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[192786_s_at] saicar synthetase/air carboxlyase

Description B0286.3 /REP_DB=WormBase Gene ID /WP=CE03863 /TR=SW:Q10457 /GB=AAA80690.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=saicar synthetase-air carboxlyase
Cluster 6grp_highest_10_10 > 47      6grp_high1_10_10 > 74      4grp_highest_8_8 > 21      4grp_high_8_8 > 23      6grp_highest_nonorm > 35      6grp_total > 64      4grp_total > 16      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2712
1 2 3 4 range
A 877.1
(-3)
P 		1639.9
(-1.3)
P 		2061.6
(-0.4)
P 		3588.7
(3)
P 		2712
B 1066.2
(-3)
P 		1366.4
(-2.3)
P 		2259.5
(-0.1)
P 		3502.4
(3)
P 		2436
C 923.8
(-3)
P 		1292.1
(-2.1)
P 		2173.8
(0)
P 		3390.3
(3)
P 		2467
avr 955.7
(-3) 		1432.8
(-1.9) 		2165
(-0.1) 		3493.8
(3) 		2538

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4063
1 2 3 4 5 6 range
A 1366.9
(-3)
P 		2785.5
(-0.6)
P 		4949.1
(3)
P 		3935.1
(1.3)
P 		3124.1
(-0.1)
P 		3992.7
(1.4)
P 		3582
B 1432
(-3)
P 		3040.4
(-0.5)
P 		5258.2
(3)
P 		3606.7
(0.4)
P 		3194
(-0.2)
P 		4201.5
(1.3)
P 		3826
C 1195
(-3)
P 		3223.3
(0.5)
P 		4669.4
(3)
P 		4040.2
(1.9)
P 		2874.1
(-0.1)
P 		4024.4
(1.9)
P 		3474
avr 1331.3
(-3) 		3016.4
(-0.2) 		4958.9
(3) 		3860.7
(1.2) 		3064.1
(-0.1) 		4072.9
(1.5) 		3628
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 452
1 2 3 4 range
A 319.4
(-3)
P 		356
(-2)
P 		538.9
(3)
P 		525.3
(2.6)
P 		220
B 340
(-3)
P 		337.5
(-3)
P 		523.6
(-0.3)
P 		746.4
(3)
P 		409
C 305.8
(-3)
P 		371.5
(-2.1)
P 		757.6
(3)
P 		571.7
(0.5)
P 		452
avr 321.7
(-3) 		355
(-2.3) 		606.7
(2.8) 		614.5
(3) 		293

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1315
1 2 3 4 5 6 range
A 252
(-3)
P 		990.7
(2.4)
P 		1077.8
(3)
P 		998
(2.4)
P 		942.7
(2)
P 		972.1
(2.2)
P 		826
B 498.3
(-3)
P 		1012
(-0.1)
P 		1276.9
(1.4)
P 		955.3
(-0.4)
P 		1297.7
(1.5)
P 		1566.7
(3)
P 		1068
C 442.9
(-3)
P 		983.5
(0.6)
P 		1188.4
(1.9)
P 		812.5
(-0.5)
P 		930
(0.2)
P 		1347.2
(3)
P 		904
avr 397.7
(-3) 		995.4
(1) 		1181
(2.2) 		921.9
(0.5) 		1056.8
(1.4) 		1295.3
(3) 		898
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192786_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5205
Sequence Type Exemplar sequence
Representative Public ID B0286.3 NCBI
Target Description B0286.3 /REP_DB=WormBase Gene ID /WP=CE03863 /TR=SW:Q10457 /GB=AAA80690.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=saicar synthetase-air carboxlyase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062370(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062370 NCBI Caenorhabditis elegans B0286.3 (B0286.3) mRNA, complete cds. 11/11 None
SNAP00000035723 ENSEMBL cdna:SNAP chromosome:CEL140:II:4359682:4372509:-1 11/11 None
GENEFINDER00000035730 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:4369741:4372509:-1 11/11 None
B0286.3 ENSEMBL cdna:known chromosome:CEL140:II:4369630:4372536:-1 gene:B0286.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:4369739-4372508(-) 100.0 100.0
Public Domain and Genome References
Gene Title saicar synthetase/air carboxlyase
Ensembl B0286.3
Entrez Gene 173772 Entrez gene
SwissProt Q10457 EMBL-EBI
WormBase CE03863 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.1028.1.A1_S_AT similar to Multifunctional protein ADE2 cfa
CANINE_2:CFA.17965.1.S1_S_AT similar to Multifunctional protein ADE2 cfa
DROSOPHILA_2:1640599_AT dm
DROSGENOME1:153428_AT dm
CHICKEN:GGA.3058.1.S1_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase gga
HG-U133_PLUS_2:201013_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A_2:201013_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-FOCUS:201013_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A:201013_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133_PLUS_2:201014_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A_2:201014_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A:201014_S_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U95AV2:39056_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HU35KSUBA:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HU35KSUBB:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HU35KSUBC:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HU35KSUBD:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HUGENEFL:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HC-G110:HUM_ALU_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HUGENEFL:X53793_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
U133_X3P:G5453538_3P_A_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
U133_X3P:HS.117950.1.S1_3P_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
U133_X3P:HS.117950.0.S2_3P_A_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A_2:214664_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133_PLUS_2:214664_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U133A:214664_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
HG-U95C:58132_AT Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase hs
MOUSE430A_2:1423564_A_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOUSE430_2:1423564_A_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOE430A:1423564_A_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOUSE430A_2:1423565_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOUSE430_2:1423565_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOE430A:1423565_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOE430A:1436298_X_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOUSE430A_2:1436298_X_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MOUSE430_2:1436298_X_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase mm
MG-U74CV2:140815_AT Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase, mRNA (cDNA clone MGC:25530 IMAGE:3586809) mm
MU19KSUBA:TC14546_F_AT Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase, mRNA (cDNA clone MGC:25530 IMAGE:3586809) mm
MU19KSUBB:TC30904_S_AT Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase, mRNA (cDNA clone MGC:25530 IMAGE:3586809) mm
MU19KSUBC:TC35638_I_AT Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase, mRNA (cDNA clone MGC:25530 IMAGE:3586809) mm
RG-U34A:RC_AA866248_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase rn
RAE230A:1387790_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase rn
RAT230_2:1387790_AT phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6164 purine nucleotide biosynthesis inferred from electronic annotation QuickGO AmiGO
6189 'de novo' IMP biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
9320 phosphoribosylaminoimidazole carboxylase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4638 phosphoribosylaminoimidazole carboxylase activity inferred from electronic annotation QuickGO AmiGO
4639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA80690 Hypothetical protein B0286.3 [Caenorhabditis elegans] ref|NP_494771.1| B0286.3 [Caenorhabditis elegans] sp|Q10457|PUR6_CAEEL Probable multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (AIR carboxylase) (AIRC)] 0.0
blast CAE60130 Hypothetical protein CBG03675 [Caenorhabditis briggsae] 0.0
blast CAI21320 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Danio rerio] 1.0E-118
Protein Domains
Database ID Description E-Value
Pfam IPR001636 EMBL-EBI SAICAR synthetase 1.0E-126
Pfam IPR000031 EMBL-EBI 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase 2.4E-81
Pfam IPR000031 EMBL-EBI 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase 2.4E-78
Sequence
Target Sequence 
>C. ELEGANS:192786_S_AT
ggggttggctctcgttttgaagaattatacaaaggttatggatatcactgccaccttctc
aaaacaccagcaaaaatgccatgttcttgtgatcatgggatctggttcggatggcgtatt
cgcacggaaaatctctgatgaagccaagaaatttggactggaaactacgctgaaagtaag
ctcagctcataaaactacctcggacactctggaagttatcgctgatttcgaagaaagtgg
agttccgacagttgtgattgcagtagctggaagatccaatggactcggtccagttattgc
tggaaactcgtctcttccggtgatcaactgcccgccaccaagtgaatcaacgagtcttga
catttggtcatcactccgaatgccgaatggaatcgggtgtactacagtgttggacccatc
ggaggccgcgcttgccgccgcaaaaatcctcgcgtctcacaatcatattgtgtttggaaa
agtgctcactgcacagctcaagaatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGGGTTGGCTCTCGTTTTGAAGAAT 464 497 741 Antisense
GGTTATGGATATCACTGCCACCTTC 203 507 774 Antisense
TCTGGTTCGGATGGCGTATTCGCAC 101 607 841 Antisense
AGCTCAGCTCATAAAACTACCTCGG 664 79 919 Antisense
AACTACCTCGGACACTCTGGAAGTT 612 135 933 Antisense
GGAAGATCCAATGGACTCGGTCCAG 102 531 1009 Antisense
GTTATTGCTGGAAACTCGTCTCTTC 566 447 1033 Antisense
TGCCCGCCACCAAGTGAATCAACGA 183 585 1069 Antisense
GACATTTGGTCATCACTCCGAATGC 216 369 1099 Antisense
TACAGTGTTGGACCCATCGGAGGCC 651 641 1143 Antisense
GTGCTCACTGCACAGCTCAAGAATC 65 481 1222 Antisense
Sequence Source Affymetrix Proprietary Database