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[192785_at] potassium channel protein

Description C24A3.6 /REP_DB=WormBase Gene ID /WP=CE24811 /GEN=twk-2 /TR=Q18120 /GB=AAA81456.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=potassium channel protein
Cluster 6grp_highest_10_10 > 52      6grp_high1_10_10 > 35      4grp_high_8_8 > 50      6grp_highest_nonorm > 10      6grp_total > 25      4grp_total > 53      6grp_highest_sub > 01_02      6grp_cgc > 33      6grp_high1_sub > 02      6grp_cgc_sub > De      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2075
1 2 3 4 range
A 1931.8
(3)
P 		807.9
(-0.7)
P 		970.8
(-0.2)
P 		107.9
(-3)
A 		1824
B 1206
(2)
P 		1434.4
(3)
P 		965.5
(0.9)
P 		98.3
(-3)
P 		1336
C 2172.9
(3)
P 		1522.4
(1.1)
P 		1311.9
(0.5)
P 		121.2
(-3)
P 		2052
avr 1770.2
(3) 		1254.9
(1.1) 		1082.7
(0.5) 		109.1
(-3) 		1661

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1287
1 2 3 4 5 6 range
A 1873.7
(3)
P 		1692.3
(2.1)
P 		1221.6
(-0.4)
P 		710.9
(-3)
P 		819.1
(-2.4)
P 		864.7
(-2.2)
P 		1163
B 1781.7
(2)
P 		1960.6
(3)
P 		1302.4
(-0.5)
P 		968
(-2.3)
P 		840.4
(-3)
P 		1202.8
(-1.1)
P 		1120
C 1555.9
(1)
P 		1992.3
(3)
P 		1080.8
(-1.3)
P 		826.6
(-2.4)
P 		705.5
(-3)
P 		1215.2
(-0.6)
P 		1287
avr 1737.1
(2.2) 		1881.7
(3) 		1201.6
(-0.7) 		835.2
(-2.7) 		788.3
(-3) 		1094.2
(-1.3) 		1093
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 704
1 2 3 4 range
A 703.4
(3)
P 		175.4
(-1.6)
P 		253.8
(-0.9)
P 		15.8
(-3)
A 		688
B 384.6
(3)
P 		354.3
(2.5)
P 		223.7
(0.3)
P 		20.9
(-3)
P 		364
C 719.3
(3)
P 		437.7
(0.6)
P 		457.3
(0.8)
P 		20.4
(-3)
P 		699
avr 602.4
(3) 		322.5
(0.1) 		311.6
(0) 		19
(-3) 		583

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 486
1 2 3 4 5 6 range
A 345.4
(-0.7)
P 		601.9
(3)
P 		266
(-1.8)
P 		180.3
(-3)
P 		247.2
(-2)
P 		210.5
(-2.6)
P 		422
B 619.9
(2.5)
P 		652.6
(3)
P 		316.3
(-2.1)
P 		256.4
(-3)
P 		341.5
(-1.7)
P 		448.5
(-0.1)
P 		396
C 576.7
(2.6)
P 		607.9
(3)
P 		275.1
(-1.5)
P 		166.2
(-3)
P 		228.3
(-2.2)
P 		406.8
(0.3)
P 		442
avr 514
(1.5) 		620.8
(3) 		285.8
(-1.8) 		201
(-3) 		272.3
(-2) 		355.3
(-0.8) 		420
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192785_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16951
Sequence Type Exemplar sequence
Representative Public ID C24A3.6 NCBI
Target Description C24A3.6 /REP_DB=WormBase Gene ID /WP=CE24811 /GEN=twk-2 /TR=Q18120 /GB=AAA81456.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=potassium channel protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077115(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077115 NCBI Caenorhabditis elegans TWiK family of potassium channels family member (twk-18) (twk-18) mRNA, complete cds. 11/11 A 
SNAP00000035244 ENSEMBL cdna:SNAP chromosome:CEL140:X:8988120:8991405:1 11/11 None
GENEFINDER00000035252 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:8988120:8991405:1 11/11 None
C24A3.6.2 ENSEMBL cdna:known chromosome:CEL140:X:8988072:8991582:1 gene:C24A3.6 11/11 None
C24A3.6.1 ENSEMBL cdna:known chromosome:CEL140:X:8988072:8991896:1 gene:C24A3.6 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:8988118-8991404(+) 100.0 100.0
Public Domain and Genome References
Gene Title potassium channel protein
Gene Symbol twk-18
Ensembl C24A3.6
Entrez Gene 181139 Entrez gene
SwissProt Q18120 EMBL-EBI
WormBase CE24811 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6813 potassium ion transport inferred from electronic annotation QuickGO AmiGO
6813 potassium ion transport inferred from direct assay QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5267 potassium channel activity inferred from electronic annotation QuickGO AmiGO
15271 outward rectifier potassium channel activity inferred from direct assay QuickGO AmiGO
15271 outward rectifier potassium channel activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA81456 Twik family of potassium channels protein 18 [Caenorhabditis elegans] ref|NP_509516.1| TWiK family of potassium channels family member (twk-18) [Caenorhabditis elegans] sp|Q18120|TWK18_CAEEL TWiK family of potassium channels protein 18 gb|AAC32861.1| potassium channel subunit n2P18 [Caenorhabditis elegans] 0.0
blast CAE57311 Hypothetical protein CBG00233 [Caenorhabditis briggsae] 0.0
Protein Domains
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509516.1 6 21-43,112-134,147-169,226-248,253-275,279-301
C24A3.6.2 6 21-43,112-134,147-169,226-248,253-275,279-301
C24A3.6.1 6 21-43,112-134,147-169,226-248,253-275,279-301
SNAP00000035244 6 21-43,112-134,147-169,226-248,253-275,279-301
GENEFINDER00000035252 6 21-43,112-134,147-169,226-248,253-275,279-301
Sequence
Target Sequence 
>C. ELEGANS:192785_AT
aacatctctctacttcacattgatttctttcacaaccatcggttttggagacattcttcc
atcggattacgatttcatgccaattgttggagttcttcttctcattggtctttctttggt
ctctacagtgatgacactcattcaacagcaaattgaagcattagcatcgggaatgaaaga
taacattgaccaagaatatgctcgtgcattgaacgaggctcgtgaagacggagaggttga
cgagcacgtagatccagaagaagatccggagaacaataaaaagtcctttgacgctgttat
ctccagaatgaactggtccaagagagggttgtattatcttcttcctgatagccagaagaa
agaactcgcaaagcagtctgagaagaaaatgggaagaaaaagtattaaaattcagactga
taacgatttgttggaaacactcattcgggaggaaattttgaaggcggagctcaacaatga
gatgcacaaatatacagcaccacgatcttcacaccagccaaaacttgtctattctgatgt
tcgcgagaaggaggttccaattgaagttgtccgtgttgagcatttca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AACATCTCTCTACTTCACATTGATT 114 139 774 Antisense
GGAGACATTCTTCCATCGGATTACG 470 519 820 Antisense
GCCAATTGTTGGAGTTCTTCTTCTC 581 277 852 Antisense
TTCTTCTCATTGGTCTTTCTTTGGT 201 691 869 Antisense
GTCTTTCTTTGGTCTCTACAGTGAT 323 469 881 Antisense
AAAGTCCTTTGACGCTGTTATCTCC 700 121 1053 Antisense
GAGGGTTGTATTATCTTCTTCCTGA 667 401 1097 Antisense
AATATACAGCACCACGATCTTCACA 657 173 1262 Antisense
TCTTCACACCAGCCAAAACTTGTCT 554 615 1279 Antisense
ACTTGTCTATTCTGATGTTCGCGAG 203 105 1296 Antisense
GAAGTTGTCCGTGTTGAGCATTTCA 508 335 1336 Antisense
Sequence Source Affymetrix Proprietary Database