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[192894_at] 3-oxo-5-alpha-steroid 4-dehydrogenase

Description F42F12.3 /REP_DB=WormBase Gene ID /WP=CE03314 /TR=Q20344 /GB=CAA92173.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=3-oxo-5-alpha-steroid 4-dehydrogenase
Cluster 6grp_highest_10_10 > 27      6grp_high1_10_10 > 62      4grp_highest_8_8 > 63      4grp_high_8_8 > 28      6grp_highest_nonorm > 53      6grp_total > 62      4grp_total > 28      6grp_highest_sub > 03_04      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 133
1 2 3 4 range
A 479
(-0.5)
P 		531.7
(3)
P 		478.4
(-0.6)
P 		441.7
(-3)
P 		90
B 471.5
(2.3)
P 		403.1
(-3)
P 		420.1
(-1.7)
P 		481.2
(3)
P 		78
C 434.3
(-1)
P 		464.7
(0.7)
P 		399
(-3)
P 		505.6
(3)
P 		107
avr 461.6
(1) 		466.5
(1.7) 		432.5
(-3) 		476.2
(3) 		44

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 798
1 2 3 4 5 6 range
A 521.9
(-2.6)
P 		599.2
(-1.9)
P 		1142.1
(3)
P 		1093.6
(2.6)
P 		629.4
(-1.6)
P 		474.3
(-3)
P 		668
B 525.5
(-2.9)
P 		557.8
(-2.7)
P 		1272
(3)
P 		935.8
(0.3)
P 		707.7
(-1.5)
P 		516.8
(-3)
P 		755
C 478
(-3)
P 		569.3
(-2.2)
P 		1033.6
(1.9)
P 		1164.4
(3)
P 		702.7
(-1)
P 		574.1
(-2.2)
P 		686
avr 508.5
(-3) 		575.4
(-2.4) 		1149.2
(3) 		1064.6
(2.2) 		679.9
(-1.4) 		521.7
(-2.9) 		641
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 110
1 2 3 4 range
A 174.4
(3)
P 		115.4
(-0.2)
P 		125.1
(0.3)
P 		64.7
(-3)
P 		110
B 150.3
(3)
P 		99.6
(-2.7)
P 		97.3
(-3)
P 		102.5
(-2.4)
P 		53
C 143.8
(3)
P 		133.6
(2)
P 		139.1
(2.5)
P 		85.2
(-3)
P 		59
avr 156.2
(3) 		116.2
(-0.3) 		120.5
(0) 		84.1
(-3) 		72

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 213
1 2 3 4 5 6 range
A 96.2
(-3)
P 		213.1
(0.9)
P 		248.7
(2)
P 		277.4
(3)
P 		189.9
(0.1)
P 		115.5
(-2.4)
P 		181
B 182.8
(-3)
P 		185.7
(-2.9)
P 		308.9
(3)
P 		247.9
(0.1)
P 		287.5
(2)
P 		192.7
(-2.5)
P 		126
C 177.2
(-2.8)
P 		173.7
(-3)
P 		263.1
(3)
P 		234.2
(1.1)
P 		227.4
(0.6)
P 		192.2
(-1.8)
P 		89
avr 152.1
(-3) 		190.8
(-1.1) 		273.6
(3) 		253.2
(2) 		234.9
(1.1) 		166.8
(-2.3) 		122
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192894_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16462
Sequence Type Exemplar sequence
Representative Public ID F42F12.3 NCBI
Target Description F42F12.3 /REP_DB=WormBase Gene ID /WP=CE03314 /TR=Q20344 /GB=CAA92173.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=3-oxo-5-alpha-steroid 4-dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077670(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077670 NCBI Caenorhabditis elegans F42F12.3 (F42F12.3) mRNA, complete cds. 11/11 None
GENEFINDER00000001335 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12350530:12351500:1 11/11 None
SNAP00000001331 ENSEMBL cdna:SNAP chromosome:CEL140:X:12350581:12351513:1 11/11 None
F42F12.3 ENSEMBL cdna:known chromosome:CEL140:X:12350509:12351513:1 gene:F42F12.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12350508-12351513(+) 100.0 100.0
Public Domain and Genome References
Gene Title 3-oxo-5-alpha-steroid 4-dehydrogenase
Ensembl F42F12.3
Entrez Gene 185670 Entrez gene
SwissProt Q20344 EMBL-EBI
WormBase CE03314 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:17023_S_AT 3-oxo-5-alpha-steroid 4-dehydrogenase, putative / steroid 5-alpha-reductase, putative at
ATH1-121501:266095_AT 3-oxo-5-alpha-steroid 4-dehydrogenase, putative / steroid 5-alpha-reductase, putative at
CANINE:1603655_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CANINE:1588705_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CANINE:1582848_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CANINE_2:CFA.3580.1.A1_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CANINE_2:CFAAFFX.16153.1.S1_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CANINE:1582849_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) cfa
CHICKEN:GGAAFFX.8291.1.S1_AT similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Steroid 5-alpha-reductase 1) (SR type 1) gga
HG-U133_PLUS_2:211056_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A:211056_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A_2:211056_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U95AV2:589_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HC-G110:589_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A:204675_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133_PLUS_2:204675_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-FOCUS:204675_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A_2:204675_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133_PLUS_2:210959_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A:210959_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HG-U133A_2:210959_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HU35KSUBC:RC_H16833_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
HUGENEFL:M32313_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
U133_X3P:G6523818_3P_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
U133_X3P:G4507200_3P_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
U133_X3P:G13623528_3P_S_AT steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) hs
MG-U74BV2:114126_AT steroid 5 alpha-reductase 1 mm
MG-U74CV2:168699_I_AT steroid 5 alpha-reductase 1 mm
MG-U74CV2:168713_I_AT steroid 5 alpha-reductase 1 mm
MG-U74CV2:168288_F_AT steroid 5 alpha-reductase 1 mm
MG-U74CV2:167514_F_AT steroid 5 alpha-reductase 1 mm
MG-U74CV2:165571_R_AT steroid 5 alpha-reductase 1 mm
MOE430B:1431101_A_AT steroid 5 alpha-reductase 1 mm
MOUSE430_2:1431101_A_AT steroid 5 alpha-reductase 1 mm
MOE430B:1454649_AT steroid 5 alpha-reductase 1 mm
MOUSE430_2:1454649_AT steroid 5 alpha-reductase 1 mm
MOE430B:1438699_AT steroid 5 alpha-reductase 1 mm
MOUSE430_2:1438699_AT steroid 5 alpha-reductase 1 mm
MOE430B:1453759_AT Steroid 5 alpha-reductase 1, mRNA (cDNA clone MGC:106228 IMAGE:5053446) mm
MOUSE430_2:1453759_AT Steroid 5 alpha-reductase 1, mRNA (cDNA clone MGC:106228 IMAGE:5053446) mm
MG-U74CV2:170119_R_AT Steroid 5 alpha-reductase 1, mRNA (cDNA clone MGC:106228 IMAGE:5053446) mm
MU19KSUBC:TC41514_AT Steroid 5 alpha-reductase 1, mRNA (cDNA clone MGC:106228 IMAGE:5053446) mm
RT-U34:J05035_AT steroid 5 alpha-reductase 1 rn
RG-U34A:J05035_AT steroid 5 alpha-reductase 1 rn
RT-U34:J05035_G_AT steroid 5 alpha-reductase 1 rn
RG-U34A:J05035_G_AT steroid 5 alpha-reductase 1 rn
RG-U34A:S81448_S_AT steroid 5 alpha-reductase 1 rn
RAE230A:1370420_AT steroid 5 alpha-reductase 1 rn
RAT230_2:1370420_AT steroid 5 alpha-reductase 1 rn
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92173 Hypothetical protein F42F12.3 [Caenorhabditis elegans] ref|NP_510071.1| F42F12.3 [Caenorhabditis elegans] 1.0E-144
blast CAA92173 Hypothetical protein F42F12.3 [Caenorhabditis elegans] ref|NP_510071.1| F42F12.3 [Caenorhabditis elegans] 1.0E-138
blast CAA92173 Hypothetical protein F42F12.3 [Caenorhabditis elegans] ref|NP_510071.1| F42F12.3 [Caenorhabditis elegans] 1.0E-130
blast CAA92168 Hypothetical protein F19H6.4 [Caenorhabditis elegans] ref|NP_510077.1| F19H6.4 [Caenorhabditis elegans] 1.0E-101
blast CAE57261 Hypothetical protein CBG00143 [Caenorhabditis briggsae] 2.0E-98
blast CAA92168 Hypothetical protein F19H6.4 [Caenorhabditis elegans] ref|NP_510077.1| F19H6.4 [Caenorhabditis elegans] 3.0E-98
blast CAE57261 Hypothetical protein CBG00143 [Caenorhabditis briggsae] 7.0E-96
Protein Domains
Database ID Description E-Value
Pfam IPR001104 EMBL-EBI 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal 1.5E-99
Pfam IPR001104 EMBL-EBI 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal 2.4E-95
Pfam IPR001104 EMBL-EBI 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal 1.5E-99
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510071.1 5 7-29,57-79,99-121,131-148,191-213
F42F12.3 5 7-29,57-79,99-121,131-148,191-213
GENEFINDER00000001335 5 2-24,50-72,92-114,124-141,184-206
SNAP00000001331 4 33-55,75-97,107-124,167-189
Sequence
Target Sequence 
>C. ELEGANS:192894_AT
gaatcaatccgaaactcgcatggtttatccaagagtctcccgcttttttcattcctttct
atttcttgtttggtggactatcttcaactggacgtattttgaattgcatttttctcgttc
attatttctacagggccttgatctatccgttccgcatccgatcgactacaaagtctccac
tcttaattgttgccgctgcagtagccttctgtacatacaacgggaccttgcaaggagttt
ggaattcctactatcaactggaggaagaattgacataccgtcatcttattggatctattc
tctatttctctggaatgtttatcaaccacaagtcagacaacatcctgatgacgttacgca
agcctggagagactgggtacaaaattccaactggatttttgtacgagtacatctcatgtc
ccaattattttggagaaatcatggaatggatcggctacgcaatcctcggctggaaccttc
ctgcactcgcgttcgcgatcttcacgtttgcgaacattggcccaagagcgattgcacatc
ac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATCAATCCGAAACTCGCATGGTT 423 327 134 Antisense
GGTGGACTATCTTCAACTGGACGTA 521 497 205 Antisense
TTTTCTCGTTCATTATTTCTACAGG 326 675 243 Antisense
TTCTACAGGGCCTTGATCTATCCGT 582 689 259 Antisense
AAGTCTCCACTCTTAATTGTTGCCG 145 159 304 Antisense
CGCTGCAGTAGCCTTCTGTACATAC 339 255 327 Antisense
GACGTTACGCAAGCCTGGAGAGACT 159 377 483 Antisense
GTACGAGTACATCTCATGTCCCAAT 192 459 534 Antisense
GGAATGGATCGGCTACGCAATCCTC 292 533 576 Antisense
TTCACGTTTGCGAACATTGGCCCAA 42 687 634 Antisense
TGGCCCAAGAGCGATTGCACATCAC 401 545 651 Antisense
Sequence Source Affymetrix Proprietary Database