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[192863_at] serine protease inhibitor

Description C05E4.1 /REP_DB=WormBase Gene ID /WP=CE07935 /GEN=srp-2 /TR=O17365 /GB=AAB71270.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine protease inhibitor
Cluster 6grp_highest_10_10 > 69      6grp_high1_10_10 > 98      4grp_highest_8_8 > 30      4grp_high_8_8 > 05      6grp_highest_nonorm > 91      6grp_total > 96      4grp_total > 04      6grp_highest_sub > In      6grp_cgc > 78      6grp_high1_sub > In      6grp_cgc_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1028
1 2 3 4 range
A 307
(-2)
P 		156.6
(-2.9)
P 		147.6
(-3)
P 		1104.2
(3)
P 		957
B 301.5
(-1.9)
P 		153.6
(-2.8)
P 		114.6
(-3)
P 		1142.6
(3)
P 		1028
C 401.4
(-1.3)
P 		131.7
(-2.9)
P 		118.7
(-3)
P 		1126.6
(3)
P 		1008
avr 336.6
(-1.7) 		147.3
(-2.9) 		127
(-3) 		1124.5
(3) 		998

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 354
1 2 3 4 5 6 range
A 113.6
(-2.4)
P 		86.6
(-3)
P 		268.6
(1)
P 		257.5
(0.8)
P 		360
(3)
P 		340.4
(2.6)
P 		273
B 155.3
(-1.9)
P 		102.2
(-3)
P 		159.4
(-1.8)
P 		233
(-0.3)
P 		365.6
(2.5)
P 		392
(3)
P 		290
C 95.6
(-3)
P 		151
(-2)
P 		188.4
(-1.4)
P 		244.8
(-0.4)
P 		292.4
(0.4)
P 		441
(3)
P 		345
avr 121.5
(-2.8) 		113.3
(-3) 		205.5
(-1) 		245.1
(-0.2) 		339.3
(1.9) 		391.1
(3) 		278
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 217
1 2 3 4 range
A 111.8
(0.7)
P 		34
(-3)
P 		38.6
(-2.8)
P 		161.6
(3)
P 		128
B 96.1
(-1.1)
P 		37.9
(-2.7)
P 		26.5
(-3)
P 		243.5
(3)
P 		217
C 132.9
(0.7)
P 		37.9
(-3)
P 		41.4
(-2.9)
P 		190
(3)
P 		152
avr 113.6
(-0.1) 		36.6
(-3) 		35.5
(-3) 		198.4
(3) 		163

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 128
1 2 3 4 5 6 range
A 20.9
(-3)
P 		30.8
(-2.3)
P 		58.5
(-0.4)
P 		65.3
(0)
P 		108.6
(3)
P 		82.9
(1.2)
P 		88
B 54
(-2)
P 		34
(-3)
P 		38.7
(-2.8)
P 		61.7
(-1.5)
P 		148.6
(3)
P 		146.2
(2.9)
P 		115
C 35.5
(-3)
P 		46.1
(-2.4)
P 		48
(-2.3)
P 		49.2
(-2.3)
P 		94.6
(0.2)
P 		147.6
(3)
P 		112
avr 36.8
(-3) 		37
(-3) 		48.4
(-2.2) 		58.7
(-1.5) 		117.3
(2.4) 		125.6
(3) 		89
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192863_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14801
Sequence Type Exemplar sequence
Representative Public ID C05E4.1 NCBI
Target Description C05E4.1 /REP_DB=WormBase Gene ID /WP=CE07935 /GEN=srp-2 /TR=O17365 /GB=AAB71270.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine protease inhibitor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070917(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070917 NCBI Caenorhabditis elegans SeRPin family member (srp-2) (srp-2) mRNA, complete cds. 11/11 None
SNAP00000009768 ENSEMBL cdna:SNAP chromosome:CEL140:V:762684:764376:1 11/11 None
GENEFINDER00000009778 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:762053:764376:1 11/11 None
C05E4.1 ENSEMBL cdna:known chromosome:CEL140:V:762647:764425:1 gene:C05E4.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:762683-764376(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine protease inhibitor
Gene Symbol srp-2
Ensembl C05E4.1
Entrez Gene 178586 Entrez gene
SwissProt O17365 EMBL-EBI
WormBase CE07935 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262440_AT serpin, putative / serine protease inhibitor, putative at
ATGENOME1:19322_AT serpin, putative / serine protease inhibitor, putative at
CANINE:1591479_AT similar to Neuroserpin precursor (Serpin I1) (Protease inhibitor 12) cfa
CANINE_2:CFA.19763.1.S1_S_AT similar to Neuroserpin precursor (Serpin I1) (Protease inhibitor 12) cfa
CANINE_2:CFA.9310.1.S1_AT similar to Neuroserpin precursor (Serpin I1) (Protease inhibitor 12) cfa
CANINE_2:CFAAFFX.22493.1.S1_AT similar to Neuroserpin precursor (Serpin I1) (Protease inhibitor 12) cfa
CANINE_2:CFAAFFX.22493.1.S1_S_AT similar to Neuroserpin precursor (Serpin I1) (Protease inhibitor 12) cfa
DROSOPHILA_2:1623459_AT Serine protease inhibitor 4 dm
DROSOPHILA_2:1632245_A_AT Serine protease inhibitor 4 dm
DROSGENOME1:146699_AT Serine protease inhibitor 4 dm
CHICKEN:GGA.4416.1.S1_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 gga
HG-U133_PLUS_2:205352_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HG-U133A:205352_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HG-FOCUS:205352_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HG-U133A_2:205352_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HU35KSUBA:Z81326_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HUGENEFL:Z81326_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
U133_X3P:G4826903_3P_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
HG-U95AV2:37259_AT serpin peptidase inhibitor, clade I (neuroserpin), member 1 hs
MG-U74AV2:99494_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOE430A:1448443_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOUSE430A_2:1448443_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOUSE430_2:1448443_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOE430A:1416702_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOUSE430A_2:1416702_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOUSE430_2:1416702_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 mm
MOE430B:1443756_AT Serine (or cysteine) peptidase inhibitor, clade I, member 1, mRNA (cDNA clone MGC:6413 IMAGE:3588856) mm
MOUSE430_2:1443756_AT Serine (or cysteine) peptidase inhibitor, clade I, member 1, mRNA (cDNA clone MGC:6413 IMAGE:3588856) mm
RG-U34C:RC_AI229145_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAE230A:1387131_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAT230_2:1387131_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAE230A:1368256_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAT230_2:1368256_AT serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAE230B:1391850_AT Serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
RAT230_2:1391850_AT Serine (or cysteine) peptidase inhibitor, clade I, member 1 rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
4867 serine-type endopeptidase inhibitor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB71270 Serpin protein 2 [Caenorhabditis elegans] ref|NP_503318.1| SeRPin family member (srp-2) [Caenorhabditis elegans] 0.0
blast AAS13528 serine or cysteine protease inhibitor [Caenorhabditis elegans] 0.0
blast CAE62273 Hypothetical protein CBG06332 [Caenorhabditis briggsae] 1.0E-135
Protein Domains
Database ID Description E-Value
Pfam IPR000215 EMBL-EBI Serpin 1.0E-77
Pfam IPR000215 EMBL-EBI Serpin 1.0E-77
Sequence
Target Sequence 
>C. ELEGANS:192863_AT
tctagacagatcccatttctcacggagctcgacgagcaccgagactacacagaggatgtc
ttattccaagtgttgtcgctaaaatacgcggatcccaagttcactctggcaattttcctt
cccaaacaaagatttggattggttgatgctctggagaaaatcaatggagaatacatccaa
aatctgctcaacgacttgaaaagtagctacgttagcgtgcaaattcccaagttcaaaatc
gaaaaagagctagacttgaaggaaacactagaggctatcggtatcaaggagatctttgcg
gaaggagctgacttatccggaatcgcggacaaggtattcatctcgtcagggatccacaaa
gcaatcattgaagtcgacgaggatgggaccacagcggcggctgcgtcggcgttcaaggtg
cagctggaaatgatgatcatggcggagcccacgcagttcgttgctgatcacccatttctg
tttgctgttctgtttg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCTAGACAGATCCCATTTCTCACGG 275 613 562 Antisense
GAGCTCGACGAGCACCGAGACTACA 1 389 586 Antisense
GGATCCCAAGTTCACTCTGGCAATT 679 511 651 Antisense
TGGCAATTTTCCTTCCCAAACAAAG 341 543 668 Antisense
ACATCCAAAATCTGCTCAACGACTT 311 107 734 Antisense
GTTAGCGTGCAAATTCCCAAGTTCA 625 445 772 Antisense
AGGAGCTGACTTATCCGGAATCGCG 401 55 864 Antisense
AGGTATTCATCTCGTCAGGGATCCA 398 57 893 Antisense
CGACGAGGATGGGACCACAGCGGCG 585 251 936 Antisense
CTGCGTCGGCGTTCAAGGTGCAGCT 511 235 962 Antisense
CCATTTCTGTTTGCTGTTCTGTTTG 181 271 1033 Antisense
Sequence Source Affymetrix Proprietary Database