothetical protein CBG08354 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.9E-46
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.8E-28
Pfam IPR003439 EMBL-EBI ABC transporter 8.8E-33
Pfam IPR003439 EMBL-EBI ABC transporter 3.3E-49
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.9E-46
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.8E-28
Pfam IPR003439 EMBL-EBI ABC transporter 8.8E-33
Pfam IPR003439 EMBL-EBI ABC transporter 3.3E-49
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.9E-46
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.8E-28
Pfam IPR003439 EMBL-EBI ABC transporter 8.8E-33
Pfam IPR003439 EMBL-EBI ABC transporter 3.3E-49
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509658.1 13 42-64,76-98,108-130,143-165,180-199,330-352,382-404,482-504,1002-1024,1056-1078,1145-1167,1239-1261,1266-1288
F21G4.2 13 42-64,76-98,108-130,143-165,180-199,330-352,382-404,482-504,1002-1024,1056-1078,1145-1167,1239-1261,1266-1288
SNAP00000036628 8 161-183,213-235,313-335,833-855,887-909,976-998,1070-1092,1097-1119
GENEFINDER00000036637 7 153-175,253-275,773-795,827-849,916-938,1010-1032,1037-1059
Sequence
Target Sequence 
>C. ELEGANS:193046_AT
gaaagtcttctgtgactctctcactcttccgcatcatcgaggctgctgaagggcagattg
ttgttgatggtatcaatttggctgagattggacttcatgatcttcgatcaaaccttacaa
tcattccacaggacccagtgttgttctcaggaactttgcgtttcaacttggatccattca
atcactactcggacggtgatatctggaaaacccttgagatggctaatttgaaggagtttg
caacagcacacaatgagcagctcaactacataatcacggaaggtggagacaacattagtg
ttggtcagcgtcagctggtttgcctcgctcgtgctcttctccgcaagactcgtgttctta
ttttggacgaagccaccgccgctgttgatgtctccactgatgctcttatccagaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAAGTCTTCTGTGACTCTCTCACT 365 361 4130 Antisense
TTCCGCATCATCGAGGCTGCTGAAG 496 697 4156 Antisense
GATTGGACTTCATGATCTTCGATCA 292 435 4215 Antisense
ACAATCATTCCACAGGACCCAGTGT 121 115 4246 Antisense
GACCCAGTGTTGTTCTCAGGAACTT 2 383 4261 Antisense
GAACTTTGCGTTTCAACTTGGATCC 610 349 4280 Antisense
GATCCATTCAATCACTACTCGGACG 1 417 4300 Antisense
GAGCAGCTCAACTACATAATCACGG 24 389 4384 Antisense
GTTGGTCAGCGTCAGCTGGTTTGCC 219 435 4429 Antisense
TCTCCGCAAGACTCGTGTTCTTATT 286 609 4467 Antisense
TCTCCACTGATGCTCTTATCCAGAA 610 609 4520 Antisense
Sequence Source Affymetrix Proprietary Database