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[192905_s_at] dihydrolipoamide succinyltransferase

Description W02F12.5 /REP_DB=WormBase Gene ID /WP=CE14480 /TR=O45148 /GB=AAC04462.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=dihydrolipoamide succinyltransferase
Cluster 6grp_highest_10_10 > 03      6grp_high1_10_10 > 22      4grp_highest_8_8 > 25      4grp_high_8_8 > 59      6grp_highest_nonorm > 05      6grp_total > 22      4grp_total > 60      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Hat      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 6730
1 2 3 4 range
A 8110.5
(2.9)
P 		7584.4
(2.4)
P 		8207
(3)
P 		2011.5
(-3)
P 		6196
B 8133.5
(3)
P 		7467.8
(2.3)
P 		7714.1
(2.6)
P 		2146.4
(-3)
P 		5987
C 6613.8
(2)
P 		6743.5
(2.2)
P 		7603.6
(3)
P 		1476.9
(-3)
P 		6127
avr 7619.3
(2.8) 		7265.2
(2.4) 		7841.6
(3) 		1878.3
(-3) 		5963

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4498
1 2 3 4 5 6 range
A 6636.8
(1.6)
P 		7391.8
(3)
P 		5606
(-0.2)
P 		5410.9
(-0.6)
P 		5037.6
(-1.3)
P 		4089.2
(-3)
P 		3303
B 6966.1
(3)
P 		6264.4
(1.9)
P 		6999.9
(3)
P 		5691.1
(1.1)
P 		4845
(-0.2)
P 		2927.5
(-3)
P 		4072
C 6207.5
(1.3)
P 		6420.9
(1.6)
P 		7425.2
(3)
P 		4347.2
(-1.4)
P 		5559.9
(0.4)
P 		3196.7
(-3)
P 		4229
avr 6603.5
(2.8) 		6692.4
(3) 		6677
(3) 		5149.7
(0.2) 		5147.5
(0.2) 		3404.5
(-3) 		3288
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2704
1 2 3 4 range
A 2953
(3)
P 		1646.4
(0.1)
P 		2145.5
(1.2)
P 		294.4
(-3)
P 		2659
B 2593.7
(3)
P 		1844.4
(0.9)
P 		1787.5
(0.7)
P 		457.4
(-3)
P 		2136
C 2189.4
(1.8)
P 		1938.8
(1.2)
P 		2650.1
(3)
P 		249
(-3)
P 		2401
avr 2578.7
(3) 		1809.9
(0.9) 		2194.4
(2) 		333.6
(-3) 		2245

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1755
1 2 3 4 5 6 range
A 1223.4
(-2.2)
P 		2628.9
(3)
P 		1220.9
(-2.2)
P 		1372.3
(-1.6)
P 		1520.1
(-1.1)
P 		995.6
(-3)
P 		1633
B 2423.9
(3)
P 		2085.1
(1.5)
P 		1699.8
(-0.3)
P 		1507.4
(-1.1)
P 		1968.5
(0.9)
P 		1091.7
(-3)
P 		1332
C 2300.9
(3)
P 		1959.2
(1.6)
P 		1889.8
(1.3)
P 		874.2
(-3)
P 		1799.1
(0.9)
P 		1070.1
(-2.2)
P 		1427
avr 1982.7
(1.8) 		2224.4
(3) 		1603.5
(-0.2) 		1251.3
(-2) 		1762.6
(0.6) 		1052.5
(-3) 		1172
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192905_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11499
Sequence Type Exemplar sequence
Representative Public ID W02F12.5 NCBI
Target Description W02F12.5 /REP_DB=WormBase Gene ID /WP=CE14480 /TR=O45148 /GB=AAC04462.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=dihydrolipoamide succinyltransferase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_072299(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_072299 NCBI Caenorhabditis elegans W02F12.5 (W02F12.5) mRNA, complete cds. 11/11 None
SNAP00000016555 ENSEMBL cdna:SNAP chromosome:CEL140:V:6709889:6711684:-1 11/11 None
GENEFINDER00000016560 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:6709889:6711684:-1 11/11 None
W02F12.5.2 ENSEMBL cdna:known chromosome:CEL140:V:6709474:6711695:-1 gene:W02F12.5 11/11 None
W02F12.5.4 ENSEMBL cdna:known chromosome:CEL140:V:6709474:6711695:-1 gene:W02F12.5 11/11 None
W02F12.5.1 ENSEMBL cdna:known chromosome:CEL140:V:6709653:6711695:-1 gene:W02F12.5 11/11 None
W02F12.5.3 ENSEMBL cdna:known chromosome:CEL140:V:6709657:6711697:-1 gene:W02F12.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:6709889-6711685(-) 100.0 100.0
Public Domain and Genome References
Gene Title dihydrolipoamide succinyltransferase
Ensembl W02F12.5
Entrez Gene 179063 Entrez gene
SwissProt O45148 EMBL-EBI
WormBase CE31083 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:19405_AT 2-oxoacid dehydrogenase family protein at
ATH1-121501:248088_AT 2-oxoacid dehydrogenase family protein at
CANINE:1598387_AT similar to dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) cfa
CANINE:1596657_X_AT similar to dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) cfa
CANINE:1594251_AT similar to dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) cfa
CANINE_2:CFA.333.2.A1_S_AT similar to dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) cfa
CANINE_2:CFAAFFX.25990.1.S1_AT similar to dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) cfa
DROSOPHILA_2:1639513_AT dm
DROSGENOME1:153115_AT dm
CHICKEN:GGA.6085.3.S1_A_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) gga
CHICKEN:GGA.6085.1.S1_A_AT Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) gga
HU35KSUBA:S72422_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HUGENEFL:D26535_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
U133_X3P:HS.296348.0.S1_3P_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U133A_2:215210_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U133_PLUS_2:215210_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U133A:215210_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U95AV2:33257_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U95AV2:33258_G_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
HG-U95B:45545_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) hs
MOE430A:1431011_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430A_2:1431011_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430_2:1431011_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MG-U74AV2:97880_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MG-U74AV2:160289_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MG-U74CV2:169046_I_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOE430A:1423710_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430A_2:1423710_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430_2:1423710_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOE430B:1430161_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430_2:1430161_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOE430B:1437775_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MOUSE430_2:1437775_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) mm
MU19KSUBA:TC17257_AT Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone IMAGE:5068310) mm
MU19KSUBB:TC26468_AT Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone IMAGE:5068310) mm
MU19KSUBB:TC29071_AT Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone IMAGE:5068310) mm
MU19KSUBB:TC30216_AT Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone IMAGE:5068310) mm
RG-U34A:D90401_G_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) rn
RG-U34A:D90401_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) rn
RG-U34C:H31874_S_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) rn
RAE230A:1370879_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) rn
RAT230_2:1370879_AT dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) rn
YEAST_2:1774126_AT Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6099 tricarboxylic acid cycle inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
45252 oxoglutarate dehydrogenase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4149 dihydrolipoyllysine-residue succinyltransferase activity inferred from electronic annotation QuickGO AmiGO
8415 acyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_504700 W02F12.5 [Caenorhabditis elegans] gb|AAC04462.2| Hypothetical protein W02F12.5 [Caenorhabditis elegans] 0.0
blast CAE71937 Hypothetical protein CBG19001 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001078 EMBL-EBI Catalytic domain of components of various dehydrogenase complexes 1.0E-126
Pfam IPR000089 EMBL-EBI Biotin/lipoyl attachment 8.0E-23
Pfam IPR001078 EMBL-EBI Catalytic domain of components of various dehydrogenase complexes 3.6E-124
Sequence
Target Sequence 
>C. ELEGANS:192905_S_AT
cttatgctatgcttactaccttcaatgagattgatatgagcagcctcatcgaaatgagaa
agacttatcagaaggattttgttgccaagcacggagttaagctcggaatgatgtctccat
ttgtccgcgctgccgcctacgctcttcaagaatctccagttgttaacgccgttctcgatg
aaaacgaaattgtctaccgtcactttgtcgatatctccgttgctgttgctacaccgaaag
gactcgttgttccagtcttgagaaatgtcgagagcatgaattatgctcaaatcgaattgg
aacttgccaatctcggagtgaaggctcgtgacggaaagctggctgttgaagatatggagg
gaggaaccttcacgatttctaacggtggagtcttcggatccatgttcggaaccccaatca
tcaatccaccacaaagtgcaattttgggaatgcacggaccagagatccgaccaatcatgc
aaatcgctttgacctacgaccacagattgatcgatggaagagaggcagtcaccttcctca
a

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTTATGCTATGCTTACTACCTTCAA 292 221 779 Antisense
GAATCTCCAGTTGTTAACGCCGTTC 698 321 928 Antisense
ACGAAATTGTCTACCGTCACTTTGT 298 93 962 Antisense
TCACTTTGTCGATATCTCCGTTGCT 606 627 978 Antisense
GTTGCTGTTGCTACACCGAAAGGAC 158 431 997 Antisense
AAGGACTCGTTGTTCCAGTCTTGAG 352 161 1016 Antisense
GGAACTTGCCAATCTCGGAGTGAAG 195 529 1077 Antisense
GGAGGAACCTTCACGATTTCTAACG 576 513 1138 Antisense
TTCGGAACCCCAATCATCAATCCAC 353 695 1183 Antisense
TCGCTTTGACCTACGACCACAGATT 278 601 1262 Antisense
GAAGAGAGGCAGTCACCTTCCTCAA 254 339 1295 Antisense
Sequence Source Affymetrix Proprietary Database