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[193025_at] P59 protein and TPR domain

Description F30H5.1 /REP_DB=WormBase Gene ID /WP=CE01925 /GEN=unc-45 /TR=Q09981 /GB=AAA68407.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=P59 protein and TPR domain
Cluster 6grp_total > 01      4grp_total > 41      6grp_cgc > 53      6grp_cgc_sub > 02      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 96
1 2 3 4 range
A 63.5
(-2.2)
A 		65.5
(-2)
A 		121.8
(3)
A 		54.8
(-3)
A 		67
B 25.8
(-3)
A 		92.7
(3)
A 		56.3
(-0.3)
A 		66.6
(0.7)
A 		67
C 66.5
(-3)
A 		85
(3)
A 		80.5
(1.5)
A 		67
(-2.8)
A 		19
avr 51.9
(-3) 		81.1
(2.1) 		86.2
(3) 		62.8
(-1.1) 		34

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 73
1 2 3 4 5 6 range
A 5.9
(-3)
A 		49.8
(3)
A 		24.4
(-0.5)
A 		13
(-2)
A 		29.2
(0.2)
A 		26.7
(-0.2)
A 		44
B 22.3
(-1.4)
A 		75.6
(3)
A 		4.5
(-2.8)
A 		2.5
(-3)
A 		22.1
(-1.4)
A 		9.7
(-2.4)
A 		73
C 56.6
(3)
A 		52.2
(2.5)
A 		24.7
(-0.9)
A 		7.2
(-3)
A 		10.6
(-2.6)
A 		18.2
(-1.7)
A 		49
avr 28.3
(-0.6) 		59.2
(3) 		17.9
(-1.8) 		7.6
(-3) 		20.6
(-1.5) 		18.2
(-1.8) 		52
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 24
1 2 3 4 range
A 23.1
(0.8)
A 		14.2
(-1.4)
A 		31.8
(3)
A 		8
(-3)
A 		24
B 8.2
(-3)
A 		22.9
(3)
A 		13
(-1)
A 		14.2
(-0.6)
A 		15
C 22
(0.8)
A 		24.4
(1.7)
A 		28.1
(3)
A 		11.3
(-3)
A 		17
avr 17.8
(0) 		20.5
(1.3) 		24.3
(3) 		11.2
(-3) 		13

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 25
1 2 3 4 5 6 range
A 1.1
(-3)
A 		17.7
(3)
A 		5.3
(-1.5)
A 		3.3
(-2.2)
A 		8.8
(-0.2)
A 		6.5
(-1)
A 		17
B 7.7
(-1.3)
A 		25.2
(3)
A 		1.1
(-2.9)
A 		0.7
(-3)
A 		9
(-1)
A 		3.6
(-2.3)
A 		25
C 21
(3)
A 		15.9
(1.4)
A 		6.3
(-1.5)
A 		1.5
(-3)
A 		3.4
(-2.4)
A 		6.1
(-1.6)
A 		20
avr 9.9
(-0.3) 		19.6
(3) 		4.2
(-2.2) 		1.8
(-3) 		7.1
(-1.2) 		5.4
(-1.8) 		18
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193025_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8352
Sequence Type Exemplar sequence
Representative Public ID F30H5.1 NCBI
Target Description F30H5.1 /REP_DB=WormBase Gene ID /WP=CE01925 /GEN=unc-45 /TR=Q09981 /GB=AAA68407.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=P59 protein and TPR domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064804(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064804 NCBI Caenorhabditis elegans UNCoordinated family member (unc-45) (unc-45) mRNA, complete cds. 11/11 A 
GENEFINDER00000018216 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:491547:502061:1 11/11 None
F30H5.1 ENSEMBL cdna:known chromosome:CEL140:III:491547:502589:1 gene:F30H5.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000018211 7/11 Cross Hyb Matching Probes None
SNAP00000018212 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:491546-502061(+) 100.0 100.0
Public Domain and Genome References
Gene Title P59 protein and TPR domain
Gene Symbol unc-45
Ensembl F30H5.1
Entrez Gene 175206 Entrez gene
SwissProt Q09981 EMBL-EBI
WormBase CE01925 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605483_AT similar to cardiomyopathy associated 4 cfa
CANINE_2:CFA.17784.1.S1_AT similar to cardiomyopathy associated 4 cfa
CANINE_2:CFA.18218.1.S1_S_AT similar to cardiomyopathy associated 4 cfa
CANINE_2:CFAAFFX.27986.1.S1_S_AT similar to cardiomyopathy associated 4 cfa
DROSOPHILA_2:1640009_AT Translocase of outer membrane 34 dm
DROSGENOME1:141789_AT Translocase of outer membrane 34 dm
CHICKEN:GGAAFFX.1457.1.S1_AT similar to cardiomyopathy associated 4; striated muscle UNC45 gga
HG-U133_PLUS_2:235261_AT Cardiomyopathy associated 4 hs
HG-U133B:235261_AT Cardiomyopathy associated 4 hs
HG-U95B:47977_AT Cardiomyopathy associated 4 hs
HG-U95C:53637_AT Cardiomyopathy associated 4 hs
HU35KSUBB:RC_AA039430_AT Cardiomyopathy associated 4 hs
HU35KSUBD:RC_AA404417_AT Cardiomyopathy associated 4 hs
U133_X3P:HS.61920.0.A1_3P_AT Cardiomyopathy associated 4 hs
MOUSE430_2:1436939_AT cardiomyopathy associated 4 mm
MOE430B:1436939_AT cardiomyopathy associated 4 mm
MG-U74BV2:112212_AT cardiomyopathy associated 4 mm
MOE430B:1441711_AT cardiomyopathy associated 4 mm
MOUSE430_2:1441711_AT cardiomyopathy associated 4 mm
MU19KSUBB:TC32743_AT Cardiomyopathy associated 4, mRNA (cDNA clone MGC:91090 IMAGE:30429260) mm
RAE230A:1377271_AT cardiomyopathy associated 4 (predicted) rn
RAT230_2:1377271_AT cardiomyopathy associated 4 (predicted) rn
Protein Similarities
Method ID Description E-Value
blast NP_497205 UNCoordinated family member (unc-45) [Caenorhabditis elegans] gb|AAA68407.1| Uncoordinated protein 45 [Caenorhabditis elegans] gb|AAD01976.1| UNC-45 [Caenorhabditis elegans] 0.0
blast CAE69240 Hypothetical protein CBG15283 [Caenorhabditis briggsae] 0.0
blast AAD01960 UNC-45 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001440 EMBL-EBI TPR repeat 1.7E-4
Pfam IPR001440 EMBL-EBI TPR repeat 0.0067
Sequence
Target Sequence 
>C. ELEGANS:193025_AT
gacactcaccaacttggcaagcgtcagtgattcgattcgtggacgaattttgaaagagaa
ggcaattccaaagattgaggaattctggtttatgacggatcacgagcatttgagagccgc
cgccgctgagcttcttctcaatttgctctttttcgagaagttttatgaggaaactgttgc
gcccggaaccgatcgtctgaaactctgggttctctactcggcagaagttgaagaggaacg
tctatcacgtgcctcggcggcaggtttcgccattcttacagaggacgagaacgcttgtgc
taggattatggacgagattaaatcatggcctgaggtgttcaaagacattgcaatgcacga
ggatgcggaaacccaacgtcgtggccttatgggaattgcgaatataatgcactcgagcaa
caaactgtgctccgaaattgtatcgtccgaagtgttccgtgtcctggtcgccgtcacaaa
gctcggcactatcaatcaggaacgggcaggctcgacggaacaggcgaaacgtggattgga
ggccgccgagaagtttggactg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACACTCACCAACTTGGCAAGCGTC 332 367 2274 Antisense
AAGCGTCAGTGATTCGATTCGTGGA 610 147 2292 Antisense
GATCACGAGCATTTGAGAGCCGCCG 508 421 2371 Antisense
GAGCTTCTTCTCAATTTGCTCTTTT 372 389 2401 Antisense
GTCTGAAACTCTGGGTTCTCTACTC 171 469 2468 Antisense
AGAGGAACGTCTATCACGTGCCTCG 358 65 2505 Antisense
CAGGTTTCGCCATTCTTACAGAGGA 108 207 2534 Antisense
AACGTCGTGGCCTTATGGGAATTGC 688 143 2648 Antisense
ACAAAGCTCGGCACTATCAATCAGG 578 111 2749 Antisense
CAATCAGGAACGGGCAGGCTCGACG 646 177 2766 Antisense
GGAGGCCGCCGAGAAGTTTGGACTG 437 513 2811 Antisense
Sequence Source Affymetrix Proprietary Database