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[193007_s_at] multidrug resistance protein

Description K08E7.9 /REP_DB=WormBase Gene ID /WP=CE11932 /GEN=pgp-1 /TR=Q21349 /GB=CAB01232.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=multidrug resistance protein
Cluster 6grp_total > 23      4grp_total > 50      6grp_cgc > 61      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S2      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 910
1 2 3 4 range
A 165.5
(-2.5)
A 		1005.2
(3)
P 		854.5
(2)
P 		95.5
(-3)
A 		910
B 175.5
(-2.4)
A 		926.6
(3)
P 		908
(2.9)
P 		96.1
(-3)
A 		831
C 143.8
(-2.7)
A 		711.7
(2.7)
P 		748
(3)
P 		113.2
(-3)
A 		635
avr 161.6
(-2.5) 		881.2
(3) 		836.8
(2.7) 		101.6
(-3) 		780

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 346
1 2 3 4 5 6 range
A 382.1
(2.6)
P 		408
(3)
P 		306.3
(1.2)
P 		248.1
(0.2)
P 		190.1
(-0.8)
P 		62
(-3)
A 		346
B 335.8
(3)
P 		333.6
(2.9)
P 		263.2
(1.3)
P 		199.5
(-0.2)
P 		148.9
(-1.4)
M 		81.1
(-3)
A 		255
C 342.6
(2.5)
P 		318.9
(2)
P 		366.9
(3)
P 		196.4
(-0.6)
P 		175.6
(-1)
P 		79.7
(-3)
A 		287
avr 353.5
(3) 		353.5
(3) 		312.1
(2.1) 		214.7
(0) 		171.5
(-0.9) 		74.3
(-3) 		279
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 247
1 2 3 4 range
A 60.2
(-1.7)
A 		218.2
(2.9)
P 		223.4
(3)
P 		14
(-3)
A 		209
B 56
(-2)
A 		228.8
(3)
P 		210.4
(2.5)
P 		20.5
(-3)
A 		208
C 47.6
(-2.3)
A 		204.6
(1.6)
P 		260.7
(3)
P 		19.1
(-3)
A 		242
avr 54.6
(-2) 		217.2
(2.6) 		231.5
(3) 		17.9
(-3) 		214

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 130
1 2 3 4 5 6 range
A 70.4
(-0.4)
P 		145.1
(3)
P 		66.7
(-0.6)
P 		62.9
(-0.8)
P 		57.4
(-1)
P 		15.1
(-3)
A 		130
B 116.8
(3)
P 		111.1
(2.6)
P 		63.9
(-0.7)
P 		52.9
(-1.4)
P 		60.5
(-0.9)
M 		30.3
(-3)
A 		87
C 127
(3)
P 		97.3
(1.2)
P 		93.4
(1)
P 		39.5
(-2.2)
P 		56.8
(-1.2)
P 		26.7
(-3)
A 		100
avr 104.7
(2.2) 		117.8
(3) 		74.7
(0.2) 		51.8
(-1.2) 		58.2
(-0.8) 		24
(-3) 		94
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193007_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9849
Sequence Type Exemplar sequence
Representative Public ID K08E7.9 NCBI
Target Description K08E7.9 /REP_DB=WormBase Gene ID /WP=CE11932 /GEN=pgp-1 /TR=Q21349 /GB=CAB01232.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=multidrug resistance protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070012(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070012 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-1) (pgp-1) mRNA, complete cds. 11/11 None
SNAP00000042651 ENSEMBL cdna:SNAP chromosome:CEL140:IV:12591798:12599138:-1 11/11 None
GENEFINDER00000042655 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:12591798:12599140:-1 11/11 None
K08E7.9 ENSEMBL cdna:known chromosome:CEL140:IV:12591683:12599138:-1 gene:K08E7.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:12591803-12599144(-) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance protein
Gene Symbol pgp-1
Ensembl K08E7.9
Entrez Gene 178215 Entrez gene
SwissProt P34712 EMBL-EBI
WormBase CE11932 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:12487_AT multidrug resistant (MDR) ABC transporter, putative at
ATH1-121501:266752_AT multidrug resistant (MDR) ABC transporter, putative at
CANINE:1602868_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 cfa
CANINE:1582410_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 cfa
CANINE_2:CFA.19.1.S1_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 cfa
CANINE:1599313_AT Multidrug resistance p-glycoprotein cfa
DROSOPHILA_2:1628659_AT Multi drug resistance 49 dm
DROSGENOME1:141779_AT Multi drug resistance 49 dm
CHICKEN:GGAAFFX.5596.4.S1_S_AT similar to Multidrug resistance protein 3 (P-glycoprotein 3) gga
HG-U95AV2:1575_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HC-G110:1575_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-FOCUS:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133_PLUS_2:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133A_2:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133A:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133_PLUS_2:243951_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133B:243951_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U95AV2:1576_G_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HC-G110:1576_G_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133A:209993_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133_PLUS_2:209993_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U133A_2:209993_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U95AV2:1682_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HC-G110:1682_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HUGENEFL:X58723_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HUGENEFL:M14758_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
U133_X3P:G9961253_3P_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
U133_X3P:G2353263_3P_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
U133_X3P:HS.129467.0.A1_3P_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HG-U95C:60295_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
HU35KSUBC:RC_AA135958_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1 hs
MOE430A:1419758_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MOUSE430A_2:1419758_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MOUSE430_2:1419758_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MU11KSUBA:M33581_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MG-U74AV2:102910_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MOE430A:1419759_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MOUSE430A_2:1419759_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MOUSE430_2:1419759_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A mm
MG-U74BV2:105261_AT ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01232 Hypothetical protein K08E7.9 [Caenorhabditis elegans] ref|NP_502413.1| P-GlycoProtein related family member (pgp-1) [Caenorhabditis elegans] sp|P34712|MDR1_CAEEL Multidrug resistance protein 1 (P-glycoprotein A) pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis elegans 0.0
blast CAA46190 P-glycoprotein A [Caenorhabditis elegans] 0.0
blast CAE67917 Hypothetical protein CBG13514 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.1E-74
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.0E-70
Pfam IPR003439 EMBL-EBI ABC transporter 4.0E-68
Pfam IPR003439 EMBL-EBI ABC transporter 1.0E-63
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.1E-74
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.0E-70
Pfam IPR003439 EMBL-EBI ABC transporter 4.0E-68
Pfam IPR003439 EMBL-EBI ABC transporter 1.0E-63
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_502413.1 11 75-97,142-164,214-233,238-257,318-340,355-377,753-775,795-817,872-894,898-915,1020-1042
K08E7.9 11 75-97,142-164,214-233,238-257,318-340,355-377,753-775,795-817,872-894,898-915,1020-1042
SNAP00000042651 11 75-97,142-164,214-233,238-257,318-340,355-377,753-775,795-817,872-894,898-915,1020-1042
GENEFINDER00000042655 11 76-98,143-165,215-234,239-258,319-341,356-378,754-776,796-818,873-895,899-916,1021-1043
Sequence
Target Sequence 
>C. ELEGANS:193007_S_AT
taccgtcgtagcgcttcttgagagattctacgacacccttggcggtgagatctttatcga
tggctccgagatcaagacgttgaaccctgagcacacaagatcacaaattgcaattgtatc
ccaggagccaacactgtttgattgctcaattgcagagaatattatctatggcttggatcc
ttcctcagttaccatggctcaagttgaagaagcagccaggcttgcgaacatccacaattt
catcgcagagcttccagaaggttttgagactcgtgtaggagaccgtggaacccagctctc
cggaggtcaaaaacaacgtatcgctattgcacgcgccctggtaaggaatcccaagatctt
actcttggacgaagctacgtcagcactggacacagaatccgagaaggttgtccaagaagc
gctggatcgtgcgagagagggaagaacctgtattgtgattgctcatcgtttgaacacagt
gatgaatgcagattgtattgctgtcgtgagcaatggtactattattgaaaaaggaaccca
cacacagttgatgtct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACCGTCGTAGCGCTTCTTGAGAGA 338 649 3369 Antisense
GTGAGATCTTTATCGATGGCTCCGA 497 481 3413 Antisense
TCAAGACGTTGAACCCTGAGCACAC 182 633 3440 Antisense
CTTCCTCAGTTACCATGGCTCAAGT 230 219 3548 Antisense
GAAGCAGCCAGGCTTGCGAACATCC 652 341 3577 Antisense
ACATCCACAATTTCATCGCAGAGCT 7 107 3596 Antisense
TGTAGGAGACCGTGGAACCCAGCTC 109 561 3642 Antisense
ACAACGTATCGCTATTGCACGCGCC 105 113 3681 Antisense
ATTGCACGCGCCCTGGTAAGGAATC 585 3 3694 Antisense
ACGAAGCTACGTCAGCACTGGACAC 209 91 3737 Antisense
AGGAACCCACACACAGTTGATGTCT 10 55 3900 Antisense
Sequence Source Affymetrix Proprietary Database