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[192871_s_at] serine/threonine kinase (2 domains)

Description C49C3.10A /REP_DB=WormBase Gene ID /WP=CE19749 /TR=Q9XUF5 /GB=CAB05163.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster 6grp_highest_10_10 > 77      6grp_high1_10_10 > 86      4grp_highest_8_8 > 19      4grp_high_8_8 > 63      6grp_highest_nonorm > 93      6grp_total > 77      4grp_total > 40      6grp_highest_sub > Da      6grp_high1_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 193
1 2 3 4 range
A 276.9
(-0.9)
P 		210.8
(-3)
P 		399.7
(3)
P 		320.6
(0.5)
P 		189
B 234.4
(-3)
P 		259
(-0.2)
P 		287
(3)
P 		257.4
(-0.4)
P 		53
C 275.9
(-2.3)
P 		271.3
(-2.5)
P 		404.1
(3)
P 		259
(-3)
P 		145
avr 262.4
(-2.2) 		247
(-3) 		363.6
(3) 		279
(-1.4) 		117

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 763
1 2 3 4 5 6 range
A 228.7
(-3)
P 		289.4
(-2.4)
P 		323.9
(-2)
P 		362.7
(-1.7)
P 		514.3
(-0.1)
P 		828.4
(3)
P 		600
B 268.3
(-3)
P 		354.4
(-2.3)
P 		277
(-2.9)
P 		430.4
(-1.6)
P 		447.8
(-1.5)
P 		977.3
(3)
P 		709
C 214.7
(-3)
P 		345.4
(-2)
P 		336.6
(-2)
P 		383.5
(-1.6)
P 		408.1
(-1.4)
P 		963
(3)
P 		748
avr 237.2
(-3) 		329.7
(-2.2) 		312.5
(-2.3) 		392.2
(-1.6) 		456.7
(-1.1) 		922.9
(3) 		686
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 97
1 2 3 4 range
A 100.8
(2.6)
P 		45.8
(-3)
P 		104.5
(3)
P 		46.9
(-2.9)
P 		59
B 74.8
(3)
P 		64
(-0.2)
P 		66.5
(0.5)
P 		54.8
(-3)
P 		20
C 91.3
(-0.1)
P 		78
(-0.9)
P 		140.8
(3)
P 		43.7
(-3)
P 		97
avr 89
(1.4) 		62.6
(-1.5) 		103.9
(3) 		48.5
(-3) 		55

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 322
1 2 3 4 5 6 range
A 42.2
(-3)
P 		102.9
(-0.7)
P 		70.5
(-1.9)
P 		92
(-1.1)
P 		155.2
(1.3)
P 		201.7
(3)
P 		160
B 93.3
(-2.5)
P 		118
(-2)
P 		67.3
(-3)
P 		114
(-2.1)
P 		181.9
(-0.7)
P 		364.4
(3)
P 		297
C 79.6
(-2.9)
P 		105.4
(-2.3)
P 		85.7
(-2.8)
P 		77.1
(-3)
P 		132.1
(-1.7)
P 		322.4
(3)
P 		245
avr 71.7
(-3) 		108.8
(-2) 		74.5
(-2.9) 		94.4
(-2.4) 		156.4
(-0.7) 		296.2
(3) 		225
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192871_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10071
Sequence Type Exemplar sequence
Representative Public ID C49C3.10A NCBI
Target Description C49C3.10A /REP_DB=WormBase Gene ID /WP=CE19749 /TR=Q9XUF5 /GB=CAB05163.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_001027915(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_001027915 NCBI Caenorhabditis elegans C49C3.10 (C49C3.10) mRNA, complete cds. 11/11 None
SNAP00000040199 ENSEMBL cdna:SNAP chromosome:CEL140:IV:17336882:17338917:-1 11/11 None
GENEFINDER00000040206 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:17336882:17342188:-1 11/11 None
C49C3.10b ENSEMBL cdna:known chromosome:CEL140:IV:17336800:17338939:-1 gene:C49C3.10 11/11 None
C49C3.10a ENSEMBL cdna:known chromosome:CEL140:IV:17336882:17338917:-1 gene:C49C3.10 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:17336887-17338923(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (2 domains)
Ensembl C49C3.10
Entrez Gene 178518 Entrez gene
WormBase CE23605 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
4867 serine-type endopeptidase inhibitor activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB54196 Hypothetical protein C49C3.10 [Caenorhabditis elegans] ref|NP_001023086.1| C49C3.10 [Caenorhabditis elegans] 0.0
blast CAB05162 Hypothetical protein C49C3.9 [Caenorhabditis elegans] ref|NP_503088.1| C49C3.9 [Caenorhabditis elegans] 0.0
blast CAE57479 Hypothetical protein CBG00447 [Caenorhabditis briggsae] 1.0E-151
blast CAE57479 Hypothetical protein CBG00447 [Caenorhabditis briggsae] 1.0E-148
blast CAE57479 Hypothetical protein CBG00447 [Caenorhabditis briggsae] 1.0E-147
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-59
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-60
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-14
hanks 3.1.5 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk6 2.0E-57
hanks 3.1.5 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk6 1.0E-57
hanks 3.1.2 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk2 3.0E-24
hanks 3.1.2 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk2 6.0E-25
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 4.8E-50
Pfam IPR000719 EMBL-EBI Protein kinase 1.8E-8
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-33
Pfam IPR000719 EMBL-EBI Protein kinase 7.3E-47
Pfam IPR000719 EMBL-EBI Protein kinase 1.8E-8
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-33
Sequence
Target Sequence 
>C. ELEGANS:192871_S_AT
ctggtccttgggatgtattctcgcagagttgctaaccggtcatgtactattccgtggcaa
agatcacattgatcagttcattttaatggttcagttcctaggaaacgcaggaccatcttt
ctactcacaaatgaatgagcatgccagaaactttttgctccgttataacctagatcagta
ccaggctccaatcaatttttactctcgctttcccgacacggtattccaaggagttttgca
attcgagccaaaggaatgtgatatgtcacgtgatcttcttttccgaatgttggttattaa
tccggacgatcgacttaatatacaaatggttttgtcgcatccgtatttgagagagatttg
gggcgaaattgtggccgaagatgtgattcctgagcctcagcctccaaatgagcttctcag
atttttcgattttcaaccttattcgagtccat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTGGTCCTTGGGATGTATTCTCGCA 409 241 678 Antisense
GCAGAGTTGCTAACCGGTCATGTAC 114 313 700 Antisense
GGTCATGTACTATTCCGTGGCAAAG 652 503 715 Antisense
GAAACGCAGGACCATCTTTCTACTC 473 357 779 Antisense
CATGCCAGAAACTTTTTGCTCCGTT 487 211 817 Antisense
GGCTCCAATCAATTTTTACTCTCGC 606 539 861 Antisense
GCTTTCCCGACACGGTATTCCAAGG 623 301 884 Antisense
TATGTCACGTGATCTTCTTTTCCGA 494 655 939 Antisense
GGTTTTGTCGCATCCGTATTTGAGA 651 505 1005 Antisense
TCAGCCTCCAAATGAGCTTCTCAGA 592 625 1074 Antisense
GATTTTCAACCTTATTCGAGTCCAT 525 429 1105 Antisense
Sequence Source Affymetrix Proprietary Database