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[192937_at] succinate semi-aldehyde dehydrogenase

Description F45H10.1 /REP_DB=WormBase Gene ID /WP=CE10542 /TR=O02266 /GB=CAB04383.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=succinate semi-aldehyde dehydrogenase
Cluster 6grp_highest_10_10 > 12      6grp_high1_10_10 > 20      4grp_highest_8_8 > 04      4grp_high_8_8 > 37      6grp_highest_nonorm > 90      6grp_total > 33      4grp_total > 42      6grp_cgc > 20      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 95.2
(-3)
P 		132.4
(3)
P 		130.6
(2.7)
P 		106
(-1.3)
P 		37
B 105.6
(-3)
P 		138.7
(3)
P 		124.9
(0.5)
P 		124.3
(0.4)
P 		33
C 110.6
(0.6)
P 		107.7
(-0.1)
P 		95.9
(-3)
P 		120.3
(3)
P 		24
avr 103.8
(-3) 		126.3
(3) 		117.1
(0.5) 		116.9
(0.5) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 137
1 2 3 4 5 6 range
A 195.4
(3)
P 		107.6
(-2.6)
P 		167.8
(1.2)
P 		162
(0.9)
P 		101.3
(-3)
P 		116.9
(-2)
P 		94
B 117
(0)
P 		110
(-0.6)
P 		147.9
(3)
P 		85.3
(-3)
P 		85.7
(-3)
P 		120
(0.3)
P 		63
C 139.2
(3)
P 		125.7
(2)
P 		116
(1.3)
P 		105.2
(0.5)
P 		83.5
(-1.2)
P 		58.7
(-3)
P 		81
avr 150.5
(3) 		114.4
(-0.6) 		143.9
(2.3) 		117.5
(-0.3) 		90.2
(-3) 		98.5
(-2.2) 		60
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 21
1 2 3 4 range
A 34.7
(3)
P 		28.7
(1.1)
P 		34.1
(2.8)
P 		15.5
(-3)
P 		19
B 33.7
(2.5)
P 		34.3
(3)
P 		28.9
(-1.2)
P 		26.5
(-3)
P 		8
C 36.6
(3)
P 		31
(0.9)
P 		33.4
(1.8)
P 		20.3
(-3)
P 		16
avr 35
(3) 		31.3
(1.4) 		32.1
(1.8) 		20.8
(-3) 		14

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 32
1 2 3 4 5 6 range
A 36
(0.6)
P 		38.3
(1.7)
P 		36.6
(0.9)
P 		41.1
(3)
P 		30.6
(-2)
P 		28.5
(-3)
P 		13
B 40.7
(1.9)
P 		36.6
(0.8)
P 		35.9
(0.6)
P 		22.6
(-3)
P 		34.8
(0.3)
P 		44.7
(3)
P 		22
C 51.6
(3)
P 		38.4
(0.5)
P 		29.5
(-1.1)
P 		21.2
(-2.7)
P 		27
(-1.6)
P 		19.6
(-3)
P 		32
avr 42.8
(3) 		37.8
(0.9) 		34
(-0.6) 		28.3
(-3) 		30.8
(-2) 		30.9
(-1.9) 		15
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192937_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2851
Sequence Type Exemplar sequence
Representative Public ID F45H10.1 NCBI
Target Description F45H10.1 /REP_DB=WormBase Gene ID /WP=CE10542 /TR=O02266 /GB=CAB04383.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=succinate semi-aldehyde dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064436(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064436 NCBI Caenorhabditis elegans ALdehyde deHydrogenase family member (alh-7) (alh-7) mRNA, complete cds. 11/11 None
SNAP00000000149 ENSEMBL cdna:SNAP chromosome:CEL140:II:13487401:13488068:-1 9/11 None
GENEFINDER00000000157 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:13487401:13491670:-1 9/11 None
F45H10.1.1 ENSEMBL cdna:known chromosome:CEL140:II:13487091:13491682:-1 gene:F45H10.1 11/11 None
F45H10.1.2 ENSEMBL cdna:known chromosome:CEL140:II:13487091:13491684:-1 gene:F45H10.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:13487087-13491667(-) 88.6 100.0
Public Domain and Genome References
Gene Title succinate semi-aldehyde dehydrogenase
Gene Symbol alh-7
Ensembl F45H10.1
Entrez Gene 174991 Entrez gene
SwissProt O02266 EMBL-EBI
WormBase CE10542 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262892_AT succinate-semialdehyde dehydrogenase (SSADH1) at
CANINE_2:CFAAFFX.16240.1.S1_AT similar to aldehyde dehydrogenase 5A1 precursor, isoform 2 cfa
CANINE_2:CFAAFFX.16240.1.S1_S_AT similar to aldehyde dehydrogenase 5A1 precursor, isoform 2 cfa
CANINE_2:CFAAFFX.16245.1.S1_S_AT similar to aldehyde dehydrogenase 5A1 precursor, isoform 2 cfa
DROSOPHILA_2:1635280_AT dm
DROSGENOME1:152837_AT dm
CHICKEN:GGAAFFX.8023.1.S1_S_AT similar to aldehyde dehydrogenase 5A1 precursor isoform 2; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase gga
CHICKEN:GGAAFFX.8023.2.S1_AT similar to aldehyde dehydrogenase 5A1 precursor isoform 2; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase gga
CHICKEN:GGAAFFX.8023.3.S1_AT similar to aldehyde dehydrogenase 5A1 precursor isoform 2; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase gga
HG-U133A:203609_S_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U133_PLUS_2:203609_S_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U133A_2:203609_S_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HU35KSUBA:RC_AA486410_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HU35KSUBC:RC_AA262077_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HUGENEFL:L34820_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
U133_X3P:G4507228_3P_A_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
U133_X3P:HS.5299.0.S2_3P_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U133A_2:203608_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-FOCUS:203608_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U133_PLUS_2:203608_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U133A:203608_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U95AV2:41790_AT aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U95D:84192_AT Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HG-U95D:88027_AT Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HU35KSUBA:AA455381_AT Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
HU35KSUBC:RC_C20982_AT Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) hs
MG-U74BV2:115718_AT aldehyde dehydrogenase 1, mitochondrial mm
MG-U74CV2:128830_R_AT aldehyde dehydrogenase 1, mitochondrial mm
MOE430B:1453065_AT aldehyde dehydrogenase 1, mitochondrial mm
MOUSE430_2:1453065_AT aldehyde dehydrogenase 1, mitochondrial mm
RG-U34A:L34821_AT aldehyde dehydrogenase family 5, subfamily A1 rn
RAE230A:1371062_AT aldehyde dehydrogenase family 5, subfamily A1 rn
RAT230_2:1371062_AT aldehyde dehydrogenase family 5, subfamily A1 rn
RAE230B:1391657_AT aldehyde dehydrogenase family 5, subfamily A1 rn
RAT230_2:1391657_AT aldehyde dehydrogenase family 5, subfamily A1 rn
YEAST_2:1775744_AT Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04383 Hypothetical protein F45H10.1 [Caenorhabditis elegans] ref|NP_496837.1| ALdehyde deHydrogenase family member (alh-7) [Caenorhabditis elegans] 0.0
blast CAE73343 Hypothetical protein CBG20774 [Caenorhabditis briggsae] 0.0
blast XP_789239 PREDICTED: similar to aldehyde dehydrogenase family 5, subfamily A1 [Strongylocentrotus purpuratus] 1.0E-136
Protein Domains
Database ID Description E-Value
Pfam IPR002086 EMBL-EBI Aldehyde dehydrogenase 2.2E-66
Pfam IPR002086 EMBL-EBI Aldehyde dehydrogenase 1.0E-126
Pfam IPR002086 EMBL-EBI Aldehyde dehydrogenase 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496837.1 2 490-512,533-552
F45H10.1.1 2 490-512,533-552
F45H10.1.2 2 490-512,533-552
Sequence
Target Sequence 
>C. ELEGANS:192937_AT
aaggatccgagctgatctgtggcggaaagcgaggcgagcatggaacatcgtacgagccga
cgctcatcacaaacgtccagtcgaacaccaacatcgcgcacaccgagatcttcggcccca
tcgcgtcggttcaaaagttccgcgacgagcaagaagtgctcgaggcggccaacaactgtc
gtgttggactagctggatacgtgttcggaagagatcaatccaggcttcaacgagtcgcaa
ggaaactcgaagtcgggatggttggagtcaatgagggcctgatcagctgtgcggaggctg
cgttcggaggagtcaaagagtcagggatcggacgtgaaggtggagctcaggggatcgacg
agttcaccaattggaactgccgtgtagcagctattccatgtatctatcacttgccaat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGGATCCGAGCTGATCTGTGGCGG 280 161 1097 Antisense
ATGGAACATCGTACGAGCCGACGCT 230 53 1136 Antisense
GCTCATCACAAACGTCCAGTCGAAC 345 301 1158 Antisense
GGTTCAAAAGTTCCGCGACGAGCAA 306 507 1224 Antisense
GGACTAGCTGGATACGTGTTCGGAA 13 525 1282 Antisense
TCAATCCAGGCTTCAACGAGTCGCA 709 631 1311 Antisense
CAATGAGGGCCTGATCAGCTGTGCG 407 181 1365 Antisense
GGAGGCTGCGTTCGGAGGAGTCAAA 436 515 1389 Antisense
GCTCAGGGGATCGACGAGTTCACCA 397 301 1441 Antisense
GGAACTGCCGTGTAGCAGCTATTCC 587 529 1469 Antisense
TTCCATGTATCTATCACTTGCCAAT 226 701 1490 Antisense
Sequence Source Affymetrix Proprietary Database