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[192798_at] diptheria toxin resistance protein

Description C14B1.5 /REP_DB=WormBase Gene ID /WP=CE17401 /TR=SW:P49958 /GB=CAA85493.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=diptheria toxin resistance protein
Cluster 6grp_highest_10_10 > 77      6grp_high1_10_10 > 77      4grp_highest_8_8 > 23      4grp_high_8_8 > 05      6grp_highest_nonorm > 84      6grp_total > 77      4grp_total > 03      6grp_highest_sub > Da      6grp_high1_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1936
1 2 3 4 range
A 645
(-2.2)
P 		456.2
(-2.8)
P 		413.5
(-3)
P 		2112.9
(3)
P 		1699
B 607.2
(-2.3)
P 		471.4
(-2.8)
P 		391.1
(-3)
P 		2326.9
(3)
P 		1936
C 625.1
(-2.3)
P 		415.5
(-3)
P 		515.4
(-2.7)
P 		2190.5
(3)
P 		1775
avr 625.8
(-2.4) 		447.7
(-3) 		440
(-3) 		2210.1
(3) 		1770

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 442
1 2 3 4 5 6 range
A 544.8
(-1.7)
P 		539
(-1.9)
P 		511.5
(-3)
P 		518
(-2.7)
P 		584.2
(-0.2)
P 		666
(3)
P 		155
B 513
(-3)
P 		543.4
(-2.4)
P 		541.5
(-2.5)
P 		555.6
(-2.2)
P 		605.8
(-1.3)
P 		834.6
(3)
P 		322
C 470
(-2.9)
P 		523.8
(-2.1)
P 		459
(-3)
P 		585.6
(-1.3)
P 		540.3
(-1.9)
P 		901
(3)
P 		442
avr 509.3
(-2.9) 		535.4
(-2.4) 		504
(-3) 		553.1
(-2) 		576.8
(-1.5) 		800.5
(3) 		297
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 405
1 2 3 4 range
A 234.9
(0.9)
P 		99
(-3)
P 		108.1
(-2.7)
P 		309.3
(3)
P 		210
B 193.6
(-1.5)
P 		116.4
(-2.6)
P 		90.6
(-3)
P 		495.9
(3)
P 		405
C 206.9
(-0.9)
P 		119.5
(-3)
P 		179.6
(-1.6)
P 		369.4
(3)
P 		250
avr 211.8
(-0.9) 		111.6
(-3) 		126.1
(-2.7) 		391.5
(3) 		280

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 211
1 2 3 4 5 6 range
A 100.4
(-3)
P 		191.7
(3)
P 		111.4
(-2.3)
P 		131.4
(-1)
P 		176.3
(2)
P 		162.1
(1.1)
P 		91
B 178.5
(-1.4)
P 		180.9
(-1.4)
P 		131.5
(-3)
P 		147.2
(-2.5)
P 		246.1
(0.8)
P 		311.2
(3)
P 		180
C 174.2
(-1.1)
P 		159.8
(-1.6)
P 		116.8
(-3)
P 		117.8
(-3)
P 		174.8
(-1.1)
P 		301.6
(3)
P 		185
avr 151
(-1.7) 		177.5
(-0.5) 		119.9
(-3) 		132.1
(-2.5) 		199.1
(0.4) 		258.3
(3) 		138
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192798_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6078
Sequence Type Exemplar sequence
Representative Public ID C14B1.5 NCBI
Target Description C14B1.5 /REP_DB=WormBase Gene ID /WP=CE17401 /TR=SW:P49958 /GB=CAA85493.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=diptheria toxin resistance protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065349(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065349 NCBI Caenorhabditis elegans C14B1.5 (C14B1.5) mRNA, complete cds. 11/11 None
GENEFINDER00000040972 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:3705265:3712953:1 10/11 None
SNAP00000040961 ENSEMBL cdna:SNAP chromosome:CEL140:III:3706865:3709102:1 11/11 None
C14B1.5.2 ENSEMBL cdna:known chromosome:CEL140:III:3706865:3709192:1 gene:C14B1.5 11/11 None
C14B1.5.1 ENSEMBL cdna:known chromosome:CEL140:III:3706865:3709177:1 gene:C14B1.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:3706864-3709102(+) 100.0 100.0
Public Domain and Genome References
Gene Title diptheria toxin resistance protein
Ensembl C14B1.5
Entrez Gene 175475 Entrez gene
SwissProt P49958 EMBL-EBI
WormBase CE17401 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:247510_AT diphthamide synthesis DPH2 family protein at
CANINE_2:CFAAFFX.29384.1.S1_AT similar to diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 cfa
DROSOPHILA_2:1625173_S_AT dm
DROSGENOME1:153715_AT dm
HG-U133A_2:222041_AT DPH1 homolog (S. cerevisiae) hs
HG-U133_PLUS_2:222041_AT DPH1 homolog (S. cerevisiae) hs
HG-U133A:222041_AT DPH1 homolog (S. cerevisiae) hs
HG-FOCUS:202632_AT DPH1 homolog (S. cerevisiae) hs
HG-U133A:202632_AT DPH1 homolog (S. cerevisiae) hs
HG-U133_PLUS_2:202632_AT DPH1 homolog (S. cerevisiae) hs
HG-U133A_2:202632_AT DPH1 homolog (S. cerevisiae) hs
HU35KSUBD:RC_R41360_S_AT DPH1 homolog (S. cerevisiae) hs
HUGENEFL:U34880_AT DPH1 homolog (S. cerevisiae) hs
U133_X3P:G4503360_3P_AT DPH1 homolog (S. cerevisiae) hs
U133_X3P:HS.26034.0.A1_3P_AT DPH1 homolog (S. cerevisiae) hs
HG-U95AV2:38477_AT DPH1 homolog (S. cerevisiae) hs
HG-U133_PLUS_2:237204_AT Candidate tumor suppressor in ovarian cancer 2 hs
HG-U133B:237204_AT Candidate tumor suppressor in ovarian cancer 2 hs
HG-U95B:45444_AT Candidate tumor suppressor in ovarian cancer 2 hs
HG-U95E:67995_AT Candidate tumor suppressor in ovarian cancer 2 hs
HG-U95D:87259_AT Candidate tumor suppressor in ovarian cancer 2 hs
HU35KSUBB:RC_N52176_AT Candidate tumor suppressor in ovarian cancer 2 hs
U133_X3P:HS.312671.0.A1_3P_AT Candidate tumor suppressor in ovarian cancer 2 hs
MG-U74BV2:117260_AT DPH1 homolog (S. cerevisiae) mm
MG-U74BV2:164584_F_AT DPH1 homolog (S. cerevisiae) mm
MOE430A:1418335_A_AT DPH1 homolog (S. cerevisiae) mm
MOUSE430A_2:1418335_A_AT DPH1 homolog (S. cerevisiae) mm
MOUSE430_2:1418335_A_AT DPH1 homolog (S. cerevisiae) mm
MOE430B:1432149_AT DPH1 homolog (S. cerevisiae) mm
MOUSE430_2:1432149_AT DPH1 homolog (S. cerevisiae) mm
YEAST_2:1775775_AT Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p Sc
Protein Similarities
Method ID Description E-Value
blast CAA85493 Hypothetical protein C14B1.5 [Caenorhabditis elegans] ref|NP_497750.1| C14B1.5 [Caenorhabditis elegans] sp|P49958|YKY5_CAEEL Hypothetical protein C14B1.5 in chromosome III 0.0
blast CAE64483 Hypothetical protein CBG09207 [Caenorhabditis briggsae] 0.0
blast CAB63431 Hypothetical protein C14B1.10 [Caenorhabditis elegans] ref|NP_497751.1| C14B1.10 [Caenorhabditis elegans] 0.0
blast CAA85487 Hypothetical protein C14B1.4 [Caenorhabditis elegans] ref|NP_497749.1| C14B1.4 [Caenorhabditis elegans] sp|Q17963|YKY4_CAEEL Hypothetical WD-repeat protein C14B1.4 in chromosome III 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR002728 EMBL-EBI Diphthamide synthesis DPH2 protein 1.0E-126
Pfam IPR005123 EMBL-EBI 2OG-Fe(II) oxygenase superfamily 1.1E-10
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 1.5E-12
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 7.2E-11
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 3.8E-11
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 6.7E-14
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 1.5E-5
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 2.5E-7
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.022
Pfam IPR002728 EMBL-EBI Diphthamide synthesis DPH2 protein 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192798_AT
agttctgggatgtacgtctccacgattggatgcatcgaaatacgatgcaattgtctatct
tggagatggacgatttcatctcgaatcaattatgattcataatccagaaattgaagcatt
ccagtatgatccttattcaagaaagttgacacgagagttttatgatcatgatttaatgcg
gaaaaatcgaattggctcgattgagattgctaggaagtgcacgacatttggccttattca
gggaactcttggacgacaaggaaacctgaaagttgttgaagaacttgaagcacagctgga
gagaaaaggaaagaagtttctgagagtcttactgtcagaaatcttcccggaaaagctggc
aatgttcccagaagtagactgttgggtgcaagtagcgtgtcctagattatcgattgattg
gggaactcagttcccgaaacctttgctctatccttttgaactcgcggttgctctcgataa
tatttcggtgccttcagatcactggccaatggactattattcgaatgattccctgggtcc
ttggac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGTTCTGGGATGTACGTCTCCACGA 105 63 582 Antisense
ACGTCTCCACGATTGGATGCATCGA 239 95 595 Antisense
GAAGCATTCCAGTATGATCCTTATT 441 341 694 Antisense
TGCACGACATTTGGCCTTATTCAGG 649 575 799 Antisense
TATTCAGGGAACTCTTGGACGACAA 446 659 816 Antisense
CTTACTGTCAGAAATCTTCCCGGAA 465 221 909 Antisense
TGTTGGGTGCAAGTAGCGTGTCCTA 110 563 961 Antisense
CTCTATCCTTTTGAACTCGCGGTTG 667 229 1027 Antisense
AACTCGCGGTTGCTCTCGATAATAT 288 141 1040 Antisense
TTTCGGTGCCTTCAGATCACTGGCC 111 671 1064 Antisense
CGAATGATTCCCTGGGTCCTTGGAC 400 241 1103 Antisense
Sequence Source Affymetrix Proprietary Database