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[192938_at] ubiquitin carboxy-terminal hydrolase

Description H34C03.2 /REP_DB=WormBase Gene ID /WP=CE19500 /TR=Q9TYY8 /GB=AAC68977.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ubiquitin carboxy-terminal hydrolase
Cluster 4grp_high_8_8 > 28      6grp_total > 27      4grp_total > 36      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 79
1 2 3 4 range
A 105.2
(3)
P 		76.3
(-1)
A 		62.2
(-3)
P 		79.7
(-0.6)
A 		43
B 95.7
(-0.9)
P 		120.5
(3)
P 		81.9
(-3)
P 		87
(-2.2)
P 		39
C 95.1
(-1)
P 		112.9
(0.5)
P 		72.9
(-3)
P 		140.9
(3)
P 		68
avr 98.7
(2.1) 		103.2
(3) 		72.3
(-3) 		102.5
(2.9) 		31

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 80
1 2 3 4 5 6 range
A 117.8
(3)
P 		37.9
(-3)
M 		40.2
(-2.8)
A 		64.3
(-1)
P 		40.5
(-2.8)
A 		76.3
(-0.1)
P 		80
B 92.4
(3)
P 		69.7
(-2.3)
P 		70.1
(-2.2)
P 		66.7
(-3)
A 		71.8
(-1.8)
A 		76.8
(-0.6)
P 		26
C 108.2
(3)
P 		91.5
(1.5)
P 		77.7
(0.3)
P 		40.7
(-3)
A 		56.8
(-1.6)
A 		70.3
(-0.4)
P 		68
avr 106.1
(3) 		66.4
(-1.8) 		62.7
(-2.2) 		57.2
(-2.9) 		56.4
(-3) 		74.5
(-0.8) 		50
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 27
1 2 3 4 range
A 38.3
(3)
P 		16.6
(-1.9)
A 		16.3
(-2)
P 		11.7
(-3)
A 		27
B 30.5
(3)
P 		29.8
(2.7)
P 		19
(-2.8)
P 		18.5
(-3)
P 		12
C 31.5
(2.3)
P 		32.5
(3)
P 		25.4
(-1.9)
P 		23.8
(-3)
P 		9
avr 33.4
(3) 		26.3
(0.2) 		20.2
(-2.1) 		18
(-3) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 32
1 2 3 4 5 6 range
A 21.7
(3)
P 		13.5
(-0.8)
M 		8.7
(-3)
A 		16.3
(0.5)
P 		12.2
(-1.4)
A 		18.6
(1.6)
P 		13
B 32.2
(3)
P 		23.2
(-0.6)
P 		17
(-3)
P 		17.7
(-2.7)
A 		29.2
(1.8)
A 		28.7
(1.6)
P 		15
C 40.1
(3)
P 		27.9
(0.7)
P 		19.8
(-0.8)
P 		8.2
(-3)
A 		18.4
(-1.1)
A 		23.5
(-0.1)
P 		32
avr 31.3
(3) 		21.5
(-0.4) 		15.2
(-2.6) 		14.1
(-3) 		19.9
(-1) 		23.6
(0.3) 		17
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192938_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10069
Sequence Type Exemplar sequence
Representative Public ID H34C03.2 NCBI
Target Description H34C03.2 /REP_DB=WormBase Gene ID /WP=CE19500 /TR=Q9TYY8 /GB=AAC68977.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ubiquitin carboxy-terminal hydrolase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068634(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068634 NCBI Caenorhabditis elegans H34C03.2 (H34C03.2) mRNA, complete cds. 11/11 None
SNAP00000021135 ENSEMBL cdna:SNAP chromosome:CEL140:IV:6758415:6761760:1 11/11 None
GENEFINDER00000021140 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:6757327:6761760:1 11/11 None
H34C03.2 ENSEMBL cdna:known chromosome:CEL140:IV:6757295:6762572:1 gene:H34C03.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:6757332-6761766(+) 100.0 100.0
Public Domain and Genome References
Gene Title ubiquitin carboxy-terminal hydrolase
Ensembl H34C03.2
Entrez Gene 177437 Entrez gene
SwissProt Q9TYY8 EMBL-EBI
WormBase CE19500 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:261217_AT ubiquitin carboxyl-terminal hydrolase family protein at
CANINE:1596143_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CANINE:1585824_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CANINE_2:CFA.12988.1.A1_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CANINE_2:CFA.18425.1.S1_S_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CANINE_2:CFA.5884.1.A1_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CANINE_2:CFAAFFX.18013.1.S1_S_AT similar to ubiquitin specific protease, proto-oncogene isoform a cfa
CHICKEN:GGAAFFX.12249.1.S1_AT ubiquitin specific peptidase 4 (proto-oncogene) gga
HG-U133_PLUS_2:211800_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-FOCUS:211800_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A:211800_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A_2:211800_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U95AV2:1357_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HC-G110:1357_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HU35KSUBD:RC_AA177104_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HUGENEFL:U20657_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A:202682_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133_PLUS_2:202682_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A_2:202682_S_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
U133_X3P:G2656142_3P_A_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
U133_X3P:HS.77500.0.S2_3P_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A_2:202681_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133_PLUS_2:202681_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133A:202681_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U95AV2:37339_AT ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133_PLUS_2:235376_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U133B:235376_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U95B:47271_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
HG-U95C:54960_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
HU35KSUBB:RC_R07444_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
HU35KSUBD:RC_W79397_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
U133_X3P:HS.110059.0.A1_3P_AT Ubiquitin specific peptidase 4 (proto-oncogene) hs
MOUSE430_2:1442319_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MOE430B:1442319_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MU11KSUBA:L00681_S_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MU11KSUBB:MSA.25991.0_S_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MG-U74AV2:99064_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MG-U74AV2:161305_R_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MOE430A:1450892_A_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MOUSE430A_2:1450892_A_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MOUSE430_2:1450892_A_AT ubiquitin specific peptidase 4 (proto-oncogene) mm
MU11KSUBB:MSA.17396.0_S_AT Ubiquitin specific peptidase 4 (proto-oncogene), mRNA (cDNA clone MGC:18374 IMAGE:3661165) mm
RG-U34B:RC_AI029306_AT similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein) rn
RAE230A:1389016_AT similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein) rn
RAT230_2:1389016_AT similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein) rn
RAE230B:1394536_AT similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein) rn
RAT230_2:1394536_AT similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6511 ubiquitin-dependent protein catabolism inferred from electronic annotation QuickGO AmiGO
6512 ubiquitin cycle inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
4221 ubiquitin thiolesterase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAC68977 Hypothetical protein H34C03.2 [Caenorhabditis elegans] ref|NP_501035.1| H34C03.2 [Caenorhabditis elegans] 0.0
blast CAE61486 Hypothetical protein CBG05381 [Caenorhabditis briggsae] 0.0
blast NP_192795 ubiquitin carboxyl-terminal hydrolase family protein [Arabidopsis thaliana] 1.0E-91
Protein Domains
Database ID Description E-Value
Pfam IPR010460 EMBL-EBI Peptidase C19, ubiquitin carboxyl-terminal hydrolase N terminus 2.5E-64
Pfam IPR001394 EMBL-EBI Peptidase C19, ubiquitin carboxyl-terminal hydrolase family 2 1.0E-126
Pfam IPR001394 EMBL-EBI Peptidase C19, ubiquitin carboxyl-terminal hydrolase family 2 1.0E-126
Pfam IPR010460 EMBL-EBI Peptidase C19, ubiquitin carboxyl-terminal hydrolase N terminus 2.5E-64
Pfam IPR001394 EMBL-EBI Peptidase C19, ubiquitin carboxyl-terminal hydrolase family 2 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192938_AT
aagagactctggactggttcacaacgaaagaacaactcggagaacaggattcgtggtact
gtcctcaatgcaagaaacacgagcgagccacgaagcaattagctctgtggaagcttccgg
agattctcattctccacttgaaacgtttccaatacaccaagtggtctcgtgagaagctga
catgggaggttgtgattcctgttcgtgggttggatcttaccgacaaagttgccaatccga
atcacgagaaagcgatctacgaccttattgccgtatcacgtcactatggatccttgagtg
gaggtcattacactgccataggctacaacgacagggaacagaaatggtttgatttcaacg
attcctcagcaaatccgacatatcctccagctgaaccctatgagtcgagcgatccctaca
ttcttgtataccgaagacgcaaattggattcaaatggaaaaccgattgagccatcagcag
tatctgaatctcttcatagtcgaccgaaaagaggagctgctccaacaatttcatctgcaa
cat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGAGACTCTGGACTGGTTCACAAC 545 153 2114 Antisense
TCGTGGTACTGTCCTCAATGCAAGA 625 605 2164 Antisense
GTGGAAGCTTCCGGAGATTCTCATT 362 491 2220 Antisense
GATTCTCATTCTCCACTTGAAACGT 619 431 2235 Antisense
AAGCGATCTACGACCTTATTGCCGT 28 151 2363 Antisense
GCCGTATCACGTCACTATGGATCCT 698 283 2383 Antisense
AGGTCATTACACTGCCATAGGCTAC 396 51 2415 Antisense
TCCTCAGCAAATCCGACATATCCTC 122 593 2476 Antisense
CTGAACCCTATGAGTCGAGCGATCC 22 239 2504 Antisense
GCGATCCCTACATTCTTGTATACCG 688 289 2522 Antisense
GCTCCAACAATTTCATCTGCAACAT 589 297 2632 Antisense
Sequence Source Affymetrix Proprietary Database