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[192993_at] potassium channel protein

Description K01D12.4 /REP_DB=WormBase Gene ID /WP=CE06043 /GEN=twk-12 /TR=Q21094 /GB=CAA99871.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=potassium channel protein
Cluster 6grp_highest_10_10 > 52      6grp_high1_10_10 > 25      4grp_highest_8_8 > 38      4grp_high_8_8 > 03      6grp_highest_nonorm > 70      6grp_total > 26      4grp_total > 05      6grp_highest_sub > 01_02      6grp_cgc > 23      6grp_high1_sub > 01_02      6grp_cgc_sub > De      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 410
1 2 3 4 range
A 230.5
(-0.2)
P 		143
(-2.9)
P 		139.7
(-3)
P 		337.6
(3)
P 		198
B 271.3
(0.5)
P 		150.7
(-2.3)
P 		123.2
(-3)
P 		374.3
(3)
P 		251
C 310.3
(-0.4)
P 		166.7
(-2.7)
P 		144.5
(-3)
P 		533
(3)
P 		389
avr 270.7
(-0.1) 		153.5
(-2.6) 		135.8
(-3) 		415
(3) 		279

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 256
1 2 3 4 5 6 range
A 350.8
(3)
P 		239.7
(-0.9)
P 		221.4
(-1.5)
P 		273.1
(0.3)
P 		212.4
(-1.8)
P 		178.2
(-3)
P 		173
B 359.3
(3)
P 		341.6
(2.4)
P 		204.8
(-2.5)
P 		190.7
(-3)
P 		232.7
(-1.5)
P 		237.7
(-1.3)
P 		169
C 247.7
(-0.6)
P 		402.9
(3)
P 		195.8
(-1.9)
P 		218.7
(-1.3)
P 		146.9
(-3)
P 		186.3
(-2.1)
P 		256
avr 319.3
(2.6) 		328.1
(3) 		207.3
(-2.5) 		227.5
(-1.6) 		197.3
(-3) 		200.7
(-2.8) 		131
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 74
1 2 3 4 range
A 83.9
(3)
P 		31.1
(-3)
P 		36.5
(-2.4)
P 		49.4
(-0.9)
P 		53
B 86.5
(3)
P 		37.2
(-2.1)
P 		28.6
(-3)
P 		79.8
(2.3)
P 		58
C 102.7
(3)
P 		47.9
(-3)
P 		50.4
(-2.7)
P 		89.9
(1.6)
P 		55
avr 91
(3) 		38.7
(-3) 		38.5
(-3) 		73
(0.9) 		53

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 82
1 2 3 4 5 6 range
A 64.7
(0.1)
P 		85.2
(3)
P 		48.2
(-2.3)
P 		69.3
(0.7)
P 		64.1
(-0)
P 		43.4
(-3)
P 		42
B 125
(3)
P 		113.7
(2.1)
P 		49.7
(-3)
P 		50.5
(-2.9)
P 		94.5
(0.6)
P 		88.6
(0.1)
P 		75
C 91.8
(0.6)
P 		122.9
(3)
P 		49.8
(-2.6)
P 		44
(-3)
P 		47.5
(-2.7)
P 		62.4
(-1.6)
P 		79
avr 93.8
(1.6) 		107.3
(3) 		49.2
(-3) 		54.6
(-2.4) 		68.7
(-1) 		64.8
(-1.4) 		58
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192993_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12794
Sequence Type Exemplar sequence
Representative Public ID K01D12.4 NCBI
Target Description K01D12.4 /REP_DB=WormBase Gene ID /WP=CE06043 /GEN=twk-12 /TR=Q21094 /GB=CAA99871.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=potassium channel protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073702(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073702 NCBI Caenorhabditis elegans TWiK family of potassium channels family member (twk-14) (twk-14) mRNA, complete cds. 11/11 None
SNAP00000007090 ENSEMBL cdna:SNAP chromosome:CEL140:V:12389870:12391301:-1 11/11 None
GENEFINDER00000007111 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:12389870:12398281:-1 11/11 None
K01D12.4 ENSEMBL cdna:known chromosome:CEL140:V:12389694:12393197:-1 gene:K01D12.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:12390071-12393197(-) 100.0 100.0
Public Domain and Genome References
Gene Title potassium channel protein
Gene Symbol twk-14
Ensembl K01D12.4
Entrez Gene 179699 Entrez gene
SwissProt Q21094 EMBL-EBI
WormBase CE06043 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.26764.1.S1_AT similar to potassium channel, subfamily K, member 13 cfa
HG-U133_PLUS_2:221325_AT potassium channel, subfamily K, member 13 hs
HG-U133A:221325_AT potassium channel, subfamily K, member 13 hs
HG-FOCUS:221325_AT potassium channel, subfamily K, member 13 hs
HG-U133A_2:221325_AT potassium channel, subfamily K, member 13 hs
U133_X3P:G11545758_3P_AT potassium channel, subfamily K, member 13 hs
HG-U95E:69411_AT potassium channel, subfamily K, member 13 hs
MOUSE430_2:1424125_AT potassium channel, subfamily K, member 13 mm
MOUSE430A_2:1424125_AT potassium channel, subfamily K, member 13 mm
MOE430A:1424125_AT potassium channel, subfamily K, member 13 mm
MOE430B:1447645_X_AT potassium channel, subfamily K, member 13 mm
MOUSE430_2:1447645_X_AT potassium channel, subfamily K, member 13 mm
MOE430B:1458781_AT Potassium channel, subfamily K, member 13 (Kcnk13), mRNA mm
MOUSE430_2:1458781_AT Potassium channel, subfamily K, member 13 (Kcnk13), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6813 potassium ion transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5267 potassium channel activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99871 Hypothetical protein K01D12.4 [Caenorhabditis elegans] ref|NP_506103.1| TWiK family of potassium channels family member (twk-14) [Caenorhabditis elegans] 0.0
blast CAE75471 Hypothetical protein CBG23471 [Caenorhabditis briggsae] 0.0
blast CAA99871 Hypothetical protein K01D12.4 [Caenorhabditis elegans] ref|NP_506103.1| TWiK family of potassium channels family member (twk-14) [Caenorhabditis elegans] 1.0E-148
blast XP_785246 PREDICTED: similar to potassium channel, subfamily K, member 13 [Strongylocentrotus purpuratus] 5.0E-65
blast AAN62847 tandem pore domain potassium channel [Aplysia californica] 4.0E-61
Protein Domains
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_506103.1 5 43-65,150-172,233-255,260-277,298-320
K01D12.4 5 43-65,150-172,233-255,260-277,298-320
SNAP00000007090 5 20-39,49-71,132-154,159-176,197-219
GENEFINDER00000007111 5 75-97,182-204,265-287,292-309,330-352
Sequence
Target Sequence 
>C. ELEGANS:192993_AT
aaacaaaccggtcacgttgctgcttaacaacgaagatttcaatgaatcttcaagctcttg
tggcggccacatggacaactggagaccctctgtgtacaaagtgttcttcattcttttttc
aatgtgcctggttttgatcaccgcctccgctggaatttattcggtcgttgaaaactggaa
ttacattgattccctatacttctgctttatcagttttgccacaatcggcttcggtgatta
tgtatcaaatcagcaggatgtaacacggatgagccctgatttgtacagatttgtcaattt
ctgtcttctgactcttggagcttgcttcttctattgtctttcaaatgtgtcttcaattgt
tgttaggcaacttttgaattggatgatcaagaaaatggatgtaaaagtcgaagaccgatc
attcttgtgctttaagaaaaaacgaagatatatgggactcggacttcgaccac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAACAAACCGGTCACGTTGCTGCTT 245 127 609 Antisense
GAATCTTCAAGCTCTTGTGGCGGCC 454 323 652 Antisense
GACAACTGGAGACCCTCTGTGTACA 191 365 682 Antisense
CAATGTGCCTGGTTTTGATCACCGC 257 183 728 Antisense
ACCGCCTCCGCTGGAATTTATTCGG 90 89 748 Antisense
TACATTGATTCCCTATACTTCTGCT 284 645 790 Antisense
GTTTTGCCACAATCGGCTTCGGTGA 557 447 821 Antisense
TCAATTTCTGTCTTCTGACTCTTGG 57 635 902 Antisense
TGACTCTTGGAGCTTGCTTCTTCTA 160 571 917 Antisense
GAAGACCGATCATTCTTGTGCTTTA 179 339 1018 Antisense
TATATGGGACTCGGACTTCGACCAC 522 653 1057 Antisense
Sequence Source Affymetrix Proprietary Database