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[193036_s_at] MULTIPLE EXOSTOSES HOMOLOG 1

Description F12F6.3 /REP_DB=WormBase Gene ID /WP=CE24898 /GEN=rib-1 /TR=Q9U3J6 /GB=CAB61014.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=MULTIPLE EXOSTOSES HOMOLOG 1
Cluster 6grp_highest_10_10 > 59      6grp_high1_10_10 > 93      4grp_high_8_8 > 17      6grp_highest_nonorm > 91      6grp_total > 95      4grp_total > 38      6grp_highest_sub > In      6grp_cgc > 77      6grp_high1_sub > 04      6grp_cgc_sub > 04_05_06      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 174
1 2 3 4 range
A 285.1
(3)
P 		173.6
(-0.9)
P 		111.4
(-3)
P 		195
(-0.1)
P 		174
B 255.6
(3)
P 		191.8
(-1.8)
P 		175.5
(-3)
P 		242.3
(2)
P 		80
C 269.2
(3)
P 		183.7
(-2.8)
P 		180.7
(-3)
P 		185.3
(-2.7)
A 		89
avr 270
(3) 		183
(-1.6) 		155.9
(-3) 		207.5
(-0.3) 		114

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 165
1 2 3 4 5 6 range
A 133.4
(-3)
P 		223.3
(0.5)
P 		170.4
(-1.6)
P 		288.1
(3)
P 		189.7
(-0.8)
P 		230.8
(0.8)
P 		155
B 221.7
(0.3)
P 		170.5
(-2.8)
P 		166.9
(-3)
P 		173
(-2.6)
P 		207.6
(-0.5)
P 		265.5
(3)
P 		99
C 231.5
(-0.8)
P 		193.9
(-3)
P 		230.5
(-0.9)
P 		250.9
(0.3)
P 		298.3
(3)
P 		257.8
(0.7)
P 		104
avr 195.5
(-2.4) 		195.9
(-2.4) 		189.3
(-3) 		237.3
(1.6) 		231.9
(1.1) 		251.4
(3) 		62
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 75
1 2 3 4 range
A 103.8
(3)
P 		37.7
(-2.3)
P 		29.1
(-3)
P 		28.5
(-3)
P 		75
B 81.5
(3)
P 		47.4
(-2)
P 		40.7
(-3)
P 		51.6
(-1.4)
P 		41
C 89.1
(3)
P 		52.8
(-0.8)
P 		63
(0.3)
P 		31.2
(-3)
A 		58
avr 91.5
(3) 		46
(-2) 		44.3
(-2.2) 		37.1
(-3) 		54

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 74
1 2 3 4 5 6 range
A 24.6
(-3)
P 		79.4
(3)
P 		37.1
(-1.6)
P 		73.1
(2.3)
P 		57.3
(0.6)
P 		56.2
(0.5)
P 		55
B 77.2
(0.8)
P 		56.8
(-1.3)
P 		40.5
(-3)
P 		45.8
(-2.5)
P 		84.4
(1.5)
P 		99
(3)
P 		59
C 85.8
(1.6)
P 		59.2
(-1.9)
P 		58.7
(-1.9)
P 		50.5
(-3)
P 		96.5
(3)
P 		86.3
(1.7)
P 		46
avr 62.5
(-0.1) 		65.1
(0.4) 		45.4
(-3) 		56.5
(-1.1) 		79.4
(2.8) 		80.5
(3) 		35
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193036_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8491
Sequence Type Exemplar sequence
Representative Public ID F12F6.3 NCBI
Target Description F12F6.3 /REP_DB=WormBase Gene ID /WP=CE24898 /GEN=rib-1 /TR=Q9U3J6 /GB=CAB61014.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=MULTIPLE EXOSTOSES HOMOLOG 1
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069779(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069779 NCBI Caenorhabditis elegans related to mammalian RIB-affecting EXT gene family member (rib-1) (rib-1) mRNA, complete cds. 11/11 A 
GENEFINDER00000024867 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11580853:11583401:1 10/11 None
F12F6.3.3 ENSEMBL cdna:known chromosome:CEL140:IV:11578727:11583890:1 gene:F12F6.3 11/11 None
F12F6.3.2 ENSEMBL cdna:known chromosome:CEL140:IV:11578761:11583890:1 gene:F12F6.3 11/11 None
F12F6.3.1 ENSEMBL cdna:known chromosome:CEL140:IV:11578762:11583890:1 gene:F12F6.3 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000024857 3/11 Cross Hyb Matching Probes None
SNAP00000024858 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11578777-11583407(+) 100.0 100.0
Public Domain and Genome References
Gene Title MULTIPLE EXOSTOSES HOMOLOG 1
Gene Symbol rib-1
Ensembl F12F6.3
Entrez Gene 178080 Entrez gene
SwissProt O01704 EMBL-EBI
WormBase CE24898 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583884_AT similar to Exostosin-1 (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1) cfa
CANINE_2:CFA.11712.1.A1_AT similar to Exostosin-1 (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1) cfa
CANINE_2:CFA.11712.1.A1_S_AT similar to Exostosin-1 (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1) cfa
DROSOPHILA_2:1637442_AT tout-velu dm
DROSGENOME1:153718_AT tout-velu dm
HG-U95AV2:222_AT exostoses (multiple) 1 hs
HC-G110:222_AT exostoses (multiple) 1 hs
HG-U133A:201995_AT exostoses (multiple) 1 hs
HG-U133_PLUS_2:201995_AT exostoses (multiple) 1 hs
HG-FOCUS:201995_AT exostoses (multiple) 1 hs
HG-U133A_2:201995_AT exostoses (multiple) 1 hs
HUGENEFL:S79639_AT exostoses (multiple) 1 hs
U133_X3P:G4557570_3P_AT exostoses (multiple) 1 hs
HG-U95AV2:32164_AT exostoses (multiple) 1 hs
HG-U133_PLUS_2:232174_AT Exostoses (multiple) 1 hs
HG-U133B:232174_AT Exostoses (multiple) 1 hs
HU35KSUBA:AA135370_AT Exostoses (multiple) 1 hs
HU35KSUBB:RC_N73878_AT Exostoses (multiple) 1 hs
HU35KSUBC:RC_AA081079_AT Exostoses (multiple) 1 hs
U133_X3P:HS2.351804.1.S1_3P_AT Exostoses (multiple) 1 hs
U133_X3P:HS2.33347.1.S1_3P_S_AT Exostoses (multiple) 1 hs
U133_X3P:HS2.306766.1.S1_3P_S_AT Exostoses (multiple) 1 hs
U133_X3P:HS.288700.0.S1_3P_AT Exostoses (multiple) 1 hs
U133_X3P:HS.188536.0.A1_3P_X_AT Exostoses (multiple) 1 hs
U133_X3P:HS.188536.0.A1_3P_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:1561056_A_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:1562863_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:1564378_A_AT Exostoses (multiple) 1 hs
HG-U133A_2:215206_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:215206_AT Exostoses (multiple) 1 hs
HG-U133A:215206_AT Exostoses (multiple) 1 hs
HG-U95B:42772_R_AT Exostoses (multiple) 1 hs
HG-U95B:45915_AT Exostoses (multiple) 1 hs
HG-U95E:80059_AT Exostoses (multiple) 1 hs
HG-U95E:85489_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:234634_AT Exostoses (multiple) 1 hs
HG-U133B:234634_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:237310_AT Exostoses (multiple) 1 hs
HG-U133B:237310_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:239227_AT Exostoses (multiple) 1 hs
HG-U133B:239227_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:239414_AT Exostoses (multiple) 1 hs
HG-U133B:239414_AT Exostoses (multiple) 1 hs
HG-U133_PLUS_2:242126_AT Exostoses (multiple) 1 hs
HG-U133B:242126_AT Exostoses (multiple) 1 hs
HG-U95B:46522_AT Exostoses (multiple) 1 hs
HG-U95B:53246_R_AT Exostoses (multiple) 1 hs
HG-U95E:67764_R_AT Exostoses (multiple) 1 hs
HG-U95D:78072_AT Exostoses (multiple) 1 hs
HG-U95D:87485_R_AT Exostoses (multiple) 1 hs
HG-U95D:87811_AT Exostoses (multiple) 1 hs
HG-U95D:89464_AT Exostoses (multiple) 1 hs
HU35KSUBB:RC_F04982_AT Exostoses (multiple) 1 hs
HU35KSUBB:RC_R08762_AT Exostoses (multiple) 1 hs
U133_X3P:HS.131793.0.A1_3P_AT Exostoses (multiple) 1 hs
U133_X3P:HS.187820.0.A1_3P_AT Exostoses (multiple) 1 hs
U133_X3P:HS.27319.0.S1_3P_AT Exostoses (multiple) 1 hs
U133_X3P:HS.285132.0.A1_3P_AT Exostoses (multiple) 1 hs
MU11KSUBB:X96639_S_AT exostoses (multiple) 1 mm
MG-U74AV2:102811_AT exostoses (multiple) 1 mm
MOE430A:1417730_AT exostoses (multiple) 1 mm
MOUSE430A_2:1417730_AT exostoses (multiple) 1 mm
MOUSE430_2:1417730_AT exostoses (multiple) 1 mm
MG-U74CV2:140833_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1456655_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1456655_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1440011_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1440011_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1439877_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1439877_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1440092_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1440092_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1458054_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1458054_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOE430B:1458296_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
MOUSE430_2:1458296_AT Exostoses (multiple) 1, mRNA (cDNA clone MGC:5903 IMAGE:3499743) mm
RG-U34C:RC_AA858704_AT similar to Ext1 rn
RAE230A:1373393_AT similar to Ext1 rn
RAT230_2:1373393_AT similar to Ext1 rn
RAE230B:1382942_AT Similar to Ext1 rn
RAT230_2:1382942_AT Similar to Ext1 rn
RAE230B:1392083_AT Similar to Ext1 rn
RAT230_2:1392083_AT Similar to Ext1 rn
RG-U34C:RC_AI236163_AT Similar to Ext1 rn
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB61014 Hypothetical protein F12F6.3 [Caenorhabditis elegans] ref|NP_502180.1| related to mammalian RIB-affecting EXT gene family member (rib-1) [Caenorhabditis elegans] 0.0
blast O01704 Multiple exostoses homolog 1 (Related to mammalian RIB protein 1) gb|AAC47509.1| multiple exostoses homolog 1 [Caenorhabditis elegans] 0.0
blast T20803 hypothetical protein F12F6.3 - Caenorhabditis elegans 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004263 EMBL-EBI Exostosin-like 1.4E-118
Pfam IPR004263 EMBL-EBI Exostosin-like 2.0E-34
Pfam IPR004263 EMBL-EBI Exostosin-like 2.6E-28
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000024867 1 5-27
Sequence
Target Sequence 
>C. ELEGANS:193036_S_AT
gtctatcaggacgatcgatgccagcgagacaatgacgagtacgaccgttgggaatacgac
gaactgcttgccaactcgaccttctgcttggttccacgtggacgacgtcttggatctttc
agattcctcgaaaccctacgatctggatgtgttcctgttgtcatctccgactcatggatt
cttccgttctcggaaacaatagattggaactcggcagccatagttgtcgctgagcgtgac
gcgctctcgattccagaattgctgatgtcgacgagccgtcgaagagtgaaagaactacgg
gaatccgctcgaaatgtctat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCTATCAGGACGATCGATGCCAGC 82 469 742 Antisense
AATACGACGAACTGCTTGCCAACTC 341 169 794 Antisense
GGTTCCACGTGGACGACGTCTTGGA 31 507 831 Antisense
GGATCTTTCAGATTCCTCGAAACCC 584 511 853 Antisense
GAAACCCTACGATCTGGATGTGTTC 381 357 871 Antisense
TGGATGTGTTCCTGTTGTCATCTCC 610 549 885 Antisense
TGTCATCTCCGACTCATGGATTCTT 102 559 900 Antisense
GGAACTCGGCAGCCATAGTTGTCGC 678 529 947 Antisense
TAGTTGTCGCTGAGCGTGACGCGCT 530 653 962 Antisense
GAATTGCTGATGTCGACGAGCCGTC 587 321 997 Antisense
ACGGGAATCCGCTCGAAATGTCTAT 590 95 1038 Antisense
Sequence Source Affymetrix Proprietary Database