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[192984_at] helix-loop-helix transcription factor

Description C18A3.8 /REP_DB=WormBase Gene ID /WP=CE01800 /TR=Q09961 /GB=AAA68375.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=helix-loop-helix transcription factor
Cluster 6grp_total > 46      4grp_total > 43      6grp_cgc > 17      6grp_cgc_sub > Cu      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 81
1 2 3 4 range
A 54.5
(-1.5)
A 		101.2
(3)
A 		84.5
(1.4)
A 		39.2
(-3)
A 		62
B 63.3
(-0.5)
A 		96.7
(3)
M 		84.1
(1.7)
A 		39.5
(-3)
A 		57
C 95.5
(0.9)
A 		120.4
(3)
A 		50.5
(-3)
A 		110.2
(2.1)
A 		70
avr 71.1
(-1.9) 		106.1
(3) 		73
(-1.6) 		63
(-3) 		43

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 119
1 2 3 4 5 6 range
A 91.1
(1.6)
A 		95.5
(1.9)
A 		71.7
(0.6)
A 		5.3
(-3)
A 		54.8
(-0.3)
A 		116.6
(3)
M 		111
B 111.6
(2.3)
P 		94.1
(0.7)
P 		82.5
(-0.3)
A 		54
(-2.9)
A 		52.8
(-3)
A 		119.4
(3)
P 		67
C 97.9
(0.6)
A 		111.1
(1.8)
A 		63.2
(-2.4)
A 		56.9
(-3)
A 		59.2
(-2.8)
A 		124.7
(3)
P 		68
avr 100.2
(1.5) 		100.2
(1.5) 		72.5
(-0.5) 		38.7
(-3) 		55.6
(-1.8) 		120.2
(3) 		82
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 29
1 2 3 4 range
A 19.9
(2.2)
A 		22
(3)
A 		22.1
(3)
A 		5.7
(-3)
A 		16
B 20.2
(1.6)
A 		23.9
(3)
M 		19.5
(1.3)
A 		8.4
(-3)
A 		16
C 31.6
(1.9)
A 		34.6
(3)
A 		17.6
(-3)
A 		18.6
(-2.6)
A 		17
avr 23.9
(1.9) 		26.8
(3) 		19.7
(0.3) 		10.9
(-3) 		16

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 43
1 2 3 4 5 6 range
A 16.8
(-0.2)
A 		34
(3)
A 		15.6
(-0.4)
A 		1.3
(-3)
A 		16.5
(-0.2)
A 		28.4
(2)
M 		33
B 38.8
(1.9)
P 		31.3
(0.4)
P 		20
(-1.9)
A 		14.3
(-3)
A 		21.4
(-1.6)
A 		44.5
(3)
P 		30
C 36.3
(1.9)
A 		33.9
(1.5)
A 		16.1
(-2.1)
A 		11.4
(-3)
A 		19.2
(-1.5)
A 		41.7
(3)
P 		30
avr 30.6
(1.4) 		33.1
(2) 		17.2
(-1.3) 		9
(-3) 		19
(-0.9) 		38.2
(3) 		29
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192984_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5067
Sequence Type Exemplar sequence
Representative Public ID C18A3.8 NCBI
Target Description C18A3.8 /REP_DB=WormBase Gene ID /WP=CE01800 /TR=Q09961 /GB=AAA68375.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=helix-loop-helix transcription factor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062730(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062730 NCBI Caenorhabditis elegans Helix Loop Helix family member (hlh-14) (hlh-14) mRNA, complete cds. 11/11 None
SNAP00000023269 ENSEMBL cdna:SNAP chromosome:CEL140:II:5737901:5738766:-1 9/11 None
GENEFINDER00000023274 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:5737901:5739168:-1 11/11 None
C18A3.8 ENSEMBL cdna:known chromosome:CEL140:II:5737901:5739757:-1 gene:C18A3.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5737897-5739030(-) 100.0 100.0
Public Domain and Genome References
Gene Title helix-loop-helix transcription factor
Gene Symbol hlh-14
Ensembl C18A3.8
Entrez Gene 182758 Entrez gene
SwissProt Q09961 EMBL-EBI
WormBase CE36629 Wormbase
Functional Annotations
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3704 specific RNA polymerase II transcription factor activity inferred from sequence similarity QuickGO AmiGO
3677 DNA binding inferred from sequence similarity QuickGO AmiGO
46982 protein heterodimerization activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA68375 Helix loop helix protein 14 [Caenorhabditis elegans] ref|NP_495131.2| Helix Loop Helix family member (hlh-14) [Caenorhabditis elegans] 1.0E-127
blast AAA68375 Helix loop helix protein 14 [Caenorhabditis elegans] ref|NP_495131.2| Helix Loop Helix family member (hlh-14) [Caenorhabditis elegans] 1.0E-116
blast AAA68375 Helix loop helix protein 14 [Caenorhabditis elegans] ref|NP_495131.2| Helix Loop Helix family member (hlh-14) [Caenorhabditis elegans] 3.0E-70
blast CAE59182 Hypothetical protein CBG02491 [Caenorhabditis briggsae] 7.0E-42
blast CAE59182 Hypothetical protein CBG02491 [Caenorhabditis briggsae] 3.0E-41
blast XP_797956 PREDICTED: similar to Achaete-scute homolog 1 (HASH1) [Strongylocentrotus purpuratus] 1.0E-9
blast CAE59798 Hypothetical protein CBG03260 [Caenorhabditis briggsae] 7.0E-9
Protein Domains
Database ID Description E-Value
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 7.8E-19
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 7.8E-19
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 7.8E-19
Sequence
Target Sequence 
>C. ELEGANS:192984_AT
tacggtttgtgccaatatccaccctcctagtcccgcccatcagattgtcccgtcccgcct
ttcctctcaccattagccttattcattcagttcacccacactcactcctagccaccaccg
tcttccctctctctttttattttcccgcccaacaaaaaaaggaagcaatggccaagaaga
atcaagttgccagaaatgagagagaacgcaagcgagttcatcaggtaaaccatggtttcg
acgtgctccgcaaccgtcttcaaccaaagaatcataccaagaaatggagcaaagcagaca
cccttcgtgaagctgtcaagtatattcaacaacttcaggttcttctcaatcaagatccac
agcaaccatcagtttcttcttcaactcccgactacacgatgaacaacagcaacaacttca
acaattatgccgtaaaagaagaattctcgatgtatttgcctcaaaactattgcccacaaa
atcaaatgtcagtacctcatggagatgtttcccataacttcaattctccaacatcatcag
tttcctcatcttcttactcaccaactcaaatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACGGTTTGTGCCAATATCCACCCT 257 643 113 Antisense
CTCTCACCATTAGCCTTATTCATTC 316 231 176 Antisense
GTAAACCATGGTTTCGACGTGCTCC 296 461 337 Antisense
AGCAGACACCCTTCGTGAAGCTGTC 273 77 405 Antisense
ACAACTTCAGGTTCTTCTCAATCAA 352 113 441 Antisense
CTCAATCAAGATCCACAGCAACCAT 99 227 457 Antisense
ACAGCAACCATCAGTTTCTTCTTCA 58 109 471 Antisense
CTTCAACTCCCGACTACACGATGAA 38 223 491 Antisense
ATTTGCCTCAAAACTATTGCCCACA 647 17 566 Antisense
TTTCCCATAACTTCAATTCTCCAAC 571 669 620 Antisense
ATCTTCTTACTCACCAACTCAAATG 301 31 660 Antisense
Sequence Source Affymetrix Proprietary Database